G. Kleymann

发表

A Generally Applicable, High-Throughput Screening–Compatible Assay to Identify, Evaluate, and Optimize Antimicrobial Agents for Drug Therapy

G. Kleymann, H. Werling, 2004, Journal of biomolecular screening.

A single drug-resistance mutation in HSV-1 UL52 primase points to a difference between two helicase-primase inhibitors in their mode of interaction with the antiviral target.

H. Field, J. Aguirre-Hernández, L. Tiley, 2008, The Journal of antimicrobial chemotherapy.

Human beta 2-adrenergic receptor produced in stably transformed insect cells is functionally coupled via endogenous GTP-binding protein to adenylyl cyclase.

F. Boege, H. Reiländer, W. Hampe, 1993, European journal of biochemistry.

Identification and biological evaluation of thiazole-based inverse agonists of RORγt.

Michael Albers, J. Edwards, J. Spurlino, 2018, Bioorganic & medicinal chemistry letters.

Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt.

Michael Albers, J. Edwards, J. Spurlino, 2020, Bioorganic & medicinal chemistry letters.

Pochonins A-F, new antiviral and antiparasitic resorcylic acid lactones from Pochonia chlamydosporia var. catenulata.

Anke Mayer-Bartschmid, M. Stadler, V. Hellwig, 2003, Journal of natural products.

A Screening Assay Based on Host-Pathogen Interaction Models Identiﬁes a Set of Novel Antifungal Benzimidazole Derivatives (cid:1)

H. Eickhoff, K. Lemuth, S. Rupp, 2011 .

High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole as a highly antimycotic agent nontoxic to cell lines.

H. Eickhoff, G. Jung, S. Rupp, 2011, Journal of medicinal chemistry.

Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach.

Michael Albers, J. Edwards, M. Cummings, 2020, Bioorganic & medicinal chemistry letters.

Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation.

O. Kinzel, Thomas Hoffmann, S. Anderhub, 2020, ACS medicinal chemistry letters.

Agents and strategies in development for improved management of herpes simplex virus infection and disease

G. Kleymann, 2005, Expert opinion on investigational drugs.

A Screening Assay Based on Host-Pathogen Interaction Models Identifies a Set of Novel Antifungal Benzimidazole Derivatives

H. Eickhoff, K. Lemuth, S. Rupp, 2011, Antimicrobial Agents and Chemotherapy.

Efficacy of a helicase-primase inhibitor in animal models of ocular herpes simplex virus type 1 infection.

H. Thompson, B. Gebhardt, E. Varnell, 2008, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

Novel agents and strategies to treat herpes simplex virus infections

G. Kleymann, Gerald Kleymann, 2003, Expert opinion on investigational drugs.

New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease

J. Keldenich, U. Bach, K. Henninger, 2002, Nature Medicine.

Helicase Primase: Targeting the Achilles Heel of Herpes Simplex Viruses

G. Kleymann, 2004, Antiviral chemistry & chemotherapy.

Helicase primase inhibitors (HPIs) are efficacious for therapy of human herpes simplex virus (HSV) disease in an infection mouse model.

T. Grunwald, F. Lange, C. Gege, 2021, Antiviral research.

Potent In Vivo Antiviral Activity of the Herpes Simplex Virus Primase-Helicase Inhibitor BAY 57-1293

U. Betz, M. Hendrix, H. Rübsamen-Waigmann, 2002, Antimicrobial Agents and Chemotherapy.

Inhibitor BAY 57-1293 Herpes Simplex Virus Primase-Helicase Potent In Vivo Antiviral Activity of the

U. Betz, M. Hendrix, H. Rübsamen-Waigmann, 2002 .

Superior Efficacy of Helicase-Primase Inhibitor BAY 57–1293 for Herpes Infection and Latency in the Guinea Pig Model of Human Genital Herpes Disease

K. Henninger, G. Kleymann, H. Ruebsamen-Waigmann, 2007, Antiviral chemistry & chemotherapy.

A helicase-primase drug candidate with sufficient target tissue exposure affects latent neural herpes simplex virus infections

D. Bernstein, A. Burger-Kentischer, T. Grunwald, 2021, Science Translational Medicine.

Discovery, SAR and Medicinal Chemistry of Herpesvirus Helicase Primase Inhibitors

G. Kleymann, 2004 .

New antiviral drugs that target herpesvirus helicase primase enzymes.

G. Kleymann, 2003, Herpes : the journal of the IHMF.

Selective and synchronous activation of early-S-phase replicons of Ehrlich ascites cells

V. Gekeler, H. Probst, G. Kleymann, 1993, Molecular and cellular biology.

Selective andSynchronous Activation ofEarly-S-Phase Replicons ofEhrlich Ascites Cells

V. Gekeler, H. Probst, G. Kleymann, 1993 .

Immunoelectron microscopy and epitope mapping with monoclonal antibodies suggest the existence of an additional N-terminal transmembrane helix in the cytochrome b subunit of bacterial ubiquinol:cytochrome-c oxidoreductases.

H. Michel, S. Iwata, K. Wiesmüller, 1995, European journal of biochemistry.

Engineered Fv Fragments as a Tool for the One-Step Purification of Integral Multisubunit Membrane Protein Complexes

H. Michel, C. Ostermeier, B. Ludwig, 1995, Bio/Technology.

Method for identifying substances with antimicrobial action

G. Kleymann, H. Werling, 2002 .

Use of nanogold- and fluorescent-labeled antibody Fv fragments in immunocytochemistry.

H. Michel, C. Ostermeier, W. Haase, 1996, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Use of antibody fragments (Fv) in immunocytochemistry.

H. Michel, C. Ostermeier, W. Haase, 1995, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.