T. P. Tang

发表

Discovery of 6-[5-(4-fluorophenyl)-3-methyl-pyrazol-4-yl]-benzoxazin-3-one derivatives as novel selective nonsteroidal mineralocorticoid receptor antagonists.

Atsushi Mizukami, Jun Fujimoto, Koji Fuji, 2014, Bioorganic & medicinal chemistry.

Asymmetric synthesis of protected 1,2-amino alcohols using tert-butanesulfinyl aldimines and ketimines.

S. Volkman, J. Ellman, T. P. Tang, 2001, The Journal of organic chemistry.

Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.

J. Blake, J. Christensen, B. Brandhuber, 2018, ACS medicinal chemistry letters.

The tert-Butanesulfinyl Group: An Ideal Chiral Directing Group and Boc-Surrogate for the Asymmetric Synthesis and Applications of β-Amino Acids.

J. Ellman, T. P. Tang, 1999 .

The tert-Butanesulfinyl Group: An Ideal Chiral Directing Group and Boc-Surrogate for the Asymmetric Synthesis and Applications of beta-Amino Acids.

J. Ellman, T. P. Tang, 1999, The Journal of organic chemistry.

Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer

J. Blake, J. Christensen, G. Vigers, 2020 .

Synthesis of Enantiomerically Pure N-tert-Butanesulfinyl Imines (tert-Butanesulfinimines) by the Direct Condensation of tert-Butanesulfinamide with Aldehydes and Ketones

J. Ellman, T. D. Owens, Guangcheng Liu, 1999 .

N-tert-butanesulfinyl imines: versatile intermediates for the asymmetric synthesis of amines.

J. Ellman, Jonathan A Ellman, Tony P Tang, 2002, Accounts of chemical research.

Development and application of a new general method for the asymmetric synthesis of syn- and anti-1,3-amino alcohols.

J. Ellman, Takuya Kochi, T. P. Tang, 2003, Journal of the American Chemical Society.

Asymmetric synthesis of syn- and anti-1,3-amino alcohols.

J. Ellman, Takuya Kochi, T. P. Tang, 2002, Journal of the American Chemical Society.

Identification of benzoxazin-3-one derivatives as novel, potent, and selective nonsteroidal mineralocorticoid receptor antagonists.

Hideki Matsui, Shoji Fukumoto, Midori Ono, 2011, Journal of medicinal chemistry.

Asymmetric synthesis of syn- and anti-1,3-amino alcohols.

J. Ellman, Takuya Kochi, T. P. Tang, 2002, Journal of the American Chemical Society.

Asymmetric synthesis of beta-amino acid derivatives incorporating a broad range of substitution patterns by enolate additions to tert-butanesulfinyl imines.

J. Ellman, T. P. Tang, 2002, The Journal of organic chemistry.

Asymmetric Synthesis of β‐Amino Acid Derivatives Incorporating a Broad Range of Substitution Patterns by Enolate Additions to tert‐Butanesulfinyl Imines.

J. Ellman, T. P. Tang, 2003 .

Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASG12D Inhibitor.

J. Blake, J. Christensen, J. Lawson, 2021, Journal of medicinal chemistry.

Design, synthesis, and structure-activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists.

Atsushi Mizukami, Hideki Matsui, Shoji Fukumoto, 2013, Bioorganic & medicinal chemistry.

Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system.

K. Scearce-Levie, M. Volgraf, G. Vigers, 2014, Journal of medicinal chemistry.

Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species.

G. Vigers, Xingrong Liu, Darin J. Smith, 2013, Journal of medicinal chemistry.

Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache.

Kirk W. Johnson, M. Blanco, D. Benesh, 2017, Bioorganic & medicinal chemistry letters.