K. Lesiak

发表

The practical synthesis of a methylenebisphosphonate analogue of benzamide adenine dinucleotide: inhibition of human inosine monophosphate dehydrogenase (type I and II).

A. Zatorski, K. Watanabe, Kyoichi A. Watanabe, 1997, Journal of medicinal chemistry.

Stereospecific synthesis of adenosine 3′,5′-(SP)- and -(RP)-cyclic phosphorothioates (cAMPS)

W. Stec, K. Lesiak, J. Baraniak, 1979 .

The solid-phase synthesis of 2-5-linked oligoriboadenylates containing 8-bromoadenine

B. Uznański, P. Torrence, K. Lesiak, 1997, Applied biochemistry and biotechnology.

Bicyclic monoterpene diols induce differentiation of S91 melanoma and PC12 pheochromocytoma cells by a cyclic guanosine-monophosphate-dependent pathway.

A. Khorlin, W. Ren, K. Lesiak, 1999, Pigment cell research.

2′,5′-Oligoadenylates: Their Role in Interferon Action and Their Potential as Chemotherapeutic Agents

H. Sawai, P. Torrence, K. Lesiak, 1983 .

AIDS dementia: Synthesis and properties of a derivative of 3′‐azido‐3′‐deoxythymidine (AZT) that may become ‘locked’ in the central nervous system

E. De Clercq, J. Balzarini, P. Torrence, 1988, FEBS letters.

Modes of action of interferon and analogues of 2-5A, a mediator of interferon action

H. Sawai, J. Balzarini, E. Clercq, 1984 .

SYNTHESIS OF METHYLENEBIS(PHOSPHONATE) ANALOGUES OF NUCLEOTIDE COENZYMES. A NOVEL COUPLING MECHANISM

Kyoichi A. Watanabe, K. Pankiewicz, K. Lesiak, 1999 .

Synthesis of a methylenebis(phosphonate) analogue of mycophenolic adenine dinucleotide: a glucuronidation-resistant MAD analogue of NAD.

K. Watanabe, K. Pankiewicz, B. Goldstein, 1998, Journal of medicinal chemistry.

Analysis of Neisseria meningitidis class 3 outer membrane protein gene variable regions and type identification using genetic techniques

C. Frasch, S. Banks, K. Lesiak, 1995, Infection and immunity.

Adducts of Mannose 6-Phosphate with 5-Iodo-2′-Deoxyuridine and 2-5A as Potential Antiviral Agents

E. Clercq, P. Torrence, K. Lesiak, 1989 .

Synthesis of a difluoromethylenephosphonate analogue of AZT 5'-triphosphate and its inhibition of HIV-1 reverse transcriptase

J. Balzarini, E. Clercq, K. Kirk, 1991 .

Formation of alpha-deoxyadenosine in polydeoxynucleotides exposed to ionizing radiation under anoxic conditions.

K. Wheeler, K. Lesiak, 1990, Radiation research.

Antibody-nucleic acid interactions. Monoclonal antibodies define different antigenic domains in 2',5'-oligoadenylates.

H. Sawai, H. Jacobsen, P. Torrence, 1985, Biochemistry.

EFFICIENT SYNTHESIS OF METHYLENEBIS(PHOSPHONATE) ANALOGUES OF P1,P2-DISUBSTITUTED PYROPHOSPHATES OF BIOLOGICAL INTEREST. A NOVEL PLAUSIBLE MECHANISM

Kyoichi A. Watanabe, K. Pankiewicz, K. Lesiak, 1997 .

A novel route to 1-aminoalkylphosphonic acid

W. Stec, K. Lesiak, 1976 .

Conformational analysis of brominated pA2'-5'A2'-5'A analogs. An NMR and model-building study.

C. Altona, P. Torrence, K. Lesiak, 1989, European journal of biochemistry.

Mechanism of HIV reverse transcriptase: enzyme-primer interaction as revealed through studies of a dNTP analogue, 3'-azido-dTTP.

S. H. Wilson, P. Kedar, P. Torrence, 1990, Biochemistry.

Aliphatic and alicyclic diols induce melanogenesis in cultured cells and guinea pig skin.

A. Khorlin, K. Watanabe, W. Ren, 1998, The Journal of investigative dermatology.

Synthesis of a novel C-nucleoside, 2-amino-7-(2-deoxy-beta-D-erythro- pentofuranosyl)-3H,5H-pyrrolo-[3,2-d]pyrimidin-4-one (2'-deoxy-9-deazaguanosine).

L. Gudas, K. Watanabe, K. Pankiewicz, 1999, Nucleosides & nucleotides.

Strategies in the Design of Oligonucleotides as Potential Antiviral Agents

H. Sawai, J. Balzarini, E. Clercq, 1984 .

DOUBLE-STRANDED RNA AND 2′,5′-OLIGOADENYLATES: COMPANIONS IN INTERFERON ACTION?

H. Sawai, R. Friedman, B. Safer, 1982 .

2',5'-oligoadenylates inhibit relaxation of supercoiled DNA by calf thymus DNA topoisomerase I.

P. Torrence, F. Castora, K. Lesiak, 1991, Journal of interferon research.

2',5'-Oligoadenylate:antisense chimeras--synthesis and properties.

P. Torrence, K. Lesiak, S. Khamnei, 1993, Bioconjugate chemistry.

A new and potent 2-5A analogue which does not require a 5'-polyphosphate to activate mouse L-cell RNase L.

A. Pabuççuoğlu, P. Torrence, K. Lesiak, 1992, Antiviral research.

Inhibition of the RNA polymerase of vesicular stomatitis virus by ppp5'A2'p5'A and related compounds.

P. Torrence, J. Lenard, K. Lesiak, 1990, Antiviral research.

Synthesis of a 5′-thiophosphate analogue of 2-5A, a phosphatase resistant activator of the 2-5A-dependent ribonuclease

R. Silverman, B. Dong, L. Guiying, 1994 .

Cordycepin analogues of 2-5A and its derivatives. Chemical synthesis and biological activity.

H. Sawai, P. Torrence, K. Lesiak, 1983, The Journal of biological chemistry.

Stereospecific synthesis of cyclic adenosine 3',5'-(SP)-[18O]phosphate

W. Stec, K. Lesiak, M. Sochacki, 1980 .

Synthesis of nonhydrolyzable analogues of thiazole-4-carboxamide and benzamide adenine dinucleotide containing fluorine atom at the C2' of adenine nucleoside: induction of K562 differentiation and inosine monophosphate dehydrogenase inhibitory activity.

K. Watanabe, K. Pankiewicz, B. Goldstein, 1997, Journal of medicinal chemistry.

Respective role of each of the purine N-6 amino groups of 5'-O-triphosphoryladenylyl(2'----5')adenylyl(2----5')adenosine in binding to and activation of RNase L.

P. Torrence, K. Lesiak, J. Imai, 1985, The Journal of biological chemistry.

Targeting RNA for degradation with a (2'-5')oligoadenylate-antisense chimera.

R. Silverman, P. Torrence, R. Maitra, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and characterization of composite nucleic acids containing 2', 5'-oligoriboadenylate linked to antisense DNA.

M. Player, W. Zhang, P. Torrence, 1996, Antisense & nucleic acid drug development.

2′,5′-Oligoadenylate Antisense Chimeras for Targeted Ablation of RNA

R. Silverman, A. Maran, B. Dong, 1994 .

Oligonucleotide structural parameters that influence binding of 5'-O-triphosphoadenylyl-(2'----5')-adenylyl-(2'----5')-adenosine to the 5'-O-triphosphoadenylyl-(2'----5')-adenylyl-(2'----5')-adenosine dependent endoribonuclease: chain length, phosphorylation state, and heterocyclic base.

H. Sawai, P. Torrence, K. Lesiak, 1984, Journal of medicinal chemistry.

Replacement of the ribofuranose oxygen of 2-5A derivatives by methylene: synthesis of an aristeromycin analog of 2-5A core 5'-monophosphate (5'-O-phosphoryladenylyl)(2'.fwdarw.5')adenylyl(2'.fwdarw.5')adenosine 5'-monophosphate

H. Sawai, P. Torrence, K. Lesiak, 1985 .

Synthesis and biological activity of tubercidin analogues of ppp5'A2'p(5'A2'p)n5'A.

P. Torrence, K. Lesiak, J. Jamoulle, 1984, Biochemistry.

A Solid-Phase Synthesis of 2′,5′-Linked Oligoadenylates (2-5A)

B. Uznański, K. Lesiak, P. Terrence, 1989 .

Replacement of the ribofuranose oxygen of 2-5A derivatives by methylene: synthesis of an aristeromycin analogue of 2-5A core 5'-monophosphate (5'-O-phosphoryladenylyl)(2'----5')adenyl(2'----5')adenosine.

H. Sawai, P. Torrence, K. Lesiak, 1985, Journal of medicinal chemistry.

Structure--activity relationships for and potentiation of the antimitogenic activity of 2-5A core derived from 2-5A, a mediator of interferon action.

E. De Clercq, J. Balzarini, P. Torrence, 1983, Journal of medicinal chemistry.

Biological activities of phosphodiester linkage isomers of 2-5A.

P. Torrence, K. Lesiak, G. Floyd-Smith, 1983, The Journal of biological chemistry.

Synthesis and biological activity of a fluorescent analogue of 2—5A

P. Torrence, K. Lesiak, 1983, FEBS letters.

Phosphorylation of 2-5A core 5'-diphosphate to 2-5A in mouse L cell extracts.

P. Torrence, K. Lesiak, 1985, Biochemical and biophysical research communications.

Immunochemical analysis of the structure of 2',5'-oligoadenylate

P. Torrence, K. Lesiak, J. Imai, 1983 .

Activation of 2-5A-dependent RNase by analogs of 2-5A (5'-O-triphosphoryladenylyl(2'----5')adenylyl(2'----5')adenosine ) using 2',5'-tetraadenylate (core)-cellulose.

R. Silverman, H. Sawai, P. Torrence, 1986, The Journal of biological chemistry.

Purine 8-bromination modulates the ribonuclease L binding and activation abilities of 2',5'-oligoadenylates. Possible influence of glycosyl torsion angle.

P. Torrence, K. Lesiak, 1987, The Journal of biological chemistry.

Synthesis and biological activities of oligo(8-bromoadenylates) as analogues of 5'-O-triphosphoadenylyl(2'----5')adenylyl(2'----5')adenosine.

P. Torrence, K. Lesiak, 1986, Journal of medicinal chemistry.

Fluorodeoxy Sugar Analogues of 2',5'-Oligoadenylates as Probes of Hydrogen Bonding in Enzymes of the 2-5A System.

A. Pabuççuoğlu, P. Torrence, K. Lesiak, 1993 .

Methods for the synthesis of analogs of (2'-5')-oligoadenylic acid.

P. Torrence, K. Lesiak, J. Jamoulle, 1986, Methods in enzymology.

Respective role of each of the purine N7 nitrogens of 5'-O-triphosphoadenylyl(2'----5')adenylyl(2'----5')adenosine in binding to and activation of the RNase L of mouse cells.

P. Torrence, K. Lesiak, J. Jamoulle, 1987, Biochemistry.

(2′‐5′)オリゴアデニル酸‐アンチセンスキメラでの分解のため標的RNA

K. Lesiak, S. Khamnei, A. Zhou, 1993 .

Photochemical crosslinking in oligonucleotide-protein complexes between a bromine-substituted 2-5A analog and 2-5A-dependent RNase by ultraviolet lamp or laser.

R. Silverman, P. Torrence, B. Bayard, 1990, Analytical biochemistry.

STEREOSPECIFIC SYNTHESIS OF CYCLIC ADENOSINE 3′,5′-(SP)-(18O)PHOSPHATE

W. Stec, K. Lesiak, M. Sochacki, 1980 .

Synthesis and biological activity of uronic acid analogues of 2-5A[5'-O-triphosphoryladenylyl(2----5')adenylyl-(2'----5')adenosine].

A. Pabuççuoğlu, J. Kinjo, P. Torrence, 1992, Drug design and discovery.

Synthesis and biological activities of oligo(8-bromoadenylates) as analogues of 5'-O-triphosphoadenylyl(2'----5')adenylyl(2'----5')adenosine.

P. Torrence, K. Lesiak, 1986, Journal of medicinal chemistry.

Cordycepin analogs of ppp5'A2'p5'A2'p5'A (2-5A) inhibit protein synthesis through activation of the 2-5A-dependent endonuclease.

H. Sawai, B. Schryver, M. van der Pas, 1985, The Journal of biological chemistry.

Oligonucleotide structural features involved in binding to and activation of the 2-5A-dependent endoribonuclease of L cells.

P. Torrence, K. Lesiak, J. Imai, 1982, Nucleic acids symposium series.

Nuclear magnetic resonance structure of d(GCATATGATAG). d(CTATCATATGC): a consensus sequence for promoters recognized by sigma K RNA polymerase.

A. Bianucci, T. James, M. Tonelli, 1998, Biochemistry.