Guangyi Jin

发表

Guanosine analog in the pyrido[2,3-d]pyrimidine ring system As a potential Toll-like receptor agonist

H. Cottam, D. Carson, Christina N. Wu, 2006, Nucleosides, nucleotides & nucleic acids.

Anti-tumor Activity of Toll-Like Receptor 7 Agonists

Ou Sha, T. Ng, Chunman Li, 2017, Front. Pharmacol..

Suppressive effects of sunitinib on a TLR activation-induced cytokine storm.

Bin-Yuan He, Xiaodong Wang, Hui Qi, 2019, European journal of pharmacology.

Amide derivatives of ethacrynic acid: synthesis and evaluation as antagonists of Wnt/beta-catenin signaling and CLL cell survival.

Shiyin Yao, H. Cottam, D. Carson, 2009, Bioorganic & medicinal chemistry letters.

Synthetic Toll-like receptor 7 ligand inhibits porcine reproductive and respiratory syndrome virus infection in primary porcine alveolar macrophages.

E. Zhou, Angke Zhang, Yongkun Du, 2016, Antiviral research.

Trichosanthin increases Granzyme B penetration into tumor cells by upregulation of CI-MPR on the cell surface

Ou Sha, T. Ng, Chunman Li, 2017, Oncotarget.

CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

Weiliang Zhu, Ji Zhou, Gengfu Xiao, 2021, bioRxiv.

New substituted quinoxalines inhibit triple-negative breast cancer by specifically downregulating the c-MYC transcription

Qiong Huang, Guangyi Jin, Ming-Hao Hu, 2019, Nucleic acids research.

Lenalidomide improves the antitumor activity of CAR-T cells directed toward the intracellular Wilms Tumor 1 antigen

Yisheng Li, Li Yu, Yonghui Li, 2021, Hematology.

Synthesis and Evaluation of Conjugates of Novel TLR7 Inert Ligands as Self-Adjuvanting Immunopotentiators.

Wenqi Jiang, Zhulin Wang, Guangyi Jin, 2015, ACS medicinal chemistry letters.

MAGEA1 and hTERT Peptide Treatment Improves the Potency of The Dendritic Cell- Cytotoxic T Lymphocytes (DC-CTL) Immunotherapy in DAC Treated Acute Myeloid Leukemia

Ji Zhou, Weiqiang Zhao, Yisheng Li, 2022, Journal of Cancer.

Analogues de purine

Christina N. Wu, Guangyi Jin, Dennis A. Carson, 2007 .

A Therapeutic Whole-Tumor-Cell Vaccine Covalently Conjugated with a TLR7 Agonist

F. Gao, Xia Wang, Yue Hao, 2022, Cells.

Antitumor activity of a novel small molecule TLR7 agonist via immune response induction and tumor microenvironment modulation.

Xinping Huang, Xiaodong Wang, L. Fu, 2016, Oncology reports.

Ethacrynic acid improves the antitumor effects of irreversible epidermal growth factor receptor tyrosine kinase inhibitors in breast cancer

N. Zhang, Xinping Huang, Boya Peng, 2016, Oncotarget.

Inhibition of cytokine production by hymenialdisine derivatives.

Theresa A Lansdell, J. Tepe, Guangyi Jin, 2004, Journal of medicinal chemistry.

A combined Globo H-OCT4-T7 immunotherapy restrains colorectal tumor growth

Maixian Liu, Xiaomei Wang, Gaixia Xu, 2021 .

Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7.

K. Messer, H. Cottam, D. Carson, 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

Gastric cancer vaccines synthesized using a TLR7 agonist and their synergistic antitumor effects with 5-fluorouracil

Xiaodong Wang, Zhulin Wang, Guangyi Jin, 2018, Journal of Translational Medicine.

Cinobufacini protects against paclitaxel-induced peripheral neuropathic pain and suppresses TRPV1 up-regulation and spinal astrocyte activation in rats.

Xiyuan Ba, Guangyi Jin, Jiali Wang, 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

A chemical conjugation of JQ‐1 and a TLR7 agonist induces tumoricidal effects in a murine model of melanoma via enhanced immunomodulation

Ji Zhou, Xiaodong Wang, Zhulin Wang, 2020, International journal of cancer.

Synergistic apoptosis-inducing effect of aspirin and isosorbide mononitrate on human colon cancer cells.

Xiaodong Wang, Guangyi Jin, Ningning Gao, 2015, Molecular medicine reports.

Selective activation of metabotropic glutamate receptor 7 blocks paclitaxel-induced acute neuropathic pain and suppresses spinal glial reactivity in rats

Zelin Huang, Changyu Jiang, Xiyuan Ba, 2020, Psychopharmacology.

Synthetic toll-like receptor 7 agonist as a conjugated adjuvant enhances the Th 1 type immunogenicity of influenza virus vaccine

Xinping Huang, D. Guo, B. Liu, 2009 .

A conjugate of octamer-binding transcription factor 4 and toll-like receptor 7 agonist prevents the growth and metastasis of testis embryonic carcinoma

Z. Cai, Xiaomei Zhu, Xiaomei Wang, 2015, Journal of Translational Medicine.

Oxaliplatin-Based Platinum(IV) Prodrug Bearing Toll-like Receptor 7 Agonist for Enhanced Immunochemotherapy

Li Tang, S. Ruan, Demin Cai, 2019, ACS omega.

Conjugation of weak ligands with weak antigens to activate TLR-7: A step toward better vaccine adjuvants.

Juan Zeng, Xiaodong Wang, Wenqi Jiang, 2016, European journal of medicinal chemistry.

PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way

Ji Zhou, Yakun Wan, Jin Ren, 2022, Journal for ImmunoTherapy of Cancer.

Gelsolin deposits in renal tissues of the patients with lupus nephritis

B. Liu, D. Guo, D. Sun, 2016 .

Selective activation of metabotropic glutamate receptor 7 blocks paclitaxel-induced acute neuropathic pain and suppresses spinal glial reactivity in rats

Zelin Huang, Changyu Jiang, Xiyuan Ba, 2020, Psychopharmacology.

polypnea in mice Central histamine contributed to temperature-induced

I. Homma, M. Izumizaki, M. Iwase, 2015 .

Synthesis and immunoregulatory activities of conjugates of a Toll-like receptor 7 inert ligand.

F. Zhong, Xiaodong Wang, Wenqi Jiang, 2014, Bioorganic & medicinal chemistry letters.

A new series of 3-alkyl phosphate derivatives of 4,5,6,7-tetrahydro-1-D-ribityl-1H-pyrazolo[3,4-d]pyrimidinedione as inhibitors of lumazine synthase: design, synthesis, and evaluation.

A. Bacher, M. Fischer, M. Cushman, 2007, The Journal of organic chemistry.

Design, synthesis, and evaluation of 9-D-ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones bearing alkyl phosphate and alpha,alpha-difluorophosphonate substituents as inhibitors of tiboflavin synthase and lumazine synthase.

A. Bacher, M. Fischer, M. Cushman, 2004, The Journal of organic chemistry.

Conjugation of TLR7 Agonist Combined with Demethylation Treatment Improves Whole-Cell Tumor Vaccine Potency in Acute Myeloid Leukemia

Ji Zhou, Yan Li, Li Yu, 2020, International journal of medical sciences.

Dopamine signaling regulates the projection patterns in the mouse chiasm

Xinping Huang, D. Guo, S. Chan, 2015, Brain Research.

Discovery of novel ibrutinib analogues to treat malignant melanoma.

S. Ren, Xiaodong Wang, Guangyi Jin, 2021, Bioorganic chemistry.

Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists.

H. Cottam, D. Carson, Michael Chan, 2006, Bioorganic & medicinal chemistry letters.

FZD7 is a novel prognostic marker and promotes tumor metastasis via WNT and EMT signaling pathways in esophageal squamous cell carcinoma

X. Guan, D. Lu, Jian-Lin Wu, 2017, Oncotarget.

Drug-like biimidazole derivatives dually target c-MYC/BCL-2 G-quadruplexes and inhibit acute myeloid leukemia.

Xiaodong Wang, Guangyi Jin, Ming-Hao Hu, 2020, Bioorganic chemistry.

Immunomodulatory and Antitumor Effects of a Novel TLR7 Agonist Combined with Lapatinib

Wenqi Jiang, Xiaodong Wang, Zhulin Wang, 2016, Scientific Reports.

Local administration of a novel Toll-like receptor 7 agonist in combination with doxorubicin induces durable tumouricidal effects in a murine model of T cell lymphoma

D. Zheng, Wenqi Jiang, Shiping He, 2015, Journal of Hematology & Oncology.

A novel TLR7 agonist as adjuvant to stimulate high quality HBsAg-specific immune responses in an HBV mouse model

Li Tang, Zhulin Wang, Guangyi Jin, 2020, Journal of Translational Medicine.

The PD-L1 and TLR7 dual-targeting nanobody-drug conjugate exerts potent antitumor efficacy by orchestrating innate and adaptive immune responses

Ji Zhou, Yakun Wan, Jin Ren, 2021, bioRxiv.

Synthetic MUC1 breast cancer vaccine containing a Toll-like receptor 7 agonist exerts antitumor effects

L. Tang, Xiaodong Wang, Zhulin Wang, 2020, Oncology letters.

Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia

R. Schwab, Shiyin Yao, H. Cottam, 2010, Proceedings of the National Academy of Sciences.

Design, synthesis, and biochemical evaluation of 1,5,6,7-tetrahydro-6,7-dioxo-9-D-ribitylaminolumazines bearing alkyl phosphate substituents as inhibitors of lumazine synthase and riboflavin synthase.

A. Bacher, R. Ladenstein, M. Fischer, 2005, The Journal of organic chemistry.

Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors.

Markus Fischer, Ekaterina Morgunova, Winfried Meining, 2005, Biochemistry.

Design, Synthesis, and Biochemical Evaluation of 1,5,6,7‐Tetrahydro‐6,7‐dioxo‐9‐D‐Ribitylaminolumazines Bearing Alkyl Phosphate Substituents as Inhibitors of Lumazine Synthase and Riboflavin Synthase.

A. Bacher, R. Ladenstein, M. Cushman, 2005 .

A new series of N-[2,4-dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid derivatives as inhibitors of lumazine synthase and riboflavin synthase: design, synthesis, biochemical evaluation, crystallography, and mechanistic implications.

A. Bacher, E. Morgunova, R. Ladenstein, 2008, The Journal of organic chemistry.

Selection of reference genes for gene expression studies in human bladder cancer using SYBR-Green quantitative polymerase chain reaction

Song Wu, J. Cui, Rong-Fu Wang, 2017, Oncology letters.

Toll‐Like Receptor 7 Inactive Ligands Enhanced Cytokine Induction by Conjugation to Weak Antigens

Wenqi Jiang, Zhulin Wang, Guangyi Jin, 2015, ChemMedChem.

Breast Cancer Vaccine Containing a Novel Toll-like Receptor 7 Agonist and an Aluminum Adjuvant Exerts Antitumor Effects

Ji Zhou, Xiaodong Wang, Jiaxin Wang, 2022, International journal of molecular sciences.

Combining thioridazine and loratadine for the treatment of gastrointestinal tumor

B. Liu, Xinping Huang, D. Guo, 2017, Oncology letters.

Conjugate of ibrutinib with a TLR7 agonist suppresses melanoma progression and enhances antitumor immunity

S. Ren, Xiaodong Wang, Guangyi Jin, 2022, International journal of biological sciences.

A novel TLR7 agonist as adjuvant to stimulate high quality HBsAg-specific immune responses in an HBV mouse model

Li Tang, Zhulin Wang, Guangyi Jin, 2020, Journal of Translational Medicine.

Selection of reference genes for gene expression studies in human bladder cancer using SYBR-Green quantitative polymerase chain reaction

Song Wu, J. Cui, Rong-Fu Wang, 2017, Oncology letters.