R. L. A. Vrueh

Targeting Hepatitis B Therapy to the Liver

T. J. Berkel, Patrick C. N. Reusen, R. L. A. Vrueh, 1996 .

Conjugation of Oligonucleotides with Steroid Structures and Their Interaction with the Low-Density Lipoprotein

T. J. Berkel, E. Biessen, E. T. Rump, 1997 .

Novel hepatotrophic prodrugs of the antiviral nucleoside 9‐(2‐phosphonylmethoxyethyl)adenine with improved pharmacokinetics and antiviral activity

A. Valentijn, J. H. Boom, P. J. Abrahams, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Modification of a Phosphorothioate Oligonucleotide with Cholesterol Induces Association of the Oligonucleotide to Serum Lipoproteins and Affects Its Biological Fate

P. D. Cook, M. Manoharan, T. J. Berkel, 1997 .

Selection of development candidates based on in vitro permeability measurements

Chao-pin Lee, Philip L. Smith, R. L. A. Vrueh, 1997 .

Lipophilic Derivatization of the Antiviral Drug 9-(2-Phosphonylmethoxyethyl)adenine and Its Incorporation into a Lactosylated Lipid Carrier to Improve Its Liver Uptake

T. J. Berkel, J. Balzarini, E. Biessen, 1997 .

Why R&D into Rare Diseases Matter

Remco L. A. de Vrueh, R. L. A. Vrueh, 2014 .

Safety-Related Regulatory Actions for Orphan Drugs in the US and EU

H. Leufkens, A. Mantel‐Teeuwisse, T. Giezen, 2010, Drug safety.

Recombinant lipoproteins: lipoprotein-like lipid particles for drug targeting.

T. V. van Berkel, J. Kuiper, T. V. Berkel, 2001, Advanced drug delivery reviews.

In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells.

P. D. Cook, M. Manoharan, T. V. van Berkel, 1997, Nucleic acids research.

Modulation of plasma protein binding and in vivo liver cell uptake of phosphorothioate oligodeoxynucleotides by cholesterol conjugation.

M. Manoharan, T. V. van Berkel, T. V. Berkel, 2000, Nucleic acids research.