Jeffery L. Smith

发表

Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity.

L. Shewchuk, P. Sabbatini, A. Hassell, 2009, Bioorganic & medicinal chemistry letters.

Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling

A. Axtman, D. Goldfarb, Michael B. Major, 2022, The Journal of biological chemistry.

Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses

T. Willson, R. Baric, M. Heise, 2022, ACS chemical biology.

Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses

M. Heise, D. Drewry, P. McPherson, 2022, Journal of medicinal chemistry.

Identification of a chemical probe for lipid kinase phosphatidylinositol-5-phosphate 4-kinase gamma (PI5P4Kγ)

D. Drewry, A. Axtman, Frances M. Potjewyd, 2022, bioRxiv.

4-Acylamino-6-arylfuro[2,3-d]pyrimidines: potent and selective glycogen synthase kinase-3 inhibitors.

A. Truesdale, Y. Maeda, Hideyuki Sato, 2004, Bioorganic & medicinal chemistry letters.

N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3.

R. Angell, P. Rowland, M. Cichy-Knight, 2007, Bioorganic & medicinal chemistry letters.

An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model.

R. A. Reid, D. J. Price, D. Drewry, 2018, Bioorganic & medicinal chemistry letters.

A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective

H. Wichterle, D. Drewry, C. Wells, 2023, bioRxiv.

Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells

M. T. Beck, T. Willson, M. Robers, 2023, bioRxiv.

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology

D. Drewry, C. Wells, A. Axtman, 2023, eLife.

Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective

H. Wichterle, D. Drewry, C. Wells, 2023, ACS chemical neuroscience.

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology

D. Drewry, C. Wells, A. Axtman, 2023, bioRxiv.

Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2.

Tammy M. Havener, D. Drewry, C. Wells, 2023, ACS medicinal chemistry letters.

Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5-a]pyrimidines Toward the Development of an In Vivo Chemical Probe for CSNK2A

T. Willson, A. Axtman, Nathaniel J. Moorman, 2023, bioRxiv.

Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1.

L. Shewchuk, T. J. Lansing, R. Mook, 2008, Bioorganic & medicinal chemistry letters.