J. Flinois

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Prediction of drug-induced liver injury in humans by using in vitro methods: the case of ximelagatran.

P. Beaune, D. Pessayre, T. Andersson, 2008, Toxicology in vitro : an international journal published in association with BIBRA.

Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol.

J P Perdrix, P. Beaune, J. Guitton, 1998, British journal of anaesthesia.

Cyclosporine‐Induced Endoplasmic Reticulum Stress Triggers Tubular Phenotypic Changes and Death

P. Beaune, N. Pallet, E. Thervet, 2008, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

A suicide gene therapy combining the improvement of cyclophosphamide tumor cytotoxicity and the development of an anti-tumor immune response.

P. Beaune, E. Tartour, I. de Waziers, 2014, Current gene therapy.

CYTOCHROME P 4502 C 9 IS THE PRINCIPAL CATALYST OF RACEMIC ACENOCOUMAROL HYDROXYLATION REACTIONS IN HUMAN LIVER MICROSOMES

H. Thijssen, P. Beaune, J. Flinois, 2000 .

Effects of the bacterial status of rats on the changes in some liver cytochrome P450 (EC 1.14.14.1) apoproteins consequent to a glucosinolate-rich diet

S. Lory, P. Beaune, S. Rabot, 1998, British Journal of Nutrition.

Hydrophobic chromatography: a one-step method for the purification of human liver microsomal epoxide hydrolase.

P. Beaune, T. Cresteil, J. Flinois, 1988, Journal of chromatography.

Induction of drug-metabolizing enzymes by tricyclic antidepressants in human liver: characterization and partial resolution of cytochromes P-450.

P. Beaune, T. Cresteil, P. Kremers, 1983, British journal of clinical pharmacology.

Enzymatic and immunological evidences that phenobarbital induces cytochrome P 450 in fetal and neonatal rat liver.

T. Cresteil, J. Flinois, J. Leroux, 1982, Biochemical and biophysical research communications.

Immunochemical characterization of some monooxygenase activities in liver microsomes from untreated and phenobarbital-treated rats.

P. Beaune, J. Flinois, J. Leroux, 1981, Biochemical and biophysical research communications.

Induction of cytochrome P-450 in rat liver by the antibiotic troleandomycin: partial purificaton and properties of cytochrome P-450-troleandomycin metabolite complexes.

P. Beaune, M. Delaforge, D. Mansuy, 1981, Biochemical and biophysical research communications.

Presence of proteins recognized by mammalian cytochrome P-450 antibodies in Euglena gracilis.

P. Beaune, I. de Waziers, J. Briand, 1993, Biochimica et biophysica acta.

Constitutive overexpression of immunoidentical forms of PCP-induced Euglena gracilis CYP-450.

P. Beaune, J. Flinois, J. Barque, 2002, Biochemical and biophysical research communications.

Evidence for the involvement of several cytochromes P-450 in the first steps of caffeine metabolism by human liver microsomes.

A. Guillouzo, F. Berthou, P. Beaune, 1991, Drug metabolism and disposition: the biological fate of chemicals.

Partial purification of human liver cytochrome P 450.

P. Beaune, D. Mansuy, P. Dansette, 1979, Biochemical and biophysical research communications.

Intralobular distribution and quantitation of cytochrome P‐450 enzymes in human liver as a function of age

P. Beaune, A. Guillouzo, F. Guengerich, 1991, Hepatology.

Purification of a new cytochrome P-450 from human liver microsomes.

P. Beaune, P. Kremers, J. Flinois, 1985, Biochimica et biophysica acta.

MONOOXYGENASE ACTIVITIES OF PARTIALLY PURIFIED CYTOCHROMES P-450 FROM HUMAN LIVER MICROSOMES

P. Beaune, P. Dansette, P. Kremers, 1980 .

Effect of microsomal preparations and induction on cytochrome P-450-dependent monooxygenases in fetal and neonatal rat liver.

T. Cresteil, J. Flinois, J. Leroux, 1979, Biochemical pharmacology.

changes and death endothelial cells: a role for endothelial phenotypic Cyclosporine triggers endoplasmic reticulum stress in

P. Beaune, E. Thervet, J. Gilleron, 2016 .

Cyclosporine triggers endoplasmic reticulum stress in endothelial cells: a role for endothelial phenotypic changes and death.

P. Beaune, N. Pallet, E. Thervet, 2009, American journal of physiology. Renal physiology.

Rapamycin inhibits human renal epithelial cell proliferation: effect on cyclin D3 mRNA expression and stability.

P. Beaune, P. Meria, B. Knebelmann, 2005, Kidney international.

Overexpression of glutamine synthetase in human primary liver cancer.

R. Gebhardt, L. Christa, C. Bréchot, 1994, Gastroenterology.

Hepatic cytochrome P450 and UDP-glucuronosyl transferase are affected by five sources of dietary fiber in germ-free rats.

P. Beaune, L. Nugon-Baudon, J. Flinois, 1996, The Journal of nutrition.

Tissue Accumulation of Lanthanum as Compared to Aluminum in Rats with Chronic Renal Failure – Possible Harmful Effects after Long-Term Exposure

M. Ziol, P. Beaune, B. Lacour, 2010, Nephron Experimental Nephrology.

Effects of various inducers on the expression of cytochromes P-450 IIC8, 9, 10 and IIIA in cultured adult human hepatocytes.

A. Guillouzo, F. Guengerich, F. Morel, 1990, Toxicology in vitro : an international journal published in association with BIBRA.

Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes.

P. Beaune, H. Thijssen, J P Flinois, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Optimization and validation of a label-free MRM method for the quantification of cytochrome P450 isoforms in biological samples

P. Beaune, Jean‐Pierre Le Caër, D. Touboul, 2014, Analytical and Bioanalytical Chemistry.

Halofantrine Metabolism in Microsomes in Man: Major Role of CYP 3A4 and CYP 3A5

R. Farinotti, L. Becquemont, V. Furlan, 1999, The Journal of pharmacy and pharmacology.

Expression of cytochrome P-450 enzymes in cultured human hepatocytes.

P. Beaune, A. Guillouzo, F. Guengerich, 1990, European journal of biochemistry.

In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation.

P. Beaune, R. Farinotti, A. Taburet, 2003, Drug metabolism and disposition: the biological fate of chemicals.

IN VITRO METABOLISM OF CHLOROQUINE : IDENTIFICATION OF CYP 2 C 8 , CYP 3 A 4 , AND CYP 2 D 6 AS THE MAIN ISOFORMS CATALYZING N-DESETHYLCHLOROQUINE FORMATION

P. Beaune, R. Farinotti, A. Taburet, 2003 .

The human colonic microflora influences the alterations of xenobiotic-metabolizing enzymes by catechins in male F344 rats.

J. Magdalou, C. Brézillon, E. Lhoste, 2003, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Pregnenolone-7β-hydroxylating activity of human cytochrome P450-1A1

P. Beaune, J. Flinois, R. Morfin, 1997, The Journal of Steroid Biochemistry and Molecular Biology.

Genetic polymorphisms of CES2 and their functional consequences.

P. Beaune, P. Laurent-Puig, S. Gad, 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide.

P. Beaune, A. Boddy, J. Idle, 1994, Biochemical pharmacology.

Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function

M. Loriot, P. Beaune, C. Duyckaerts, 2009, Drug Metabolism and Disposition.

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M. Loriot, P. Beaune, C. Duyckaerts, 2009 .

Human cytochromes P450 expressed in Escherichia coli: production of specific antibodies.

P. Beaune, I. de Waziers, J. Gautier, 1996, Toxicology.

In vitro metabolism of quinidine: the (3S)-3-hydroxylation of quinidine is a specific marker reaction for cytochrome P-4503A4 activity in human liver microsomes.

P. Beaune, K. Brøsen, J. Flinois, 1999, The Journal of pharmacology and experimental therapeutics.

The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways.

P. Beaune, K. Brøsen, J. Flinois, 1996, The Journal of pharmacology and experimental therapeutics.

Metabolism rate of oxodipine in rats and humans: comparison of in vivo and in vitro data.

P. Beaune, I. de Waziers, J. Flinois, 1992, The Journal of pharmacology and experimental therapeutics.

Improvement of Cyclophosphamide Activation by CYP2B6 Mutants: From in Silico to ex Vivo

Laurent Corcos, François André, Marcel Delaforge, 2008, Molecular Pharmacology.

Influence of ethanol and benzene on cytochrome P-450 fractions in rat liver microsomes.

P. Beaune, J. Flinois, J. Leroux, 1983, Drug Metabolism And Disposition.

Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function

M. Loriot, P. Beaune, C. Duyckaerts, 2009, Drug Metabolism and Disposition.

Cyclosporine‐Induced Endoplasmic Reticulum Stress Triggers Tubular Phenotypic Changes and Death

P. Beaune, N. Pallet, E. Thervet, 2008, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.