S. Nagasawa

发表

Membrane cofactor protein (CD46) protects cells predominantly from alternative complement pathway-mediated C3-fragment deposition and cytolysis.

H. Ariga, J. Atkinson, T. Seya, 1993, Journal of immunology.

Studies on alpha 2-macroglobulin in bovine plasma. II. Interaction of alpha2-macroglobulin and trypsin.

T. Suzuki, S. Nagasawa, B. H. Han, 1970, Journal of biochemistry.

The role of tyrosine phosphorylation and Ca2+ accumulation in Fc gamma-receptor-mediated phagocytosis of human neutrophils.

S. Nagasawa, K. Kobayashi, K. Takahashi, 1995, Journal of biochemistry.

Modulation of complement regulatory function and measles virus receptor function by the serine-threonine-rich domains of membrane cofactor protein (CD46).

H. Ariga, T. Seya, K. Iwata, 1994, The Biochemical journal.

cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein.

T. Muta, H. Nishimura, S. Nagasawa, 1995, FEBS letters.

Molecular remodelling of human CD46 for xenotransplantation: designing a potent complement regulator without measles virus receptor activity

T. Kinoshita, Y. Murakami, T. Seya, 2000, Immunology.

Lipopolysaccharide stimulates HepG2 human hepatoma cells in the presence of lipopolysaccharide-binding protein via CD14.

A. Nanbo, T. Muta, H. Nishimura, 1999, European journal of biochemistry.

Blocking measles virus infection with a recombinant soluble form of, or monoclonal antibodies against, membrane cofactor protein of complement (CD46).

Y. Yanagi, T. Seya, M. Matsumoto, 1995, Immunology.

The CD46 transmembrane domain is required for efficient formation of measles-virus-mediated syncytium.

K. Tanaka, Y. Yanagi, T. Seya, 1997, The Biochemical journal.

Studies on human kininogens. I. Isolation, characterization, and cleavage by plasma kallikrein of high molecular weight (HMW)-kininogen.

S. Nagasawa, T. Nakayasu, 1979, Journal of biochemistry.

A Novel Negative Regulator Molecule, Cho‐1, Is Involved in the Cytotoxicity by Human Natural Killer Cells but Not in Cytotoxic T Lymphocytes

K. Kamiguchi, N. Sato, Y. Tamura, 1999, Microbiology and immunology.

Glomerular deposition of C4 cleavage fragment (C4d) and C4-binding protein in idiopathic membranous glomerulonephritis.

T. Yoshiki, N. Itami, S. Nagasawa, 1989, Nephron.

Isolation of an iC3b forming enzyme from peritoneal polymorphonuclear leukocytes of guinea pigs.

T. Seya, S. Nagasawa, 1983, Biochemical and biophysical research communications.

Identification of alpha 2-macroglobulin as a carrier protein for IL-6.

T. Hirano, T. Matsuda, T. Kishimoto, 1989, Journal of immunology.

Studies on human high molecular weight (HMW) kininogen. II. Structural change of HMW kininogen by the action of human plasma kallikrein.

S. Nagasawa, K. Mori, 1981, Journal of biochemistry.

Studies on human high molecular weight (HMW) kininogen. III. Cleavage of HMW kininogen by the action of human salivary kallikrein.

W. Sakamoto, S. Nagasawa, K. Mori, 1981, Journal of biochemistry.

HMW and LMW kininogens.

S. Iwanaga, H. Kato, S. Nagasawa, 1981, Methods in enzymology.

Cleavage of C2 by C1s into the antigenically distinct fragments C2a and C2b: demonstration of binding of C2b to C4b.

R. Stroud, S. Nagasawa, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Isolation of a complex of the subcomponents of the activated first component of complement, Cl Cl , from ACD‐Human plasma

K. Takahashi, Kazuhiko Takahashi, S. Nagasawa, 1974, FEBS letters.

Lipopolysaccharide binding protein from normal human plasma purified with high efficiency.

A. Nanbo, H. Nishimura, S. Nagasawa, 1997, Protein expression and purification.

A gross structure of an activated form of a subunit of the first component of human complement. Cl

K. Takahashi, Kazuhiko Takahashi, S. Nagasawa, 1975, FEBS letters.

The NH2-terminal sequences of a subunit of the first component of human complement, Cls, and its activated form Cls¯

Kazuhiko Takahashi, S. Nagasawa, J. Koyama, 1975 .

Studies on prekallikrein of bovine plasma. I. Purification and properties.

S. Nagasawa, H. Takahashi, T. Suzuki, 1972, Journal of biochemistry.

Novel function of C4a anaphylatoxin. Release from monocytes of protein which inhibits monocyte chemotaxis.

S. Tanase, K. Takagi, T. Yamamoto, 1993, The American journal of pathology.

Location of the interchain disulfide bonds of the fourth component of human complement (C4): evidence based on the liberation of fragments secondary to thiol-disulfide interchange reactions.

J. Atkinson, T. Seya, S. Nagasawa, 1986, Journal of immunology.

Monoclonal Antibodies Against Senile Plaque Amyloid in Alzheimer’s Disease

T. Tabira, T. Kunishita, K. Oguma, 1990 .

Effect of C1-inhibitor, benzamidine, and heat treatment on the hydrolytic activity of a subcomponent of the first component of human complement, C1s.

K. Takahashi, S. Nagasawa, J. Koyama, 1980, Biochimica et biophysica acta.

Effect of C1q on the processing of immune complexes by human neutrophils.

S. Nagasawa, K. Kobayashi, K. Takahashi, 1994, Immunology.

Partial purification and autocatalytic activation of the subunit of the first component of human complement, C1r

Kazuhiko Takahashi, S. Nagasawa, J. Koyama, 1976 .

Structural and Functional Properties of Complement-activating Protein M161Ag, a Mycoplasma fermentans Gene Product That Induces Cytokine Production by Human Monocytes*

T. Seya, M. Matsumoto, M. Nishiguchi, 1998, The Journal of Biological Chemistry.

Cellular responses of guinea-pig macrophages to C4a; inhibition of C3a-induced O2- generation by C4a.

T. Imamichi, Y. Murakami, S. Nagasawa, 1993, Immunology letters.

EFFECTS OF TRANSFECTED COMPLEMENT REGULATORY PROTEINS, MCP, DAF, AND MCP/DAF HYBRID, ON COMPLEMENT‐MEDIATED SWINE ENDOTHELIAL CELL LYSIS

H. Izutani, G. Matsumiya, T. Seya, 1994, Transplantation.

Characterization of C3a anaphylatoxin receptor on guinea-pig macrophages.

T. Imamichi, Y. Murakami, S. Nagasawa, 1993, Immunology.

Role of Syk in Fcγ receptor‐coupled tyrosine phosphorylation of Cbl in a manner susceptible to inhibition by protein kinase C

H. Band, O. Hazeki, T. Yamashita, 1999, European journal of immunology.

[15] HMW and LMW kininogens

S. Iwanaga, H. Kato, S. Nagasawa, 1981 .

Location of the inter-chain disulfide bonds of the third component of human complement.

T. Matsuda, T. Seya, S. Nagasawa, 1985, Biochemical and Biophysical Research Communications - BBRC.

Studies on α2-Macroglobulin in Bovine PlasmaI. Purification, Physical Properties, and Chemical Compositions

Tomoji Suzuki, S. Nagasawa, B. H. Han, 1970 .

Separation of a new substrate, kininogen-I, for plasma kallikrein in bovine plasma.

T. Suzuki, S. Nagasawa, K. Horiuchi, 1967, Journal of biochemistry.

An improved method for the purification of kininogen-II from bovine plasma.

T. Suzuki, H. Kato, S. Nagasawa, 1967, Journal of Biochemistry (Tokyo).

Mechanism of action of the C3b inactivator: requirement for a high molecular weight cofactor (C3b-C4bINA cofactor) and production of a new C3b derivative (C3b').

R. Stroud, S. Nagasawa, Shigeharu Nagasawa, 1977, Immunochemistry.

Human factor H and C4b-binding protein serve as factor I-cofactors both encompassing inactivation of C3b and C4b.

K. Nakamura, T. Seya, M. Matsumoto, 1995, Molecular immunology.

Cleavage of C4b by C3b inactivator: production of a nicked form of C4b, C4b', as an intermediate cleavage product of C4b by C3b inactivator.

R. Stroud, S. Nagasawa, C. Ichihara, 1980, Journal of immunology.

Molecular cloning of a complementary DNA for a membrane cofactor protein (MCP, CD46)/measles virus receptor on Vero cells and its functional characterization.

Y. Murakami, T. Seya, S. Nagasawa, 1996, Biological & pharmaceutical bulletin.

Activation of the alternative pathway of complement by apoptotic Jurkat cells

S. Tsuji, S. Nagasawa, Hiroyuki Matsui, 1994, FEBS letters.

Conversion of bovine prekallikrein to kallikrein. Evidence of limited proteolysis of prekallikrein by bovine hageman factor (factor XII)

Hidenobu Takahashi, Tomoji Suzuki, S. Nagasawa, 1972, FEBS letters.

Purification and properties of bovine serum kallikrein activated with casein.

T. Suzuki, S. Nagasawa, M. Yano, 1970, Journal of biochemistry.

Partial purification of bovine plasma kallikreinogen, its activation by the Hageman factor.

M. Koida, J. Schoenmakers, S. Nagasawa, 1968, Biochemical and biophysical research communications.

Protein Components which Relate to the Kinin Releasing System in Bovine Plasma

Tomoji Suzuki, S. Nagasawa, H. Takahashi, 1972 .

Evidence for the location of methionyl-lysyl-bradykinin moieties at the carboxyl terminus and inside of bovine kininogen-I.

S. Nagasawa, M. Yano, T. Suzuki, 1970, Biochemical and biophysical research communications.

Studies of 2 -macroglobulin in bovine plasma. 3. Its actions on bovine plasma kallikrein, plasmin and thrombin.

T. Suzuki, S. Nagasawa, H. Sugihara, 1971, Journal of biochemistry.

A novel protein that participates in nonself discrimination of malignant cells by homologous complement

J. Takeda, T. Seya, M. Matsumoto, 1997, Nature Medicine.

Molecular cloning and characterization of guinea pig FcγRIII: expression but not function is independent of the γ chain of FcγFceRI

M. Murakami, T. Yamashita, T. Uede, 1996 .

Generation of the bioactive kallikrein-derived fragment, C3d-k, by HANE-plasma.

J. Atkinson, T. Seya, S. Nagasawa, 1985, Clinical and experimental immunology.

Generation ofthebioactive kallikrein-deriv

J. Atkinson, T. Seya, S. Nagasawa, 1985 .

Bovine prekallikrein activator with functional activity as Hageman factor.

T. Suzuki, S. Nagasawa, M. Komiya, 1972, Journal of biochemistry.

Partial purification of bovine plasma kallikrein activated by contact with glass.

T. Suzuki, S. Nagasawa, K. Horiuchi, 1967, Journal of biochemistry.

The N-terminal sequence of the light chain derivative of bovine plasmin.

S. Nagasawa, T. Suzuki, T. Suzuki, 1970, Biochemical and biophysical research communications.

Studies on prekallikrein of bovine plasma. II. Activation of prekallikrein with proteinases and properties of kallikrein activated by bovine Hageman factor.

S. Nagasawa, H. Takahashi, T. Suzuki, 1980, Journal of biochemistry.

Enzymatic and chemical cleavages of human kininogens

S. Nagasawa, T. Nakayasu, 1975 .

Partial purification and some properties of high molecular weight kininogen, bovine kininogen-I.

T. Suzuki, S. Nagasawa, M. Yano, 1971, Journal of biochemistry.

Evidence that a nicked C4b, C4b′, is a functionally active C4b derivative

S. Nagasawa, Mina Yamazaki, Chikako Ichihara, 1986, FEBS letters.

A simple method for purification of bovine plasminogen.

S. Nagasawa, T. Suzuki, T. Suzuki, 1969, Journal of biochemistry.

Relationship between tertiary structure and kinin yielding ability of bovine kininogen.

H. Kato, S. Nagasawa, T. Suzuki, 1967, Biochemical and biophysical research communications.

Studies on the chemical nature of bovine bradykininogen: determinations of amino acid, carbohydrate, amino and carboxyl terminal residues.

T. Suzuki, S. Iwanaga, T. Sato, 1966, Journal of biochemistry.

Purification and Properties of Bradykininogen and of the Bradykinin-Releasing and -Destroying Enzymes in Snake Venom

S. Iwanaga, Tadashi Sato, Tomoji Suzuki, 1966 .

Purification and characterization of a novel substrate for plasma kallikrein (PK-120) in human plasma.

H. Nishimura, S. Nagasawa, X. Pu, 1994, Biochimica et biophysica acta.

Biochemistry and Biological Reactions of Complement Proteins

T. Lint, R. Stroud, J. Volanakis, 1979 .

Formation of a conformationally changed C1r, a subcomponent of the first component of human complement, as an intermediate of its autoactivation reaction

Kazuhiko Takahashi, S. Nagasawa, Y. Kasahara, 1982, FEBS letters.

A monomeric human C4b-binding protein (C4bp) more efficiently inactivates C3b than natural C4bp: participation of C-terminal domains in factor I-cofactor activity.

Y. Murakami, T. Seya, M. Matsumoto, 1998, Molecular immunology.

Regulatory system of guinea-pig complement C3b: tests for compatibility of guinea-pig factors H and I with human factors.

T. Seya, K. Hazeki, S. Nagasawa, 1991, Molecular immunology.

Regulatory system of guinea-pig complement C3b: two factor I-cofactor proteins on guinea-pig peritoneal granulocytes.

T. Seya, K. Hazeki, S. Nagasawa, 1990, Biochemical and Biophysical Research Communications - BBRC.

Using polymerized C9 to produce a monoclonal antibody against a neoantigen of the human terminal complement complex.

S. Nagasawa, Y. Kusunoki, Y. Takekoshi, 1990, Journal of Pharmacobio-Dynamics.

Detergent-resistant membrane domains are required for mast cell activation but dispensable for tyrosine phosphorylation upon aggregation of the high affinity receptor for IgE.

T. Yamashita, K. Murakami, T. Yamaguchi, 2001, Journal of biochemistry.

Regulation of mast cell signaling through high-affinity IgE receptor by CD45 protein tyrosine phosphatase.

S. Sato, T. Yamashita, K. Murakami, 2000, International immunology.

C5b‐8 Step Lysis of Swine Endothelial Cells by Human Complement and Functional Feature of Transfected CD59

T. Seya, M. Matsumoto, M. Hatanaka, 1996, Scandinavian journal of immunology.

Limited proteolysis of complement protein C3b by regulatory enzyme C3b inactivator: isolation and characterization of a biologically active fragment, C3d,g.

T. Seya, S. Nagasawa, 1985, Journal of biochemistry.

A Comparative Study on the Hydroperoxide and Thiol Specificity of the Glutathione Peroxidase Family and Selenoprotein P*

J. Yodoi, Yoshiro Saito, Takaaki Hayashi, 2002, The Journal of Biological Chemistry.

Activation of the alternative pathway of human complement by apoptotic human umbilical vein endothelial cells.

K. Kaji, S. Tsuji, S. Nagasawa, 1994, Journal of biochemistry.

Small cell carcinoma of the lung and its histological origin. Report of a case.

M. Fukuoka, K. Furuse, T. Fujimoto, 1979, The American journal of surgical pathology.

Diversity of Sites for Measles Virus Binding and for Inactivation of Complement C3b and C4b on Membrane Cofactor Protein CD46 (*)

H. Ariga, M. Okabe, Y. Yanagi, 1995, The Journal of Biological Chemistry.

Purification and characterization of a macromolecular weight cofactor for C3b-inactivator, C4bC3bINA-cofactor, of human plasma.

R. Stroud, S. Nagasawa, 1980, Molecular immunology.

Identification and Role of Non-Beta Components of Senile Plaque Amyloid in Alzheimer’s Disease

Kunihiko Kobayashi, H. Chiba, N. Fujii, 1995 .

Effect of iC3b binding to immune complexes upon the phagocytic response of human neutrophils: synergistic functions between FcγR and CR3

M. Sakai, K. Takahashi, S. Nagasawa, 1995, FEBS letters.

Monoclonal anti-human C4b antibodies: stabilization and inhibition of the classical-pathway C3 convertase.

T. Nakamura, S. Nagasawa, J. Koyama, 1986, Molecular immunology.

Enhancement of macrophage phagocytosis upon iC3b deposition on apoptotic cells

S. Tsuji, F. Takizawa, S. Nagasawa, 1996, FEBS letters.

Regulation of complement-mediated swine endothelial cell lysis by a surface-bound form of human C4b binding protein.

T. Seya, M. Matsumoto, M. Hatanaka, 1998, Transplantation.

Effect of transfectant molecules, MCP, DAF, and MCP/DAF hybrid on xenogeneic vascular endothelium.

H. Izutani, G. Matsumiya, M. Matsumoto, 1994, Transplantation proceedings.

Expression of a hybrid complement regulatory protein, membrane cofactor protein decay accelerating factor on Chinese hamster ovary. Comparison of its regulatory effect with those of decay accelerating factor and membrane cofactor protein.

H. Ariga, T. Seya, K. Iwata, 1994, Journal of immunology.

Evidence that C4b-binding protein is an acute phase protein.

M. Nukatsuka, S. Nagasawa, Y. Kusunoki, 1989, Biochemical and biophysical research communications.

Biosynthesis of s-methyl-L-cysteine and s-methyl-L-cysteine sulfoxide from methionine in garlic.

T. Suzuki, S. Nagasawa, M. Sugii, 1963, Chemical & pharmaceutical bulletin.

Characterization of the interaction between human protein S and C4b-binding protein (C4bp).

M. Nukatsuka, S. Nagasawa, 1987, Journal of biochemistry.

Mapping of the sites responsible for factor I-cofactor activity for cleavage of C3b and C4b on human C4b-binding protein (C4bp) by deletion mutagenesis.

T. Fujita, T. Matsuda, Y. Murakami, 2002, Journal of biochemistry.

Human plasma prekallikrein as a protein complex.

S. Nagasawa, T. Nakayasu, 1973, Journal of biochemistry.

Human cell receptor CD46 is down regulated through recognition of a membrane-proximal region of the cytoplasmic domain in persistent measles virus infection

S. Yant, T. Seya, A. Hirano, 1996, Journal of virology.

Domain structure of bi-functional selenoprotein P.

Yoshiro Saito, Kazuhiko Takahashi, S. Nagasawa, 2004, The Biochemical journal.

Domain structure of bifunctional selenoprotein P

Yoshiro Saito, Kazuhiko Takahashi, S. Nagasawa, 2004 .

Human lymphocytes are more susceptible to measles virus than granulocytes, which is attributable to the phenotypic differences of their membrane cofactor protein (CD46).

Y. Yanagi, T. Seya, M. Matsumoto, 1995, Immunology letters.

STUDIES ON THE CHEMICAL STRUCTURE OF COLISTIN. II. AMINO ACID SEQUENCE OF COLISTIN A.

T. Suzuki, S. Nagasawa, K. Fujikawa, 1963, Journal of biochemistry.

Generation of C3d,g and C3d by urokinase-treated plasma in association with fibrinolysis.

J. Atkinson, T. Seya, H. Hasegawa, 1985, Complement.

Bactericidal/permeability‐increasing protein promotes complement activation for neutrophil‐mediated phagocytosis on bacterial surface

A. Nanbo, T. Baba, Y. Murakami, 2001, Immunology.

Molecular remodeling of complement regulatory proteins for xenotransplantation.

Y. Murakami, T. Seya, M. Matsumoto, 1999, Immunopharmacology.

Molecular cloning and characterization of guinea pig FcyRIII: expression but not function is independent of the y chain of FceRI

T. Yamashita, T. Uede, M. Murakami, 2004 .

Probing the C4-binding site on C1s with monoclonal antibodies. Evidence for a C4/C4b-binding site on the gamma-domain.

H. Kitamura, S. Kuramitsu, T. Seya, 1989, Journal of immunology.

Purification and characterization of the C3 convertase of the classical pathway of human complement system by size exclusion high-performance liquid chromatography.

S. Nagasawa, J. Koyama, N. Yamashita, 1985, Journal of Biochemistry (Tokyo).

C-reactive protein: Fc-gamma receptor-mediated effects on human peripheral blood basophils in vitro.

S. Nagasawa, 2009 .

Limited proteolysis of the third component of human complement, C3, by heat treatment.

T. Seya, S. Nagasawa, 1981, Journal of biochemistry.

Enhancement of FcγR- and CR3-Mediated Neutrophil Phagocytosis by Cerebrosides

Kazuhiko Takahashi, M. Sakai, S. Nagasawa, 2000 .

C4b-binding protein and a 60,000-Dalton plasma protein share antigenic determinants with membrane cofactor protein of complement.

J. Atkinson, T. Seya, S. Nagasawa, 1990, Journal of immunology.

Effect of transfected MACIF (CD59) on complement-mediated swine endothelial cell lysis, compared with those of membrane cofactor protein (CD46) and decay-accelerating factor (CD55).

H. Izutani, M. Matsumoto, M. Hatanaka, 1995, Transplantation Proceedings.

Homologous complement activation on drug-induced apoptotic cells from a human lung adenocarcinoma cell line.

T. Seya, M. Matsumoto, K. Kodama, 1997, Immunobiology.

New approach to prevent complement activation on xenografts: effects of a surface-bound form of human C4b binding protein.

T. Ito, T. Seya, S. Mikata, 1998, Transplantation Proceedings.

Mechanism of kinin release from human low-molecular-mass-kininogen by the synergistic action of human plasma kallikrein and leukocyte elastase.

S. Nagasawa, F. Sato, 1988, Biological chemistry Hoppe-Seyler.

Limited proteolysis of a chemically modified third component of human complement, C3, by cathepsin G of human leukocytes.

T. Matsuda, T. Koide, S. Nagasawa, 1985, Journal of biochemistry.

Post‐translational modification and intracellular localization of a splice product of CD46 cloned from human testis: role of the intracellular domains in O‐glycosylation

Nagasawa, T. Seya, M. Matsumoto, 1998, Immunology.

Human C4b‐binding protein, C4bp

T. Koide, S. Nagasawa, J. Koyama, 1983, FEBS letters.

Limited chymotryptic cleavage of human C4-binding protein: isolation of a carbohydrate-containing core domain and an active fragment.

K. Mizuguchi, S. Nagasawa, J. Koyama, 1982, Journal of biochemistry.

Urinary excretion of terminal complement complexes in glomerular disease.

A. Sagawa, N. Itami, S. Nagasawa, 1991, Nephron.

An improved method for the purification of kininogen-II from bovine plasma.

T. Suzuki, H. Kato, S. Nagasawa, 1967, Journal of biochemistry.

Partial purification and some properties of high molecular weight kininogen, bovine kininogen-I.

T. Suzuki, S. Nagasawa, M. Yano, 1971, Journal of biochemistry.

Kinin release from human LMW-kininogen by the cooperative action of human plasma kallikrein and leukocyte elastase.

S. Nagasawa, F. Sato, 1989, Advances in experimental medicine and biology.

Studies on the structure of bovine kininogen: cleavages of disulfide bonds and of methionyl bonds in kininogen-II.

T. Suzuki, H. Kato, S. Nagasawa, 1970, Journal of biochemistry.