P. Lebrun

发表

Relaxation response to pinacidil and diazoxide in the mouse isolated distal colon.

P. Lebrun, J. Fontaine, 1990, Pharmacology.

Significance of transglutaminase-mediated crosslinking of proteins in insulin release

R. Gomis, W. Malaisse, A. Herchuelz, 1983 .

KATP Channel Subunits Are Expressed in the Epididymal Epithelium in Several Mammalian Species1

E. Quertinmont, P. Lybaert, M. Pétein, 2008, Biology of reproduction.

Improved methodology for the detection and quantification of the acrosome reaction in mouse spermatozoa.

P. Lybaert, A. Danguy, P. Lebrun, 2009, Histology and histopathology.

Mechanisms of Sulfonylurea-lnduced Insulin Release

W. Malaisse, P. Lebrun, 1990, Diabetes Care.

Sensitivity to Cd2+ but resistance to Ni2+ of Ca2+ inflow into rat pancreatic islets.

A. Herchuelz, P. Lebrun, P. Plasman, 1990, The American journal of physiology.

Dual effect of 1.4-dihydropyridines on Ca2+ inflow into rat pancreatic islet cells

A. Herchuelz, P. Lebrun, P. Plasman, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

metabolic data Ketone bodies and islet function: 86Rb handling and

T. Yılmaz, W. Malaisse, A. Sener, 2013 .

Ketone bodies and islet function: 86Rb handling and metabolic data.

T. Yılmaz, W. Malaisse, A. Sener, 1990, The American journal of physiology.

Cationic and secretory effects of glimepiride and glibenclamide in perifused rat islets.

W. Malaisse, P. Lebrun, 1992, Pharmacology & toxicology.

Modalities of Gliclazide-induced Ca2+ Influx into the Pancreatic B-Cell

W. Malaisse, A. Herchuelz, P. Lebrun, 1982, Diabetes.

Design and synthesis of new potassium channel activators derived from the ring opening of diazoxide: study of their vasodilatory effect, stimulation of elastin synthesis and inhibitory effect on insulin release.

B. Pirotte, G. Faury, S. Khelili, 2015, Bioorganic & medicinal chemistry.

New R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans as K(ATP) channel openers: modulation of the 4-position.

P. Tullio, B. Pirotte, P. Lebrun, 2009, Bioorganic & medicinal chemistry.

Detection of K(ATP) channels subunits in human term placental explants and evaluation of their implication in human placental lactogen (hPL) and human chorionic gonadotropin (hCG) release.

C. Delporte, P. Lybaert, P. Lebrun, 2013, Placenta.

Calcium Regulation of Insulin Release

W. Malaisse, P. Lebrun, A. Herchulez, 1985 .

Effects of glucose on 45Ca2+ outflow, cytosolic Ca2+ concentration and insulin release from freshly isolated and cultured adult rat islets.

A. Boschero, A. Herchuelz, S. Bordin, 1990, Cell calcium.

Effects of neurotensin on the isolated mouse distal colon.

P. Lebrun, J. Fontaine, 1985, European journal of pharmacology.

Resistance to apamin of the Ca2+‐activated K+ permeability in pancreatic B‐cells

W. Malaisse, A. Herchuelz, I. Atwater, 1983, FEBS letters.

Resistance to aminooxyacetate of the ionic response to tolbutamide in pancreatic islets.

W. Malaisse, A. Herchuelz, P. Lebrun, 1984, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Paradoxical activation by glucose of quinine-sensitive potassium channels in the pancreatic B-cell.

W. Malaisse, A. Herchuelz, P. Lebrun, 1982, Biochemical and biophysical research communications.

Hydroxylamine, a nitric oxide donor, inhibits insulin release and activates K+ATP channels.

A. Herchuelz, R. Ouedraogo, P. Lebrun, 1996, European journal of pharmacology.

Apoptosis in human term placenta is not increased during labor but can be massively induced in vitro.

A. Moens, J. Delogne-Desnoeck, P. Lebrun, 1999, Biology of reproduction.

Activation, but not inhibition, by glucose of Ca2+-dependent K+ permeability in the rat pancreatic B-cell.

W. Malaisse, A. Herchuelz, P. Lebrun, 1983, Biochimica et biophysica acta.

Synthesis, characterization and biological evaluation of benzothiazoles and tetrahydrobenzothiazoles bearing urea or thiourea moieties as vasorelaxants and inhibitors of the insulin releasing process.

E. Goffin, B. Pirotte, G. Faury, 2016, European journal of medicinal chemistry.

Synthesis and pharmacological evaluation of 4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethylsulfonylphenyl)acylamide derivatives as potential activators of ATP sensitive potassium channels.

P. Arkhammar, P. Wahl, M. Antoine, 2005, Bioorganic & medicinal chemistry.

Triphenylphosphonium salts of 1,2,4-benzothiadiazine 1,1-dioxides related to diazoxide targeting mitochondrial ATP-sensitive potassium channels.

A. Mouithys-Mickalad, B. Elmoualij, P. Chiap, 2013, Bioorganic & medicinal chemistry letters.

Cell culture conditions influence glucose-induced [Ca2+]i responses in isolated rat pancreatic B cells.

A. Herchuelz, P. Lebrun, M. Antoine, 1997, Advances in experimental medicine and biology.

Evidence for two distinct modalities of CA2+ influx into pancreatic B cell.

W. Malaisse, A. Herchuelz, P. Lebrun, 1982, The American journal of physiology.

Hydroxylated analogues of ATP-sensitive potassium channel openers belonging to the group of 6- and/or 7-substituted 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides: toward an improvement in sulfonylurea receptor 1 selectivity and metabolism stability.

A. Servais, P. Chiap, M. Fillet, 2011, Journal of medicinal chemistry.

Impact of the nature of the substituent at the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides on their opening activity toward ATP-sensitive potassium channels.

C. Michaux, B. Pirotte, P. Lebrun, 2011, Journal of medicinal chemistry.

Coupling of Liquid Chromatography/Tandem Mass Spectrometry and Liquid Chromatography/Solid-Phase Extraction/NMR Techniques for the Structural Identification of Metabolites following In Vitro Biotransformation of SUR1-Selective ATP-Sensitive Potassium Channel Openers

P. Chiap, M. Frédérich, B. Pirotte, 2010, Drug Metabolism and Disposition.

Mechanism of 3-phenylpyruvate-induced insulin release. Secretory, ionic and oxidative aspects.

M. Welsh, W. Malaisse, F. Malaisse-Lagae, 1983, The Biochemical journal.

KATP channel openers: tissue selectivity of original 3-alkylaminopyrido- and 3-alkylaminobenzothiadiazine 1,1-dioxides.

B. Pirotte, N. Morel, P. Ghisdal, 2008, Biochemical pharmacology.

In vitro and in vivo effects of new insulin releasing agents.

B. Masereel, B. Pirotte, M. Antoine, 2002, Biochemical pharmacology.

Ketone bodies and islet function: 45Ca handling, insulin synthesis, and release.

W. Malaisse, I. Valverde, A. Sener, 1990, The American journal of physiology.

RELATIONS BETWEEN IMMUNOREACTIVE SOMATOMEDIN C, INSULIN AND T3 PATTERNS DURING FASTING IN OBESE SUBJECTS

A. Caufriez, R. Furlanetto, A. Herchuelz, 1984, Clinical endocrinology.

The stimulus-secretion coupling of amino acid-induced insulin release

W. Malaisse, A. Herchuelz, A. Sener, 1981, Pflügers Archiv.

Synthesis and characterization of a quinolinonic compound activating ATP‐sensitive K+ channels in endocrine and smooth muscle tissues

B. Pirotte, M. Antoine, B. Rigo, 2001, British journal of pharmacology.

Synergistic effect of a tumor-promoting phorbol ester and a hypoglycemic sulfonylurea upon insulin release.

W. Malaisse, F. Malaisse-Lagae, A. Herchuelz, 1983, Endocrinology.

Effect of the absence of bicarbonate upon intracellular pH and calcium fluxes in pancreatic islet cells.

W. Malaisse, A. Herchuelz, P. Lebrun, 1982, Biochimica et biophysica acta.

Metabolic response of pancreatic islets to the anomers of D-mannose

W. Malaisse, A. Herchuelz, A. Sener, 1982 .

Cooling dissociates glucose‐induced insulin release from electrical activity and cation fluxes in rodent pancreatic islets.

E. Rojas, W. Malaisse, A. Herchuelz, 1984, The Journal of physiology.

A role for Na/Ca exchange in the pancreatic B cell. Studies with thapsigargin and caffeine.

A. Herchuelz, P. Lebrun, 1993, Biochemical pharmacology.

Impairment by aminooxyacetate of ionic response to nutrients in pancreatic islets.

W. Malaisse, A. Herchuelz, P. Lebrun, 1983, The American journal of physiology.

Regulation of calcium fluxes in rat pancreatic islets. Quinine mimics the dual effect of glucose on calcium movements.

W. Malaisse, A. Herchuelz, A. Sener, 1981, Biochimica et biophysica acta.

1,4,2-Benzo/pyridodithiazine 1,1-dioxides structurally related to the ATP-sensitive potassium channel openers 1,2,4-Benzo/pyridothiadiazine 1,1-dioxides exert a myorelaxant activity linked to a distinct mechanism of action.

E. Goffin, B. Pirotte, P. Lebrun, 2013, Journal of medicinal chemistry.

New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino)-2H-1-benzopyrans structurally related to (+/-)-cromakalim as tissue-selective pancreatic beta-cell K(ATP) channel openers.

J. Wouters, C. Michaux, B. Pirotte, 2008, Bioorganic & medicinal chemistry.

New insights into the development of ATP-sensitive potassium channel openers

B. Pirotte, M. Antoine, P. Lebrun, 2005 .

A potent diazoxide analogue activating ATP-sensitive K+ channels and inhibiting insulin release

P. Arkhammar, B. Pirotte, M. Antoine, 2000, Diabetologia.

Formalin-induced central sensitization in the rat: somatosensory evoked potential data

F. Colin, J. Manil, P. Lebrun, 2000, Neuroscience Letters.

Modulation of the insulinotropic action of glibenclamide and glimepiride by nutrient secretagogues in pancreatic islets from normoglycemic and hyperglycemic rats.

W. Malaisse, A. Sener, P. Lebrun, 1993, Biochemical pharmacology.

Galanin: Ca2+-dependent contractile effects on the isolated mouse distal colon.

P. Lebrun, J. Fontaine, 1989, European journal of pharmacology.

Na+−K+ pump activity and the glucose-stimulated Ca2+-sensitive K+ permeability in the pancreatic B-cell

W. Malaisse, A. Herchuelz, P. Lebrun, 2005, The Journal of Membrane Biology.

Dissociation by methylamine of insulin release from glucose-induced electrical activity in isolated mouse islets of Langerhans.

W. Malaisse, L. Rosário, A. Herchuelz, 1985, Metabolism: clinical and experimental.

Effect of calcium antagonists on potassium conductance in islet cells.

W. Malaisse, A. Herchuelz, P. Lebrun, 1981, Biochemical pharmacology.

Insulinotropic effect of new glibenclamide isosteres.

B. Masereel, L. Pochet, M. Dunne, 1999, The Journal of pharmacology and experimental therapeutics.

Insulinotropic Effect of New Glibenclamide Isosteres 1

B. Masereel, L. Pochet, M. Dunne, 1999 .

The Stimulus-Secretion Coupling of Amino Acid-induced Insulin Release: Secretory and Oxidative Response of Pancreatic Islets to L-Asparagine

M. Welsh, W. Malaisse, F. Malaisse-Lagae, 1984, Diabetes.

Effect of extracellular phosphate on Ca2+ and K+ fluxes in pancreatic islets

W. Malaisse, A. Herchuelz, P. Lebrun, 1984, Journal of endocrinological investigation.

Mechanism of arginine-stimulated Ca2+ influx into pancreatic B cell.

A. Boschero, W. Malaisse, A. Herchuelz, 1984, The American journal of physiology.

Activation of ATP-dependent K+ channels and inhibition of insulin release: effect of BPDZ 62.

B. Masereel, A. Herchuelz, B. Pirotte, 1996, The Journal of pharmacology and experimental therapeutics.

Metabolic, cationic and secretory response to D-glucose in depolarized and Ca(2+)-deprived rat islets exposed to diazoxide.

W. Malaisse, M. Antoine, Q. Nguyen, 2000, Cell calcium.

The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener.

F. Ashcroft, P. Wahl, B. Pirotte, 2002, Diabetes.

Do hypoglycemic sulfonylureas inhibit Na+,K+-ATPase activity in pancreatic islets?

W. Malaisse, A. Herchuelz, P. Lebrun, 1985, The American journal of physiology.

Methylamines and islet function: cationic aspects

R. Gomis, B. Billaudel, W. Malaisse, 1984, Journal of endocrinological investigation.

Methylamine and islet function: possible relationship to Ca2+-sensitive transglutaminase

R. Gomis, W. Malaisse, A. Herchuelz, 1984, Molecular and Cellular Endocrinology.

Impairment of insulin release by methylation inhibitors.

W. Malaisse, F. Malaisse-Lagae, A. Herchuelz, 1984, Biochemical pharmacology.

Increase in CO3H— influx and cellular pH in glucose‐stimulated pancreatic islets

W. Malaisse, M. Deleers, P. Lebrun, 1983, FEBS letters.

Anomeric specificity of D-mannose metabolism in pancreatic islets.

W. Malaisse, F. Malaisse-Lagae, A. Herchuelz, 1982, Biochemical and biophysical research communications.

Nutrient-induced intracellular calcium movement in rat pancreatic B cell.

W. Malaisse, A. Herchuelz, P. Lebrun, 1982, American Journal of Physiology.

Ionic mechanism of diphenylhydantoin action on glucose-induced insulin release.

W. Malaisse, A. Herchuelz, A. Sener, 1981, European journal of pharmacology.

Anticonvulsant activity of piperine on seizures induced by excitatory amino acid receptor agonists.

R. D'Hooge, P. Deyn, P. De Deyn, 1996, Arzneimittel-Forschung.

4H-1,2,4-Pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2, 4-pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors: design, synthesis, pharmacology,

J Delarge, P Lebrun, M. Spedding, 1998, Journal of medicinal chemistry.

Synthesis and structural studies of a new class of heterocyclic compounds: 1,2,4-Pyridothiadiazine 1,1-dioxides, pyridyl analogues of 1,2,4-benzothiadiazine 1,1-dioxides

P. Tullio, O. Diouf, B. Masereel, 1995 .

Intrathecal Catheterization and Solvents Interfere with Cortical Somatosensory Evoked Potentials Used in Assessing Nociception in Awake Rats

F. Camu, M. Zizi, P. Lebrun, 2004, Anesthesia and analgesia.

Preparation and pharmacological evaluation of the R- and S-enantiomers of 3-(2-butylamino)-4H- and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide, two tissue selective ATP-sensitive potassium channel openers.

M. Fillet, B. Pirotte, L. Dupont, 1999, Bioorganic & medicinal chemistry.

Chloro-substituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel activators: impact of the position of the chlorine atom on the aromatic ring on activity and tissue selectivity.

P. Wahl, B. Pirotte, J. Hansen, 2010, Journal of medicinal chemistry.

Effect on K(ATP) channel activation properties and tissue selectivity of the nature of the substituent in the 7- and the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides.

B. Pirotte, M. Antoine, R. Ouedraogo, 2005, Journal of medicinal chemistry.

3-(Alkylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as powerful inhibitors of insulin release from rat pancreatic B-cells: a new class of potassium channel openers?

B. Masereel, A. Herchuelz, B. Pirotte, 1993, Journal of medicinal chemistry.

Toward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides.

P. Wahl, B. Pirotte, M. Antoine, 2003, Journal of medicinal chemistry.

Synthesis and Structural Studies of a New Class of Heterocyclic Compounds: 1,2,4-Pyridothiadiazine 1,1-Dioxides, Pyridyl Analogues of 1,2,4-Benzothiadiazine 1,1-Dioxides.

P. Tullio, O. Diouf, B. Masereel, 2010 .

2-Alkyl-3-Alkylamino-2H-Benzo- and Pyridothiadiazine 1,1-Dioxides: From K+ATP Channel Openers to Ca++ Channel Blockers?

P. Tullio, B. Pirotte, M. Antoine, 2002, Biological chemistry.

3-and 4-substituted 4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potassium channel openers: synthesis, pharmacological evaluation, and structure-activity relationships.

O. Diouf, B. Masereel, B. Pirotte, 1996, Journal of medicinal chemistry.

Blockade of calcium entry in smooth muscle cells by the antidepressant imipramine.

N. Morel, P. Lebrun, A. Vanbellinghen, 2004, Biochemical pharmacology.

Recent advances in the chemistry of potassium channel openers

B. Pirotte, J. Fontaine, P. Lebrun, 1995 .

Original 2-alkylamino-6-halogenoquinazolin-4(3H)-ones and K(ATP) channel activity.

B. Pirotte, L. Dupont, M. Antoine, 2001, Journal of medicinal chemistry.

3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers: effect of 6,7-disubstitution on potency and tissue selectivity.

B. Pirotte, M. Antoine, P. Francotte, 2005, Journal of medicinal chemistry.

Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells.

B. Pirotte, S. Khelili, P. Lebrun, 2012, European journal of medicinal chemistry.

Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas

P. Tullio, B. Masereel, J. Dogné, 1997 .

Three-dimensional quantitative structure-activity relationships of ATP-sensitive potassium (KATP) channel openers belonging to the 3-alkylamino-4H-1,2,4-benzo- and 3-alkylamino-4H-1,2,4-pyridothiadiazine 1,1-dioxide families.

Pierre Francotte, Bernard Pirotte, Philippe Lebrun, 2006, Journal of medicinal chemistry.

The stimulus-secretion coupling of glucose-induced insulin release. XLVII. The possible role of calmodulin.

W. Malaisse, A. Herchuelz, I. Valverde, 1981, Endocrinology.

3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to diazoxide and pinacidil as potassium channel openers acting on vascular smooth muscle cells: design, synthesis, and pharmacological evaluation.

B. Pirotte, L. Dupont, J. Fontaine, 2000, Journal of medicinal chemistry.

3-Alkylamino-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as Potent KATP-Channel Activators: Structural Study and Influence of Stereochemistry

P. Tullio, B. Pirotte, L. Dupont, 1999 .

A pyridothiadiazine (BPDZ 44) as a new and potent activator of ATP-sensitive K+ channels.

A. Herchuelz, B. Pirotte, M. Antoine, 1994, Biochemical pharmacology.

Human chorionic gonadotrophin early pregnancy levels are more closely related to changes in β-subunit trophoblast production than to variations in α-subunit production

E. Jauniaux, J. Delogne-Desnoeck, P. Lebrun, 1997 .

In-vivo and in-vitro assessment of the influence of ritodrine and oxytocin on the placental secretion of human chorionic gonadotrophin and placental lactogen.

J. Delogne-Desnoeck, C. Robyn, P. Lebrun, 1996, Human reproduction.

Calcium influx similarly stimulates the release of chorionic gonadotrophin and placental lactogen from human placental explants

C. Robyn, B. Polliotti, P. Lebrun, 1992 .

Secretory characteristics and viability of human term placental tissue after overnight cold preservation.

A. Moens, J. Delogne-Desnoeck, P. Lebrun, 2000, Human reproduction.

Stimulatory effects of extracellular calcium on chorionic gonadotrophin and placental lactogen release by human placental explants.

C. Robyn, B. Polliotti, P. Lebrun, 1990, Placenta.

Ca2+ entry through L-type voltage-sensitive Ca2+ channels stimulates the release of human chorionic gonadotrophin and placental lactogen by placental explants.

C. Robyn, B. Polliotti, P. Lebrun, 1994, Biochimica et biophysica acta.

Pinacidil inhibits insulin release by increasing K+ outflow from pancreatic B-cells.

A. Herchuelz, P. Lebrun, M. Hermann, 1988, European journal of pharmacology.

Evidence for a Clathrin-Mediated Recycling of Albumin in Human Term Placenta1

P. Lybaert, A. Boom, J. Delogne-Desnoeck, 2006, Biology of reproduction.

Release of endogenous GABA from the rat brain: methodological aspects and the effects of catecholamines.

J. Korf, K. Venema, P. Lebrun, 1981, Advances in biochemical psychopharmacology.

Physiological concentrations of albumin stimulate chorionic gonadotrophin and placental lactogen release from human term placental explants.

J. Delogne-Desnoeck, P. Lebrun, A. Vanbellinghen, 2001, Human reproduction.

Failure of Leiurus quinquestriatus venom to affect potassium movements in pancreatic islets.

A. Herchuelz, J. Dehaye, P. Lebrun, 1988, Biochemical and biophysical research communications.

4,6-Disubstituted 2,2-dimethylchromans structurally related to the K(ATP) channel opener cromakalim: design, synthesis, and effect on insulin release and vascular tone.

B. Pirotte, M. Antoine, P. Lebrun, 2005, Journal of medicinal chemistry.

Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: from potassium channel openers to calcium entry blockers?

B. Pirotte, P. Lebrun, P. de Tullio, 2014, European journal of medicinal chemistry.

Modulation of the 6-position of benzopyran derivatives and inhibitory effects on the insulin releasing process.

S. Dilly, B. Pirotte, P. Lebrun, 2011, Bioorganic & medicinal chemistry.

BPDZ 154 activates adenosine 5'-triphosphate-sensitive potassium channels: in vitro studies using rodent insulin-secreting cells and islets isolated from patients with hyperinsulinism.

P. Clayton, K. Hussain, J. Saudubray, 2002, The Journal of clinical endocrinology and metabolism.

Contractile effects of substance P and other tachykinins on the mouse isolated distal colon

P. Lebrun, J. Fontaine, 1989, British Journal of Pharmacology.

Pharmacological analysis of the effects of Bay K 8644 and organic calcium antagonists on the mouse isolated distal colon

J. Fontaine, P. Lebrun, 1988, British journal of pharmacology.

Mechanical and ionic response of rat aorta to diazoxide.

A. Herchuelz, G. Berkenboom, P. Lebrun, 1992, European journal of pharmacology.

Characterization and potential roles of calretinin in rodent spermatozoa.

B. Schwaller, P. Lybaert, D. Gall, 2018, Cell calcium.

Dynamics of the cationic, bioelectrical and secretory responses to formycin A in pancreatic islet cells

P. Rorsman, M. Holmquist, E. Renström, 2005, Pflügers Archiv.

Effects of maitotoxin on ionic and secretory events in rat pancreatic islets.

A. Herchuelz, P. Lebrun, M. Hermann, 1987, Biochemical and biophysical research communications.

N-methyl-d-aspartate receptor activation by guanidinosuccinate but not by methylguanidine: Behavioural and electrophysiological evidence

R. D'Hooge, F. Colin, J. Manil, 1996, Neuropharmacology.

Verapamil, a phenylalkylamine Ca2 + channel blocker, inhibits ATP-sensitive K + channels in insulin-secreting cells from rats

A. Herchuelz, B. Pirotte, R. Ouédraogo, 1997, Diabetologia.

The stimulus-secretion coupling of glucose-induced insulin release XLVI. Physiological role of l-glutamine as a fuel for pancreatic islets

W. Malaisse, A. Herchuelz, A. Sener, 1980, Molecular and Cellular Endocrinology.

insulin synthesis, and release Ketone bodies and islet function: 45Ca handling,

Philippe Lebrun, Javier Camara, Isabel Valverde, 2013 .

Sodium nitroprusside inhibits glucose-induced insulin release by activating ATP-sensitive K+ channels.

A. Herchuelz, P. Lebrun, M. Hermann, 1993, Biochimica et biophysica acta.

Minireview K+ channel openers and insulin release

A. Herchuelz, M. Antoine, P. Lebrun, 1992 .

Design, synthesis, and pharmacological evaluation of R/S-3,4-dihydro-2,2-dimethyl- 6-halo-4-(phenylaminocarbonylamino)-2H-1-benzopyrans: toward tissue-selective pancreatic beta-cell KATP channel openers structurally related to (+/-)-cromakalim.

B. Pirotte, D. Gall, P. Lebrun, 2006, Journal of medicinal chemistry.

Effect on insulin release of compounds structurally related to the potassium‐channel opener 7‐chloro‐3‐isopropylamino‐4H‐1,2,4‐benzothiadiazine 1,1‐dioxide (BPDZ 73): introduction of heteroatoms on the 3‐alkylamino side chain of the benzothiadiazine 1,1‐dioxide ring

P. Tullio, B. Pirotte, M. Antoine, 2001, The Journal of pharmacy and pharmacology.

Deciphering Structure–Activity Relationships in a Series of 2,2‐Dimethylchromans Acting as Inhibitors of Insulin Release and Smooth Muscle Relaxants

B. Pirotte, P. Lebrun, Xavier Florence, 2017, ChemMedChem.

Phe-Met-Arg-Phe-NH2 (FMRFa)-related peptides inhibit Na/Ca exchange in pancreatic B cells.

A. Herchuelz, A. Vandermeers, F. Van Eylen, 1997, Advances in experimental medicine and biology.

Effects of Phe‐Met‐Arg‐Phe‐NH2 (FMRFa)‐Related Peptides on Na‐Ca Exchange and Ionic Fluxes in Rat Pancreatic B Cells

A. Herchuelz, A. Vandermeers, P. Gourlet, 1996, Annals of the New York Academy of Sciences.

Stimulus-secretion coupling of arginine-induced insulin release. Insulinotropic action of agmatine.

W. Malaisse, A. Sener, F. Blachier, 1989, Biochemical pharmacology.

Mode of action of hypoglycaemic sulfonylureas in the pancreatic B-cell: coinciding and conflicting views

W. Malaisse, A. Herchuelz, A. Sener, 1983 .

Inhibition of Na/Ca exchange by Phe-Met-Arg-Phe-NH2 (FMRFa)-related peptides in intact rat pancreatic B-cells

A. Herchuelz, A. Vandermeers, P. Gourlet, 1994, Molecular and Cellular Endocrinology.

Paradoxical inhibitory effect of cromakalim on 86Rb outflow from pancreatic islet cells.

A. Herchuelz, P. Lebrun, M. Hermann, 1990, The Journal of pharmacology and experimental therapeutics.

Effects of the calcium channel agonist, BAY K 8644, on electrical activity in mouse pancreatic B-cells.

I. Atwater, P. Lebrun, 1985, Biophysical journal.

Inhibition of Na/Ca exchange stimulates insulin release from isolated rat pancreatic islets

A. Herchuelz, P. Lebrun, F. Eylen, 1994, Fundamental & clinical pharmacology.

RP 49356: inhibitory effects of ionic and secretory events in rat pancreatic islets.

A. Herchuelz, P. Lebrun, M. Hermann, 1991, European journal of pharmacology.

Effect of extracellular sodium removal upon 86Rb outflow from pancreatic islet cells.

A. Herchuelz, P. Lebrun, P. Plasman, 1989, Biochimica et biophysica acta.

Na+-H+ exchange in the process of glucose-induced insulin release from the pancreatic B-cell. Effects of amiloride on 86Rb, 45Ca fluxes and insulin release.

A. Herchuelz, M. Deleers, E. van Ganse, 1986, Biochimica et biophysica acta.

Nutrient-induced changes in the pH of pancreatic islet cells.

W. Malaisse, M. Deleers, P. Lebrun, 1985, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Effects of cations, ionophores and hypoglycemic sulfonylureas on the fluorescence of fluorescein-labelled pancreatic islets.

W. Malaisse, M. Deleers, P. Lebrun, 1984, Research communications in chemical pathology and pharmacology.

Ionic determinants of bioelectrical spiking activity in the pancreatic B-cell

W. Malaisse, A. Herchuelz, P. Lebrun, 1982, Pflügers Archiv.

The riddle of formycin A insulinotropic action.

P. Rorsman, P. D. van Poelje, W. Malaisse, 1996, Biochemical and Molecular Medicine.

Tricyclic antidepressant imipramine reduces the insulin secretory rate in islet cells of Wistar albino rats through a calcium antagonistic action

S. Schiffmann, D. Gall, P. Lebrun, 2004, Diabetologia.

3-Morpholinosydnonimine as instigator of a glibenclamide-sensitive reduction in the insulin secretory rate.

A. Herchuelz, R. Ouedraogo, P. Lebrun, 1997, Biochemical pharmacology.

Simultaneous measurement of 45Ca outflow and human placental lactogen release from placental explants.

C. Robyn, P. Lebrun, A. Vanbellinghen, 1995, Cell calcium.

4-Phenylureido/thioureido-substituted 2,2-dimethylchroman analogs of cromakalim bearing a bulky 'carbamate' moiety at the 6-position as potent inhibitors of glucose-sensitive insulin secretion.

B. Pirotte, P. Lebrun, P. de Tullio, 2016, European journal of medicinal chemistry.

2,2-Dimethyl-3,4-dihydro-2H-1,4-benzoxazines as isosteres of 2,2-dimethylchromans acting as inhibitors of insulin release and vascular smooth muscle relaxants.

B. Pirotte, P. Lebrun, Xavier Florence, 2019, MedChemComm.

Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release.

P. Arkhammar, P. Wahl, M. Antoine, 2004, Journal of medicinal chemistry.

Ionic and secretory response of pancreatic islet cells to minoxidil sulfate.

A. Herchuelz, P. Lebrun, M. Hermann, 1991, The Journal of pharmacology and experimental therapeutics.

A. Herchuelz, P. Lebrun, M. Hermann, 1989, The Journal of pharmacology and experimental therapeutics.

Selective pancreatic ATP-sensitive potassium channel openers for the treatment of glucose homeostasis disorders

P. Tullio, B. Pirotte, M. Antoine, 2006 .

Synthesis and pharmacological evaluation of some N-arylsulfonyl-N-methyl-N'-(2,2-dimethyl-2H-1-benzopyran-4-yl)ureas structurally related to cromakalim.

B. Pirotte, S. Khelili, P. Lebrun, 2006, Bioorganic & medicinal chemistry.

The release of human chorionic gonadotrophin and placental lactogen by placental explants can be stimulated by Ca2+ entry through a Na(+)-Ca2+ exchange process.

C. Robyn, B. Polliotti, P. Lebrun, 1994, Placenta.

Colloidal effect of albumin on the placental lactogen and chorionic gonadotrophin releases from human term placental explants.

J. Delogne-Desnoeck, P. Lebrun, A. Vanbellinghen, 2004, Biochemical and biophysical research communications.

Characterization of the process of sodium-calcium exchange in pancreatic islet cells.

A. Herchuelz, P. Lebrun, P. Plasman, 1990, The American journal of physiology.

Synthesis and structural studies of a new class of heterocyclic compounds: 1,2,4-Pyridothiadiazine 1,1-dioxides, pyridyl analogues of 1,2,4-benzothiadiazine 1,1-dioxides

P. Tullio, O. Diouf, B. Masereel, 1995 .

Inhibition of Na/Ca exchange in pancreatic islet cells by 3',4'-dichlorobenzamil.

A. Herchuelz, E. Cragoe, P. Lebrun, 1991, Biochemical pharmacology.

Effects of thioacetamide on pancreatic islet B-cell function

W. Malaisse, A. Sener, M. Ravazzola, 2004, Endocrine.

4-Phenylureido/thioureido-substituted 2,2-dimethylchroman analogs of cromakalim bearing a bulky 'carbamate' moiety at the 6-position as potent inhibitors of glucose-sensitive insulin secretion.

B. Pirotte, P. Lebrun, P. de Tullio, 2016, European journal of medicinal chemistry.

Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators.

B. Pirotte, S. Khelili, P. Lebrun, 2008, Bioorganic & medicinal chemistry.

The Stimulus-Secretion Coupling of Amino Acid-induced Insulin Release: Secretory and Oxidative Response of Pancreatic Islets to L-Asparagine

M. Welsh, W. Malaisse, A. Herchuelz, 1984, Diabetes.

Effect of Temperature upon Potassium-Stimulated Insulin Release and Calcium Entry in Mouse and Rat Islets

W. Malaisse, A. Herchuelz, A. Gonçalves, 1986, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Cationic and secretory effects of BPDZ 44 and diazoxide in rat pancreatic islets

P. Tullio, A. Herchuelz, B. Pirotte, 1994, Experientia.

Pyridothiadiazines as potent inhibitors of glucose-induced insulin release.

A. Herchuelz, B. Pirotte, M. Antoine, 1997, Advances in experimental medicine and biology.

Hypoglycemic sulfonylureas antagonize the effects of cromakalim and pinacidil on 86Rb fluxes and contractile activity in the rat aorta.

A. Herchuelz, G. Berkenboom, P. Lebrun, 1990, Pharmacology.

Chaotic and irregular bursting electrical activity in mouse pancreatic B-cells.

I. Atwater, P. Lebrun, 1985, Biophysical journal.