Jill Kohler

发表

Gastrointestinal Inhibition of Sodium-Hydrogen Exchanger 3 Reduces Phosphorus Absorption and Protects against Vascular Calcification in CKD.

Andrew G. Spencer, D. Charmot, M. Navre, 2015, Journal of the American Society of Nephrology : JASN.

Preclinical and Healthy Volunteer Studies of Potential Drug–Drug Interactions Between Tenapanor and Phosphate Binders

Andrew G. Spencer, D. Charmot, K. Kozuka, 2016, Clinical pharmacology in drug development.

Combination treatment with tenapanor and sevelamer synergistically reduces urinary phosphorus excretion in rats.

G. Chertow, A. King, Jill Kohler, 2020, American journal of physiology. Renal physiology.

Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5).

Andrew G. Spencer, J. Caldwell, D. Charmot, 2018, Journal of medicinal chemistry.

Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability

J. Caldwell, T. Knöpfel, C. Wagner, 2018, Science Translational Medicine.

Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice

J. Caldwell, A. King, D. Dragoli, 2019, American journal of physiology. Gastrointestinal and liver physiology.

Intestinal Inhibition of the Na+/H+ Exchanger 3 Prevents Cardiorenal Damage in Rats and Inhibits Na+ Uptake in Humans

Andrew G. Spencer, D. Charmot, M. Navre, 2014, Science Translational Medicine.

RDX5791, a First-in-Class Minimally Systemic NHE3 Inhibitor in Clinical Development for CIC and IBS-C, Increases Intestinal Sodium Leading to Enhanced Intestinal Fluid Volume and Transit

Andrew G. Spencer, D. Charmot, M. Navre, 2011 .

Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na+/H+ Exchanger Isoform 3

Andrew G. Spencer, D. Charmot, M. Navre, 2022, ACS medicinal chemistry letters.

Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice

J. Caldwell, A. King, D. Dragoli, 2019, American journal of physiology. Gastrointestinal and liver physiology.