Simon Leiris

发表

Discovery of a Novel Metallo-β-Lactamase Inhibitor That Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae

I. Morrissey, D. Davies, S. Magnet, 2018, Antimicrobial Agents and Chemotherapy.

Synthesis of new sulfonate and phosphonate derivatives for cation-independent mannose 6-phosphate receptor targeting.

Marcel Garcia, M. Gary‐Bobo, A. Morère, 2008, Bioorganic & medicinal chemistry letters.

Virtual Screening Approach to Identifying a Novel and Tractable Series of Pseudomonas aeruginosa Elastase Inhibitors.

A. K. Forrest, D. Davies, M. Lemonnier, 2021, ACS medicinal chemistry letters.

Substituted α-mercaptoketones, new types of specific neprilysin inhibitors.

B. Roques, M. Fournié-Zaluski, H. Poras, 2017, Bioorganic & medicinal chemistry letters.

Novel calcium sensing receptor ligands: a patent survey

R. Dodd, L. Kiefer, Simon Leiris, 2011, Expert opinion on therapeutic patents.

Synthesis and biological evaluation of cyclic nitrogen mustards based on carnitine framework.

A. Morère, M. Lucas, Simon Leiris, 2010, European journal of medicinal chemistry.

Novel Specific Metallo-β-Lactamase Inhibitor ANT2681 Restores Meropenem Activity to Clinically Effective Levels against NDM-Positive Enterobacterales

I. Morrissey, D. Davies, M. Lemonnier, 2021, Antimicrobial Agents and Chemotherapy.

Discovery of ANT3310, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii.

I. Morrissey, D. Davies, S. Mangani, 2020, Journal of medicinal chemistry.

ANT2681: SAR studies leading to the identification of a metallo-β-lactamase inhibitor with potential for clinical use in combination with meropenem for the treatment of infections caused by NDM-producing Enterobacteriaceae.

D. Davies, S. Mangani, P. Warn, 2020, ACS infectious diseases.

SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model

N. Jennings, D. Davies, S. Mangani, 2018, ACS infectious diseases.

Synthesis and biological activities of topopyrones.

S. Hecht, Mark A. Elban, Simon Leiris, 2012, Journal of natural products.

Influence of the Benzyloxycarbonyl Protective Group on Glycosylation with Mannopyranosyl Donors

J. Montero, Fouzi Mouffouk, A. Morère, 2006 .

Synthesis and evaluation of verticipyrone analogues as mitochondrial complex I inhibitors.

Sidney M. Hecht, Krystal S. Tsosie, S. Hecht, 2010, Bioorganic & medicinal chemistry.

Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models

D. Davies, M. Lemonnier, Doris L. LaRock, 2023, ACS infectious diseases.

Synthesis and biological activities of topopyrones.

S. Hecht, Mark A. Elban, Simon Leiris, 2012, Journal of natural products.

Meropenem-ANT3310, a unique β-lactam-β-lactamase inhibitor combination with expanded antibacterial spectrum against Gram-negative pathogens including carbapenem-resistant Acinetobacter baumannii

Simon Leiris, Kirsty Holden, J. Bousquet, 2024, Antimicrobial agents and chemotherapy.