T. Brown

发表

Metabolism and disposition of gemcitabine, and oncolytic deoxycytidine analog, in mice, rats, and dogs.

W. D. Daniels, L. Shipley, T. Brown, 1992, Drug metabolism and disposition: the biological fate of chemicals.

Recombinant oncostatin M stimulates the production of acute phase proteins in HepG2 cells and rat primary hepatocytes in vitro.

J. Gauldie, H. Baumann, C. Richards, 1992, Journal of immunology.

Characterization of a CD43/Leukosialin-mediated Pathway for Inducing Apoptosis in Human T-Lymphoblastoid Cells*

S. Nadler, H. Marquardt, R. Mittler, 1996, The Journal of Biological Chemistry.

Characterisation of constrictor endothelin receptors in the human internal thoracic artery and saphenous vein.

M. Amrani, M. Yacoub, A. Roach, 1999, Journal of cardiovascular pharmacology.

New non peptidic C5a receptor antagonists

P. Lockey, I. McLay, A. Morley, 1997 .

Effect of the Membrane Lipid Environment on the Properties of Insulin Receptors

A. A. Spector, B. Ginsberg, I. Simon, 1981, Diabetes.

Regulation of insulin receptors in erythroid cells.

B. Ginsberg, T. Brown, 1982, Metabolism: clinical and experimental.

Modulation of rat hepatic cytochromes P450 by chronic methapyrilene treatment.

S. Wrighton, C. V. Van Pelt, P. Thomas, 1991, Biochemical pharmacology.

Detection of pancreatic islet 64,000 M(r) autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase.

B. Michelsen, T. Delovitch, M. Christie, 1993, The Journal of clinical investigation.

In vitro expression of endothelin-1 (ET-1) and the ETA and ETB ET receptors by the prostatic epithelium and stroma.

A. Roach, B. Williams, T. Brown, 1997, The Journal of clinical endocrinology and metabolism.

Properties and regulation of the T lymphocyte insulin receptor.

L. Ercolani, B. Ginsberg, T. Brown, 1983, Journal of receptor research.

Decrease in Insulin Receptors During Friend Erythroleukemia Cell Differentiation

M. Raizada, B. Ginsberg, T. Brown, 1979, Diabetes.

Selective regulation of metalloproteinase inhibitor (TIMP-1) by oncostatin M in fibroblasts in culture.

J. Gauldie, C. Richards, M. Shoyab, 1993, Journal of immunology.

New Glucocorticosteroids with an improved therapeutic ratio?

M. Belvisi, M. Foster, T. Brown, 2001, Pulmonary pharmacology & therapeutics.

Regulation of IL-6 expression by oncostatin M.

J. Liu, M. Shoyab, T. Brown, 1991, Journal of immunology.

Regulation of inflammatory responses by oncostatin M.

K. L. Donaldson, A. Wahl, P. Wallace, 1999, Journal of immunology.

Oncostatin M inhibits IL-1-induced expression of IL-8 and granulocyte-macrophage colony-stimulating factor by synovial and lung fibroblasts.

C. Richards, T. Brown, F. Botelho, 1996, Journal of immunology.

Atypical antagonism observed with BQ-123 in human saphenous vein.

M. Yacoub, A. Roach, A. Chester, 1998, Journal of cardiovascular pharmacology.

Muscarinic analgesics with potent and selective effects on the gastrointestinal tract: potential application for the treatment of irritable bowel syndrome.

F. Bymaster, P. Suzdak, Michael D B Swedberg, 1997, Journal of medicinal chemistry.

Tunicamycin blocks the emergence and maintenance of insulin receptors on mitogen-activated human T lymphocytes.

L. Ercolani, B. Ginsberg, T. Brown, 1984, Metabolism: clinical and experimental.

Effect of Endothelin Antagonists With or Without BQ 788 on ET‐1 Responses in Pithed Rats

A. Roach, R. Brázdil, T. Brown, 1995, Journal of cardiovascular pharmacology.

Modification of membrane physical properties, biological response and insulin binding in Friend cells by low serum concentration.

B. Ginsberg, I. Simon, T. Brown, 1987, Biochimica et biophysica acta.

Demonstration of receptors for insulin-like growth factor-II on human T-lymphocytes.

L. Ercolani, B. Ginsberg, T. Brown, 1985, Journal of receptor research.

Abnormal insulin binding and membrane physical properties of a Friend erythroleukemia clone resistant to dimethylsulfoxide-induced differentiation.

B. Ginsberg, I. Simon, T. Brown, 1984, Biochimica et biophysica acta.

Evidence for endothelin involvement in the pulmonary vasoconstrictor response to systemic hypoxia in the isolated rat lung.

A. Roach, B. Woodward, R. M. Smith, 1997, The Journal of pharmacology and experimental therapeutics.

Antibodies to Islet 37k Antigen, But Not to Glutamate Decarboxylase, Discriminate Rapid Progression to IDDM in Endocrine Autoimmunity

E. Bonifacio, E. Bosi, S. Genovese, 1994, Diabetes.

Identification of a non peptidic RANTES antagonist.

P. Lockey, I. McLay, R. Williams, 1998, Bioorganic & medicinal chemistry letters.

Failure to detect anti-idiotypic antibodies in the autoimmune response to IA-2 in Type 1 diabetes

C. C. Richardson, R. Feltbower, B. Rees Smith, 2013, Autoimmunity.

Calcium regulation of phospholipase A2 is independent of calmodulin.

T. Brown, M. Withnall, B. K. Diocee, 1984, Biochemical and biophysical research communications.

Pancreatic phospholipase A2 is not regulated by calmodulin.

T. Brown, M. Withnall, 1982, Biochemical and biophysical research communications.

Oncostatin M induces tyrosine phosphorylation in endothelial cells and activation of p62yes tyrosine kinase.

P. Linsley, G. Schieven, J. Ledbetter, 1992, Journal of immunology.

Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme

M. Christie, T. Brown, D. Cassidy, 1992, Diabetologia.

The effect of fetal calf serum on intracellular calcium in GH3 cells.

B. Brown, P. Dobson, I. Wrench, 1988, Biochemical and biophysical research communications.

Transactivation Activity Separation of Transrepression from Glucocorticoid and the Relevance of In Vitro Therapeutic Benefit of a Dissociated

C. Battram, M. Belvisi, S. Bottoms, 2001 .

Syntheses and biological activities of potent potassium channel openers derived from (+/-)-2-oxo-1-pyridin-3-yl-cyclohexanecarbothioic acid methylamide: new potassium channel openers.

J. Mason, N. Vicker, T. Brown, 1993, Journal of medicinal chemistry.

Selective endothelin A receptor ligands. 1. Discovery and structure-activity of 2,4-disubstituted benzoic acid derivatives

Richard A. Lewis, P. Lockey, A. Roach, 1997 .

Regulation of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor expression by oncostatin M.

J. Liu, M. Shoyab, T. Brown, 1993, Blood.

Differences between the effects of cromakalim and nifedipine on agonist‐induced responses in rabbit aorta

S. Duty, D. Newgreen, J. Longmore, 1991, British Journal of Pharmacology.

Synthesis, antiviral activity, and biological properties of vinylacetylene analogs of enviroxime

L. Vance, L. Shipley, B. Heinz, 1997 .

Purification and characterization of cytostatic lymphokines produced by activated human T lymphocytes. Synergistic antiproliferative activity of transforming growth factor beta 1, interferon-gamma, and oncostatin M for human melanoma cells.

H. Marquardt, M. Lioubin, T. Brown, 1987, Journal of immunology.

Selective endothelin A receptor antagonists. 4. Discovery and structure-activity relationships of stilbene acid and alcohol derivatives.

P. Lockey, A. Roach, I. McLay, 1998, Journal of medicinal chemistry.

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

A. Aruffo, J. Ledbetter, C. Larsen, 1997, The Journal of experimental medicine.

The Role of Extracellular Vesicles in the Development of a Cancer Stem Cell Microenvironment Niche and Potential Therapeutic Targets: A Systematic Review

V. James, T. Brown, 2021, Cancers.

The Protein Kinase Cβ–Selective Inhibitor, Enzastaurin (LY317615.HCl), Suppresses Signaling through the AKT Pathway, Induces Apoptosis, and Suppresses Growth of Human Colon Cancer and Glioblastoma Xenografts

R. Campbell, P. Iversen, J. Graff, 2005 .

Selective ET(A) antagonists. 5. Discovery and structure-activity relationships of phenoxyphenylacetic acid derivatives.

A. Roach, I. McLay, A. Morley, 2000, Journal of medicinal chemistry.

Determination of xanomeline (LY246708 tartrate), an investigational agent for the treatment of Alzheimer's disease, in rat and monkey plasma by capillary gas chromatography with nitrogen-phosphorus detection.

L. Shipley, T. Brown, 1995, Journal of chromatography. B, Biomedical applications.

Synthesis and biological activity of trans(+-)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-oxide (RP 49356) and analogues: a new class of potassium channel opener.

J. Mason, I. McLay, T. Brown, 1992, Journal of medicinal chemistry.

RP 49356 and cromakalim relax airway smooth muscle in vitro by opening a sulphonylurea-sensitive K+ channel: a comparison with nifedipine.

D. Raeburn, T. Brown, 1991, Journal of Pharmacology and Experimental Therapeutics.

Intratumor pharmacokinetics, flow resistance, and metabolism during gemcitabine infusion in ex vivo perfused human small cell lung cancer.

R. Jain, P. Kristjansen, L. Shipley, 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

Selective endothelin A receptor antagonists. 2. Discovery and structure-activity relationships of 5-ketopentanoic acid derivatives

C. Mccarthy, T. Brown, P. Astles, 1997 .