M. Bensellam

发表

Emerging Roles of Metallothioneins in Beta Cell Pathophysiology: Beyond and above Metal Homeostasis and Antioxidant Response

D. R. Laybutt, J. Jonas, M. Bensellam, 2021, Biology.

Glucose-induced O ( 2 ) consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic Beta-cells . "

J. Pouysségur, D. R. Laybutt, C. Magnan, 2019 .

Glucose-Induced O2 Consumption Activates Hypoxia Inducible Factors 1 and 2 in Rat Insulin-Secreting Pancreatic Beta-Cells

J. Pouysségur, D. R. Laybutt, C. Magnan, 2012, PloS one.

Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans

D. R. Laybutt, P. Gilon, H. Thomas, 2019, Diabetologia.

XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice

C. Ip, D. R. Laybutt, W. E. Hughes, 2022, Diabetologia.

Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia

A. Biankin, Jianmin Wu, A. Mawson, 2015, PloS one.

Inhibitor of differentiation proteins protect against oxidative stress by regulating the antioxidant–mitochondrial response in mouse beta cells

D. R. Laybutt, J. Chan, M. Montgomery, 2015, Diabetologia.

Aspalathin Protects Insulin-Producing β Cells Against Glucotoxicity and Oxidative Stress-Induced Cell Death.

L. Bouwens, C. Muller, J. Jonas, 2020, Molecular nutrition & food research.

Mesenchymal Stem Cells: A Very First Step Towards Large Scale Cell Culture Strategies

J. Wérenne, M. Bensellam, C. Bassens, 2005 .

NPY signalling in early osteoblasts controls glucose homeostasis

P. Baldock, H. Herzog, A. D. Nguyen, 2015, Molecular metabolism.

Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in β-Cell Gene Expression and Progression to Diabetes

D. R. Laybutt, T. Biden, J. Chan, 2013, Diabetes.

The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions

D. R. Laybutt, J. Jonas, M. Bensellam, 2012, Molecular and Cellular Endocrinology.

Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- and high-glucose concentrations

F. Schuit, L. Overbergh, J. Jonas, 2009, Diabetologia.

Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions.

D. R. Laybutt, J. Jonas, M. Bensellam, 2017, The Journal of endocrinology.

Physiological ER Stress: The Model of Insulin-Secreting Pancreatic b-Cells

P. Gilon, J. Jonas, M. Bensellam, 2012 .

Glucose regulation of islet stress responses and β‐cell failure in type 2 diabetes

Y. Guiot, J. Duprez, J. Jonas, 2009, Diabetes, obesity & metabolism.

Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells

D. R. Laybutt, J. Chan, J. Jonas, 2016, Diabetologia.

SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans

L. Ruiz, F. Reimann, F. Gribble, 2020, Molecular metabolism.

NADPH oxidase-2 does not contribute to β-cell glucotoxicity in cultured pancreatic islets from C57BL/6J mice

A. Carpinelli, J. Jonas, L. Roma, 2017, Molecular and Cellular Endocrinology.

Proof-of-concept for 2D/CT element analysis of entire cryofrozen islets of Langerhans using a cryoloop synchrotron X-ray fluorescence setup

L. Vincze, D. Brückner, J. Garrevoet, 2020 .

Prolonged culture of human pancreatic islets under glucotoxic conditions changes their acute beta cell calcium and insulin secretion glucose response curves from sigmoid to bell-shaped

P. Gilon, A. Wojtusciszyn, C. Broca, 2022, Diabetologia.

Pancreatic PYY Is Critical in the Control of Insulin Secretion and Glucose Homeostasis in Female Mice.

D. R. Laybutt, J. Lau, H. Herzog, 2015, Endocrinology.

The balance between adaptive and apoptotic unfolded protein responses regulates β-cell death under ER stress conditions through XBP1, CHOP and JNK

D. R. Laybutt, J. Chan, M. Bensellam, 2015, Molecular and Cellular Endocrinology.

Evidence against a role for NLRP3-driven islet inflammation in db/db mice

M. Febbraio, D. R. Laybutt, G. Lancaster, 2018, Molecular metabolism.

Phlda3 regulates beta cell survival during stress

M. Joglekar, A. Hardikar, D. R. Laybutt, 2019, Scientific Reports.

Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets

F. Schuit, Y. Guiot, J. Jonas, 2007, Diabetologia.

Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity

P. Timpson, C. Ip, D. R. Laybutt, 2021, Nature Communications.

Y1 receptor deficiency in β-cells leads to increased adiposity and impaired glucose metabolism

D. R. Laybutt, H. Herzog, Yanchuan Shi, 2018, Scientific Reports.

Transcriptome analysis of islets from diabetes‐resistant and diabetes‐prone obese mice reveals novel gene regulatory networks involved in beta‐cell compensation and failure

D. R. Laybutt, R. Lin, J. Chan, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Inhibition of Y1 receptor signaling improves islet transplant outcome

S. Grey, C. Ip, D. R. Laybutt, 2017, Nature Communications.

Hypoxia induces beta cell death by inhibiting the adaptive UPR.

D. R. Laybutt, J. Chan, J. Jonas, 2015 .

Y1 receptor deficiency in β-cells leads to increased adiposity and impaired glucose metabolism

D. R. Laybutt, H. Herzog, Yanchuan Shi, 2018, Scientific Reports.