Wei-sheng Huang

发表

Structural Analysis of DFG‐in and DFG‐out Dual Src‐Abl Inhibitors Sharing a Common Vinyl Purine Template

T. Clackson, T. Zhou, T. Sawyer, 2009, Chemical biology & drug design.

Green phosphorescent iridium dendrimers containing dendronized benzoimidazole-based ligands for OLEDs

Jiann T. Lin, Hong-Cheu Lin, Wei-sheng Huang, 2008 .

BINOL-linked 1,2,3-triazoles: an unexpected fluorescent sensor with anion–π interaction for iodide ions

Li Li, Wei-sheng Huang, J. Zou, 2014 .

DMSO as oxidant and sulfenylating agent for metal-free oxidation and methylthiolation of alcohol-containing indoles

Zheng Xu, Ke-Fang Yang, Li Li, 2015 .

Studies on organophosphorus compounds 98. Spectroscopic investigations of 1-substituted 5-trifluoromethyl imidazole- 4-phosphonate and 1-substituted-5-trifluoromethyl imidazole- 4-carboxylate

C. Yuan, Yixin Zhang, Wei-sheng Huang, 1996 .

Catalytic Asymmetric Synthesis of α,α-Difluoromethylated and α-Fluoromethylated Tertiary Alcohols.

X. Pannecoucke, P. Jubault, T. Poisson, 2019, Organic letters.

General Catalytic Enantioselective Access to Monohalomethyl and Trifluoromethyl Cyclopropanes.

X. Pannecoucke, P. Jubault, T. Poisson, 2018, Chemistry.

Catalytic Enantioselective Synthesis of Highly Functionalized Difluoromethylated Cyclopropanes.

X. Pannecoucke, P. Jubault, T. Poisson, 2017, Angewandte Chemie.

Enantioselective cyanosilylation of aldehydes catalyzed by a multistereogenic salen–Mn(III) complex with a rotatable benzylic group as a helping hand

Zheng Xu, Ke-Fang Yang, Yun‐Long Wei, 2015 .

The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models

T. Clackson, R. Anjum, V. Rivera, 2016, Clinical Cancer Research.

Abstract #3738: Discovery of potent and selective orally active inhibitors of anaplastic lymphoma kinase (ALK)

T. Clackson, R. Anjum, V. Rivera, 2009 .

AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance.

T. Clackson, B. Druker, A. Corbin, 2009, Cancer cell.

Development of Highly Enantioselective Polymeric Catalysts Using Rigid and Sterically Regular Chiral Polybinaphthols

L. Pu, Q. Hu, Wei-sheng Huang, 1997 .

Studies on organophosphorus compounds. Part 96. Nucleophilicity of the isocyano carbon atom in diethyl isocyanomethylphosphonate. First generation of a phosphorylated nitrile ylide and new syntheses of pyrrolinephosphonates and pyrrolephosphonates

C. Yuan, Yixin Zhang, Wei-sheng Huang, 1996 .

New synthetic methods for carbocyclic and heterocyclic compounds bearing phosphonate moiety with biological significances

Wei-sheng Huang, Chengqian Yuan, Chang-Zhi Li, 1993 .

Fluorinated Organophosphorus Compounds as a New Class of Agrochemicals

C. Yuan, Shoujun Chen, Yixin Zhang, 2000 .

Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase including the T315I gatekeeper mutant.

Wei-Sheng Huang, Jan Romero, Shuangying Liu, 2010, Journal of medicinal chemistry.

Asymmetric Disilylation of Spirocyclic Palladacyclopentanes via Tandem Heck/C−H Activation of Aryl Iodides

Zheng Xu, F. Ye, Ke-Fang Yang, 2021, Asian Journal of Organic Chemistry.

Modular construction of multifunctional ligands for the enantioselective ruthenium-catalyzed carbenoid N–H insertion reaction: an enzyme-like and substrate-sensitive catalyst system

Zheng Xu, Ke-Fang Yang, Wei-sheng Huang, 2015 .

Conformational conversion and chain ordering in cyclo olefin copolymer (COC)

F. Chang, P. P. Chu, Wei-sheng Huang, 2000 .

Benzimidazole/amine-based compounds capable of ambipolar transport for application in single-layer blue-emitting OLEDs and as hosts for phosphorescent emitters.

Jiann T. Lin, Chung‐Chih Wu, Li-Yin Chen, 2008, Angewandte Chemie.

Highly Phosphorescent Bis-Cyclometalated Iridium Complexes Containing Benzoimidazole-Based Ligands

Yuh-Sheng Wen, Wei-Sheng Huang, Yu-Tai Tao, 2004 .

Asymmetric Epoxidation of alpha,beta-Unsaturated Ketones Catalyzed by Chiral Polybinaphthyl Zinc Complexes: Greatly Enhanced Enantioselectivity by a Cooperation of the Catalytic Sites in a Polymer Chain.

L. Pu, Q. Hu, Wei-sheng Huang, 1999, The Journal of organic chemistry.

New and improved ligands for highly enantioselective catalytic diphenylzinc additions to aryl aldehydes

L. Pu, Wei-sheng Huang, 2000 .

From Highly Enantioselective Monomeric Catalysts to Highly Enantioselective Polymeric Catalysts: Application of Rigid and Sterically Regular Chiral Binaphthyl Polymers to the Asymmetric Synthesis of Chiral Secondary Alcohols

L. Pu, Wei-sheng Huang, A. Q. Hu, 1999 .

THE FIRST HIGHLY ENANTIOSELECTIVE CATALYTIC DIPHENYLZINC ADDITIONS TO ALDEHYDES : SYNTHESIS OF CHIRAL DIARYLCARBINOLS BY ASYMMETRIC CATALYSIS

L. Pu, Wei-sheng Huang, 1999 .

A Highly General Catalyst for the Enantioselective Reaction of Aldehydes with Diethylzinc

L. Pu, Wei-sheng Huang, A. Q. Hu, 1998 .

Investigation of the Mitsunobu Reaction of BINOL and Cinchona Alkaloids: Inversion or Retention of Configuration?

Yu-Ming Cui, Wei-sheng Huang, Jingfeng Zou, 2014 .

Highly Diastereoselective Hydrosilane-assisted Rhodium-Catalyzed Spiro-type Cycloisomerization of Succinimide and Pyrazolone -based Functional 1,6-Dienes.

Li Li, Wei-sheng Huang, Jun Yan, 2021, Chemistry, an Asian journal.

Catalytic asymmetric reductive coupling of alkynes and aldehydes: enantioselective synthesis of allylic alcohols and alpha-hydroxy ketones.

T. Jamison, Wei-sheng Huang, K. Miller, 2003, Journal of the American Chemical Society.

Rhodium catalysed enantioselective synthesis of mono-(halo)-methyl-cyclopropanes.

X. Pannecoucke, P. Jubault, T. Poisson, 2019, Organic & biomolecular chemistry.

Functionalized Major-Groove and Minor-Groove Chiral Polybinaphthyls: Application in the Asymmetric Reaction of Aldehydes with Diethylzinc

L. Pu, Q. Hu, Wei-sheng Huang, 1997 .

Greatly enhanced enantioselectivity by an apparently remote steric effect in the 1,1′-binaphthyl-catalyzed alkynylzinc addition to aldehydes

L. Pu, Wei-sheng Huang, Ming‐Hua Xu, 2002 .

Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase.

T. Clackson, R. Anjum, V. Rivera, 2016, Journal of medicinal chemistry.

Catalytic asymmetric bromochlorination of aromatic allylic alcohols promoted by multifunctional Schiff base ligands.

Zheng Xu, Ke-Fang Yang, Yu-Ming Cui, 2016, Organic & biomolecular chemistry.

New strategy for the synthesis of functionalized phosponic acids

C. Yuan, Ya-ping Zhang, Shoujun Chen, 1996 .

STUDIES ON ORGANOPHOSPHORUS COMPOUNDS 93 REACTION OF TRIVALENT PHOSPHORUS REAGENTS WITH N-SUBSTITUTED TRIFLUOROCETMIDOYL CHLORIDES. A NOVEL SYNTHESIS OF 1-(N-SUBSTITUTED AMINO)-2,2,2-TRIFLUOROETHYLPHOSPHONATES

C. Yuan, Yixin Zhang, Wei-sheng Huang, 1995 .

STUDIES ON ORGANOPHOSPHORUS COMPOUNDS 95. A NOVEL SYNTHESIS OF 2-TRIFLUOROMETHYL-2-(SUBSTITUTED AMINO)ETHYLPHOSPHONATES

C. Yuan, Wei-sheng Huang, 1995 .

Expeditious synthesis of C2- or N4-aryl-1,4-benzothiazin-3-one via orthogonal Pd-catalyzed C-arylation and Cu-catalyzed N-arylation

W. Shakespeare, Wei-sheng Huang, Rongsong Xu, 2014 .

Recent Advances in Transition-Metal-Catalyzed Silylations of Arenes with Hydrosilanes: C–X Bond Cleavage or C–H Bond Activation Synchronized with Si–H Bond Activation

Zheng Xu, Wei-sheng Huang, Jin Zhang, 2015 .

Aromatic amide-derived non-biaryl atropisomers as highly efficient ligands in silver-catalyzed asymmetric cycloaddition reactions.

Zheng Xu, T. Song, C. Xia, 2015, Angewandte Chemie.

Facile Synthesis of 9-(Arenethenyl)purines via Heck Reaction of 9-Vinylpurines and Aryl Halides.

Wei-sheng Huang, 2007 .

Mobocertinib (TAK-788): A Targeted Inhibitor of EGFR Exon 20 Insertion Mutants in Non-Small Cell Lung Cancer.

Kwok-Kin Wong, T. Clackson, A. Gould, 2021, Cancer discovery.

Structural Mechanism of the Pan‐BCR‐ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance

T. Clackson, V. Rivera, T. Zhou, 2011, Chemical biology & drug design.

Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors.

T. Clackson, V. Rivera, T. Zhou, 2013, Journal of medicinal chemistry.

Discovery of Mobocertinib, a Potent, Oral Inhibitor of EGFR Exon 20 Insertion Mutations in Non-Small Cell Lung Cancer.

T. Clackson, A. Gould, V. Rivera, 2022, Bioorganic & medicinal chemistry letters.

AP24163 Inhibits the Gatekeeper Mutant of BCR‐ABL and Suppresses In vitro Resistance

John T. Powers, G. Daley, T. Clackson, 2010, Chemical biology & drug design.

9-(Arenethenyl)purines as dual Src/Abl kinase inhibitors targeting the inactive conformation: design, synthesis, and biological evaluation.

G. Daley, T. Clackson, M. Azam, 2009, Journal of medicinal chemistry.

Orally Active Inhibitors of the Imatinib Resistant Bcr-Abl Mutant T315I.

T. Clackson, B. Druker, A. Corbin, 2006 .

Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant.

Wei-Sheng Huang, Jan Romero, Shuangying Liu, 2011, Bioorganic & medicinal chemistry letters.

Novel N9-arenethenyl purines as potent dual Src/Abl tyrosine kinase inhibitors.

T. Clackson, T. Sawyer, W. Shakespeare, 2008, Bioorganic & medicinal chemistry letters.

Derives heterocycliques insatures

T. Sawyer, W. Shakespeare, D. Dalgarno, 2006 .

Facile synthesis of 1,4-benzothiazin-3-ones from Cu-catalyzed coupling of 2-iodoanilines and 2-mercaptoacetate

W. Shakespeare, Wei-sheng Huang, Rongsong Xu, 2013 .

Abstract 3623: Efficacy and pharmacodynamic analysis of AP26113, a potent and selective orally active inhibitor of Anaplastic Lymphoma Kinase (ALK)

Juan J. Miret, Wei-Sheng Huang, Shuangying Liu, 2010 .

A New Approach to Highly Enantioselective Polymeric Chiral Catalysts.

L. Pu, Q. Hu, Wei-sheng Huang, 1998 .

New and Improved Ligands for Highly Enantioselective Catalytic Diphenylzinc Additions to Aryl Aldehydes.

L. Pu, Wei-sheng Huang, 2000 .

The First Highly Enantioselective Catalytic Diphenylzinc Additions to Aldehydes: Synthesis of Chiral Diarylcarbinols by Asymmetric Catalysis.

L. Pu, Wei-sheng Huang, 1999 .

Recent Advances in Transition-Metal-Catalyzed Silylations of Arenes with Hydrosilanes: C–X Bond Cleavage or C–H Bond Activation Synchronized with Si–H Bond Activation

Zheng Xu, Wei-sheng Huang, Jin Zhang, 2015, Synthesis.

Abstract 2644: AP32788, a potent, selective inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, in preclinical models

V. Rivera, T. Zhou, M. Greenfield, 2016 .

Structural Mechanism of the Pan‐BCR‐ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance

T. Clackson, V. Rivera, T. Zhou, 2011, Chemical biology & drug design.

Rhodium catalysed enantioselective synthesis of mono-(halo)-methyl-cyclopropanes.

X. Pannecoucke, P. Jubault, T. Poisson, 2019, Organic & biomolecular chemistry.

An Efficient Synthesis of Nilotinib (AMN107)

W. Shakespeare, Wei-sheng Huang, 2007 .

Abstract 2827: Discovery of AP26113, a potent, orally active inhibitor of anaplastic lymphoma kinase and clinically relevant mutants

T. Clackson, V. Rivera, W. Shakespeare, 2015 .

Abstract 1292: Preclinical characterization of THE-630, a next-generation inhibitor for KIT-mutant gastrointestinal stromal tumors (GIST)

J. Pritchard, Mengrou Lu, W. Shakespeare, 2021, Experimental and Molecular Therapeutics.

DMSO as Oxidant and Sulfenylating Agent for Metal‐Free Oxidation and Methylthiolation of Alcohol‐Containing Indoles.

Zheng Xu, Ke-Fang Yang, Li Li, 2015 .