F. Kappler

发表

31P–Nuclear Magnetic Resonance Evidence of an Activated Hexose-Monophosphate Shunt in Hyperglycemic Rat Lenses In Vivo

T. Brown, B. Szwergold, A. Taylor, 1995, Diabetes.

Fructose-3-phosphate production and polyol pathway metabolism in diabetic rat hearts.

T. Brown, B. Szwergold, A. Taylor, 1997, Metabolism: clinical and experimental.

Study of the metabolism of choline and phosphatidylcholine in tumors in vivo using phosphonium‐choline

T. Brown, J. Koutcher, B. Szwergold, 1997, Magnetic resonance in medicine.

Modulation of in vivo 3-deoxyglucosone levels.

T. Brown, K. Brown, F. Kappler, 2003, Biochemical Society transactions.

A new inhibitor for fructosamine 3‐kinase (Amadorase)

M. Schwartz, H. J. Tsai, F. Kappler, 2006 .

Identification of fructose 3-phosphate in the lens of diabetic rats.

T. Brown, B. Szwergold, F. Kappler, 1990, Science.

Meglumine Exerts Protective Effects against Features of Metabolic Syndrome and Type II Diabetes

G. Prendergast, Minzhou Huang, Arturo Bravo-Nuevo, 2014, PloS one.

Quantitation of 3-deoxyglucosone levels in human plasma.

T. Brown, B. Szwergold, T. Orchard, 1997, Archives of biochemistry and biophysics.

DYN 12, a small molecule inhibitor of the enzyme amadorase, lowers plasma 3-deoxyglucosone levels in diabetic rats.

T. Brown, M. Schwartz, F. Kappler, 2001, Diabetes technology & therapeutics.

Species- or isozyme-specific enzyme inhibitors. 4. Design of a two-site inhibitor of adenylate kinase with isozyme selectivity.

A. Hampton, F. Kappler, D. Picker, 1982, Journal of medicinal chemistry.

Diabetic ketoacidosis and its treatment increase plasma 3-deoxyglucosone.

R. Mehta, W. Hoffman, F. Kappler, 2003, Clinical biochemistry.

Human retinal pigment epithelial cells cultured in hyperglycemic media accumulate increased amounts of glycosaminoglycan precursors.

T. Brown, B. Szwergold, F. Matschinsky, 1992, Investigative ophthalmology & visual science.

Production and Metabolism of 3-Deoxyglucosone in Humans

T. Brown, B. Szwergold, P. Beisswenger, 2005 .

Effect of pH on the bioenergetics of perfused porcine lenses.

T. Brown, B. Szwergold, S. Lal, 1994, Current eye research.

Production of fructose and fructose-3-phosphate in maturing rat lenses.

T. Brown, B. Szwergold, A. Taylor, 1995, Investigative ophthalmology & visual science.

Biosynthesis of carolic acid in Pencillium charlesii: the intermediate precursors

G. Pandey, F. Kappler, J. L. Bloomer, 1972 .

Microbial metabolites. Part XI. Total synthesis and absolute configuration of (S)-carlosic acid (4-butyryl-2,5-dihydro-3-hydroxy-5-oxo-furan-2-acetic acid) and conversion of (R)-5-methyltetronic acid into (R)-carolic acid {3,4-dihydro-8-methylfuro[3,4-b]oxepin-5,6(2H,8H)-di-one}

F. Kappler, J. L. Bloomer, 1976 .

Total synthesis of a .alpha.-carboxymethyltetronic acid. (S)-Carlosic acid

F. Kappler, J. L. Bloomer, 1974 .

A biogenetically-patterned synthesis of optically active tetronic acids via acylation. (R)-carolic acid and analogues

F. Kappler, J. L. Bloomer, 1973 .

Toward the synthesis of isozyme-specific enzyme inhibitors. Potent inhibitors of rat methionine adenosyltransferases. Effect of one-atom elongation of the ribose-P alpha bridge in two covalent adducts of L-methionine and beta,gamma-imido-ATP.

V. M. Vrudhula, A. Hampton, F. Kappler, 1988, Journal of medicinal chemistry.

Evidence for the conformation about the C(5′)-O(5′) bond of AMP complexed to AMP kinase: Substrate properties of a vinyl phosphonate analog of AMP

A. Hampton, F. Kappler, F. Perini, 1976 .

Use of a vinyl phosphonate analog of ATP as a rotationally constrained probe of the C5′O5′ torsion angle in ATP complexed to methionine adenosyl transferase

T. Hai, A. Hampton, F. Kappler, 1985 .

Structural studies of a phosphocholine substituted beta-(1,3);(1,6) macrocyclic glucan from Bradyrhizobium japonicum USDA 110.

B. Szwergold, A. Benesi, D. Rolin, 1992, Biochimica et biophysica acta.

Interactions of the epimeric 5'-C-methyl and 5'-C-carbamyl derivatives of adenosine monophosphate with adenosine monophosphate utilizing enzymes.

P. J. Harper, A. Hampton, F. Kappler, 1973, Biochemistry.

Species- or isozyme-specific enzyme inhibitors. 5. Differential effects of thymidine substituents on affinity for rat thymidine kinase isozymes.

A. Hampton, F. Kappler, R. R. Chawla, 1982, Journal of Medicinal Chemistry.

Design of species- or isozyme-specific enzyme inhibitors. 1. Effect of thymidine substituents on affinity for the thymidine site of hamster cytoplasmic thymidine kinase.

A. Hampton, F. Kappler, R. R. Chawla, 1979, Journal of medicinal chemistry.

DESIGN OF SPECIES- OR ISOZYME-SPECIFIC ENZYME INHIBITORS. I. EFFECT OF THYMIDINE SUBSTITUENTS ON AFFINITY FOR THE THYMIDINE SITE OF HAMSTER CYTOPLASMIC THYMIDINE KINASE

A. Hampton, F. Kappler, R. R. Chawla, 1979 .

Zwitterionic 3'-O-acyl derivatives of thymidine 5'-phosphate as potential sources of intracellular thymidine 5'-phosphate in cells in culture.

J. J. Freed, A. Hampton, F. Kappler, 1986, Journal of medicinal chemistry.

Species- or isozyme-specific enzyme inhibitors. 8. Synthesis of disubstituted two-substrate condensation products as inhibitors of rat adenylate kinases.

T. Hai, A. Hampton, F. Kappler, 1982, Journal of medicinal chemistry.

Approaches to isozyme-specific inhibitors. 16. A novel methyl-C5' covalent adduct of L-ethionine and beta,gamma-imido-ATP as a potent multisubstrate inhibitor of rat methionine adenosyltransferases.

C. Afshar, S. Ginell, V. M. Vrudhula, 1989, Journal of medicinal chemistry.

Approaches to isozyme-specific inhibitors. 17. Attachment of a selectivity-inducing substituent to a multisubstrate adduct. Implications for facilitated design of potent, isozyme-selective inhibitors.

A. Hampton, F. Kappler, 1990, Journal of medicinal chemistry.

Design of species- or isozyme-specific enzyme inhibitors. 2. Differences between a bacterial and a mammalian thymidine kinase in the effect of thymidine substituents on affinity for the thymidine site.

A. Hampton, F. Kappler, R. R. Chawla, 1979, Journal of medicinal chemistry.

SPECIES- OR ISOZYME-SPECIFIC ENZYME INHIBITORS. 5. DIFFERENTIAL EFFECTS OF THYMIDINE SUBSTITUENTS ON AFFINITY FOR RAT THYMIDINE KINASE ISOZYMES

A. Hampton, F. Kappler, R. R. Chawla, 1982 .

Identification of D-sorbitol 3-phosphate in the normal and diabetic mammalian lens.

T. Brown, B. Szwergold, P. Pfeffer, 1989, The Journal of biological chemistry.

The Role of 3-Deoxyglucosone and the Activity of its Degradative Pathways in the Etiology of Diabetic Microvascular Disease

T. Brown, B. Szwergold, S. Howell, 2005 .

Identification of galactitol 2-phosphate and galactitol 3-phosphate in the lens of galactose-fed rats.

T. Brown, B. Szwergold, W. Randall, 1995, Metabolism: clinical and experimental.

Species- or isozyme-specific enzyme inhibitors. 6. Synthesis and evaluation of two-substrate condensation products as inhibitors of hexokinases and thymidine kinases.

A Hampton, F Kappler, T T Hai, 1982, Journal of medicinal chemistry.

Phosphomonoester concentrations differ between chronic lymphocytic leukemia cells and normal human lymphocytes.

T. Brown, W. Negendank, K. Padavic-Shaller, 2002, Leukemia research.

Identification of a putative tumor marker in breast and colon cancer.

T R Brown, T. Brown, B. Szwergold, 1993, Cancer research.

DESIGN OF SUBSTRATE-SITE-DIRECTED INHIBITORS OF ADENYLATE KINASE AND HEXOKINASE. EFFECT OF SUBSTRATE SUBSTITUENTS ON AFFINITY FOR THE ADENINE NUCLEOTIDE SITES

Takuma Sasaki, A. Hampton, F. Kappler, 1977 .

Design of substrate-site-directed inhibitors of adenylate kinase and hexokinase. Effect of substrate substituents on affinity on affinity for the adenine nucleotide sites.

A. Hampton, F. Kappler, T. Sasaki, 1976, Journal of medicinal chemistry.

Metabolism of fructose-3-phosphate in the diabetic rat lens.

T. Brown, B. Szwergold, A. Taylor, 1995, Archives of biochemistry and biophysics.

Detection of fructose-3-phosphokinase activity in intact mammalian lenses by 31P NMR spectroscopy.

T. Brown, B. Szwergold, S. Lal, 1993, The Journal of biological chemistry.

Identification of sorbitol 3-phosphate and fructose 3-phosphate in normal and diabetic human erythrocytes.

T. Brown, B. Szwergold, A. Petersen, 1990, The Journal of biological chemistry.

Fructose metabolism in the human erythrocyte. Phosphorylation to fructose 3-phosphate.

T. Brown, B. Szwergold, A. Petersen, 1992, The Biochemical journal.

Two dicarbonyl compounds, 3-deoxyglucosone and methylglyoxal, differentially modulate dermal fibroblasts.

M. Schwartz, Danielle T. Loughlin, Sihem Sassi-Gaha, 2010, Matrix biology : journal of the International Society for Matrix Biology.

31P–Nuclear Magnetic Resonance Evidence of an Activated Hexose-Monophosphate Shunt in Hyperglycemic Rat Lenses In Vivo

T. Brown, B. Szwergold, A. Taylor, 1995, Diabetes.