K. R. Kakularam

发表

The Reaction Specificity of Mammalian ALOX15 Orthologs is Changed During Late Primate Evolution and These Alterations Might Offer Evolutionary Advantages for Hominidae

H. Kuhn, G. Püschel, D. Heydeck, 2022, Frontiers in Cell and Developmental Biology.

Thr92Ala polymorphism in the type 2 deiodinase gene: an evolutionary perspective

H. Kuhn, S. Cantara, M. G. Castagna, 2020, Journal of Endocrinological Investigation.

Paralog- and ortholog-specificity of inhibitors of human and mouse lipoxygenase-isoforms.

H. Kuhn, I. Ivanov, D. Heydeck, 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Evolutionary aspects of lipoxygenases and genetic diversity of human leukotriene signaling

H. Kuhn, R. Schumann, D. Heydeck, 2014, Progress in Lipid Research.

Male Knock-in Mice Expressing an Arachidonic Acid Lipoxygenase 15B (Alox15B) with Humanized Reaction Specificity Are Prematurely Growth Arrested When Aging

H. Kuhn, M. Rothe, G. Püschel, 2022, Biomedicines.

Leukotriene signaling in the extinct human subspecies Homo denisovan and Homo neanderthalensis. Structural and functional comparison with Homo sapiens.

P. Reddanna, H. Kuhn, D. Heydeck, 2015, Archives of biochemistry and biophysics.

Functional Characterization of Transgenic Mice Overexpressing Human 15-Lipoxygenase-1 (ALOX15) under the Control of the aP2 Promoter

C. Ufer, T. Liehr, H. Kuhn, 2023, International journal of molecular sciences.

Oxygenation of endocannabinoids by mammalian lipoxygenase isoforms.

H. Kuhn, M. Rothe, I. Ivanov, 2021, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Eicosanoid biosynthesis in marine mammals

H. Kuhn, D. Heydeck, F. Reisch, 2020, The FEBS journal.

Design, synthesis and evaluation of 2-aryl quinoline derivatives against 12R-lipoxygenase (12R-LOX): Discovery of first inhibitor of 12R-LOX.

P. Reddanna, Nooruddin Khan, M. Pal, 2023, Bioorganic chemistry.

Molecular basis for the catalytic inactivity of a naturally occurring near-null variant of human ALOX15.

P. Reddanna, P. Scheerer, H. Kuhn, 2013, Biochimica et biophysica acta.

The Augmenting Effects of Desolvation and Conformational Energy Terms on the Predictions of Docking Programs against mPGES-1

Ashish Gupta, Neha Chaudhary, Kumar Reddy Kakularam, 2015, PloS one.

Understanding the Dual Inhibition of COX-2 and Carbonic Anhydrase-II by Celecoxib and CG100649 Using Density Functional Theory Calculations and other Molecular Modelling Approaches.

P. Reddanna, P. Aparoy, Omkar Singh, 2015, Protein and peptide letters.

N-Substituted 5-(1H-Indol-2-yl)-2-methoxyanilines Are Allosteric Inhibitors of the Linoleate Oxygenase Activity of Selected Mammalian ALOX15 Orthologs: Mechanism of Action.

Àngels González-Lafont, J. M. Lluch, H. Kuhn, 2022, Journal of Medicinal Chemistry.

Transgenic mice overexpressing human ALOX15 under the control of the aP2 promoter are partly protected in the complete Freund’s adjuvant-induced paw inflammation model

K. Weylandt, H. Kuhn, D. Heydeck, 2023, Inflammation Research.

Leukotriene signaling in the extinct human subspecies Homo denisovan and Homo neanderthalensis. Structural and functional comparison with Homo sapiens.

P. Reddanna, H. Kuhn, D. Heydeck, 2015, Archives of biochemistry and biophysics.

Bony Fish Arachidonic Acid 15-Lipoxygenases Exhibit Different Catalytic Properties than Their Mammalian Orthologs, Suggesting Functional Enzyme Evolution during Vertebrate Development

P. Aparoy, D. Heydeck, K. R. Kakularam, 2023, International journal of molecular sciences.

Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants.

P. Reddanna, H. Kuhn, K. Hofheinz, 2013, Archives of biochemistry and biophysics.