J. Delarge

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Isosterism among analogues of torasemide: conformational, electronic and lipophilic properties.

J. Wouters, B. Masereel, J. Dogné, 2000, European journal of medicinal chemistry.

Recent advances in inducible cyclooxygenase (COX-2) inhibition

P. Tullio, J. Dogné, Y. Henrotin, 2000 .

New trends in dual 5-LOX/COX inhibition.

J. Dogné, B. Pirotte, F. Julémont, 2002, Current medicinal chemistry.

Synthesis and pharmacology of pyrid-3-ylsulfonylcyanoguanidines as diuretics

P. Tullio, B. Masereel, J. Liégeois, 1995 .

Therapeutic and chemical developments of cholecystokinin receptor ligands

B. Pirotte, J. Delarge, P. de Tullio, 2000, Expert opinion on investigational drugs.

Thromboxane A2 Inhibition

B. Masereel, J. Dogné, P. Benoit, 2012, American journal of respiratory medicine : drugs, devices, and other interventions.

Torasemide inhibits NaCl reabsorption in the thick ascending limb of the loop of Henle

R. Greger, E. Schlatter, A. Stefano, 1986, Pflügers Archiv.

Analogues of torasemide — structure function relationships —experiments in the thick ascending limb of the loop of Henle of rabbit nephron

P. Wangemann, J. Liégeois, R. Greger, 2004, Pflügers Archiv.

The Mode of Action of Diuretics

O. Eidelman, B. Masereel, E. Lohrmann, 1991 .

AB0223 Evaluation of classical nsaids and cox-2 selective inhibitors on purified ovine enzymes and human whole blood

B. Masereel, J. Dogné, Y. Henrotin, 2001, Prostaglandins, leukotrienes, and essential fatty acids.

Na+,2Cl-,K+ cotransport system as a marker of antihypertensive activity of new torasemide derivatives.

B. Masereel, B. Pirotte, P. Parenti, 1992, European journal of pharmacology.

2,4,7‐Trimethyl‐2,3‐dihydro‐4H‐pyrido[4,3‐e]‐1,2,4‐thiadiazinium 1,1‐Dioxide Iodide

P. Tullio, O. Diouf, B. Masereel, 1995 .

Anticonvulsant Activity of Pyrid‐3‐yl‐Sulfonyl Ureas and Thioureas

J. Poupaert, B. Masereel, J. Dogné, 1997, Epilepsia.

Synthesis and biological evaluation of aroylguanidines related to amiloride as inhibitors of the human platelet Na(+)/H(+) exchanger.

B. Masereel, D. Laeckmann, C. Prosperi-Meys, 2002, Bioorganic & medicinal chemistry.

Synthesis and pharmacology of pyrid-3-yl sulfonylureas and thioureas as astrocytic Na+ 2Cl- K+ cotransporter inhibitors

P. Tullio, P. Renard, B. Masereel, 1994 .

Terbogrel, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition.

B. Norberg, J. Wouters, B. Masereel, 2000, Acta crystallographica. Section C, Crystal structure communications.

Thromboxane A2 Receptor Antagonism in Man and Rat by a Sulphonylcyanoguanidine (BM‐144) and a Sulphonylurea (BM‐500)

B. Masereel, L. Pochet, J. Fontaine, 1999, The Journal of pharmacy and pharmacology.

Activity of a novel dual thromboxane A(2)receptor antagonist and thromboxane synthase inhibitor (BM-573) on platelet function and isolated smooth muscles.

B. Masereel, S. Rolin, J. Dogné, 2001, Prostaglandins, leukotrienes, and essential fatty acids.

Recent developments of thromboxane modulators

B. Masereel, J. Dogné, J. Delarge, 2001 .

Activation of ATP-dependent K+ channels and inhibition of insulin release: effect of BPDZ 62.

B. Masereel, A. Herchuelz, B. Pirotte, 1996, The Journal of pharmacology and experimental therapeutics.

Pharmacological evaluation of the novel thromboxane modulator BM-567 (II/II). Effects of BM-567 on osteogenic sarcoma-cell-induced platelet aggregation.

M. Merville, V. Benoît, B. Masereel, 2003, Prostaglandins, leukotrienes, and essential fatty acids.

New trends in thromboxane and prostacyclin modulators.

B. Masereel, J. Dogné, J. David, 2000, Current medicinal chemistry.

Effects of a novel non-carboxylic thromboxane A2 receptor antagonist (BM-531) derived from torasemide on platelet function.

S. Rolin, J. Dogné, J. David, 2000, Prostaglandins, leukotrienes, and essential fatty acids.

4H-1,2,4-Pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2, 4-pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors: design, synthesis, pharmacology,

J Delarge, P Lebrun, M. Spedding, 1998, Journal of medicinal chemistry.

Synthesis and structural studies of a new class of heterocyclic compounds: 1,2,4-Pyridothiadiazine 1,1-dioxides, pyridyl analogues of 1,2,4-benzothiadiazine 1,1-dioxides

P. Tullio, O. Diouf, B. Masereel, 1995 .

Preparation and pharmacological evaluation of the R- and S-enantiomers of 3-(2-butylamino)-4H- and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide, two tissue selective ATP-sensitive potassium channel openers.

M. Fillet, B. Pirotte, L. Dupont, 1999, Bioorganic & medicinal chemistry.

Pyridothiadiazinedioxides structurally related to quinazolinones cholecystokinin/gastrin receptor ligands: synthesis and biological evaluation.

O. Diouf, P. Renard, B. Masereel, 1998, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

3-(Alkylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as powerful inhibitors of insulin release from rat pancreatic B-cells: a new class of potassium channel openers?

B. Masereel, A. Herchuelz, B. Pirotte, 1993, Journal of medicinal chemistry.

Synthesis and structural studies of 3-alkylamino-pyrido[4,3-e]-1,2,4- thiadiazine 1,1-dioxides: A new class of heterocyclic compounds with therapeutical promises

P. Tullio, J. Dogné, B. Pirotte, 1999 .

Study of the ring closure reaction of o-aminoarylsulfonamides with 1,1′-thiocarbonyldiimidazole.

P. Tullio, B. Pirotte, F. Lacan, 1998 .

Synthesis and Biological Evaluation of New 3‐Aralkylamino‐2‐aryl‐2H‐1,2,4‐pyridothiadiazine 1,1‐dioxides as Potential CCK‐Receptor Ligands

P. Tullio, O. Diouf, P. Renard, 1997, The Journal of pharmacy and pharmacology.

Synthesis and Structural Studies of a New Class of Heterocyclic Compounds: 1,2,4-Pyridothiadiazine 1,1-Dioxides, Pyridyl Analogues of 1,2,4-Benzothiadiazine 1,1-Dioxides.

P. Tullio, O. Diouf, B. Masereel, 2010 .

3-and 4-substituted 4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potassium channel openers: synthesis, pharmacological evaluation, and structure-activity relationships.

O. Diouf, B. Masereel, B. Pirotte, 1996, Journal of medicinal chemistry.

Esters and amides of 6-(chloromethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid as inhibitors of alpha-chymotrypsin: significance of the "aromatic" nature of the novel ester-type coumarin for strong inhibitory activity.

J Delarge, B. Masereel, B. Pirotte, 1996, Journal of medicinal chemistry.

Specific inhibitors of human leukocyte elastase

B. Masereel, B. Pirotte, L. Pochet, 2000 .

6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid as a core structure for specific inhibitors of human leukocyte elastase.

B. Pirotte, L. Pochet, M. Reboud-Ravaux, 1999, Journal of medicinal chemistry.

Esters and Amides of 6‐(Chloromethyl)‐2‐oxo‐2H‐1‐benzopyran‐3‐ carboxylic Acid as Inhibitors of α‐Chymotrypsin: Significance of the “Aromatic” Nature of the Novel Ester‐Type Coumarin for Strong Inhibitory Activity.

P. Tullio, B. Masereel, B. Pirotte, 1996 .

Original 2-alkylamino-6-halogenoquinazolin-4(3H)-ones and K(ATP) channel activity.

B. Pirotte, L. Dupont, M. Antoine, 2001, Journal of medicinal chemistry.

Antibacterial activity of 5-acylaminothiazole derivatives, synthetic drugs related to beta-lactam antibiotics.

J. Frère, B. Pirotte, J. Coyette, 1991, The Journal of antibiotics.

"Fries like" rearrangement: a novel and efficient method for the synthesis of 6-acyl-2(3H)-benzoxazolones and 6-acyl-2(3H)-benzothiazolones

J. Poupaert, D. Lesieur, B. Masereel, 1998 .

Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas

P. Tullio, B. Masereel, J. Dogné, 1997 .

Effective resolution of racemic pirlindole at the preparative scale

P. Tullio, P. Hubert, J. Liégeois, 1998 .

Ligand effects in the hydrogenation of methacycline to doxycycline and epi-doxycycline catalysed by rhodium complexes molecular structure of the key catalyst [closo-3,3-(η2,3-C7H7CH2)-3,1,2-RhC2B9H11]

J. Liégeois, B. Pirotte, V. Bregadze, 1997 .

Study of the influence of both cyclodextrins and L-lysine on the aqueous solubility of nimesulide; isolation and characterization of nimesulide-L-lysine-cyclodextrin complexes.

L Delattre, J Delarge, L. Delattre, 1997, Journal of pharmaceutical sciences.

Stereoselective hydrogenation of methacycline to Doxycycline catalysed by rhodium-carborane complexes

B. Pirotte, V. Bregadze, I. V. Pisareva, 1993 .

3-Alkylamino-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as Potent KATP-Channel Activators: Structural Study and Influence of Stereochemistry

P. Tullio, B. Pirotte, L. Dupont, 1999 .

A pyridothiadiazine (BPDZ 44) as a new and potent activator of ATP-sensitive K+ channels.

A. Herchuelz, B. Pirotte, M. Antoine, 1994, Biochemical pharmacology.

Absolute Configuration of (R)-1-Phenylethylammonium (S)-2-(6-Methoxy-2-naphthyl)propionate

B. Pirotte, L. Dupont, J. Delarge, 1996 .

Recent advances in the chemistry of cholecystokinin receptor ligands (agonists and antagonists).

B. Pirotte, J. Delarge, P. de Tullio, 1999, Current medicinal chemistry.

Effect of potassium channel openers on the firing rate of hippocampal pyramidal cells and A10 dopaminergic neurons in vitro.

J. Scuvée-Moreau, A. Dresse, B. Vrijens, 1997, Archives of physiology and biochemistry.

Recent advances in antiplatelet agents.

B. Masereel, J. Dogné, J. David, 2002, Current Medicinal Chemistry.

A Sulphonylthiourea (BM 20) Related to Torasemide: a new Loop Diuretic with Relative Potassium‐sparing Properties

B. Masereel, B. Pirotte, G. Rorive, 1993, The Journal of pharmacy and pharmacology.

Pharmacology of the thromboxane receptor antagonist and thromboxane synthase inhibitor BM-531.

P. Kolh, B. Masereel, S. Rolin, 2006, Cardiovascular drug reviews.

Structure determination and comparison of BM567, a sulfonylurea, with terbogrel, two compounds with dual action, thromboxane receptor antagonism and thromboxane synthase inhibition.

J. Wouters, B. Masereel, S. Rolin, 2001, Bioorganic & medicinal chemistry letters.

In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators

Y. Henrotin, G. Deby-dupont, X. de Leval, 2001, Inflammation Research.

Advances in the field of COX-2 inhibition

J. Dogné, B. Pirotte, F. Julémont, 2002 .

3‐Isopropylamino‐4‐methyl‐4H‐pyrido[4,3‐e][1,2,4]thiadiazine 1,1‐Dioxide

P. Tullio, B. Pirotte, L. Dupont, 1996 .

Structural Study of Pinacidil, a Potassium‐Channel Opener Belonging to the chemical class of N‐alkyl‐N″‐cyano‐N′‐pyridylguanidines

P. Tullio, B. Masereel, B. Pirotte, 1993 .

First preparative enantiomer resolution of pirlindole, a potent antidepressant drug

P. Tullio, P. Hubert, J. Liégeois, 1998 .

Recent advances in inducible cyclooxygenase (COX-2) inhibition.

J Delarge, J. Dogné, Y. Henrotin, 2000, Current medicinal chemistry.

Synthesis and structural studies of a new class of heterocyclic compounds: 1,2,4-Pyridothiadiazine 1,1-dioxides, pyridyl analogues of 1,2,4-benzothiadiazine 1,1-dioxides

P. Tullio, O. Diouf, B. Masereel, 1995 .

Novel inhibitors of the sodium-calcium exchanger: benzene ring analogues of N-guanidino substituted amiloride derivatives.

B. Masereel, J. Liégeois, A. Herchuelz, 2001, European journal of medicinal chemistry.

Abstract of the 68th Meeting (Spring Meeting) 6–9 March 1990, Heidelberg

A. Konnerth, B. Sakmann, P. Jonas, 1990, Pflügers Archiv.

Cationic and secretory effects of BPDZ 44 and diazoxide in rat pancreatic islets

P. Tullio, A. Herchuelz, B. Pirotte, 1994, Experientia.

Pyridothiadiazines as potent inhibitors of glucose-induced insulin release.

A. Herchuelz, B. Pirotte, M. Antoine, 1997, Advances in experimental medicine and biology.

Synthesis and structural studies of 3-alkylamino-pyrido[4,3-e]-1,2,4- thiadiazine 1,1-dioxides: A new class of heterocyclic compounds with therapeutical promises

P. Tullio, J. Dogné, B. Pirotte, 1999 .

Evaluation of the Inhibitory Activity on Serine and Aspartic Proteases of 4‐Amino‐4H‐1,2,4‐triazole and 5‐Aminothiazole Derivatives Structurally Related to β‐Lactam Antibiotics

B. Masereel, B. Pirotte, M. Reboud-Ravaux, 1993, The Journal of pharmacy and pharmacology.