C. Goodwin

发表

Characterization of a class of peptide boronates with neutral P1 side chains as highly selective inhibitors of thrombin.

E. Skordalakes, G. Claeson, V. Kakkar, 1995, Journal of medicinal chemistry.

Synthesis of ortho-modified mercapto- and piperazino-methyl-phenylboronic acid derivatives

M. Scully, J. Deadman, A. Burd, 2002 .

Tissue factor pathway inhibitor in endothelial cells colocalizes with glycolipid microdomains/caveolae. Regulatory mechanism(s) of the anticoagulant properties of the endothelium.

M. Scully, V. Kakkar, J. Emeis, 1997, Arteriosclerosis, thrombosis, and vascular biology.

Prothrombin cleavage by human vascular smooth muscle cells: A potential alternative pathway to the coagulation cascade

D. Cooper, C. Kanthou, O. Benzakour, 1995, Journal of cellular biochemistry.

Non-specific influence of chemical modification upon the properties of antithrombin III:modification of carboxyl groups.

M. Scully, V. Kakkar, C. Goodwin, 1992, Thrombosis research.

Increased expression of procoagulant activity on the surface of human platelets exposed to heavy-metal compounds.

M. Scully, V. Kakkar, C. Wheeler-Jones, 1995, The Biochemical journal.

Substrate-related phosphonopeptides, a new class of thrombin inhibitors

G. Claeson, M. Scully, V. Kakkar, 1991 .

Plasma levels of tissue factor pathway inhibitor in thrombophilic patients.

M. Scully, E. Melissari, V. Kakkar, 1993, Thrombosis research.

SUBSTRATE RELATED O,O-DIALKYLDIPEPTIDYLY ψ CARBOXYBENZYLPHOSPHONATES, A NEW TYPE OF THROMBIN INHIBITOR

E. Skordalakes, V. Kakkar, J. Deadman, 2000 .

The use of isosteric bonds in the design of thrombin inhibitors.

G. Claeson, M. Scully, V. Kakkar, 1993, Advances in experimental medicine and biology.

Substrate Related O,O-Dialkyldipeptidylaminophosphonates, A New Type of Thrombin Inhibitor

E. Skordalakes, M. Scully, V. Kakkar, 1996 .

Inhibition of human alpha-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate.

E. Skordalakes, M. Scully, V. Kakkar, 2001, Journal of molecular biology.

Facile routes to 1-halo-1-alkyl boronic esters as precursors for novel thrombin inhibitors

G. Claeson, M. Scully, V. Kakkar, 1994 .

X-Ray Crystallographic Analyses of Human α-Thrombin Complexed to Peptidyl Aminophosphonates: Evidence of a Binding Mechanism

E. Skordalakes, M. Scully, V. Kakkar, 1999 .

Synthesis and biological activity of ketomethylene pseudopeptide analogues as thrombin inhibitors.

G. Claeson, V. Kakkar, C A Goodwin, 1992, Journal of medicinal chemistry.

Inhibition of fibrinolytic activity by hyaluronan and its alcohol ester derivatives.

M. Scully, M. O'regan, V. Kakkar, 1995, Thrombosis research.

Substrate-related phosphonopeptides as thrombin inhibitors.

G. Claeson, M. Scully, J. Deadman, 1993, Advances in experimental medicine and biology.

Generation of ligand conformations in continuum solvent consistent with protein active site topology: application to thrombin.

Jörg Weiser, Paulette A Greenidge, M. Scully, 2003, Journal of medicinal chemistry.

Design of a novel class of bifunctional thrombin inhibitors, synthesised by the first application of peptide boronates in solid phase chemistry

E. Skordalakes, M. Scully, V. Kakkar, 1997 .

Thrombin receptor activating peptide does not stimulate platelet procoagulant activity.

M. Scully, J. Deadman, C. Wheeler-Jones, 1994, Biochemical and Biophysical Research Communications - BBRC.