C. Owen

发表

Medicinal Chemistry: Some 1‐[(Benzofuran‐2‐yl)methyl]imidazoles as Inhibitors of 17α‐Hydroxylase:17, 20‐lyase (P450 17) and Their Specificity Patterns

H. J. Smith, P. Nicholls, S. A. Bahshwan, 1998 .

A novel steroidal saponin glycoside from Fagonia indica induces cell-selective apoptosis or necrosis in cancer cells.

A. Waheed, James Barker, S. Barton, 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Novel acylated steroidal glycosides from Caralluma tuberculata induce caspase-dependent apoptosis in cancer cells.

A. Waheed, James Barker, G. Khan, 2011, Journal of ethnopharmacology.

Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES).

C. Owen, Sabbir Ahmed, K. James, 2002, The Journal of steroid biochemistry and molecular biology.

Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17alpha-hydroxylase/17,20-lyase (P-450(17alpha)).

I. Shahid, C. Owen, Sabbir Ahmed, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17α-hydroxylase/17,20-lyase (P45017α)

I. Shahid, Chirag H. Patel, C. Owen, 2006 .

Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).

Chirag H. Patel, C. Owen, Sabbir Ahmed, 2006, Bioorganic & medicinal chemistry letters.

The mechanism of the irreversible inhibition of estrone sulfatase (ES) through the consideration of a range of methane- and amino-sulfonate-based compounds.

C. Owen, Sabbir Ahmed, C. Patel, 2002, Bioorganic & medicinal chemistry letters.

Evidence for the mechanism of the irreversible inhibition of oestrone sulphatase (ES) by aminosulphonate based compounds

C. Owen, Sabbir Ahmed, C. Patel, 2002, The Journal of Steroid Biochemistry and Molecular Biology.

Inhibition of Aromatase (P450Arom) by some 1‐(Benzofuran‐2‐ylmethyl)imidazoles

R. Whomsley, P. Nicholls, C. Owen, 1999, The Journal of pharmacy and pharmacology.

Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid.

C. Owen, Sabbir Ahmed, C. Patel, 2004, Bioorganic & medicinal chemistry letters.

Design, synthesis, and evaluation of 4-(4'-aminobenzyl)-2-oxazolidinones as novel inhibitors of the cytochrome P-450 enzyme aromatase.

C. Owen, Sabbir Ahmed, S. Adat, 2002, Bioorganic chemistry (Print).

Review of estrone sulfatase and its inhibitors--an important new target against hormone dependent breast cancer.

C. Owen, Sabbir Ahmed, C. Patel, 2002, Current medicinal chemistry.

Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a series of 4-hydroxyphenyl ketones as potential inhibitors of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3).

C. Owen, Sabbir Ahmed, S. Dhanani, 2006, Bioorganic & medicinal chemistry letters.

Biochemical evaluation of extracts from Caralluma tuberculata against hormone-dependent breast cancer cells

A. Waheed, Y. Bibi, C. Owen, 2009 .

The design, synthesis, and in vitro biochemical evaluation of a series of esters of 4-[(aminosulfonyl)oxy]benzoate as novel and highly potent inhibitors of estrone sulfatase.

C. Owen, Sabbir Ahmed, C. Patel, 2003, Biochemical and biophysical research communications.

Structure‐activity relationship determination within a group of substituted phenyl sulfamate based compounds against the enzyme oestrone sulfatase

C. Owen, Sabbir Ahmed, C. Patel, 2003, The Journal of pharmacy and pharmacology.

The design, synthesis, and biochemical evaluation of derivatives of biphenyl sulfamate-based compounds as novel inhibitors of estrone sulfatase.

C. Owen, Sabbir Ahmed, K. James, 2002, Biochemical and biophysical research communications.

Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES).

C. Owen, Sabbir Ahmed, C. Patel, 2002, Bioorganic & medicinal chemistry letters.

Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism.

M. Patel, C. Owen, C. Patel, 2001, Bioorganic & medicinal chemistry letters.

17alpha-hydroxylase/17,20-lyase (p450(17alpha)) inhibitors in the treatment of prostate cancer: a review.

C. Owen, 2009, Anti-Cancer Agents in Medicinal Chemistry.