J. Hofmann

发表

Decreased potency of MDR‐modulators under serum conditions determined by a functional assay

C. Ludescher, W. Hilbe, W. Eisterer, 1995, British journal of haematology.

Dehydroepiandrosterone sulfate directly activates protein kinase C-beta to increase human neutrophil superoxide generation.

J. Lord, W. Arlt, A. Taylor, 2010, Molecular endocrinology.

Enhancement of the antiproliferative activity of cis‐diamminedichloroplatinum(II) by quercetin

H. Grunicke, H. Fiebig, D. Berger, 1990, International journal of cancer.

Inhibition of cell proliferation, protein kinase C, and phorbol ester-induced fos expression by the dihydropyridine derivative B859-35.

H. Grunicke, A. Egle, W. Doppler, 1991, Cancer research.

Reversal of multidrug resistance by B859-35, a metabolite of B859-35, niguldipine, verapamil and nitrendipine

H. Grunicke, M. Spitaler, C. Ludescher, 2005, Journal of Cancer Research and Clinical Oncology.

B‐859‐35, a new drug with anti‐tumor activity reverses multi‐drug resistance

H. Grunicke, F. Ueberall, J. Hofmann, 1991, International journal of cancer.

Resistance to the new anti-cancer phospholipid ilmofosine (BM 41 440).

S. Hofer, H. Grunicke, M. Rybczyńska, 1997, British Journal of Cancer.

Protein kinase Cgamma in colon cancer cells: expression, Thr514 phosphorylation and sensitivity to butyrate-mediated upregulation as related to the degree of differentiation.

A. Csordás, P. Gálfi, J. Hofmann, 2010, Chemico-biological interactions.

The phospholipid- and calcium-dependent protein kinase as a target in tumor chemotherapy.

H. Grunicke, K. Maly, F. Uberall, 1989, Advances in enzyme regulation.

The protein kinase C inhibitor ilmofosine (BM 41 440) arrests cells in G2 phase and suppresses CDC2 kinase activation through a mechanism different from that of DNA damaging agents.

K. Kohn, P. O'Connor, J. Jackman, 1994, Biochemical and biophysical research communications.

Oleanolic acid derivative methyl 3, 11-dioxoolean-12-en-28-olate targets multidrug resistance related to ABCB1

M. Rybczyńska, B. Rubiś, B. Bednarczyk-Cwynar, 2011, Pharmacological reports : PR.

Plasma membrane as target of alkylating agents.

H. Ringsdorf, H. Lindner, H. Grunicke, 1985, Advances in enzyme regulation.

Inhibition of Cell Proliferation , Protein Kinase C , and Phorbol Ester-induced fos Expression by the Dihydropyridine Derivative B 859-35

H. Grunicke, A. Egle, W. Doppler, 2006 .

A cold-active extracellular metalloprotease from Pedobacter cryoconitis--production and properties.

B. Sarg, H. Lindner, R. Margesin, 2005, Research in microbiology.

Barbituric acid derivative BAS 02104951 inhibits PKCε, PKCη, PKCε/RACK2 interaction, Elk-1 phosphorylation in HeLa and PKCε and η translocation in PC3 cells following TPA-induction.

T. Langer, J. Kirchmair, P. Gruber, 2011, Journal of biochemistry.

Protection of Ehrlich Ascites Tumor Cells against the Antiproliferative Effect of Mechlorethamine ( Nitrogen Mustard ) by 5-A

H. Grunicke, K. Maly, J. Hofmann, 2006 .

Enhancement of the Antiproliferative Effect of cis-Diamminedichloroplatinum (II) and Other Antitumor Agents by Inhibitors of Enzymes Involved in Growth Factor Signal-Transduction

H. Grunicke, F. Überall, A. Egle, 1991 .

Nuclear Components and Plasma Membrane as Targets of Chemotherapeutic Agents

W. Helliger, B. Puschendorf, H. Grunicke, 1989 .

Differential sensitivity of histone acetylation in nitrogen-mustard sensitive and resistant cells. Relation to drug uptake, formation and repair of DNA-interstrand cross-links.

W. Helliger, B. Puschendorf, H. Grunicke, 1988, European journal of cancer & clinical oncology.

Protection of Ehrlich ascites tumor cells against the antiproliferative effect of mechlorethamine (nitrogen mustard) by 5-N,N-dimethylamiloride.

H. Grunicke, W. Doppler, K. Maly, 1988, Cancer research.

New Strategies for the Improvement of Alkylating Antitumor Agents

H. Ringsdorf, H. Lindner, B. Puschendorf, 1987 .

N-benzoxazol-2-yl-N′-1-(isoquinolin-3-yl-ethylidene)-hydrazine, a novel compound with antitumor activity, induces radicals and dissipation of mitochondrial membrane potential

D. Condorelli, M. Hermann, G. Musumarra, 2009, Investigational New Drugs.

The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease

N. Lisiak, E. Totoń, M. Rybczyńska, 2012, European journal of pharmacology.

Regulation of phospholipase D isoenzymes by transforming Ras and atypical protein kinase C-iota.

H. Grunicke, M. Spitaler, J. Mwanjewe, 2001, The Biochemical journal.

Desensitization of the Ca2+-mobilizing system to serum growth factors by Ha-ras and v-mos

R. Jaggi, H. Grunicke, W. Doppler, 1988, Molecular and cellular biology.

Resistance to chemotherapy

J. Hofmann, 2008, British Journal of Cancer.

Human platelets attenuate Aspergillus species via granule-dependent mechanisms.

M. Dierich, J. Donnelly, C. Lass‐Flörl, 2008, The Journal of infectious diseases.

Azinyl and diazinyl hydrazones derived from aryl N-heteroaryl ketones: synthesis and antiproliferative activity.

T. Langer, J. Osterreicher, H. Grunicke, 1997, Journal of medicinal chemistry.

2‐benzoxazolyl and 2‐benzimidazolyl hydrazones derived from 2‐acetylpyridine: A novel class of antitumor agents

H. Fiebig, G. Puerstinger, M. Jenny, 2001, International journal of cancer.

Synthesis, cytotoxicity, and antitumor activity of copper(II) and iron(II) complexes of (4)N-azabicyclo[3.2.2]nonane thiosemicarbazones derived from acyl diazines.

W. Jäger, H. Fiebig, W. Holzer, 2001, Journal of medicinal chemistry.

Synthesis, Cytotoxic, and Antitumor Activities of 2‐Pyridylhydrazones Derived from 3‐Benzoylpyridazines

J. Hofmann, G. Heinisch, T. Roth, 2014, Archiv der Pharmazie.

Synthesis of a fluoroalkene peptidomimetic precursor of N-acetyl-l-glutamyl-l-alanine

H. Parrot-Lopez, P. Goekjian, J. Hofmann, 2007 .

Synthesis, structure-activity relationships, and antitumor studies of 2-benzoxazolyl hydrazones derived from alpha-(N)-acyl heteroaromatics.

Johann Hofmann, Johnny Easmon, Gerhard Pürstinger, 2006, Journal of medicinal chemistry.

Novel boronated derivatives of 5,10,15,20-tetraphenylporphyrin: synthesis and toxicity for drug-resistant tumor cells.

V. Ol’shevskaya, A. Shtil, A. Mironov, 2006, Bioorganic & medicinal chemistry.

Thiazolyl and benzothiazolyl hydrazones derived from α-(N)-acetylpyridines and diazines: synthesis, antiproliferative activity and CoMFA studies

T. Langer, H. Grunicke, J. Hofmann, 1997 .

Effects of the selective bisindolylmaleimide protein kinase C inhibitor GF 109203X on P-glycoprotein-mediated multidrug resistance.

H. Grunicke, C. Schächtele, F. Überall, 1996, British Journal of Cancer.

Modulation of protein kinase C in antitumor treatment.

J. Hofmann, 2001, Reviews of physiology, biochemistry and pharmacology.

Cytotoxic and cytostatic effects of antitumor agents induced at the plasma membrane level.

H. Grunicke, J. Hofmann, 1992, Pharmacology & therapeutics.

Alkylating antitumor agents reduce histone acetyl-transferase activity.

W. Helliger, B. Puschendorf, H. Grunicke, 1986, Advances in enzyme regulation.

Rapid functional assay for the detection of multidrug-resistant cells using the fluorescent dye rhodamine 123.

H. Grunicke, C. Ludescher, J. Hofmann, 1991, Blood.

A sensitive radioimmuno assay for thymine dimers

H. Klocker, H. Burtscher, B. Auer, 2004, Molecular and General Genetics MGG.

A Sensitive Radioimmuno Assay for Thymine

H. Klocker, B. Auer, M. Schweiger, 1982 .

Nitrogen mustard interference with potassium transport systems in Ehrlich ascites tumor cells

H. Grunicke, W. Doppler, K. Maly, 2004, Journal of Cancer Research and Clinical Oncology.

Effects of nitrogen mustard on potassium transport systems and membrane structure of Ehrlich ascites tumor cells.

H. Grunicke, R. Greinert, A. Stier, 1985, Advances in enzyme regulation.

Synergistic enhancement of the antiproliferative activity ofcis-diamminedichloroplatinum(II) by the ether lipid analogue BM41440, an inhibitor of protein kinase C

H. Grunicke, F. Ueberall, K. Maly, 1989, Lipids.

Zapotin (5,6,2′,6′-tetramethoxyflavone) Modulates the Crosstalk Between Autophagy and Apoptosis Pathways in Cancer Cells with Overexpressed Constitutively Active PKCϵ

E. Totoń, M. Rybczyńska, J. Budzianowski, 2016, Nutrition and Cancer.

Impact of PKCε downregulation on autophagy in glioblastoma cells

J. Barciszewski, E. Totoń, M. Rybczyńska, 2018, BMC Cancer.

Detection of activity of P‐glycoprotein in human tumour samples using rhodamine 123

M. Spitaler, C. Ludescher, J. Thaler, 1992, British journal of haematology.

Mechanism of action of dexniguldipine-HCl (B8509-035), a new potent modulator of multidrug resistance.

S. Hofer, V. Gekeler, H. Glossmann, 1995, Biochemical pharmacology.

The New Anticancer Drug Ilmofosine Enhances the Activity of CIS-Platin and Reverses Multidrug Resistance

H. Grunicke, F. Überall, M. Spitaler, 1993 .

Role of protein kinases in antitumor drug resistance

H. Grunicke, F. Überall, J. Hofmann, 2005, Annals of Hematology.

Effects of miltefosine on various biochemical parameters in a panel of tumor cell lines with different sensitivities.

H. Grunicke, M. Rybczyńska, N. Knebel, 2001, Biochemical pharmacology.

MDR1 causes resistance to the antitumour drug miltefosine

H. Grunicke, M. Rybczyńska, F. Sharom, 2001, British Journal of Cancer.

PKC-independent modulation of multidrug resistance in cells with mutant (V185) but not wild-type (G185) P-glycoprotein by bryostatin 1.

H. Grunicke, M. Spitaler, W. Hilbe, 1998, Biochemical pharmacology.

Telomerase downregulation induces proapoptotic genes expression and initializes breast cancer cells apoptosis followed by DNA fragmentation in a cell type dependent manner

N. Lisiak, E. Totoń, M. Rybczyńska, 2013, Molecular Biology Reports.

Scientific Proceedings Second International Symposium on Cytostatic Drug Resistance

R. Pieters, K. Sikora, W. Siegert, 1991, Journal of Cancer Research and Clinical Oncology.

Enhancement of the antiproliferative effect of cis‐diamminedichloroplatinum(II) and nitrogen mustard by inhibitors of protein kinase C

H. Grunicke, F. Überall, W. Doppler, 1988, International journal of cancer.

Thienoquinolines as Novel Disruptors of the PKCε/RACK2 Protein–Protein Interaction

T. Langer, M. Preobrazhenskaya, J. Kirchmair, 2014, Journal of medicinal chemistry.

Multidrug resistance in acute leukemia: a comparison of different diagnostic methods

M. Spitaler, C. Ludescher, G. Pall, 1997, Leukemia.

Activity of P-glycoprotein in B-cell chronic lymphocytic leukemia determined by a flow cytometric assay.

C. Huber, C. Ludescher, W. Hilbe, 1993, Journal of the National Cancer Institute.

Amiloride and 5-N,N-dimethylamiloride inhibit the carrier mediated uptake of choline in Ehrlich ascites tumor cells.

H. Grunicke, W. Doppler, K. Maly, 1987, Biochemical pharmacology.

Signal transduction of constitutively active protein kinase C epsilon.

E. Totoń, M. Rybczyńska, E. Rosivatz, 2009, Cellular signalling.

Thiazolyl and Benzothiazolyl Hydrazones Derived from α‐(N)‐ Acetylpyridines and Diazines: Synthesis, Antiproliferative Activity and CoMFA Studies.

T. Langer, H. Grunicke, G. Puerstinger, 1997 .

Protein kinase C isozymes as potential targets for anticancer therapy.

J. Hofmann, 2004, Current cancer drug targets.

The protein kinase C inhibitor CGP 41251, a staurosporine derivative with antitumor activity, reverses multidrug resistance

S. Hofer, H. Grunicke, W. Hilbe, 1994, International journal of cancer.

Low frequency of activity of P-glycoprotein (P-170) in acute lymphoblastic leukemia compared to acute myeloid leukemia.

C. Ludescher, W. Hilbe, W. Eisterer, 1995, Leukemia.

The involvement of protein kinase C isoenzymes alpha, epsilon and zeta in the sensitivity to antitumor treatment and apoptosis induction.

H. Grunicke, T. Seppi, B. Wiesenhofer, 1999, Anticancer research.

Modulators of protein-protein interactions: novel approaches in targeting protein kinases and other pharmaceutically relevant biomolecules.

Peter Gruber, Johannes Kirchmair, Johann Hofmann, 2011, Current topics in medicinal chemistry.

Protein kinase C effectors bind to multidrug ABC transporters and inhibit their activity.

A. Goffeau, J. M. Pérez-Victoria, A. di Pietro, 2001, Biochemistry.

Low incidence of activity of P-glycoprotein (P-170) in de novo acute lymphoblastic leukemia determined by a flow cytometric assay [letter; comment]

C. Ludescher, W. Hilbe, W. Eisterer, 1993 .

Telomerase downregulation induces proapoptotic genes expression and initializes breast cancer cells apoptosis followed by DNA fragmentation in a cell type dependent manner

N. Lisiak, E. Totoń, M. Rybczyńska, 2013, Molecular Biology Reports.

Impact of PKCε downregulation on autophagy in glioblastoma cells

J. Barciszewski, E. Totoń, M. Rybczyńska, 2018, BMC Cancer.

The Copper-Containing Monocarboranylporphyrin: A Prototype of New DNA-Binding Cytotoxic Compounds

A. Shishkin, V. Ol’shevskaya, A. Shtil, 2005, Doklady Biochemistry and Biophysics.

using the fluorescent dye rhodamine 123 (letter; comment) Rapid functional assay for the detection of multidrug-resistant cells

H. Grunicke, C. Ludescher, J. Hofmann, 2013 .

Protein kinase C isoenzymes, p53, accumulation of rhodamine 123, glutathione-S-transferase, topoisomerase II and MRP in multidrug resistant cell lines.

H. Grunicke, M. Spitaler, V. Gekeler, 1996, Anticancer research.