Naoshi Yamamoto

发表

Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine.

M. Yanagisawa, Y. Nagumo, Y. Irukayama-Tomobe, 2020, Bioorganic & medicinal chemistry letters.

The application of a specific morphinan template to the synthesis of galanthamine

H. Nagase, Tsuyoshi Saitoh, Noriki Kutsumura, 2017 .

Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies.

Yurie Watanabe, M. Yanagisawa, D. Kuroda, 2017, Journal of medicinal chemistry.

Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in D-nor-nalfurafine derivatives

M. Yanagisawa, Y. Nagumo, Y. Irukayama-Tomobe, 2022, Bioorganic & Medicinal Chemistry Letters.

Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity.

M. Yanagisawa, H. Gouda, Y. Nagumo, 2017, Bioorganic & medicinal chemistry letters.

Alkenylresorcinols and cytotoxic activity of the constituents isolated from Labisia pumila.

F. Abas, N. Al-Mekhlafi, K. Shaari, 2012, Phytochemistry.

Synthesis of (-)-homogalanthamine from naltrexone.

H. Tomoda, H. Nagase, J. Inokoshi, 2011, Journal of Organic Chemistry.

Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library.

T. Sakurai, M. Yanagisawa, H. Gouda, 2021, European journal of medicinal chemistry.

Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity.

M. Yanagisawa, Y. Nagumo, Y. Irukayama-Tomobe, 2019, Bioorganic & medicinal chemistry letters.

Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring.

M. Yanagisawa, H. Gouda, Y. Nagumo, 2019, Bioorganic & medicinal chemistry.

Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor.

M. Yanagisawa, H. Gouda, Y. Nagumo, 2017, Bioorganic & medicinal chemistry letters.

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain.

Y. Nagumo, H. Nagase, A. Saitoh, 2015, Bioorganic & medicinal chemistry.

Novel Baeyer–Villiger-type oxidation of 4,5-epoxymorphinan derivatives

Y. Nagumo, H. Nagase, Tsuyoshi Saitoh, 2020 .

The effect of 17-N substituents on the activity of the opioid κ receptor in nalfurafine derivatives.

N. Wada, H. Nagase, Shigeto Hirayama, 2013, Bioorganic & medicinal chemistry letters.

Design and synthesis of KNT-127, a δ-opioid receptor agonist effective by systemic administration.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of Unnatural Morphinan Compounds to Induce Itch-like Behaviors in Mice: Towards the Development of MRGPRX2 Selective Ligands.

A. Inoue, Y. Nagumo, H. Nagase, 2021, Bioorganic & medicinal chemistry letters.

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: part 3, novel propellane derivatives with pentacyclic skeletons.

S. Hirono, H. Gouda, H. Nagase, 2012, Bioorganic & medicinal chemistry letters.

Synthesis of a stable iminium salt and propellane derivatives.

S. Hirono, H. Nagase, K. Kamiya, 2008, The Journal of organic chemistry.

ZnCl2-Promoted Intramolecular Hetero-Diels-Alder Reaction of o-Alkynylphenylcarbodiimides for Synthesis of Dihydrodibenzo[b,g][1,8]naphthyridines.

Takao Saito, H. Nagase, Noriki Kutsumura, 2016, Chemical & pharmaceutical bulletin.

Synthetic Studies on α,α-Disubstituted Amino Acids Employing (2S,4R)-4-Hydroxyproline as the Chiral Pool: Preparation of Methyl O-Benzyl-2-(α-cyanomethyl)-D-tyrosinate and Dimethyl 2-(4-hydroxybenzyl)-L-aspartate

T. Honda, N. Kojima, Naoshi Yamamoto, 2012 .

Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism.

S. Hirono, H. Gouda, H. Nagase, 2014, Bioorganic & Medicinal Chemistry Letters.

Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives.

Y. Nagumo, H. Nagase, Tsuyoshi Saitoh, 2017, Bioorganic & medicinal chemistry.

Synthesis of heterocyclic compounds with adamantane-like cage structures consisting of phosphorus, sulfur, and carbon

Y. Nagumo, H. Nagase, Tsuyoshi Saitoh, 2017 .

Formal Synthesis of Sceletium Alkaloids (.+-.)-Mesembrine and (.+-.)-Mesembranol.

T. Honda, Naoshi Yamamoto, Kazunori Takahashi, 2012 .

FORMAL SYNTHESIS OF SCELETIUM ALKALOIDS, (±)-MESEMBRINE AND (±)-MESEMBRANOL (Dedicated to Dr. Albert Padwa on his 75th birthday)

T. Honda, Naoshi Yamamoto, Hironobu Arai, 2012 .

Oxidative Cleavage of the Acyl‐Carbon Bond in Phenylacetone with Electrogenerated Superoxide Anions

Y. Einaga, H. Nagase, Tsuyoshi Saitoh, 2018, ChemElectroChem.

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: part 1.

H. Nagase, H. Mochizuki, H. Fujii, 2011, Bioorganic & medicinal chemistry letters.

Discovery of Orexin 2 Receptor Selective and Dual Orexin Receptor Agonists based on the Tetralin Structure: Switching of Receptor Selectivity by Chirality on the Tetralin Ring.

M. Yanagisawa, Y. Nagumo, H. Nagase, 2022, Bioorganic & Medicinal Chemistry Letters.

Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-Plasmodium falciparum Activities

S. Ōmura, Y. Nagumo, H. Nagase, 2020, Molecules.

Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5-trioxazatriquinane skeleton.

Y. Nagumo, H. Nagase, Tsuyoshi Saitoh, 2023, Bioorganic & medicinal chemistry letters.

Design and Synthesis of Orexin 1 Receptor-Selective Agonists.

A. Inoue, K. Takeuchi, Y. Nagumo, 2023, Journal of medicinal chemistry.

Synthesis of opioid ligands having oxabicyclo[2.2.2]octane and oxabicyclo[2.2.1]heptane skeletons

H. Nagase, K. Yoza, N. Sato, 2007 .

Unexpected Rearrangement Reactions of the 14-Aminonaltrexone Skeleton.

Y. Nagumo, H. Nagase, Tsuyoshi Saitoh, 2023, Organic letters.

Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group.

M. Yanagisawa, Y. Nagumo, H. Nagase, 2019, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton.

M. Yanagisawa, Y. Nagumo, H. Nagase, 2021, Bioorganic & medicinal chemistry letters.

Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors.

M. Yanagisawa, Y. Nagumo, H. Nagase, 2022, Bioorganic & medicinal chemistry letters.

Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism.

S. Hirono, H. Gouda, H. Nagase, 2014, Bioorganic & medicinal chemistry letters.