J. Nilson

发表

The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis.

W. Shen, H. Ingraham, M. Nachtigal, 1994, Genes & development.

Maximal Expression of Foxl2 in Pituitary Gonadotropes Requires Ovarian Hormones

M. Herndon, J. Nilson, Maria K. Herndon, 2015, PloS one.

Cold-Shock-Domain Protein A (CSDA) Contributes Posttranscriptionally to Gonadotropin-Releasing Hormone-Regulated Expression of Egr1 and Indirectly to Lhb1

M. Herndon, J. Nilson, Theodore R. Chauvin, 2012, Biology of reproduction.

GnRH-regulated expression of Jun and JUN target genes in gonadotropes requires a functional interaction between TCF/LEF family members and beta-catenin.

J. Grammer, J. Nilson, Travis B. Salisbury, 2009, Molecular endocrinology.

Welcoming beta-catenin to the gonadotropin-releasing hormone transcriptional network in gonadotropes.

J. Nilson, Travis B. Salisbury, April K. Binder, 2008, Molecular endocrinology.

Maximal activity of the luteinizing hormone β-subunit gene requires β-catenin

J. Grammer, J. Nilson, Travis B. Salisbury, 2007 .

Characterization and nucleotide sequence of the gene for the common alpha subunit of the bovine pituitary glycoprotein hormones.

C. Moncman, F. Rottman, R. Goodwin, 1983, Nucleic Acids Research.

Conditional Deletion of Beta-Catenin Mediated by Amhr2cre in Mice Causes Female Infertility1

M. Hunzicker-Dunn, J. H. Hernandez Gifford, J. Nilson, 2009, Biology of reproduction.

The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus.

K. Parker, Y. Ikeda, X. Luo, 1995, Molecular endocrinology.

Follicle-stimulating hormone/cAMP regulation of aromatase gene expression requires β-catenin

J. Weck, M. Hunzicker-Dunn, A. Zeleznik, 2006, Proceedings of the National Academy of Sciences.

In vitro expression of the diphtheria toxin A-chain gene under the control of human chorionic gonadotropin gene promoters as a means of directing toxicity to ovarian cancer cell lines.

I. Maxwell, L. M. Glodé, W. Lee, 1997, American journal of obstetrics and gynecology.

Nucleotide sequence of bovine prolactin messenger RNA. Evidence for sequence polymorphism.

F. Rottman, S. Horowitz, J. Nilson, 1982, The Journal of biological chemistry.

Molecular cloning of gene sequences for avian fatty acid synthase and evidence for nutritional regulation of fatty acid synthase mRNA concentration.

R. A. Jenik, A. Goodridge, S. Morris, 1982, The Journal of biological chemistry.

Targeted overexpression of luteinizing hormone causes ovary-dependent functional adenomas restricted to cells of the Pit-1 lineage.

J. Lewin, H. Mohammad, A. Parlow, 2003, Endocrinology.

Transgenic mice with chronically elevated luteinizing hormone are infertile due to anovulation, defects in uterine receptivity, and midgestation pregnancy failure.

R. Keri, J. Nilson, R. J. Mann, 1999, Endocrinology.

Transcriptional repression of the alpha-subunit gene by androgen receptor occurs independently of DNA binding but requires the DNA-binding and ligand-binding domains of the receptor.

E. Wilson, L. Heckert, J. Nilson, 1997, Molecular endocrinology.

AR suppresses transcription of the alpha glycoprotein hormone subunit gene through protein-protein interactions with cJun and activation transcription factor 2.

J. Jorgensen, J. Nilson, 2001, Molecular endocrinology.

GnRH regulation of Jun and Atf3 requires calcium, calcineurin, and NFAT.

J. D. Stanton, M. Herndon, J. Grammer, 2012, Molecular endocrinology.

Reexpression of p8 contributes to tumorigenic properties of pituitary cells and appears in a subset of prolactinomas in transgenic mice that hypersecrete luteinizing hormone.

D. Seachrist, H. Mohammad, C. Quirk, 2004, Molecular endocrinology.

The transcriptional response of the human chorionic gonadotropin beta-subunit gene to cAMP is cycloheximide sensitive and is mediated by cis-acting sequences different from that found in the alpha-subunit gene.

W. Miller, R. Fenstermaker, A. Milsted, 1989, Molecular endocrinology.

Endocrine Regulation of Glycoprotein Hormone Alpha Subunit Gene Expression in Transgenic Mice

R. Keri, C. Clay, D. Hamernik, 1994 .

Different combinations of regulatory elements may account for expression of the glycoprotein hormone alpha-subunit gene in primate and horse placenta.

C. Clay, D. Hamernik, R. Fenstermaker, 1990, Molecular endocrinology.

Different combinations of regulatory elements may explain why placenta-specific expression of the glycoprotein hormone alpha-subunit gene occurs only in primates and horses.

R. Keri, C. Clay, D. Hamernik, 1991, Biology of reproduction.

Cyclic AMP regulation of the human glycoprotein hormone alpha-subunit gene is mediated by an 18-base-pair element.

E. Vallen, J. Bokar, A. Milsted, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Estradiol inhibits transcription of the human glycoprotein hormone alpha-subunit gene despite the absence of a high affinity binding site for estrogen receptor.

R. Keri, C. Clay, D. Hamernik, 1991, Molecular endocrinology.

Targeted ablation of pituitary gonadotropes in transgenic mice.

L. Jin, R. Lloyd, S. Camper, 1991, Molecular endocrinology.

Estradiol Inhibition of Expression of the Human Glycoprotein Hormone α-Subunit Gene Through an ERE-Independent Mechanism

R. Keri, D. Hamernik, B. Andersen, 1992 .

In vitro effects of thyroid-stimulating hormone on total and polysomal ribonucleic acid synthesis in monolayer cultures of sheep thyroid cells.

D. Orlicky, J. Nilson, P. Kerkof, 1980, Endocrinology.

Characterization of the cAMP responsive elements from the genes for the alpha-subunit of glycoprotein hormones and phosphoenolpyruvate carboxykinase (GTP). Conserved features of nuclear protein binding between tissues and species.

W. Roesler, R. Hanson, D. Kaetzel, 1988, The Journal of biological chemistry.

The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus.

K. Parker, Y. Ikeda, R. Abbud, 1995, Molecular endocrinology.

Measurement of messenger ribonucleic acid for luteinizing hormone beta-subunit, alpha-subunit, growth hormone, and prolactin after hypothalamic pituitary disconnection in ovariectomized ewes.

D. Hamernik, T. Nett, M. E. Crowder, 1986, Endocrinology.

and a-Subunit during Gestation and the Postpartum Period in Ewes'

M. Wise, M. Nejedlík, J. Nilson, 1985 .

Effects of estradiol-17ß administration on steady-state messenger ribonucleic acid (MRNA) encoding equine α and LH/CGß subunits in pituitaries of ovariectomized pony mares

M. Wolfe, D. Sharp, J. Nilson, 2001 .

Chronically elevated luteinizing hormone depletes primordial follicles in the mouse ovary.

J. Flaws, A. Hirshfield, R. Abbud, 1997, Biology of reproduction.

High levels of luteinizing hormone analog stimulate gonadal and adrenal tumorigenesis in mice transgenic for the mouse inhibin-α-subunit promoter/Simian virus 40 T-antigen fusion gene

M. Poutanen, R. Keri, I. Huhtaniemi, 2003, Oncogene.

LH Hypersecreting Mice: A Model for Ovarian Granulosa Cell Tumors

R. Keri, G. Owens, J. Nilson, 2001 .

Luteinizing hormone induction of ovarian tumors: oligogenic differences between mouse strains dictates tumor disposition.

J. Nadeau, F. Abdul-Karim, K. Lozada, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Experimental evidence that changes in oocyte growth influence meiotic chromosome segregation.

C. Hodges, P. Hunt, D. Jennings, 2002, Human reproduction.

Expression of alpha subunit and luteinizing hormone beta genes in the ovine anterior pituitary. Estradiol suppresses accumulation of mRNAS for both alpha subunit and luteinizing hormone beta.

T. Nett, M. E. Crowder, J. Virgin, 1983, The Journal of biological chemistry.

Formation of cystic ovarian follicles associated with elevated luteinizing hormone requires estrogen receptor-beta.

K. Korach, J. F. Couse, A. Nyska, 2004, Endocrinology.

A single gene encodes the beta-subunits of equine luteinizing hormone and chorionic gonadotropin.

C. Clay, M. Wolfe, D. Threadgill, 1992, Molecular endocrinology.

Disruption of N-linked glycosylation of bovine luteinizing hormone beta-subunit by site-directed mutagenesis dramatically increases its intracellular stability but does not affect biological activity of the secreted heterodimer.

C. Clay, D. Kaetzel, J. Virgin, 1989, Molecular endocrinology.

Site-Directed Mutagenesis of the Human Chorionic Gonadotropin β-Subunit: Bioactivity of a Heterologous Hormone, Bovine α-Human des-(122–145)β

D. Kaetzel, D. Puett, J. Nilson, 1989 .

Expression of the genes encoding bovine LH in a line of Chinese hamster ovary cells.

D. Kaetzel, J. Nilson, 2019, Journal of reproduction and fertility. Supplement.

The common α subunit of bovine glycoprotein hormones: Limited formation of native structure by the totally nonglycosylated polypeptide chain

J. Pierce, A. Thomason, T. Strickland, 1985, Journal of cellular biochemistry.

Cyclic AMP regulates transcription of the genes encoding human chorionic gonadotropin with different kinetics.

A. Milsted, R. Cox, J. Nilson, 1987, DNA.

The sialylated oligosaccharides of recombinant bovine lutropin modulate hormone bioactivity.

D. Kaetzel, J. Baenziger, P. Smith, 1990, The Journal of biological chemistry.

Coordinate regulation of the messenger ribonucleic acids encoding the α- and β-subunits of human chorionic gonadotropin in HeLa cells and butyrate-resistant variants

A. Milsted, R. Cox, B. Silver, 1985 .

Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors.

T. Wagner, C. Clay, T. Nett, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Expression by Transgenic Mouse Placenta of a Human Placental Hormone, the β-Subunit of Human Chorionic Gonadotropin

I. Boime, J. Nilson, B. L. Strauss, 1993 .

Cyclic AMP and phorbol esters interact synergistically to regulate expression of the chorionic gonadotropin genes.

A. Milsted, B. Andersen, J. Nilson, 1988, The Journal of biological chemistry.

Elevated luteinizing hormone in prepubertal transgenic mice causes hyperandrogenemia, precocious puberty, and substantial ovarian pathology.

K. Risma, A. Hirshfield, J. Nilson, 1997, Endocrinology.

Characterization of the equine glycoprotein hormone alpha-subunit gene reveals divergence in the mechanism of pituitary and placental expression.

P. Budworth, R. Keri, C. Clay, 1997, Biology of reproduction.

Expression of the beta subunit of chorionic gonadotropin in transgenic mice.

I. Boime, J. Nilson, M. Pixley, 1994, The Journal of biological chemistry.

The gene for the beta subunit of bovine luteinizing hormone encodes a gonadotropin mRNA with an unusually short 5'-untranslated region.

A. Thomason, J. Virgin, B. Silver, 1985, The Journal of biological chemistry.

Elevated luteinizing hormone induces expression of its receptor and promotes steroidogenesis in the adrenal cortex.

M. Poutanen, R. Keri, I. Huhtaniemi, 2000, The Journal of clinical investigation.

A Steroidogenic Factor-1 Binding Site Is Required for Activity of the Luteinizing Hormone Subunit Promoter in Gonadotropes of Transgenic Mice (*)

R. Keri, J. Nilson, 1996, The Journal of Biological Chemistry.

Multiple and overlapping combinatorial codes orchestrate hormonal responsiveness and dictate cell-specific expression of the genes encoding luteinizing hormone.

J. Jorgensen, C. Quirk, J. Nilson, 2004, Endocrine reviews.

Immortalization of equine trophoblast cell lines of chorionic girdle cell lineage by simian virus-40 large T antigen.

D. K. Reed, D. Antczak, R. Eckert, 2001, The Journal of endocrinology.

AR suppresses transcription of the LHbeta subunit by interacting with steroidogenic factor-1.

J. Jorgensen, J. Nilson, 2001, Molecular endocrinology.

Use of oligodeoxynucleotide primers to determine poly(adenylic acid) adjacent sequences in messenger ribonucleic acid. 3'-Terminal noncoding sequence of bovine growth hormone messenger ribonucleic acid.

F. Rottman, C. Astell, S. Gillam, 1980, Biochemistry.

The α-Subunit of the Glycoprotein Hormones: Evolution of a Combinatorial Code for Placenta-Specific Expression

J. Nilson, R. Pittman, 1993 .

Obesity in transgenic female mice with constitutively elevated luteinizing hormone secretion.

M. Koulu, U. Pesonen, M. Poutanen, 2003, American journal of physiology. Endocrinology and metabolism.

Different Composite Regulatory Elements Direct Expression of the Human α Subunit Gene to Pituitary and Placenta (*)

L. Heckert, J. Nilson, K. Schultz, 1995, The Journal of Biological Chemistry.

Functional analysis of the placenta-specific enhancer of the human glycoprotein hormone alpha subunit gene. Emergence of a new element.

C. Clay, T. A. Farmerie, J. Nilson, 1994, The Journal of biological chemistry.

Expression profiling analyses of gonadotropin responses and tumor development in the absence of inhibins.

K. Burns, M. Matzuk, G. Owens, 2003, Endocrinology.

Consequences of elevated luteinizing hormone on diverse physiological systems: use of the LHbetaCTP transgenic mouse as a model of ovarian hyperstimulation-induced pathophysiology.

R. Keri, J. Nilson, R. J. Mann, 2003, Recent progress in hormone research.

Ovulatory surges of human CG prevent hormone-induced granulosa cell tumor formation leading to the identification of tumor-associated changes in the transcriptome.

R. Keri, G. Owens, J. Nilson, 2002, Molecular endocrinology.

Transcriptional repression of the glycoprotein hormone alpha subunit gene by androgen may involve direct binding of androgen receptor to the proximal promoter.

F. S. French, E. Wilson, R. Keri, 1993, The Journal of biological chemistry.

Activin Induces x-Zone Apoptosis That Inhibits Luteinizing Hormone-Dependent Adrenocortical Tumor Formation in Inhibin-Deficient Mice

F. Beuschlein, G. Hammer, A. Parlow, 2003, Molecular and Cellular Biology.

Intracellular Calcium Signaling Is Required for GnRH Mediated Regulation of T-Cell Factor Dependent Transcription in Gonadotropes.

J. Grammer, J. Nilson, Travis B. Salisbury, 2009 .

13 – RECOMBINANT PROTEIN EXPRESSION IN TRANSGENIC MICE

R. Abbud, J. Nilson, 1999 .

A single Pitx1 binding site is essential for activity of the LHbeta promoter in transgenic mice.

K. Lozada, R. Keri, C. Quirk, 2001, Molecular endocrinology.

Chapter 2 – Control of Hormone Gene Expression

C. Quirk, M. Herndon, J. Nilson, 2016 .

The cAMP Response Elements of the α Subunit Gene Bind Similar Proteins in Trophoblasts and Gonadotropes but Have Distinct Functional Sequence Requirements*

L. Heckert, J. Nilson, K. Schultz, 1996, The Journal of Biological Chemistry.

Molecular Mechanisms Underlying Placenta- and Pituitary-Specific Expression of the Glycoprotein Hormone α-Subunit Gene

J. Nilson, 1993 .

Amplification of the transcriptional signal mediated by the tandem cAMP response elements of the glycoprotein hormone alpha-subunit gene occurs through several distinct mechanisms.

D. Hamernik, J. Bokar, R. Bohinski, 1990, Molecular endocrinology.

Expression of the glycoprotein hormone alpha-subunit gene in the placenta requires a functional cyclic AMP response element, whereas a different cis-acting element mediates pituitary-specific expression

R. Keri, T. Wagner, D. Hamernik, 1989, Molecular and cellular biology.

CRE‐Binding Proteins Interact Cooperatively to Enhance Placental‐Specific Expression of the Glycoprotein Hormone Alpha‐Subunit Gene a

R. Keri, R. Fenstermaker, J. Bokar, 1989, Annals of the New York Academy of Sciences.

Maximal activity of the luteinizing hormone beta-subunit gene requires beta-catenin.

J. Grammer, J. Nilson, Travis B. Salisbury, 2007, Molecular endocrinology.

Embryonic Expression of the Luteinizing Hormone β Gene Appears to Be Coupled to the Transient Appearance of p8, a High Mobility Group-related Transcription Factor*

D. Seachrist, C. Quirk, J. Nilson, 2003, The Journal of Biological Chemistry.

Ontogeny of pituitary hormone mRNAs in the bovine fetus. Quantitation of pre-prolactin mRNA as a function of gestation.

F. Rottman, K. Barringer, E. Convey, 1980, The Journal of biological chemistry.

Construction and characterization of a cDNA clone containing a portion of the bovine prolactin sequence.

J. Blenis, W. Salser, F. Rottman, 1980, Nucleic acids research.

Purification of pre-prolactin mRNA from bovine anterior pituitary glands.

F. Rottman, E. Convey, J. Nilson, 1979, The Journal of biological chemistry.

Developmental expression of growth hormone and prolactin genes in the bovine pituitary.

S. Camper, F. Rottman, J. Virgin, 1983, The Journal of biological chemistry.

Multiple characteristics of a pentameric regulatory array endow the human alpha-subunit glycoprotein hormone promoter with trophoblast specificity and maximal activity.

P. Budworth, P. G. Quinn, J. Nilson, 1997, Molecular endocrinology.

The human alpha subunit glycoprotein hormone gene utilizes a unique CCAAT binding factor.

J H Nilson, B. Andersen, G C Kennedy, 1990, The Journal of biological chemistry.

An NF-Y Binding Site Is Important for Basal, but Not Gonadotropin-releasing Hormone-stimulated, Expression of the Luteinizing Hormone β Subunit Gene*

R. Keri, C. Quirk, J. Nilson, 2000, The Journal of Biological Chemistry.

Measurement of messenger RNA for luteinizing hormone beta-subunit and alpha-subunit during gestation and the postpartum period in ewes.

T. Nett, M. Wise, M. Nejedlík, 1985, Biology of reproduction.

Regulation of Luteinizing Hormone β and α Messenger Ribonucleic Acid by Estradiol or Gonadotropin-Releasing Hormone Following Pituitary Stalk Section in Ovariectomized Pony Mares1

M. Wolfe, M. Peltier, D. Sharp, 1995 .

Lhcgr expression in granulosa cells: roles for PKA-phosphorylated β-catenin, TCF3, and FOXO1.

J. Weck, M. Hunzicker-Dunn, J. Nilson, 2013, Molecular endocrinology.

Gonadotrope- and thyrotrope-specific expression of the human and bovine glycoprotein hormone alpha-subunit genes is regulated by distinct cis-acting elements.

R. Keri, C. Clay, D. Hamernik, 1992, Molecular Endocrinology.

Chronic hypersecretion of luteinizing hormone in transgenic mice selectively alters responsiveness of the alpha-subunit gene to gonadotropin-releasing hormone and estrogens.

T. Nett, R. Abbud, J. Nilson, 1999, Molecular endocrinology.

Characterization of Integrin Expression in the Mouse Ovary1

K. Burns, M. Matzuk, G. Owens, 2002, Biology of reproduction.

The society for the study of reproduction

M. Wiltbank, P. Hoyer, J. Gadsby, 1985, Steroids.

Transcriptional Repression of the α-Subunit Gene by Androgen Receptor Occurs Independently of DNA Binding but Requires the DNA-Binding and Ligand-Binding Domains of the Receptor

L. Heckert, J. Nilson, Elizabeth M. Wilson, 1997 .

Methotrexate-induced amplification of the bovine lutropin genes in Chinese hamster ovary cells. Relative concentration of the alpha and beta subunits determines the extent of heterodimer assembly.

D. Kaetzel, J. Nilson, 1988, The Journal of biological chemistry.

Expression of biologically active bovine luteinizing hormone in Chinese hamster ovary cells.

T. Nett, D. Kaetzel, A. Thomason, 1985, Proceedings of the National Academy of Sciences of the United States of America.