A. Sugawara

发表

NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin.

S. Ōmura, N. Yamaotsu, S. Hirono, 2010, Bioorganic & medicinal chemistry.

Discovery of a Cyclic Depsipeptide from Chaetomium mollipilium by the Genome Mining Approach.

T. Ozaki, Kento Tsukada, Teigo Asai, 2022, Organic letters.

Solution-phase total synthesis of the hydrophilic natural product argifin using 3,4,5-tris(octadecyloxy)benzyl tag

S. Ōmura, K. Nagasawa, K. Shiomi, 2011 .

Chitinase inhibitors: extraction of the active framework from natural argifin and use of in situ click chemistry

S. Ōmura, K. Sharpless, K. Shiomi, 2009, The Journal of Antibiotics.

Borrelidin analogues with antimalarial activity: design, synthesis and biological evaluation against Plasmodium falciparum parasites.

S. Ōmura, Yōko Takahashi, K. Otoguro, 2013, Bioorganic & medicinal chemistry letters.

Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity.

S. Ōmura, Y. Yamaguchi, K. Sharpless, 2007, Bioorganic & medicinal chemistry letters.

Leucomycin A3, a 16-membered macrolide antibiotic, inhibits influenza A virus infection and disease progression

S. Ōmura, Kazuo Suzuki, T. Nakayama, 2014, The Journal of Antibiotics.

Characteristics of carotenoid distribution in various tissues from red‐ and white‐fleshed chinook salmon, Oncorhynchus tshawytscha (Walbaum)

W. Heard, N. Fukuda, A. Sugawara, 1994 .

Macrolides Promote CCL2-Mediated Macrophage Recruitment and Clearance of Nasopharyngeal Pneumococcal Colonization in Mice.

S. Ōmura, K. Yanagihara, S. Kohno, 2015, The Journal of infectious diseases.

Non-antibiotic 12-membered macrolides: design, synthesis and biological evaluation in a cigarette-smoking model

S. Ōmura, Hideaki Shima, K. Akagawa, 2015, The Journal of Antibiotics.

Three-dimensional solution structure of bottromycin A2: a potent antibiotic active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci.

S. Ōmura, S. Hirono, H. Gouda, 2012, Chemical & pharmaceutical bulletin.

Effects of a Novel Nonantibiotic Macrolide, EM900, on Cytokine and Mucin Gene Expression in a Human Airway Epithelial Cell Line

S. Ōmura, H. Ishinaga, H. Jono, 2011, Pharmacology.

Human acidic mammalian chitinase as a novel target for anti-asthma drug design using in silico screening.

S. Ōmura, S. Hirono, H. Gouda, 2013, Bioorganic & medicinal chemistry.

Solid-phase total synthesis of the chitinase inhibitor Argadin using a supported acetal resin

S. Ōmura, H. Gouda, K. Shiomi, 2009, The Journal of Antibiotics.

Argifin; efficient solid phase total synthesis and evaluation of analogues of acyclic peptide.

S. Ōmura, Y. Saito, H. Gouda, 2009, Bioorganic & medicinal chemistry.

An architectonic macrolide library based on a C2-symmetric macrodiolide toward pharmaceutical compositions

S. Ōmura, S. Hirono, H. Gouda, 2015 .

STRUCTURE OF THE BIOLOGICAL ACTIVE CYCLOPEPTIDES PRODUCED BY ALTERNARIA MALI ROBERTS

Takeshi Matsumoto, Y. Mori, T. Okuno, 1975 .

Asymmetric Total Synthesis of Indole Alkaloids Containing an Indoline Spiroaminal Framework.

S. Ōmura, K. Otoguro, Takeshi Yamada, 2015, Chemistry.

Chemical Degradation-Inspired Total Synthesis of the Antibiotic Macrodiolide, Luminamicin.

T. Sunazuka, Y. Inahashi, T. Hirose, 2022, Journal of the American Chemical Society.

Asymmetric total synthesis of neoxaline.

S. Ōmura, Takeshi Yamada, T. Sunazuka, 2013, Journal of the American Chemical Society.

Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase.

Satoshi Omura, Shuichi Hirono, Yoshifumi Saito, 2015, Journal of medicinal chemistry.

Computational analysis of the binding affinities of the natural-product cyclopentapeptides argifin and argadin to chitinase B from Serratia marcescens.

S. Ōmura, S. Hirono, H. Gouda, 2008, Bioorganic & medicinal chemistry.

Unified enantioselective total synthesis of 3,6-dioxygenated diketopiperazine natural products, diatretol and lepistamides A, B and C

Shunya Takahashi, Takeshi Yamada, T. Sunazuka, 2021 .

Jietacins, azoxy antibiotics with potent nematocidal activity: Design, synthesis, and biological evaluation against parasitic nematodes.

S. Ōmura, Yōko Takahashi, C. Mertens, 2017, European journal of medicinal chemistry.

Novel 12-membered non-antibiotic macrolides, EM900 series with anti-inflammatory and/or immunomodulatory activity; synthesis, structure–activity relationships and in vivo study

S. Ōmura, Hideaki Shima, K. Akagawa, 2012, The Journal of Antibiotics.

Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents.

S. Ōmura, S. Hirono, Hideaki Shima, 2011, Bioorganic & medicinal chemistry letters.

Macrolides with Promotive Activity of Monocyte to Macrophage Differentiation

S. Ōmura, K. Akagawa, T. Nagamitsu, 2005, The Journal of Antibiotics.

Molecular modeling of human acidic mammalian chitinase in complex with the natural-product cyclopentapeptide chitinase inhibitor argifin.

S. Ōmura, S. Hirono, Y. Saito, 2009, Bioorganic & medicinal chemistry.

Jietacins with potent nematocidal activity; efficient isolation of novel analogs and divergent total synthesis of jietacin A, B, C, and D

S. Ōmura, Yukihiro Asami, K. Shiomi, 2015 .

Toward the total synthesis of luminamicin; an anaerobic antibiotic: construction of highly functionalized cis-decalin containing a bridged ether moiety

S. Ōmura, H. Takada, T. Sunazuka, 2017, The Journal of Antibiotics.

Toward the total synthesis of Luminamicin: construction of 14-membered lactone framework possessing versatile enol ether moiety

S. Ōmura, H. Takada, Kaoru Nakamura, 2012 .

Two New Terpenes Isolated from Dictyostelium Cellular Slime Molds

H. Kikuchi, Y. Oshima, Y. Kubohara, 2020, Molecules.

Azithromycin, a 15-membered macrolide antibiotic, inhibits influenza A(H1N1)pdm09 virus infection by interfering with virus internalization process

S. Ōmura, Kazuo Suzuki, K. Akagawa, 2019, The Journal of Antibiotics.

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.

James B. Munro, Daniel S. Terry, Luis R. Castillo-Menendez, 2019, Nature.

Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor

S. Ōmura, S. Hirono, H. Nakano, 2013, Proceedings of the National Academy of Sciences.

Development of Indole Alkaloid-Type Dual Immune Checkpoint Inhibitors Against CTLA-4 and PD-L1 Based on Diversity-Enhanced Extracts

O. Yamada, Yoshihide Suzuki, H. Kikuchi, 2021, Frontiers in Chemistry.

5-O-Mycaminosyltylonolide antibacterial derivatives: design, synthesis and bioactivity

S. Ōmura, Ayumi Tsutsui, H. Matsui, 2017, The Journal of Antibiotics.

Jietacins, azoxy natural products, as novel NF-κB inhibitors: Discovery, synthesis, biological activity, and mode of action.

S. Ōmura, T. Sunazuka, R. Horie, 2019, European journal of medicinal chemistry.

Total syntheses of the AChE inhibitors (-)-arisugacins F and G.

S. Ōmura, K. Otoguro, Y. Harigaya, 2003, The Journal of antibiotics.

Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines

S. Ōmura, H. Handa, T. Itoi, 2015, International journal of oncology.

Identification and Functional Characterization of Fungal Chalcone Synthase and Chalcone Isomerase

A. Inoue, T. Ozaki, Kento Tsukada, 2023, Journal of natural products.

Three-dimensional solution structure of EM703 with potent promoting activity of monocyte-to-macrophage differentiation.

S. Ōmura, S. Hirono, H. Gouda, 2006, Bioorganic & medicinal chemistry letters.

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.

James B. Munro, Daniel S. Terry, Luis R. Castillo-Menendez, 2019, Nature.

Cinatrins D and E, and virgaricin B, three novel compounds produced by a fungus, Virgaria boninensis FKI-4958

S. Ōmura, T. Ishii, R. Masuma, 2015, The Journal of Antibiotics.

Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening.

Young Do Kwon, Joel R Courter, Peter D Kwong, 2011, Bioorganic & medicinal chemistry.

An Inducible Cell-Cell Fusion System with Integrated Ability to Measure the Efficiency and Specificity of HIV-1 Entry Inhibitors

Alon Herschhorn, J. Sodroski, Amos B. Smith, 2011, PloS one.

Stereo- and substituent-enabled divergent synthesis of 5,6-spiroketal analogs of avermectin containing a triazole function

S. Ōmura, Takeshi Yamada, T. Sunazuka, 2017 .

Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site

A. Debnath, Judith M. LaLonde, P. Kwong, 2014, PloS one.

Macrolides Promote CCL2-Mediated Macrophage Recruitment and Clearance of Nasopharyngeal Pneumococcal Colonization in Mice.

S. Ōmura, K. Yanagihara, S. Kohno, 2015, The Journal of infectious diseases.