N. Mclean

发表

Towards an interpretation of 13C chemical shifts in bathorhodopsin, a functional intermediate of a G-protein coupled receptor.

M. Levitt, J. Lugtenburg, P. Bovee-Geurts, 2009, Biochimica et biophysica acta.

Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.

Adam R. Johnson, N. C. Ray, Rohan V Mendonca, 2019, Bioorganic & medicinal chemistry letters.

Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer.

Jun Liang, Y. Ran, L. Friedman, 2020, ACS medicinal chemistry letters.

Syntheses of 13C2-labelled 11Z-retinals

L. Brown, Richard C. D. Brown, A. Gansmüller, 2011 .

Light penetration and photoisomerization in rhodopsin studied by numerical simulations and double-quantum solid-state NMR spectroscopy.

M. Levitt, P. Bovee-Geurts, Richard C. D. Brown, 2009, Journal of the American Chemical Society.

A large geometric distortion in the first photointermediate of rhodopsin, determined by double-quantum solid-state NMR

M. Levitt, P. Bovee-Geurts, Richard C. D. Brown, 2012, Journal of Biomolecular NMR.

Microwave assisted Petasis boronic-Mannich reactions

M. Whittaker, Heather Tye, N. Mclean, 2004 .

Stereocontrolled synthesis of (-)-galanthamine.

N. Camp, Richard C. D. Brown, N. Mclean, 2007, Organic letters.

Stereocontrolled synthesis of (-)-galanthamine.

N. Camp, Richard C. D. Brown, N. Mclean, 2007, Organic letters.

A large geometric distortion in the first photointermediate of rhodopsin, determined by double-quantum solid-state NMR

M. Levitt, P. Bovee-Geurts, Richard C. D. Brown, 2012, Journal of biomolecular NMR.

The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).

S. Steinbacher, Steve Price, E. Gancia, 2016, Journal of medicinal chemistry.

GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer.

Siew K. Yeap, N. C. Ray, Jun Liang, 2021, Journal of medicinal chemistry.

Discovery of GNE-502 as an Orally Bioavailable and Potent Degrader for Estrogen Receptor Positive Breast Cancer.

Jun Liang, Y. Ran, L. Friedman, 2021, Bioorganic & medicinal chemistry letters.

Synthesis of (-)-Galanthamine

N. Camp, Richard C. D. Brown, N. Mclean, 2007 .

Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoform.

Steve Price, M. Belvin, BinQing Wei, 2013, Bioorganic & medicinal chemistry letters.

Optimization of an Imidazo[1,2-a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy.

E. Hennessy, Nichola L. Davies, A. Doherty, 2021, Journal of medicinal chemistry.

Double-quantum 13C nuclear magnetic resonance of bathorhodopsin, the first photointermediate in mammalian vision.

M. Levitt, J. Lugtenburg, P. Bovee-Geurts, 2008, Journal of the American Chemical Society.

Analytical theory of γ-encoded double-quantum recoupling sequences in solid-state nuclear magnetic resonance

M. Levitt, Richard C. D. Brown, G. Pileio, 2007 .