A. Dounay

发表

Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway.

P. Verhoest, A. Dounay, J. Tuttle, 2015, Journal of medicinal chemistry.

Discovery of hydroxamate bioisosteres as KAT II inhibitors with improved oral bioavailability and pharmacokinetics

J. Pandit, R. Obach, Ji-Young Kim, 2013 .

PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency.

J. Pandit, Ji-Young Kim, P. Verhoest, 2013, Bioorganic & medicinal chemistry letters.

Novel 1,2-dihydroquinazolin-2-ones: Design, synthesis, and biological evaluation against Trypanosoma brucei.

F. Gamarro, D. González-Pacanowska, C. Butler, 2017, Bioorganic & medicinal chemistry letters.

The asymmetric intramolecular Heck reaction in natural product total synthesis.

L. Overman, A. Dounay, 2003, Chemical reviews.

Okadaic acid: the archetypal serine/threonine protein phosphatase inhibitor.

C. Forsyth, A. Dounay, Forsyth Cj, 2002, Current medicinal chemistry.

Globally Distributed Drug Discovery of New Antibiotics: Design and Combinatorial Synthesis of Amino Acid Derivatives in the Organic Chemistry Laboratory

A. Malm, Daniel G. Rivera, Isaac W. Lamb, 2019, Journal of Chemical Education.

A safe and selective method for reduction of 2-nitrophenylacetic acid systems to N-aryl hydroxamic acids using continuous flow hydrogenation

P. Jans, A. Dounay, O. Ichire, 2017 .

Sequential catalytic asymmetric Heck-iminium ion cyclization: enantioselective total synthesis of the Strychnos alkaloid minfiensine.

L. Overman, A. Wrobleski, A. Dounay, 2005, Journal of the American Chemical Society.

Catalytic asymmetric synthesis of quaternary carbons bearing two aryl substituents. Enantioselective synthesis of 3-alkyl-3-aryl oxindoles by catalytic asymmetric intramolecular heck reactions.

L. Overman, M. Oestreich, Jeremy J. Kodanko, 2003, Journal of the American Chemical Society.

Total synthesis of the strychnos alkaloid (+)-minfiensine: tandem enantioselective intramolecular Heck-iminium ion cyclization.

L. Overman, A. Wrobleski, P. Humphreys, 2008, Journal of the American Chemical Society.

The Asymmetric Intramolecular Heck Reaction in Natural Product Total Synthesis

L. Overman, A. Dounay, 2003 .

A general strategy for the synthesis of cyclic N-aryl hydroxamic acids via partial nitro group reduction.

Ji-Young Kim, P. Verhoest, Laura A McAllister, 2011, The Journal of organic chemistry.

Telaprevir (Incivek) and Boceprevir (Victrelis): NS3/4A Inhibitors for Treatment for Hepatitis C Virus (HCV)

A. Dounay, 2015 .

Direct synthesis of substituted tetrahydrofurans via regioselective dehydrative polyol cyclization cascades

C. Forsyth, A. Saito, G. J. Florence, 2002 .

Synthetic studies toward the C5-C20 domain of the azaspiracids.

C. Forsyth, A. Dounay, 2001, Organic letters.

Multi-Institution Research and Education Collaboration Identifies New Antimicrobial Compounds.

Amelia A. Fuller, Matthew A Cooper, William L Scott, 2020, ACS chemical biology.

Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions.

J. Pandit, Ji-Young Kim, P. Verhoest, 2013, ACS medicinal chemistry letters.

Sequential Catalytic Asymmetric Heck—Iminium Ion Cyclization: Enantioselective Total Synthesis of the Strychnos Alkaloid Minfiensine.

L. Overman, A. Wrobleski, A. Dounay, 2005 .

Quantitative Translational Analysis of Brain Kynurenic Acid Modulation via Irreversible Kynurenine Aminotransferase II Inhibition

K. A. Welch, T. Maurer, P. Verhoest, 2018, Molecular Pharmacology.

Expedient access to the okadaic acid architecture: a novel synthesis of the C1-C27 domain.

C. Forsyth, V. A. Frydrychowski, A. Dounay, 2001, The Journal of organic chemistry.

Synthesis of ortho-substituted nitroaromatics via improved Negishi coupling conditions

Ji-Young Kim, P. Verhoest, Jaclyn L Henderson, 2011 .

Biotherapeutic potential and synthesis of okadaic acid.

C. Forsyth, A. Dounay, R. Urbanek, 2000, Ernst Schering Research Foundation workshop.

Reduction of Brain Kynurenic Acid Improves Cognitive Function

Brooke M. Roberts, Graham V. Williams, T. Kiss, 2014, The Journal of Neuroscience.

Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia.

J. Pandit, Ji-Young Kim, M. Hayward, 2012, ACS medicinal chemistry letters.

The Asymmetric Intramolecular Mizoroki–Heck Reaction in Natural Product Total Synthesis

L. Overman, A. Dounay, 2009 .

Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists.

N. Barta, D. Ortwine, David L. Gray, 2010, Bioorganic & Medicinal Chemistry Letters.

Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of Rat Prefrontal Cortical Dopamine Response to Dual Acting Norepinephrine Reuptake Inhibitor and 5-HT1A Partial Agonist

T. Haske, N. Barta, David L. Gray, 2012, The AAPS Journal.

Design, synthesis, and pharmacological evaluation of azetedine and pyrrolidine derivatives as dual norepinephrine reuptake inhibitors and 5-HT(1A) partial agonists.

C. J. O’Donnell, David L. Gray, B. Campbell, 2011, Bioorganic & medicinal chemistry letters.

Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists.

N. Barta, David L. Gray, B. Campbell, 2009, Bioorganic & medicinal chemistry letters.

Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway.

P. Verhoest, A. Dounay, J. Tuttle, 2015, Journal of medicinal chemistry.

Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of Rat Prefrontal Cortical Dopamine Response to Dual Acting Norepinephrine Reuptake Inhibitor and 5-HT1A Partial Agonist

T. Haske, N. Barta, David L. Gray, 2012, The AAPS Journal.