G. Lountos

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Biomolecular Interactions of Small‐molecule Inhibitors Affecting the YopH Protein Tyrosine Phosphatase

Bryan M. Zhao, J. Tropea, D. Waugh, 2013, Chemical biology & drug design.

Crystal structures and functional studies of T4moD, the toluene 4-monooxygenase catalytic effector protein.

B. Fox, A. Orville, J. Studts, 2005, Biochemistry.

Crystal structure of Tdp1 catalytic domain in complex with compound XZ578

Y. Pommier, J. Tropea, D. Waugh, 2019 .

X‐ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper‐dependent hydrophobic pocket

Y. Pommier, R. Shoemaker, J. Tropea, 2011, FEBS letters.

Crystal structure of UDP-glucose pyrophosphorylase from Yersinia pestis, a potential therapeutic target against plague.

D. Waugh, Morgan E. Gibbs, G. Lountos, 2019, Acta crystallographica. Section F, Structural biology communications.

Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9.

W. M. Hewitt, R. Nussinov, B. Ma, 2016, Angewandte Chemie.

Role of Glu312 in binding and positioning of the substrate for the hydride transfer reaction in choline oxidase.

O. Quaye, G. Gadda, A. Orville, 2008, Biochemistry.

Characterization of a broadly specific cadaverine N-hydroxylase involved in desferrioxamine B biosynthesis in Streptomyces sviceus

L. Giddings, J. Tropea, D. Waugh, 2021, PloS one.

Convergent evolution of the Hedgehog/Intein fold in protein splicing

Salla I. Virtanen, Hannes M. Beyer, A. Wlodawer, 2020, bioRxiv.

The Convergence of the Hedgehog/Intein Fold in Different Protein Splicing Mechanisms

Salla I. Virtanen, Hannes M. Beyer, A. Wlodawer, 2020, International journal of molecular sciences.

The crystal structure of NAD(P)H oxidase from Lactobacillus sanfranciscensis: insights into the conversion of O2 into two water molecules by the flavoenzyme.

Tracey L. Thaler, A. Bommarius, A. Orville, 2006, Biochemistry.

Crystallographic, spectroscopic, and computational analysis of a flavin C4a-oxygen adduct in choline oxidase.

G. Gadda, A. Orville, Rajeev Prabhakar, 2009, Biochemistry.

Crystallization and preliminary analysis of a water-forming NADH oxidase from Lactobacillus sanfranciscensis.

A. Bommarius, A. Orville, William B. Wellborn, 2004, Acta crystallographica. Section D, Biological crystallography.

Unique Structural Fold of LonBA Protease from Bacillus subtilis, a Member of a Newly Identified Subfamily of Lon Proteases

A. Wlodawer, A. Gustchina, Mi Li, 2022, International journal of molecular sciences.

Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1

Y. Pommier, J. Tropea, T. Burke, 2022, Frontiers in Chemistry.

Structural basis for cell type specific DNA binding of C/EBPβ: the case of cell cycle inhibitor p15INK4b promoter.

A. Wlodawer, Maria Miller, J. Tropea, 2022, Journal of structural biology.

Structure of B-DNA with cations tethered in the major groove.

L. Marky, L. Williams, B. Gold, 2005, Biochemistry.

Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy.

Y. Pommier, R. Shoemaker, J. Tropea, 2011, Journal of structural biology.

Cellular Inhibition of Checkpoint Kinase 2 (Chk2) and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor PV1019 [7-Nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]

Y. Pommier, A. Monks, R. Shoemaker, 2009, Journal of Pharmacology and Experimental Therapeutics.

Overproduction, purification and structure determination of human dual-specificity phosphatase 14.

J. Tropea, D. Waugh, S. Cherry, 2009, Acta crystallographica. Section D, Biological crystallography.

Structure of human dual-specificity phosphatase 27 at 2.38 Å resolution.

J. Tropea, D. Waugh, G. Lountos, 2011, Acta crystallographica. Section D, Biological crystallography.

Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor

Yves Pommier, Y. Pommier, R. Shoemaker, 2008, Protein science : a publication of the Protein Society.

Utilization of nitrophenylphosphates and oxime-based ligation for the development of nanomolar affinity inhibitors of the Yersinia pestis outer protein H (YopH) phosphatase.

D. Waugh, T. Burke, R. Ulrich, 2011, Journal of medicinal chemistry.

Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases

Sarah L. Keasey, Bryan M. Zhao, J. Tropea, 2015, PloS one.

Structural analysis of human dual-specificity phosphatase 22 complexed with a phosphotyrosine-like substrate.

J. Tropea, D. Waugh, S. Cherry, 2015, Acta crystallographica. Section F, Structural biology communications.

High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design.

Bryan M. Zhao, D. Waugh, T. Burke, 2018, Acta crystallographica. Section D, Structural biology.

Structure of the Trypanosoma cruzi protein tyrosine phosphatase TcPTP1, a potential therapeutic target for Chagas' disease.

J. Tropea, D. Waugh, G. Lountos, 2012, Molecular and biochemical parasitology.

Development of antiproliferative phenylmaleimides that activate the unfolded protein response.

A. Monks, C. Hose, M. Dyba, 2010, Bioorganic & medicinal chemistry.

A rapid oxime linker-based library approach to identification of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH.

Fa Liu, R. Hakami, D. Waugh, 2010, Bioorganic & medicinal chemistry letters.

Isothiazolidinone (IZD) as a phosphoryl mimetic in inhibitors of the Yersinia pestis protein tyrosine phosphatase YopH.

D. Waugh, T. Burke, R. Ulrich, 2011, Acta crystallographica. Section D, Biological crystallography.

Small molecule microarray identifies inhibitors of tyrosyl-DNA phosphodiesterase 1 that simultaneously access the catalytic pocket and two substrate binding sites†

Y. Pommier, J. Tropea, D. Waugh, 2021, Chemical science.

Cryo-EM structure of substrate-free E. coli Lon protease provides insights into the dynamics of Lon machinery

A. Wlodawer, R. Ghirlando, A. Gustchina, 2019, Current research in structural biology.

Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification

Y. Pommier, J. Tropea, T. Burke, 2023, RSC chemical biology.

Structures of the Middle East respiratory syndrome coronavirus 3C‐like protease reveal insights into substrate specificity

D. Waugh, G. Lountos, D. Needle, 2015, Acta crystallographica. Section D, Biological crystallography.

Structure of human dual-specificity phosphatase 7, a potential cancer drug target.

J. Tropea, D. Waugh, B. P. Austin, 2015, Acta crystallographica. Section F, Structural biology communications.

Crystal structure of the human dual specificity phosphatase 1 catalytic domain

J. Tropea, D. Waugh, S. Cherry, 2018, Protein science : a publication of the Protein Society.

Abstract A120: Cellular inhibition of Chk2 kinase and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019

Y. Pommier, A. Monks, R. Shoemaker, 2009 .

Cellular inhibition of Chk 2 kinase and potentiation of camptothecins and radiation by the novel Chk 2 inhibitor PV 1019

Y. Pommier, A. Monks, R. Shoemaker, 2009 .

Structure of the cytoplasmic domain of Yersinia pestis YscD, an essential component of the type III secretion system.

J. Tropea, D. Waugh, G. Lountos, 2012, Acta crystallographica. Section D, Biological crystallography.

Atomic resolution structure of the cytoplasmic domain of Yersinia pestis YscU, a regulatory switch involved in type III secretion

D. Waugh, B. P. Austin, G. Lountos, 2009, Protein science : a publication of the Protein Society.

Targeting Protein-Protein Interactions of Tyrosine Phosphatases with Microarrayed Fragment Libraries Displayed on Phosphopeptide Substrate Scaffolds.

Bryan M. Zhao, J. Tropea, D. Waugh, 2019, ACS combinatorial science.

Self-inhibited state of Venezuelan equine encephalitis virus (VEEV) nsP2 cysteine protease: a crystallographic and molecular dynamics analysis.

A. Wlodawer, D. Waugh, J. Tőzsér, 2023, Journal of molecular biology.

MBP-binding DARPins facilitate the crystallization of an MBP fusion protein

D. Waugh, G. Lountos, R. Gumpena, 2018, Acta crystallographica. Section F, Structural biology communications.

Faculty Opinions recommendation of Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix.

D. Waugh, G. Lountos, 2020 .

A Small-Molecule Microarray Approach for the Identification of E2 Enzyme Inhibitors in Ubiquitin-Like Conjugation Pathways

W. M. Hewitt, J. Tropea, D. Waugh, 2017, SLAS discovery : advancing life sciences R & D.

Structure of the Trypanosoma cruzi protein tyrosine phosphatase TcPTP1, a potential therapeutic target for Chagas' disease.

J. Tropea, D. Waugh, G. Lountos, 2012, Molecular and biochemical parasitology.

Atomic resolution structure of the cytoplasmic domain of Yersinia pestis YscU, a regulatory switch involved in type III secretion

D. Waugh, B. P. Austin, G. Lountos, 2009, Protein science : a publication of the Protein Society.

Engineering of glycerol dehydrogenase for improved activity towards 1, 3-butanediol

C. Ching, Hongfang Zhang, Rongrong Jiang, 2010, Applied Microbiology and Biotechnology.

Crystallization and preliminary analysis of native and N-terminal truncated isoforms of toluene-4-monooxygenase catalytic effector protein.

B. Fox, A. Orville, J. Studts, 2003, Acta crystallographica. Section D, Biological crystallography.

P1' specificity of the S219V/R203G mutant tobacco etch virus protease.

J. Tropea, J. Tőzsér, S. Cherry, 2024, Proteins.

Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening.

Y. Pommier, J. Tropea, D. Waugh, 2019, Nucleic acids research.