F. Bourbonais

发表

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

F. Jiang, Beth L. Pietrak, T. Riera, 2014, Nature Communications.

Pyridones as glucokinase activators: identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle.

J. Pfefferkorn, P. Oates, J. Litchfield, 2009, Bioorganic & medicinal chemistry letters.

The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus.

Michael D. Hamilton, J. Pfefferkorn, N. Barucci, 2012, Bioorganic & medicinal chemistry letters.

The Activation of Glycogen Synthase by Insulin Switches from Kinase Inhibition to Phosphatase Activation during Adipogenesis in 3T3-L1 Cells*

A. Saltiel, M. Brady, F. Bourbonais, 1998, The Journal of Biological Chemistry.

Optimizing glucokinase activator binding kinetics to lower in vivo hypoglycemia risk

T. Rolph, J. Pfefferkorn, K. Borzilleri, 2014 .

Novel and selective spiroindoline-based inhibitors of Sky kinase.

N. Powell, F. Schwende, Amy M. Delaney, 2012, Bioorganic & medicinal chemistry letters.

Modulation of glucokinase by glucose, small-molecule activator and glucokinase regulatory protein: steady-state kinetic and cell-based analysis.

J. Pfefferkorn, J. Landro, F. Bourbonais, 2012, The Biochemical journal.

Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.

Jing Chen, David B Duignan, Robert Aiello, 2012, Journal of medicinal chemistry.

Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif.

K. Gajiwala, M. Hickey, J. Pfefferkorn, 2013, Bioorganic & medicinal chemistry letters.

Comparison of Proteomic Quantification Approaches for Hepatic Drug Transporters: Multiplexed Global Quantitation Correlates with Targeted Proteomic Quantitation

A. D. Rodrigues, B. Erickson, M. Varma, 2018, Drug Metabolism and Disposition.