Keiichi Kuwano

发表

Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.

Y. Sugiyama, T. Asaki, K. Kuwabara, 2007, Bioorganic & medicinal chemistry.

Selexipag: An Oral and Selective IP Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.

M. Clozel, J. Gatfield, T. Asaki, 2015, Journal of medicinal chemistry.

A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form, {4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)

K. Kosugi, A. Hashino, K. Kuwabara, 2008, Journal of Pharmacology and Experimental Therapeutics.

A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form, {4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)

K. Kosugi, A. Hashino, K. Kuwabara, 2008, Journal of Pharmacology and Experimental Therapeutics.

Long-Acting Prostacyclin Receptor Agonist Prodrug

A. Hashino, T. Asaki, K. Kuwabara, 2007 .

The selective PGI2 receptor agonist selexipag ameliorates Sugen 5416/hypoxia-induced pulmonary arterial hypertension in rats

K. Kosugi, Keiichi Kuwano, Y. Numakura, 2020, PloS one.

A comparison of vasodilation mode among selexipag (NS‐304; [2‐{4‐[(5,6‐diphenylpyrazin‐2‐yl)(isopropyl)amino]butoxy}‐N‐(methylsulfonyl)acetamide]), its active metabolite MRE‐269 and various prostacyclin receptor agonists in rat, porcine and human pulmonary arteries

K. Kosugi, K. Tajima, Keiichi Kuwano, 2017, European journal of pharmacology.

Role of protein kinase C in the reduction of infarct size by N‐methyl‐1‐deoxynojirimycin, an α‐1,6‐glucosidase inhibitor

M. Arai, K. Kuwano, G. Takemura, 2001, British journal of pharmacology.

2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), an Orally Available and Long-Acting Prostacyclin Receptor Agonist Prodrug

Tetsuhiro Yamada, Asami Hashino, Kenji Kuwabara, 2007, Journal of Pharmacology and Experimental Therapeutics.

Antiproliferative effect of selexipag active metabolite MRE‐269 on pulmonary arterial smooth muscle cells from patients with chronic thromboembolic pulmonary hypertension

A. Ogawa, H. Matsubara, K. Kosugi, 2023, Pulmonary circulation.