A. D. Borthwick

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2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 2. Synthesis, chirality, and pharmacokinetics.

P. Woollard, P. Wyatt, F. Nerozzi, 2005, Journal of medicinal chemistry.

2,5-Diketopiperazines as potent and selective oxytocin antagonists 1: Identification, stereochemistry and initial SAR.

P. Wyatt, F. Nerozzi, A. Szardenings, 2005, Bioorganic & Medicinal Chemistry Letters.

Oxytocin Antagonists and Agonists

A. D. Borthwick, 2006 .

Retosiban and Epelsiban: Potent and Selective Orally Available Oxytocin Antagonists

J. Liddle, A. D. Borthwick, 2013 .

Use of a novel and highly selective oxytocin receptor antagonist to characterize uterine contractions in the rat.

P. Woollard, D. Brooks, J. Liddle, 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

Pyrrolidine-5,5-trans-lactams as novel mechanism-based inhibitors of human cytomegalovirus protease. Part 3: potency and plasma stability.

T. Haley, A. Mason, A. D. Borthwick, 2002, Bioorganic & medicinal chemistry letters.

Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 1. The alpha-methyl-trans-lactam template.

G. Hart, T. Haley, A. Pennell, 2000, Journal of medicinal chemistry.

Design and synthesis of pyrrolidine-5,5'-trans-lactams (5-oxo-hexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 4. Antiviral activity and plasma stability.

James M. Woolven, P. Ertl, N. Parry, 2003, Journal of medicinal chemistry.

2,5-diketopiperazines in food and beverages: Taste and bioactivity

A. D. Borthwick, N. C. Da Costa, 2017, Critical reviews in food science and nutrition.

2,5-Diketopiperazines: synthesis, reactions, medicinal chemistry, and bioactive natural products.

A. D. Borthwick, 2012, Chemical reviews.

Pyridyl-2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists: synthesis, pharmacokinetics, and in vivo potency.

I. E. Smith, P. Woollard, J. Liddle, 2006, Journal of medicinal chemistry.

Synthesis of Chiral Carbocyclic Nucleosides

A. D. Borthwick, K. Biggadike, 1992 .

Oral oxytocin antagonists.

A. D. Borthwick, 2010, Journal of Medicinal Chemistry.

Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs.

Stefan Senger, Matthew Campbell, Savvas Kleanthous, 2010, Bioorganic & medicinal chemistry letters.

Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs.

Stefan Senger, Matthew Campbell, Savvas Kleanthous, 2008, Bioorganic & medicinal chemistry letters.

Structure- and property-based design of factor Xa inhibitors: pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs.

Stefan Senger, Matthew Campbell, Savvas Kleanthous, 2006, Bioorganic & medicinal chemistry letters.

Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxohexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 2. Potency and chirality.

Peter Ertl, James M. Woolven, P. Ertl, 2002, Journal of medicinal chemistry.

Design and synthesis of monocyclic beta-lactams as mechanism-based inhibitors of human cytomegalovirus protease.

J. Bédard, T. Mansour, H. Jin, 1998, Bioorganic & medicinal chemistry letters.

Chapter 15. Antiviral Agents

P. Wyatt, R. Boehme, A. D. Borthwick, 1994 .

Design of translactam HCMV protease inhibitors as potent antivirals

A. D. Borthwick, 2005, Medicinal research reviews.

Design and Synthesis of Monocyclic β‐Lactams as Mechanism‐Based Inhibitors of Human Cytomegalovirus Protease.

J. Bédard, T. Mansour, H. Jin, 1998 .

1,5 Allylic abstraction, cyclisation: A new route to five membered carbocycles

S. Caddick, P. Parsons, A. D. Borthwick, 1990 .

An efficient synthesis of a chiral carbocyclic 2′-deoxyribonucleoside synthon by directed reduction

A. D. Borthwick, A. M. Exall, G. Weingarten, 1994 .

Approaches to bicyclic ring systems via 1,5 allylic abstraction cyclisation

S. Caddick, P. Parsons, A. D. Borthwick, 1992 .

Fluorocarbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluorocarbocyclic 2'-deoxy guanosines.

S. Roberts, J. Coates, D. Ryan, 1991, Journal of medicinal chemistry.

3'-deoxy-3'-fluoro-xylo-neplanocin A

A. D. Borthwick, K. Biggadike, 1992 .

4′-Modification of carbocyclic nucleosides: synthesis of 4′-α-fluoro, 4′α-hydroxy and 4′,6′-unsaturated derivatives of the antiviral agent 2′-ara-fluoro carbocyclic guanosine

A. D. Borthwick, K. Biggadike, 1990 .

Enantiospecific synthesis of the potent anti-herpetic carbocyclic 9-(2′deoxy-2′-flouro-β-D-arabinofuranosyl) guanine (+)CAFG from arsiteromycin

A. D. Borthwick, K. Biggadike, C. Mo, 1990 .

Fluoro carbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluoro carbocyclic pyrimidine nucleosides including carbocyclic 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-methyluracil and carbocyclic 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil.

S. Roberts, J. Coates, B. E. Kirk, 1990, Journal of medicinal chemistry.

Synthesis and enzymatic resolution of carbocyclic 2′-ara-fluoro-guanosine: a potent new anti-herpetic agent

J. Cameron, S. Roberts, B. E. Kirk, 1988 .

Use of diethylaminosulphur trifluoride (DAST) in the preparation of synthons of carbocyclic nucleosides

S. Roberts, B. E. Kirk, A. D. Borthwick, 1988 .

Synthesis and Enzymatic Resolution of Carbocyclic 2′-Ara-fluoroguanosine (I): A Potent New Anti-Herpetic Agent.

J. Cameron, S. Roberts, B. E. Kirk, 1988 .

Short convergent route to chiral pyrimidine analogues of 2′-deoxy neplanocin A

A. D. Borthwick, A. M. Exall, K. Biggadike, 1990 .

Use of Diethylaminosulfur Trifluoride (DAST) in the Preparation of Synthons of Carbocyclic Nucleosides.

S. Roberts, B. E. Kirk, A. D. Borthwick, 1988 .

Synthesis of fluorinated carbocyclic nucleosides: preparation of (±)-carbocyclic-FMAU and some congeners

A. Slawin, B. E. Kirk, A. D. Borthwick, 1987 .

Short convergent route to homochiral carbocyclic-2′-deoxynucleosides and carbocyclic ribonucleosides

S. Roberts, B. E. Kirk, A. D. Borthwick, 1987 .

Synthesis of fluorinated carbocyclic nucleosides: preparation of carbocyclic 1-(2′-deoxy-6′-fluororibofuranosyl)-5-iodouracils

A. Slawin, S. Roberts, B. E. Kirk, 1987 .

Short Convergent Route to Chiral Pyrimidine Analogues of 2′-Deoxy Neplanocin A.

A. D. Borthwick, A. M. Exall, K. Biggadike, 1990 .

A short, convergent synthesis of two chiral antiviral agents, (+) carbocyclic 2′-deoxy-5-[(E)-2-bromovinyl] uridine and (+) carbocyclic 2′-deoxyGuanosine

A. D. Borthwick, A. M. Exall, G. Weingarten, 1995 .

Stereoselective synthesis of gem-dimethyl-5,5-pyrrolidine-trans-lactam (5-oxo-hexahydropyrrolo[3,2-b]pyrrole)

A. Pennell, A. D. Borthwick, D. E. Davies, 2001 .

An improved synthesis of the strained pyrrolidine-5,5-translactam ring system

A. Pennell, A. Mason, A. D. Borthwick, 1999 .

A Short, Convergent Synthesis of Two Chiral Antiviral Agents, (+)- Carbocyclic 2′-Deoxy-5-((E)-2-Bromovinyl) Uridine and (+)-Carbocyclic 2′-Deoxyguanosine.

A. D. Borthwick, A. M. Exall, G. Weingarten, 1996 .

Synthesis of Fluorinated Carbocyclic Nucleosides: Preparation of (.+-.)-Carbocyclic-FMAU and Some Congeners.

A. Slawin, S. Roberts, B. E. Kirk, 1987 .

Chiral carbocylic nucleosides: The synthesis and antiviral activity of 4′-hydroxy and 4′-fluorocarbocyclic - 2′- deoxyguanosines

J. Coates, I. L. Paternoster, A. D. Borthwick, 1993 .

Short Convergent Route to Homochiral Carbocyclic 2′-Deoxynucleosides and Carbocyclic Ribonucleosides.

S. Roberts, B. E. Kirk, A. D. Borthwick, 1988 .

Synthesis of Fluorinated Carbocyclic Nucleosides: Preparation of Carbocyclic 1-(2′-Deoxy-6′-fluororibofuranosyl)-5-iodouracils.

A. Slawin, S. Roberts, B. E. Kirk, 1987 .

The design of orally bioavailable 2, 5‐diketopiperazine oxytocin antagonists: from concept to clinical candidate for premature labor

J. Liddle, A. D. Borthwick, 2011, Medicinal research reviews.

The chemistry of fungi. Part LXV. The structures of ergochrysin A, isoergochrysin A, and ergoxanthin, and of secalonic acids A, B, C, and D

W. Whalley, J. Hooper, A. D. Borthwick, 1971 .

Recent advances in the design of RAR α and RAR β agonists as orally bioavailable drugs. A review

J. Corcoran, A. D. Borthwick, M. B. Goncalves, 2020, Bioorganic & medicinal chemistry.

Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist

David R Adams, J. Corcoran, S. Kalindjian, 2017, Bioorganic & medicinal chemistry.

Synthesis of Benzodioxinopyrroles as selective α2-adrenoceptor antagonists

P. Procopiou, P. C. Cherry, A. Pipe, 1995 .

The discovery of GSK221149A: a potent and selective oxytocin antagonist.

Michael J Allen, John Liddle, Fabrizio Nerozzi, 2008, Bioorganic & medicinal chemistry letters.

Stereochemical Aspects of the anti-HCMV Activity of Cytidine Nucleoside Analogues

J. Gillard, T. Mansour, J. Coates, 1995 .

2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 3. Synthesis, pharmacokinetics, and in vivo potency.

P. Woollard, F. Nerozzi, K. Valko, 2006, Journal of medicinal chemistry.