J. Jacobs

发表

Gastrointestinal Inhibition of Sodium-Hydrogen Exchanger 3 Reduces Phosphorus Absorption and Protects against Vascular Calcification in CKD.

Andrew G. Spencer, D. Charmot, M. Navre, 2015, Journal of the American Society of Nephrology : JASN.

Novel Treatments from Inhibition of the Intestinal Sodium–Hydrogen Exchanger 3

C. Kovesdy, L. Quarles, A. Adebiyi, 2021, International journal of nephrology and renovascular disease.

Small Intestinal Phosphate Absorption: Novel Therapeutic Implications

J. Yee, S. Sprague, J. Jacobs, 2021, American Journal of Nephrology.

Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5).

Andrew G. Spencer, J. Caldwell, D. Charmot, 2018, Journal of medicinal chemistry.

An Evaluation of the Pharmacodynamics, Safety, and Tolerability of the Potassium Binder RDX7675

B. Pitt, V. Zann, J. Jacobs, 2018, Journal of clinical pharmacology.

Evaluation of the Pharmacodynamic Effects of the Potassium Binder RDX7675 in Mice

J. Caldwell, A. King, J. Jacobs, 2017, Journal of cardiovascular pharmacology and therapeutics.

Palatability and physical properties of potassium-binding resin RDX7675: comparison with sodium polystyrene sulfonate

J. McDermott, V. Zann, J. Jacobs, 2017, Drug design, development and therapy.

Pharmacodynamics, Safety, and Tolerability of the NHE3 Inhibitor Tenapanor: Two Trials in Healthy Volunteers

J. Jacobs, D. Rosenbaum, Andrew T. Yan, 2018, Clinical Drug Investigation.

Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice

J. Caldwell, A. King, D. Dragoli, 2019, American journal of physiology. Gastrointestinal and liver physiology.

Intestinal Inhibition of the Na+/H+ Exchanger 3 Prevents Cardiorenal Damage in Rats and Inhibits Na+ Uptake in Humans

Andrew G. Spencer, D. Charmot, M. Navre, 2014, Science Translational Medicine.

RDX5791, a First-in-Class Minimally Systemic NHE3 Inhibitor in Clinical Development for CIC and IBS-C, Increases Intestinal Sodium Leading to Enhanced Intestinal Fluid Volume and Transit

Andrew G. Spencer, D. Charmot, M. Navre, 2011 .

Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na+/H+ Exchanger Isoform 3

Andrew G. Spencer, D. Charmot, M. Navre, 2022, ACS medicinal chemistry letters.

The prognostic value of the EEG in asphyxiated newborns

J. Rotteveel, H. B. M. Lieshout, J. W. F. M. Jacobs, 1995, Acta neurologica Scandinavica.

Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice

J. Caldwell, A. King, D. Dragoli, 2019, American journal of physiology. Gastrointestinal and liver physiology.