Linghui Kong

发表

Discovery of an M-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active κ-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile.

Wei-Chang Fu, Wei Li, Lin-qian Yu, 2021, Journal of medicinal chemistry.

Discovery of a highly selective and potent kappa opioid receptor agonist from N-cyclopropylmethyl-7α-phenyl-6,14-endoethano-tetrahydro- northebaines with reduced central nervous system (CNS) side effects navigated by the message-address concept.

Wei Li, Wei-Chang Fu, Deng-Qi Xue, 2019, Journal of medicinal chemistry.

Endow activated carbon with the ability to activate peroxymonosulfate for the treatment of refractory organics

Rongxing Shen, Linghui Kong, Wan‐Zhong Lang, 2022, Green Chemical Engineering.

Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion

Wei Li, Jing Chen, Liming Shao, 2021, Acta Pharmacologica Sinica.

SLL-627 Is a Highly Selective and Potent κ Opioid Receptor (KOR) Agonist with an Unexpected Nonreduction in Locomotor Activity.

Wei-Chang Fu, Wei Li, Siyuan Tang, 2022, Journal of medicinal chemistry.

7β-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues.

Wei-Chang Fu, Wei Li, Deng-Qi Xue, 2018, Bioorganic & medicinal chemistry.

Rapid progress in neuroimaging technologies fuels central nervous system translational medicine.

K. Kaitin, Qian He, Linghui Kong, 2023, Drug discovery today.

Reversal of subtype-selectivity and function by the introduction of a para-benzamidyl substituent to N-cyclopropylmethyl nornepenthone.

Wei-Chang Fu, Wei Li, Qiong Xie, 2023, European journal of medicinal chemistry.

Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based κ Opioid Receptor (κOR) Agonists Using the Strategy of Bridging.

Wei-Chang Fu, Wei Li, Li-ying Xiao, 2021, ACS chemical neuroscience.

Discovery of an Ortho-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethano-tetrahydronorthebaine Derivative as a Selective and Potent Kappa Opioid Receptor Agonist with Subsided Sedative Effect.

Wei Li, Liming Shao, Qian He, 2024, Journal of medicinal chemistry.