T. Kiso

发表

Discovery of a 1-isopropyltetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain.

M. Inoue, Toshihiro Watanabe, Akiko Koakutsu, 2015, Bioorganic & medicinal chemistry.

Discovery of an 8-methoxytetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain without CYP inhibition liability.

M. Inoue, Toshihiro Watanabe, N. Katayama, 2015, Bioorganic & medicinal chemistry.

ASP8477, a fatty acid amide hydrolase inhibitor, exerts analgesic effects in rat models of neuropathic and dysfunctional pain.

T. Sekizawa, T. Watabiki, T. Kiso, 2020, European journal of pharmacology.

Automated measurement of spontaneous pain‐associated limb movement and drug efficacy evaluation in a rat model of neuropathic pain

Y. Shimizu, T. Sekizawa, S Kawasaki-Yatsugi, 2012, European journal of pain.

Spinal mechanism of standard analgesics: evaluation using mouse models of allodynia.

T. Aoki, N. Matsuoka, T. Kiso, 2010, European journal of pharmacology.

L-2,5-dihydrophenylalanine, an inducer of cathepsin-dependent apoptosis in human promyelocytic leukemia cells (HL-60).

M. Taniguchi, X. Ping, Y. Usuki, 2001, The Journal of antibiotics.

New thiazole derivatives as potent and selective 5-hydroxytriptamine 3 (5-HT3) receptor agonists for the treatment of constipation.

T. Mase, S. Akuzawa, M. Ohta, 2003, Bioorganic & medicinal chemistry.

A novel 5-HT3 receptor agonist, YM-31636, increases gastrointestinal motility without increasing abdominal pain.

K. Miyata, T. Kiso, H. Ito, 2001, European journal of pharmacology.

Analgesic effects of ASP3662, a novel 11β‐hydroxysteroid dehydrogenase 1 inhibitor, in rat models of neuropathic and dysfunctional pain

T. Sekizawa, H. Uchino, T. Kiso, 2018, British journal of pharmacology.

Comparative study of the affinities of the 5-HT3 receptor antagonists, YM060, YM114 (KAE-393), granisetron and ondansetron in rat vagus nerve and cerebral cortex

A. Nishida, S. Akuzawa, K. Miyata, 1995, Neuropharmacology.

Effects of pregabalin and duloxetine on neurotransmitters in the dorsal horn of the spinal cord in a rat model of fibromyalgia

Masako Furutani, T. Kiso, Y. Funatsu, 2018, European journal of pharmacology.

Neurometer measurement of current stimulus threshold in rats.

N. Matsumoto, T. Toya, Y. Nagakura, 2001, The Journal of pharmacology and experimental therapeutics.

Pharmacological characterization and gene expression profiling of an L5/L6 spinal nerve ligation model for neuropathic pain in mice

M. Okabe, T. Aoki, N. Matsuoka, 2008, Neuroscience.

A KCa3.1 Channel Opener, ASP0819, Modulates Nociceptive Signal Processing from Peripheral Nerves in Fibromyalgia-Like Pain in Rats

T. Kiso, S. Kakimoto, N. Takeshita, 2021, Journal of pain research.

In vitro and in vivo pharmacological characterization of ASP8477: A novel highly selective fatty acid amide hydrolase inhibitor

T. Ozawa, N. Tsuji, T. Watabiki, 2017, European journal of pharmacology.

Allodynia and Hyperalgesia in Adjuvant-Induced Arthritic Rats: Time Course of Progression and Efficacy of Analgesics

A. Kohara, Tokio Yamaguchi, M. Okada, 2003, Journal of Pharmacology and Experimental Therapeutics.

Antinociceptive profile of a selective metabotropic glutamate receptor 1 antagonist YM-230888 in chronic pain rodent models.

H. Itahana, Y. Shitaka, A. Kohara, 2007, European journal of pharmacology.

The selective 5-hydroxytryptamine (5-HT)4-receptor agonist RS67506 enhances lower intestinal propulsion in mice.

K. Miyata, Y. Nagakura, T. Kiso, 1997, Japanese journal of pharmacology.

Effect of ramosetron on short-circuit current response in rat colonic mucosa.

K. Miyata, T. Kiso, H. Ito, 1997, European journal of pharmacology.

UK-2A, B, C and D, novel antifungal antibiotics from streptomyces sp. 517-02 VI (3). Role of substituents on dilactone ring of UK-2A and antimycin A3 against generation of reactive oxygen species in porcine renal proximal tubule LLC-PK1 cells.

M. Taniguchi, Ken-Ichi Fujita, Toshio Tanaka, 2004, The Journal of antibiotics.

UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02 VI (2). Structure-activity relationships of UK-2A.

M. Taniguchi, Ken-Ichi Fujita, X. Ping, 2001, The Journal of antibiotics.

Amelioration of Neuropathic Pain by Novel Transient Receptor Potential Vanilloid 1 Antagonist AS1928370 in Rats without Hyperthermic Effect

T. Aoki, N. Matsuoka, A. Kohara, 2011, Journal of Pharmacology and Experimental Therapeutics.

Investigation of the effects of YM-31636, a novel 5-HT3 receptor agonist, on defecation in normal and constipated ferrets.

K. Miyata, T. Kiso, H. Ito, 2001, European journal of pharmacology.

Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro.

S. Akuzawa, K. Miyata, Y. Nagakura, 2000, European journal of pharmacology.

Intrathecal administration of AS1928370, a transient receptor potential vanilloid 1 antagonist, attenuates mechanical allodynia in a mouse model of neuropathic pain.

T. Aoki, N. Matsuoka, T. Watabiki, 2011, Biological & pharmaceutical bulletin.

The effect of the selective 5-HT(3) receptor agonist on ferret gut motility.

K. Miyata, Tokio Yamaguchi, Y. Nagakura, 2002, Life sciences.

Screening for Microtubule-Disrupting Antifungal Agents by Using a Mitotic-Arrest Mutant of Aspergillus nidulans and Novel Action of Phenylalanine Derivatives Accompanying Tubulin Loss

M. Taniguchi, Ken-Ichi Fujita, Toshio Tanaka, 2004, Antimicrobial Agents and Chemotherapy.

Analgesic effects of novel lysophosphatidic acid receptor 5 antagonist AS2717638 in rodents

H. Hiyama, T. Aoki, T. Sekizawa, 2017, Neuropharmacology.

Corrigendum to “Discovery of novel tetrahydroisoquinoline derivatives as orally active N-type calcium channel blockers with high selectivity for hERG potassium channels” [Bioorg. Med. Chem. 22 (2014) 6899–6907]

M. Inoue, Hiroyoshi Yamada, Toshihiro Watanabe, 2015 .

Enhanced insulin secretion and sensitization in diabetic mice on chronic treatment with a transient receptor potential vanilloid 1 antagonist.

T. Shimokawa, H. Tanaka, A. Shimaya, 2011, Life sciences.

JPET #050781 1 Title page Title: Allodynia and Hyperalgesia in Adjuvant-Induced Arthritic Rats: Time-Course of Their Progression and Efficacy of Analgesics for Them

A. Kohara, A. Iwai, T. Toya, 2003 .

An evaluation tool for FKBP12-dependent and -independent mTOR inhibitors using a combination of FKBP-mTOR fusion protein, DSC and NMR

F. Inagaki, M. Yokochi, Ken-ichi Suzumura, 2011, Protein engineering, design & selection : PEDS.

The role of 5-hydroxytryptamine3 and 5-hydroxytryptamine4 receptors in the regulation of gut motility in the ferret.

K. Miyata, Y. Nagakura, T. Kiso, 2000, Life sciences.

Design, synthesis, and biological evaluation of novel biphenyl-4-carboxamide derivatives as orally available TRPV1 antagonists.

Toshihiro Watanabe, S. Tamura, S. Shirakami, 2018, Bioorganic & medicinal chemistry.

Amelioration of Neuropathic Pain by Novel Transient Receptor Potential Vanilloid 1 Antagonist AS1928370 in Rats without Hyperthermic Effect

T. Aoki, N. Matsuoka, A. Kohara, 2011, Journal of Pharmacology and Experimental Therapeutics.

Discovery of novel tetrahydroisoquinoline derivatives as orally active N-type calcium channel blockers with high selectivity for hERG potassium channels.

M. Inoue, Hiroyoshi Yamada, Toshihiro Watanabe, 2014, Bioorganic & medicinal chemistry.