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Heterologous Hyperimmune Polyclonal Antibodies Against SARS-CoV-2: A Broad Coverage, Affordable, and Scalable Potential Immunotherapy for COVID-19

J. Gutiérrez, J. Drexler, M. Flores-Díaz, 2021, Frontiers in Medicine.

Preclinical Evaluation of Caprylic Acid-Fractionated IgG Antivenom for the Treatment of Taipan (Oxyuranus scutellatus) Envenoming in Papua New Guinea

David J. Williams, J. Gutiérrez, S. Jensen, 2011, PLoS neglected tropical diseases.

Comparative proteomic analysis of the venom of the taipan snake, Oxyuranus scutellatus, from Papua New Guinea and Australia: role of neurotoxic and procoagulant effects in venom toxicity.

David J. Williams, J. Calvete, J. Gutiérrez, 2012, Journal of proteomics.

Snake venomics of African spitting cobras: toxin composition and assessment of congeneric cross-reactivity of the pan-African EchiTAb-Plus-ICP antivenom by antivenomics and neutralization approaches.

J. Calvete, L. Sanz, J. Gutiérrez, 2011, Journal of proteome research.

Venom of Bothrops asper from Mexico and Costa Rica: intraspecific variation and cross-neutralization by antivenoms.

J. Gutiérrez, M. Jiménez-Corona, M. Herrera, 2012, Toxicon : official journal of the International Society on Toxinology.

Antivenomic assessment of the immunological reactivity of EchiTAb-Plus-ICP, an antivenom for the treatment of snakebite envenoming in sub-Saharan Africa.

J. Calvete, L. Sanz, J. Gutiérrez, 2010, The American journal of tropical medicine and hygiene.

Proteomics and antivenomics of Papuan black snake (Pseudechis papuanus) venom with analysis of its toxicological profile and the preclinical efficacy of Australian antivenoms.

David J. Williams, J. Calvete, L. Sanz, 2017, Journal of proteomics.

Antivenomic characterization of two antivenoms against the venom of the taipan, Oxyuranus scutellatus, from Papua New Guinea and Australia.

David J. Williams, J. Gutiérrez, S. Serrano, 2014, The American journal of tropical medicine and hygiene.

Human plasma‐derived immunoglobulin G fractionated by an aqueous two‐phase system, caprylic acid precipitation, and membrane chromatography has a high purity level and is free of detectable in vitro thrombogenic activity

T. Burnouf, M. Herrera, G. León, 2015, Vox sanguinis.

Neutralization of the neuromuscular inhibition of venom and taipoxin from the taipan (Oxyuranus scutellatus) by F(ab')2 and whole IgG antivenoms.

David J. Williams, J. Gutiérrez, L. Rodrigues-Simioni, 2016, Toxicology letters.

Role of the animal model on the pharmacokinetics of equine-derived antivenoms.

J. Gutiérrez, A. Rojas, Aarón Gómez, 2013, Toxicon : official journal of the International Society on Toxinology.

Lachesis stenophrys venom reduces the equine antibody response towards Bothrops asper venom used as co-immunogen in the production of polyspecific snake antivenom.

J. Gutiérrez, M. Herrera, G. León, 2015, Toxicon : official journal of the International Society on Toxinology.

Comparison of adjuvant emulsions for their safety and ability to enhance the antibody response in horses immunized with African snake venoms

Cecilia Díaz, Mauricio Arguedas, Aarón Gómez, 2022, Vaccine: X.

Intrageneric cross-reactivity of monospecific rabbit antisera against venoms of the medically most important Bitis spp. and Echis spp. African snakes

J. Gutiérrez, Stephanie Chaves-Araya, Cecilia Díaz, 2022, PLoS neglected tropical diseases.

Freeze-dried EchiTAb+ICP antivenom formulated with sucrose is more resistant to thermal stress than the liquid formulation stabilized with sorbitol.

J. Gutiérrez, R. Harrison, M. Herrera, 2017, Toxicon : official journal of the International Society on Toxinology.

Proteomic, toxicological and immunogenic characterization of Mexican west-coast rattlesnake (Crotalus basiliscus) venom and its immunological relatedness with the venom of Central American rattlesnake (Crotalus simus).

J. Gutiérrez, Aarón Gómez, M. Herrera, 2017, Journal of proteomics.

Expanding the neutralization scope of the EchiTAb‐plus‐ICP antivenom to include venoms of elapids from Southern Africa

A. Alape-Girón, M. Herrera, G. León, 2017, Toxicon : official journal of the International Society on Toxinology.

Development of a chicken-derived antivenom against the taipan snake (Oxyuranus scutellatus) venom and comparison with an equine antivenom.

David J. Williams, J. Gutiérrez, Aarón Gómez, 2016, Toxicon : official journal of the International Society on Toxinology.

Assessment of snake antivenom purity by comparing physicochemical and immunochemical methods.

J. Gutiérrez, M. Herrera, G. León, 2013, Biologicals : journal of the International Association of Biological Standardization.

Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms.

J. Gutiérrez, M. Herrera, G. León, 2013, Toxicon : official journal of the International Society on Toxinology.

Comparative study of the efficacy and safety of two polyvalent, caprylic acid fractionated [IgG and F(ab')2] antivenoms, in Bothrops asper bites in Colombia.

J. Gómez, J. Gutiérrez, Y. Angulo, 2012, Toxicon : official journal of the International Society on Toxinology.

High Efficacy of Therapeutic Equine Hyperimmune Antibodies Against SARS-CoV-2 Variants of Concern

J. Gutiérrez, C. Reusken, J. Drexler, 2021, bioRxiv.

Assessing the preclinical efficacy of antivenoms: from the lethality neutralization assay to antivenomics.

J. Calvete, L. Sanz, J. Gutiérrez, 2013, Toxicon : official journal of the International Society on Toxinology.

Snake venomics and antivenomics of Protobothrops mucrosquamatus and Viridovipera stejnegeri from Taiwan: keys to understand the variable immune response in horses.

J. Calvete, L. Sanz, J. Gutiérrez, 2012, Journal of proteomics.

Low pH formulation of whole IgG antivenom: impact on quality, safety, neutralizing potency and viral inactivation.

J. Gutiérrez, T. Burnouf, G. León, 2012, Biologicals : journal of the International Association of Biological Standardization.

Assessment of the impact of solvent/detergent treatment on the quality and potency of a whole IgG equine antivenom.

J. Gutiérrez, T. Burnouf, C. Su, 2009, Biologicals : journal of the International Association of Biological Standardization.

Stability of equine IgG antivenoms obtained by caprylic acid precipitation: towards a liquid formulation stable at tropical room temperature.

J. Gutiérrez, G. Solano, M. Herrera, 2009, Toxicon : official journal of the International Society on Toxinology.

Snake venomics and antivenomics of Bothrops colombiensis, a medically important pitviper of the Bothrops atrox-asper complex endemic to Venezuela: Contributing to its taxonomy and snakebite management.

J. Calvete, L. Sanz, J. Gutiérrez, 2009, Journal of proteomics.

An improved technique for the assessment of venom‐induced haemorrhage in a murine model

J. Gutiérrez, T. Jenkins, Trenton K Stewart, 2017, Toxicon : official journal of the International Society on Toxinology.

Cross‐reactivity and cross‐immunomodulation between venoms of the snakes Bothrops asper, Crotalus simus and Lachesis stenophrys, and its effect in the production of polyspecific antivenom for Central America

J. Gutiérrez, M. Herrera, G. León, 2017, Toxicon : official journal of the International Society on Toxinology.

Comparison of the adjuvant activity of emulsions with different physicochemical properties on the antibody response towards the venom of West African carpet viper (Echis ocellatus)

J. Gutiérrez, M. Montero, M. Herrera, 2017, Toxicon : official journal of the International Society on Toxinology.

Active immunization of cattle with a bothropic toxoid does not abrogate envenomation by Bothrops asper venom, but increases the likelihood of survival.

C. Rodríguez, Aarón Gómez, M. Herrera, 2017, Biologicals : journal of the International Association of Biological Standardization.

Industrial Production and Quality Control of Snake Antivenoms

J. Gutiérrez, Diego A. Navarro, Andrés Hernández, 2016 .

Effect of geographical variation of Echis ocellatus, Naja nigricollis and Bitis arietans venoms on their neutralization by homologous and heterologous antivenoms.

J. Gutiérrez, G. Solano, M. Herrera, 2015, Toxicon : official journal of the International Society on Toxinology.

Purification of equine whole IgG snake antivenom by using an aqueous two phase system as a primary purification step.

J. Gutiérrez, M. Herrera, G. León, 2015, Biologicals : journal of the International Association of Biological Standardization.

Comparison of the effect of Crotalus simus and Crotalus durissus ruruima venoms on the equine antibody response towards Bothrops asper venom: implications for the production of polyspecific snake antivenoms.

J. Gutiérrez, M. C. Dos-Santos, M. Herrera, 2011, Toxicon : official journal of the International Society on Toxinology.

Purification of IgG and albumin from human plasma by aqueous two phase system fractionation

J. Gutiérrez, Y. Angulo, T. Burnouf, 2012, Biotechnology progress.

Study of the design and analytical properties of the lethality neutralization assay used to estimate antivenom potency against Bothrops asper snake venom.

J. Gutiérrez, G. Solano, Aarón Gómez, 2010, Biologicals : journal of the International Association of Biological Standardization.

Development and characterization of two equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19

J. Gutiérrez, Charles Bailey, Aarthi Narayanan, 2021, Scientific Reports.

Development and pre-clinical characterization of two therapeutic equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19

J. Gutiérrez, Charles Bailey, Aarthi Narayanan, 2020, bioRxiv.

Vipera berus berus Venom from Russia: Venomics, Bioactivities and Preclinical Assessment of Microgen Antivenom

J. Calvete, J. Gutiérrez, R. Al-Shekhadat, 2019, Toxins.

Expanding the neutralization scope of the Central American antivenom (PoliVal-ICP) to include the venom of Crotalus durissus pifanorum.

J. Gutiérrez, Cecilia Díaz, Mauricio Arguedas, 2021, Journal of proteomics.

Immune response towards snake venoms.

J. Gutiérrez, Andrés Hernández, M. Herrera, 2011, Inflammation & allergy drug targets.

Development of a new polyspecific antivenom for snakebite envenoming in Sri Lanka: Analysis of its preclinical efficacy as compared to a currently available antivenom.

J. Gutiérrez, A. Alape-Girón, I. Gawarammana, 2016, Toxicon : official journal of the International Society on Toxinology.

Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms.

J. Gutiérrez, A. Yarlequé, I. S. Sano-Martins, 2010, Toxicon : official journal of the International Society on Toxinology.

Preclinical assessment of the efficacy of a new antivenom (EchiTAb-Plus-ICP) for the treatment of viper envenoming in sub-Saharan Africa.

J. Calvete, J. Gutiérrez, D. Warrell, 2010, Toxicon : official journal of the International Society on Toxinology.

Human heterophilic antibodies against equine immunoglobulins: assessment of their role in the early adverse reactions to antivenom administration.

J. Gutiérrez, B. Lomonte, K. Barbaro, 2008, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Toxicological profile of medically relevant Crotalus species from Mexico and their neutralization by a Crotalus basiliscus/Bothrops asper antivenom.

G. Solano, A. Alagón, G. León, 2020, Toxicon : official journal of the International Society on Toxinology.

Toxicity of Bothrops sp snake venoms from Ecuador and preclinical assessment of the neutralizing efficacy of a polyspecific antivenom from Costa Rica.

J. Gutiérrez, M. Herrera, G. León, 2014, Toxicon : official journal of the International Society on Toxinology.

Neutralization of Bothrops mattogrossensis snake venom from Bolivia: experimental evaluation of llama and donkey antivenoms produced by caprylic acid precipitation.

J. Gutiérrez, G. Solano, M. Herrera, 2010, Toxicon : official journal of the International Society on Toxinology.

Preclinical efficacy against toxic activities of medically relevant Bothrops sp. (Serpentes: Viperidae) snake venoms by a polyspecific antivenom produced in Mexico.

J. Gutiérrez, M. Herrera, G. León, 2016, Revista de biologia tropical.

Influence of sexual dimorphism on venom composition in Bothrops asper and Crotalus simus (Serpentes: Viperidae) and its potential implications on the snake antivenom production.

G. Solano, Aarón Gómez, Á. Segura, 2021, Toxicon : official journal of the International Society on Toxinology.

Intraspecific variability of the Central American rattlesnake (Crotalus simus) venom and its usefulness to obtain a representative standard venom.

G. Solano, Aarón Gómez, G. León, 2021, Toxicon : official journal of the International Society on Toxinology.

Current technology for the industrial manufacture of snake antivenoms

J. Gutiérrez, G. Solano, Aarón Gómez, 2018, Toxicon : official journal of the International Society on Toxinology.

Freeze-dried snake antivenoms formulated with sorbitol, sucrose or mannitol: comparison of their stability in an accelerated test.

José Vega-Baudrit, Guillermo León, J. Gutiérrez, 2014, Toxicon : official journal of the International Society on Toxinology.

Pathogenesis of dermonecrosis induced by venom of the spitting cobra, Naja nigricollis: An experimental study in mice.

J. Gutiérrez, A. Arias, M. Herrera, 2016, Toxicon : official journal of the International Society on Toxinology.

Proteomic and toxinological characterization of the venom of the South African Ringhals cobra Hemachatus haemachatus.

J. Gutiérrez, B. Lomonte, M. Herrera, 2018, Journal of proteomics.

Dagestan blunt-nosed viper, Macrovipera lebetina obtusa (Dwigubsky, 1832), venom. Venomics, antivenomics, and neutralization assays of the lethal and toxic venom activities by anti-Macrovipera lebetina turanica and anti-Vipera berus berus antivenoms

J. Calvete, R. Al-Shekhadat, D. Pla, 2020, Toxicon: X.

In Vitro Tests for Assessing the Neutralizing Ability of Snake Antivenoms: Toward the 3Rs Principles

J. Gutiérrez, G. Solano, M. Herrera, 2021, Frontiers in Immunology.

Preclinical Evaluation of the Efficacy of Antivenoms for Snakebite Envenoming: State-of-the-Art and Challenges Ahead

J. Calvete, L. Sanz, J. Gutiérrez, 2017, Toxins.

Bothrops asper envenoming in cattle: Clinical features and management using equine-derived whole IgG antivenom.

M. Herrera, C. Rodríguez, G. León, 2016, Veterinary journal.

Comparative venomics and preclinical efficacy evaluation of a monospecific Hemachatus antivenom towards sub-Saharan Africa cobra venoms.

J. Calvete, J. Gutiérrez, D. Pla, 2021, Journal of proteomics.

Effect of premedication with subcutaneous adrenaline on the pharmacokinetics and immunogenicity of equine whole IgG antivenom in a rabbit model.

J. Gutiérrez, A. Machado, G. Solano, 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Intravenous administration of equine-derived whole IgG antivenom does not induce early adverse reactions in non-envenomed horses and cows.

J. Gutiérrez, M. Herrera, G. León, 2010, Biologicals (Print).

A synthetic biology approach for consistent production of plant‐made recombinant polyclonal antibodies against snake venom toxins

J. Forment, J. Calvete, J. Gutiérrez, 2017, Plant biotechnology journal.

Factors associated with adverse reactions induced by caprylic acid-fractionated whole IgG preparations: comparison between horse, sheep and camel IgGs.

J. Gutiérrez, B. Lomonte, J. Chippaux, 2005, Toxicon : official journal of the International Society on Toxinology.

Clinical effects of immunization, bleeding, and albumin-based fluid therapy in horses used as immunoglobulin source to produce a polyspecific antivenom (Echitab-plus-ICP) towards venoms of African snakes

J. Gutiérrez, J. M. Estrada, G. Solano, 2023, Toxicon: X.

In vitro Characterization of Anti-SARS-CoV-2 Intravenous Immunoglobulins (IVIg) Produced From Plasma of Donors Immunized With the BNT162b2 Vaccine and Its Comparison With a Similar Formulation Produced From Plasma of COVID-19 Convalescent Donors

J. Drexler, A. Alape-Girón, Stephanie Chaves-Araya, 2022, Frontiers in Medical Technology.