A. McLachlan

发表

The nucleocapsid of hepatitis B virus is both a T-cell-independent and a T-cell-dependent antigen.

D. Milich, A. McLachlan, 1986, Science.

Structurally Diverse Histone Deacetylase Photoreactive Probes: Design, Synthesis, and Photolabeling Studies in Live Cells and Tissue

J. Frasor, N. Mahmud, R. Ranjan, 2019, ChemMedChem.

A transgenic mouse model of the chronic hepatitis B surface antigen carrier state.

R. Palmiter, F. Chisari, C. Pinkert, 1985, Science.

The serology of chronic hepatitis B infection revisited.

K. Koike, K. Kurokawa, T. Maruyama, 1993, The Journal of clinical investigation.

Alpha/Beta Interferon Differentially Modulates the Clearance of Cytoplasmic Encapsidated Replication Intermediates and Nuclear Covalently Closed Circular Hepatitis B Virus (HBV) DNA from the Livers of Hepatocyte Nuclear Factor 1α-Null HBV Transgenic Mice

M. Yaniv, M. Pontoglio, A. McLachlan, 2005, Journal of Virology.

Nuclear Covalently Closed Circular Viral Genomic DNA in the Liver of Hepatocyte Nuclear Factor 1α-Null Hepatitis B Virus Transgenic Mice

M. Yaniv, M. Pontoglio, L. Guidotti, 2001, Journal of Virology.

Regulation of transcription from the human muscle phosphofructokinase P2 promoter by the Sp1 transcription factor.

J. Johnson, A. Raney, A. McLachlan, 1994, DNA and cell biology.

Alternative splicing of the transcript encoding the human muscle isoenzyme of phosphofructokinase.

P. Sharma, B. Babior, G. R. Reddy, 1990, The Journal of biological chemistry.

Differential Inhibition of Nuclear Hormone Receptor-Dependent Hepatitis B Virus Replication by the Small Heterodimer Partner

A. McLachlan, Claudia E. Oropeza, Lie Li, 2008, Journal of Virology.

Krüppel-Like Factor 9 Promotes Hepatic Cytochrome P 450 2 D 6 Expression during Pregnancy in CYP 2 D 6-Humanized Mice s

Wei Zhang, R. Urrutia, Hyunyoung Jeong, 2014 .

Krüppel-Like Factor 9 Promotes Hepatic Cytochrome P450 2D6 Expression during Pregnancy in CYP2D6-Humanized Mice

Wei Zhang, R. Urrutia, Hyunyoung Jeong, 2014, Molecular Pharmacology.

Krüppel-like Factor 9 (KLF9) Promotes hepatic Cytochrome P450 (CYP) 2D6 Expression during Pregnancy in CYP2D6-humanized Mice Role of KLF9 in CYP2D6 induction during pregnancy

R. Urrutia, Hyunyoung Jeong, K. Koh, 2014 .

Peroxisome proliferator-activated receptor γ coactivator family members competitively regulate hepatitis b virus biosynthesis.

A. McLachlan, Saira Iram, Claudia E. Oropeza, 2019, Virology.

Replication of the Wild Type and a Natural Hepatitis B Virus Nucleocapsid Promoter Variant Is Differentially Regulated by Nuclear Hormone Receptors in Cell Culture

Hong Tang, A. Raney, A. McLachlan, 2001, Journal of Virology.

Limited Effects of Fasting on Hepatitis B Virus (HBV) Biosynthesis in HBV Transgenic Mice

K. Kaestner, A. McLachlan, Claudia E. Oropeza, 2008, Journal of Virology.

Transcription and replication of a natural hepatitis B virus nucleocapsid promoter variant is regulated in vivo by peroxisome proliferators.

H. Tang, A. Raney, A. McLachlan, 2001, Virology.

In Vivo Regulation of Hepatitis B Virus Replication by Peroxisome Proliferators

J. Peters, Susan Y Chi, L. Guidotti, 1999, Journal of Virology.

Selective effect of β-catenin on nuclear receptor-dependent hepatitis B virus transcription and replication.

A. McLachlan, G. Tarnow, 2022, Virology.

Members of the nuclear receptor superfamily regulate transcription from the hepatitis B virus nucleocapsid promoter

J. Johnson, A. Raney, J. Johnson, 1997, Journal of virology.

Retroviral-mediated transfer and expression of hepatitis B e antigen in human primary skin fibroblasts and Epstein-Barr virus-transformed B lymphocytes.

F. Chisari, M. Mondelli, A. Raney, 1989, Virology.

Distinct phenotypic spectra of hepatocellular carcinoma in liver-specific tumor suppressor-deficient hepatitis B virus transgenic mice.

M. Maienschein-Cline, A. McLachlan, Claudia E. Oropeza, 2022, Virology.

A single 10-residue pre-S(1) peptide can prime T cell help for antibody production to multiple epitopes within the pre-S(1), pre-S(2), and S regions of HBsAg.

A. Moriarty, G. B. Thornton, D. Milich, 1987, Journal of immunology.

Two distinct but overlapping antibody binding sites in the pre-S(2) region of HBsAg localized within 11 continuous residues.

F. Chisari, G. B. Thornton, T. Nakamura, 1986, Journal of immunology.

Nonoverlapping T and B cell determinants on an hepatitis B surface antigen pre-S(2) region synthetic peptide

F. Chisari, G. B. Thornton, D. Milich, 1986, The Journal of experimental medicine.

Immune response to the pre-S(1) region of the hepatitis B surface antigen (HBsAg): a pre-S(1)-specific T cell response can bypass nonresponsiveness to the pre-S(2) and S regions of HBsAg.

F. Chisari, S. Kent, D. Milich, 1986, Journal of immunology.

Distinction between immunogenicity and tolerogenicity among HBcAg T cell determinants. Influence of peptide-MHC interaction.

R. Houghten, G. B. Thornton, D. Milich, 1989, Journal of immunology.

Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice

R. Palmiter, F. Chisari, C. Pinkert, 1986, Journal of virology.

Transcriptional regulation of hepatitis B virus by nuclear hormone receptors is a critical determinant of viral tropism.

H. Tang, A. McLachlan, Hong Tang, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Functional characterization of the interferon regulatory element in the enhancer 1 region of the hepatitis B virus genome.

Hong Tang, A. McLachlan, F. F. Alcantara, 2002, Nucleic acids research.

Characterization of functional Sp1 transcription factor binding sites in the hepatitis B virus nucleocapsid promoter

A. Raney, P. Zhang, A. McLachlan, 1993, Journal of virology.

Characterization ofFunctional SplTranscription Factor Binding Sites intheHepatitis B Virus Nucleocapsid Promotert

A. McLachlan, 1993 .

Characterization of the hepatitis B virus X- and nucleocapsid gene transcriptional regulatory elements.

A. Raney, P. Zhang, A. McLachlan, 1992, Virology.

Cloning and characterization of the human muscle phosphofructokinase gene.

P. Sharma, J. Johnson, B. Babior, 1992, DNA and cell biology.

Promoter-specific transactivation of hepatitis B virus transcription by a glutamine- and proline-rich domain of hepatocyte nuclear factor 1

A. Easton, A. Raney, D. Milich, 1991, Journal of virology.

Complex regulation of transcription from the hepatitis B virus major surface antigen promoter in human hepatoma cell lines

A. Raney, D. Milich, A. McLachlan, 1991, Journal of virology.

Differentiation-specific transcriptional regulation of the hepatitis B virus large surface antigen gene in human hepatoma cell lines

A. Easton, A. Raney, D. Milich, 1990, Journal of virology.

Avian and Mammalian Hepadnaviruses Have Distinct Transcription Factor Requirements for Viral Replication

Hong Tang, A. McLachlan, 2002, Journal of Virology.

Characterization of the hepatitis B virus large surface antigen promoter Sp1 binding site.

A. Raney, A. McLachlan, 1995, Virology.

Characterization of hepatitis B virus major surface antigen gene transcriptional regulatory elements in differentiated hepatoma cell lines

A. Raney, D. Milich, A. McLachlan, 1989, Journal of virology.

Distinct Regulation of Hepatitis B Virus Biosynthesis by Peroxisome Proliferator-Activated Receptor (cid:1) Coactivator 1 (cid:2) and Small Heterodimer Partner in Human Hepatoma Cell Lines (cid:1)

Caitlin R. Ondracek, A. McLachlan, Claudia E. Oropeza, 2009 .

Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?

J. Price, A. Raney, D. Milich, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of transcription from the hepatitis B virus large surface antigen promoter by hepatocyte nuclear factor 3

A. Raney, P. Zhang, A. McLachlan, 1995, Journal of virology.

PGC1α Transcriptional Adaptor Function Governs Hepatitis B Virus Replication by Controlling HBcAg/p21 Protein-Mediated Capsid Formation

B. Cakal, A. McLachlan, Saira Iram, 2017, Journal of Virology.

Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice.

R. Palmiter, F. Chisari, C. Pinkert, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Mechanisms of Inhibition of Nuclear Hormone Receptor-Dependent Hepatitis B Virus Replication by Hepatocyte Nuclear Factor 3β

Hong Tang, A. McLachlan, 2002, Journal of Virology.

The Regulation of HBV Transcription and Replication.

T. Y. Taha, A. McLachlan, Claudia E. Oropeza, 2020, Advances in experimental medicine and biology.

Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease.

S. Cotler, E. Kallwitz, A. McLachlan, 2008, World journal of gastroenterology.

Distinct H-2-linked regulation of T-cell responses to the pre-S and S regions of the same hepatitis B surface antigen polypeptide allows circumvention of nonresponsiveness to the S region.

F. Chisari, G. B. Thornton, D. Milich, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Functional identification of agretopic and epitopic residues within an HBcAg T cell determinant.

R. Houghten, D. Milich, A. McLachlan, 1989, Journal of immunology.

Hepatitis B virus core antigen has two nuclear localization sequences in the arginine-rich carboxyl terminus

S. Eckhardt, D. Milich, A. McLachlan, 1991, Journal of virology.

Hepatitis B Virus Core Antigen Has Two Nuclear Localization Sequences in the Arginine-Rich Carboxyl Terminust

S. Eckhardt, D. Milich, A. McLachlan, 2022 .

Comparative immunogenicity of hepatitis B virus core and E antigens.

P. Wingfield, S. Stahl, G. B. Thornton, 1988, Journal of immunology.

Immune response to hepatitis B virus core antigen (HBcAg): localization of T cell recognition sites within HBcAg/HBeAg.

A. Moriarty, G. B. Thornton, D. Milich, 1987, Journal of immunology.

Hepatitis B virus transcription and replication.

H. Tang, A. McLachlan, A. L. Anderson, 2001, Drug news & perspectives.

Antibody production to the nucleocapsid and envelope of the hepatitis B virus primed by a single synthetic T cell site

G. B. Thornton, D. Milich, A. McLachlan, 1987, Nature.

Relative DNA Methylation and Demethylation Efficiencies during Postnatal Liver Development Regulate Hepatitis B Virus Biosynthesis

M. Maienschein-Cline, T. Y. Taha, A. McLachlan, 2020, Journal of Virology.

Hepatic deficiency of the pioneer transcription factor FoxA restricts hepatitis B virus biosynthesis by the developmental regulation of viral DNA methylation

K. Kaestner, M. Maienschein-Cline, A. Lyubimov, 2017, PLoS pathogens.

Independent Activation of Hepatitis B Virus Biosynthesis by Retinoids, Peroxisome Proliferators, and Bile Acids

A. McLachlan, Claudia E. Oropeza, Vanessa C. Reese, 2012, Journal of Virology.

Proliferators , and Bile Acids Biosynthesis by Retinoids , Peroxisome Independent Activation of Hepatitis B Virus

A. McLachlan, Claudia E. Oropeza, Vanessa C. Reese, 2012 .

Limited Effects of Bile Acids and Small Heterodimer Partner on Hepatitis B Virus Biosynthesis In Vivo

D. Moore, A. McLachlan, Vanessa C. Reese, 2011, Journal of Virology.

Role of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α in AKT/PKB-Mediated Inhibition of Hepatitis B Virus Biosynthesis

Caitlin R. Ondracek, A. McLachlan, Caitlin R Ondracek, 2011, Journal of Virology.

Multiple nuclear receptors may regulate hepatitis B virus biosynthesis during development.

Caitlin R. Ondracek, A. McLachlan, Claudia E. Oropeza, 2011, The international journal of biochemistry & cell biology.

Developmental Regulation of Hepatitis B Virus Biosynthesis by Hepatocyte Nuclear Factor 4α

F. Gonzalez, B. Sáinz, S. Uprichard, 2009, PloS one.

Hepatocyte Nuclear Factor 3β Inhibits Hepatitis B Virus Replication In Vivo

Hong Tang, R. Costa, D. Hughes, 2002, Journal of Virology.

Hepatocyte Nuclear Factor 3 (cid:2) Inhibits Hepatitis B Virus Replication In Vivo†

R. Costa, Hong Tang, D. Hughes, 2002 .

Complementarity between epsilon and phi sequences in pregenomic RNA influences hepatitis B virus replication efficiency.

A. McLachlan, Claudia E. Oropeza, 2007, Virology.

A pregenomic RNA sequence adjacent to DR1 and complementary to epsilon influences hepatitis B virus replication efficiency.

Hong Tang, A. McLachlan, 2002, Virology.

T-cell recognition of pre-S regions of HBsAg can bypass nonresponse to the S region.

G. B. Thornton, D. Milich, A. McLachlan, 1987, Advances in experimental medicine and biology.

Characterization of a functional hepatocyte nuclear factor 3 binding site in the hepatitis B virus nucleocapsid promoter.

J. Johnson, A. Raney, J. Johnson, 1995, Virology.

Characterization of the minimal elements of the hepatitis B virus large surface antigen promoter.

A. Easton, A. Raney, A. McLachlan, 1994, The Journal of general virology.

Molecular Biology of the Hepatitis B Virus

A. McLachlan, 1991 .

Importance of subtype in the immune response to the pre-S(2) region of the hepatitis B surface antigen. II. Synthetic Pre-S(2) immunogen.

A. Moriarty, G. Bitter, D. Milich, 1990, Journal of immunology.

Importance of subtype in the immune response to the pre-S(2) region of the hepatitis B surface antigen. I. T cell fine specificity.

G. B. Thornton, K. Langley, D. Milich, 1990, Journal of immunology.

Regulation of transcription from the hepatitis B virus major surface antigen promoter by the Sp1 transcription factor

A. Raney, A. McLachlan, H. Le, 1992, Journal of virology.

Differentiation-specific transcriptional regulation of the hepatitis B virus nucleocapsid gene in human hepatoma cell lines.

P. Zhang, A. McLachlan, 1994, Virology.

The Biology of Hepatitis B Virus

A. Raney, A. McLachlan, 2018 .

Modulation of hepatitis B virus pregenomic RNA stability and splicing by histone deacetylase 5 enhances viral biosynthesis

D. Loeb, P. Petukhov, T. Y. Taha, 2020, PLoS pathogens.

Expression of hepatitis B virus surface and core antigens: influences of pre-S and precore sequences

F. Chisari, A. Raney, J. Sorge, 1987, Journal of virology.

Hepatitis B synthetic immunogen comprised of nucleocapsid T-cell sites and an envelope B-cell epitope.

A. Moriarty, G. B. Thornton, D. Milich, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Identification of a Novel OX40L+ Dendritic Cell Subset That Selectively Expands Regulatory T-Cells BY ALEJANDRA MARINELARENA

M. Federle, N. Freitag, B. Layden, 2020 .

Hepatocyte-targeted RNAi Therapeutics for the Treatment of Chronic Hepatitis B Virus Infection

Alan McLachlan, Darren H. Wakefield, Qili Chu, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Characterization of the hepatitis B virus major surface antigen promoter hepatocyte nuclear factor 3 binding site.

A. Raney, A. McLachlan, 1997, The Journal of general virology.

Cloning and expression of a human muscle phosphofructokinase cDNA.

P. Sharma, B. Babior, G. R. Reddy, 1989, Gene.

Transcriptional Regulation oftheHepatitis B VirusLargeSurface Antigen GeneinHumanHepatomaCellLinest

A. McLachlan, 1990 .

Autoantibody production in hepatitis B e antigen transgenic mice elicited with a self T-cell peptide and inhibited with nonself peptides.

R. Houghten, G. B. Thornton, A. Raney, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Heterogeneous phenotypes of Pten-null hepatocellular carcinoma in hepatitis B virus transgenic mice parallels liver lobule zonal gene expression patterns.

M. Maienschein-Cline, Caitlin R. Ondracek, A. McLachlan, 2021, Virology.

β-Catenin Signaling Regulates the In Vivo Distribution of Hepatitis B Virus Biosynthesis across the Liver Lobule

A. McLachlan, G. Tarnow, 2021, Journal of virology.

Distinct Regulation of Hepatitis B Virus Biosynthesis by Peroxisome Proliferator-Activated Receptor γ Coactivator 1α and Small Heterodimer Partner in Human Hepatoma Cell Lines

Caitlin R. Ondracek, A. McLachlan, Claudia E. Oropeza, 2009, Journal of Virology.

Novel clustering of Sp1 transcription factor binding sites at the transcription initiation site of the human muscle phosphofructokinase P1 promoter.

J. Johnson, A. McLachlan, 1994, Nucleic acids research.

Peroxisome Proliferator-Activated Receptor γ Coactivator 1α and Small Heterodimer Partner Differentially Regulate Nuclear Receptor-Dependent Hepatitis B Virus Biosynthesis

Caitlin R. Ondracek, A. McLachlan, Claudia E. Oropeza, 2009, Journal of Virology.

Regulation ofTranscription fromtheHepatitis B VirusMajor Surface Antigen PromoterbytheSplTranscription Factort

A. McLachlan, 1992 .

Vecteurs retroviraux d'expression et procedes de production d'antigenes du virus d'hepatite b

J. Sorge, D. Milich, A. McLachlan, 1988 .

RNAi therapeutics for the treatment of chronic hepatitis B virus infection

Darren H. Wakefield, D. Lewis, P. Hadwiger, 2012 .

Ten-eleven translocation (Tet) methylcytosine dioxygenase-dependent viral DNA demethylation mediates in vivo hepatitis B virus (HBV) biosynthesis

M. Maienschein-Cline, A. McLachlan, Claudia E. Oropeza, 2024, Journal of virology.

Multiple nuclear receptors may regulate hepatitis B virus biosynthesis during development.

A. McLachlan, Claudia E. Oropeza, Lie Li, 2011, The international journal of biochemistry & cell biology.