Kiyo-aki Ishii

发表

Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.

Minqi Li, Kenji Kohno, Toshihiro Kobayashi, 2007, Cell metabolism.

Mineralocorticoid receptor function in bone metabolism and its role in glucocorticoid-induced osteopenia.

K. Ikeda, G. Schütz, Masako Ito, 2014, Biochemical and biophysical research communications.

Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle

M. Honda, S. Kaneko, Hiroaki Takayama, 2017, Nature Medicine.

Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat.

Hiroaki Takayama, T. Takamura, Y. Saito, 2021, Cell reports.

Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice.

S. Kaneko, Hiroaki Takayama, H. Misu, 2016, Biochemical and biophysical research communications.

Effects of eicosapentaenoic acid on serum levels of selenoprotein P and organ‐specific insulin sensitivity in humans with dyslipidemia and type 2 diabetes

Hiroaki Takayama, T. Takamura, K. Tokuyama, 2021, Journal of diabetes investigation.

Forkhead box protein O1 (FoxO1) knockdown accelerates the eicosapentaenoic acid (EPA)-mediated Selenop downregulation independently of sterol regulatory element-binding protein-1c (SREBP-1c) in H4IIEC3 hepatocytes.

Hiroaki Takayama, Takayoshi Shirasaki, T. Takamura, 2022, Endocrine journal.

Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans

S. Kaneko, Hiroaki Takayama, T. Takamura, 2021, Frontiers in Nutrition.

Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity.

M. Honda, S. Kaneko, H. Misu, 2019, Cell host & microbe.

Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET

M. Honda, Hiroaki Takayama, Takayoshi Shirasaki, 2022, Nature Communications.

A novel PHEX mutation associated with vitamin D-resistant rickets

T. Takamura, Y. Niida, Kiyo-aki Ishii, 2019, Human Genome Variation.

LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH

S. Kaneko, Yasuhiko Yamamoto, Hiroaki Takayama, 2021, Scientific reports.

Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation

H. Aburatani, C. Lelliott, K. Ikeda, 2009, Nature Medicine.

p62‐mediated autophagy affects nutrition‐dependent insulin receptor substrate 1 dynamics in 3T3‐L1 preadipocytes

S. Kaneko, H. Misu, T. Takamura, 2018, Journal of diabetes investigation.

Osteosarcoma-Derived Small Extracellular Vesicles Enhance Tumor Metastasis and Suppress Osteoclastogenesis by miR-146a-5p

Katsuhiro Hayashi, N. Yamamoto, H. Tsuchiya, 2021, Frontiers in Oncology.

Lauric acid impairs insulin-induced Akt phosphorylation by upregulating SELENOP expression via HNF4α induction.

Hiroaki Takayama, S. Matsugo, T. Takamura, 2022, American journal of physiology. Endocrinology and metabolism.

Cyclosporine A Downregulates Selenoprotein P Expression via a Signal Transducer and Activator of Transcription 3–Forkhead Box Protein O1 Pathway in Hepatocytes In Vitro

Hiroaki Takayama, T. Takamura, Ryota Tanida, 2022, The Journal of Pharmacology and Experimental Therapeutics.

Metabolic regulation of osteoclast differentiation and function

H. Aburatani, A. Hirao, K. Ikeda, 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle

M. Honda, Hiroaki Takayama, H. Misu, 2017, Nature Medicine.

Plasma half-life and tissue distribution of leukocyte cell-derived chemotaxin 2 in mice

Hiroaki Takayama, H. Misu, K. Chikamoto, 2020, Scientific Reports.

Role of selenoprotein P expression in the function of pancreatic β cells: Prevention of ferroptosis-like cell death and stress-induced nascent granule degradation.

Yoshiro Saito, N. Noguchi, T. Takamura, 2022, Free radical biology & medicine.

Circulating Concentrations of Insulin Resistance-Associated Hepatokines, Selenoprotein P and Leukocyte Cell-Derived Chemotaxin 2, during an Oral Glucose Tolerance Test in Humans.

S. Kaneko, Hiroaki Takayama, H. Misu, 2019, Biological & pharmaceutical bulletin.

Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes

S. Kaneko, H. Iwama, K. Murao, 2017, The Journal of Biological Chemistry.

LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH

Hiroaki Takayama, T. Takamura, S. Yamagoe, 2021, Scientific Reports.

Insulin Suppresses Ubiquitination via the Deubiquitinating Enzyme Ubiquitin-Specific Protease 14, Independent of Proteasome Activity in H4IIEC3 Hepatocytes

Hiroaki Takayama, T. Takamura, Kiyo-aki Ishii, 2022, The Journal of Pharmacology and Experimental Therapeutics.

Insulin Suppresses Ubiquitination via the Deubiquitinating Enzyme USP14, Independent of Proteasome Activity in H4IIEC3 Hepatocytes.

Hiroaki Takayama, Kiyo-aki Ishii, Akihiro Kikuchi, 2022 .

Diabetes accelerates steatohepatitis in mice: liver pathology and single-cell gene expression signatures.

M. Honda, Hiroaki Takayama, Ryota Tanida, 2024, The American journal of pathology.