Yi Wang

发表

Design, synthesis and antitumor study of a series of N-Cyclic sulfamoylaminoethyl substituted 1,2,5-oxadiazol-3-amines as new indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors.

W. Guo, Xiaohua Liu, P. Sun, 2019, European journal of medicinal chemistry.

PI3Kα inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8+T cells and promoting fatty acid metabolism

Jian Ding, Ling-hua Meng, Landian Hu, 2021, Journal for ImmunoTherapy of Cancer.

Decrease in phosphorylated ERK indicates the therapeutic efficacy of a clinical PI3Kα-selective inhibitor CYH33 in breast cancer.

Yi Chen, Jian Ding, Ling-hua Meng, 2018, Cancer letters.

Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO-1) Inhibitors Based on Ortho-Naphthaquinone-Containing Natural Product

W. Guo, P. Sun, Linghua Meng, 2019, Molecules.

SAF-248, a novel PI3Kδ-selective inhibitor, potently suppresses the growth of diffuse large B-cell lymphoma

Yi Chen, Ling-hua Meng, Jian Ding, 2021, Acta Pharmacologica Sinica.

A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity.

Kaixian Chen, Hualiang Jiang, Qin Chen, 2010, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of thieno[3,2‐d]pyrimidine derivatives as potential simplified phosphatidylinositol 3‐kinase alpha inhibitors

Jian Zhang, K. Song, Xiuyan Yang, 2019, Chemical biology & drug design.

Design, synthesis and antiproliferative activity evaluation of a series of pyrrolo[2,1-f][1,2,4]triazine derivatives.

Jian Ding, Linghua Meng, Xi Zhang, 2020, Bioorganic & medicinal chemistry letters.

6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.

Jian Ding, Linghua Meng, Yuxiu Liu, 2017, Journal of medicinal chemistry.

Discovery and SAR of thiazolidine-2,4-dione analogues as insulin-like growth factor-1 receptor (IGF-1R) inhibitors via hierarchical virtual screening.

Cheng Luo, Honglin Li, Yi Wang, 2010, Journal of Medicinal Chemistry.

Discovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity.

Yaming Zhou, Xiaofeng Liu, Yun Ling, 2017, ACS medicinal chemistry letters.

Targeting PI3Kα overcomes resistance to KRasG12C inhibitors mediated by activation of EGFR and/or IGF1R

Lan Xu, Linghua Meng, Xi Zhang, 2022, Acta Pharmacologica Sinica.

Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors.

Yi Chen, Jian Ding, Xiaoyan Chen, 2020, European journal of medicinal chemistry.

SAF-248, a novel PI3Kδ-selective inhibitor, potently suppresses the growth of diffuse large B-cell lymphoma

Ling-hua Meng, Jian Ding, M. Geng, 2021, Acta Pharmacologica Sinica.

Repressing MYC by targeting BET synergizes with selective inhibition of PI3Kα against B cell lymphoma.

Yi Chen, Ling-hua Meng, Jian Ding, 2021, Cancer letters.

Adaptive resistance to PI3Kα-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells

Ling-hua Meng, Landian Hu, Jiangqing Ding, 2021, Cell death & disease.

Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors

Yi Chen, Lan Xu, Linghua Meng, 2023, Signal Transduction and Targeted Therapy.

Unbiased screening reveals that blocking exportin 1 overcomes resistance to PI3Kα inhibition in breast cancer

Qiao-jun He, Linghua Meng, Xi Zhang, 2019, Signal Transduction and Targeted Therapy.

Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO-1) Inhibitors Based on Ortho-Naphthaquinone-Containing Natural Product

W. Guo, P. Sun, Linghua Meng, 2019, Molecules.

Drug Transporter-independent Liver Cancer Cell Killing by a Marine Steroid Methyl Spongoate via Apoptosis Induction*

Z. Miao, Jian Ding, Lin-jiang Tong, 2011, The Journal of Biological Chemistry.

A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity.

Kaixian Chen, Hualiang Jiang, Qin Chen, 2010, Journal of medicinal chemistry.