C. N. Filer

发表

Morphinan alkaloids labeled with tritium: synthesis and applications.

C. N. Filer, 2013, Journal of labelled compounds & radiopharmaceuticals.

Tritiated dihydro compounds employed as radioligand surrogates

C. N. Filer, 2011 .

Delta-9-Tetrahydrocannabinolic Acid B: A Mechanism for its Formation in Cannabis.

C. N. Filer, 2022, Cannabis and cannabinoid research.

Acidic Cannabinoid Decarboxylation.

C. N. Filer, 2021, Cannabis and cannabinoid research.

Minnesota wild hemp: a crucial botanical source in early cannabinoid discovery

C. N. Filer, 2020, Journal of Cannabis Research.

MDV3100: Tritium labeling at high specific activity.

S. Chakravarty, C. N. Filer, C. Byon, 2016, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

Tritium labelling of several cancer pathway agents at high specific activity

D. Ahern, C. N. Filer, Charles A. Hainley, 2011 .

Potent antiviral agent WIN 54954: high specific activity labelling with tritium

C. N. Filer, Judith A. Egan, R. P. Nugent, 2004, Applied Radiation and Isotopes.

The preparation of isotopically labelled macrocyclic compounds by organic synthesis

C. N. Filer, 2001 .

Synthesis and characterization of the potent cannabinoid agonist (naphthyl-3H) WIN 55212-2 at high specific activity

C. N. Filer, R. Seguin, 2003 .

Synthesis and characterization of [N-methyl-3H]loperamide.

C. N. Filer, Judith A. Egan, R. P. Nugent, 2014, Journal of labelled compounds & radiopharmaceuticals.

Spiperone: Tritium labelling at high specific activity.

C. N. Filer, E. Shelton, A. G. Laseter, 2019, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

Tritium labelling of two potent dopamine D2 receptor agonists at high specific activity.

S. Pounds, C. N. Filer, J. Andrews, 2021, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

The preparation of dopaminergic agonist [5,8-3H] (+/-) 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene at high specific activity

C. N. Filer, D. Orphanos, 2002 .

Labelling of the natural product D-threo-chloramphenicol with 14C at high specific activity

C. N. Filer, Charles A. Hainley, D. Orphanos, 2018, Journal of Radioanalytical and Nuclear Chemistry.

Tritium labelling and characterization of the cognition enhancing drug tacrine using several precursors.

C. N. Filer, Judith A. Egan, R. P. Nugent, 2002, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

Trace amine receptor ligands: tritiation at high specific activity

D. Ahern, C. N. Filer, D. Orphanos, 2012, Journal of Radioanalytical and Nuclear Chemistry.

High specific activity tritiation of various methylated histamine analogues

C. N. Filer, E. Do, J. Andrews, 2019, Journal of Radioanalytical and Nuclear Chemistry.

The preparation and characterization of [3H] histamine.2HCl at high specific activity1

D. Ahern, C. N. Filer, 1987 .

Synthesis and characterization of tritium-labelled substances.

C. N. Filer, 2018, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

GABAergic radioligands labelled with tritium

C. N. Filer, 2010 .

The preparation of [pentane-5,5,5-3H3]-abnormal-cannabidiol

S. Carr, J. Herbert, S. Byard, 2011 .

Radiolabeling of serotonergic ligands with tritium and iodine-125

C. N. Filer, 2008 .

Synthesis of some 6-keto morphinan mu opiate receptor agonists labelled with tritium at high specific activity

D. Ahern, C. N. Filer, Judith A. Egan, 2013, Journal of Radioanalytical and Nuclear Chemistry.

High specific activity tritium labelling of some sigma-1 receptor agonists

D. Ahern, C. N. Filer, R. Seguin, 2012, Journal of Radioanalytical and Nuclear Chemistry.

Synthesis and characterization of [vinylidene‐3H] (−)‐α‐kainic acid at high specific activity

D. Ahern, C. N. Filer, R. Seguin, 2002 .

Kainic acid: its tritiation revisited with added technical details

C. N. Filer, R. Seguin, 2020, Journal of Radioanalytical and Nuclear Chemistry.

Tritium-labelled alkaloids: Synthesis and applications.

C. N. Filer, 2017, Journal of labelled compounds & radiopharmaceuticals.

Reflections on New England Nuclear (NEN)

C. N. Filer, 2007 .

The endogenous GABA analogue gamma-hydroxybutyric acid: Tritium labeling at high specific activity

C. N. Filer, Judith A. Egan, 2004 .

Synthesis of dual 14C-labeled (+)-calanolide A, a naturally occurring anti-HIV agent

A. Khilevich, M. Flavin, J. Rizzo, 1997 .

Isoquinolines. 8. Ethylene oxide mediated conversion of isoquinolines to isoquinolones and oxazolidines. Its extension to related nitrogen heterocycles

J. Neumeyer, C. N. Filer, F. Granchelli, 1979 .

Synthesis and characterization of [2‐3H] (1R,2S)‐ (−)‐2‐amino‐1,2‐diphenylethanol

C. N. Filer, Judith A. Egan, 2001 .

Tritiation of two potent catecholamine beta-adrenergic receptor agonists

D. Ahern, C. N. Filer, D. Orphanos, 2013, Journal of Radioanalytical and Nuclear Chemistry.

An alternative and simple synthesis of [14 C]potassium cyanate.

C. N. Filer, C. Peng, 2020, Journal of labelled compounds & radiopharmaceuticals.

Understanding the observed decreasing specific activity value in the series: aryl iodide, aryl bromide, aryl chloride during palladium catalyzed tritium dehalogenations

C. N. Filer, 2013, Journal of Radioanalytical and Nuclear Chemistry.

The synthesis of [fluorophenyl‐3H(N)] ocfentanil and [fluorophenyl‐3H(N)] brifentanil

C. N. Filer, R. P. Nugent, B. Huang, 1995 .

The synthesis of dopaminergic radioligands labelled with tritium and iodine‐125

C. N. Filer, 2007 .

High specific activity tritiation of several biologically active indoles.

S. Pounds, C. N. Filer, R. P. Nugent, 2011, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

Direct metal‐catalyzed tritiation of organic compounds

C. N. Filer, 2010 .

Preparation of (-)-[8,9-3H]apomorphine at high specific activity

D. Ahern, C. N. Filer, 1980 .

Synthesis of [Ring‐3H] Dopamine and Fluoro Analogues at High Specific Activity

C. N. Filer, R. Seguin, D. Orphanos, 2006 .

Tritium labelling of dopaminergic ligands domperidone and (+/-)-7-hydroxy DPAT.

S. Pounds, C. N. Filer, R. Seguin, 2005, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

A convenient synthesis of the muscarinic cholinergic antagonist (R)-[N-methyl-3 H]quinuclidinyl benzilate methiodide.

C. N. Filer, R. Seguin, 2019, Journal of labelled compounds & radiopharmaceuticals.

Tritium labelled photoaffinity agents

C. N. Filer, 2009 .

Tritiation and characterization of several polyamine natural products.

C. N. Filer, J. Morrison, 2015, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

Generation and use of tritiated borane in situ for formamide tritiation to an N-methyl-3 H group.

C. N. Filer, R. P. Nugent, 2018, Journal of labelled compounds & radiopharmaceuticals.

Ibotenic Acid Decarboxylation to Muscimol: Dramatic Solvent and Radiolytic Rate Acceleration

C. N. Filer, J. Lacy, C. Peng, 2005 .

High specific activity tritium labelling of biologically active small peptides and a related analogue

C. N. Filer, Judith A. Egan, 2015, Journal of Radioanalytical and Nuclear Chemistry.

Tritium labelling of several potent fluorinated antipsychotic drugs at high specific activity.

D. Ahern, C. N. Filer, A. G. Laseter, 2007, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

The preparation and characterization of (±)-[phenoxy-3H(N)] phenoxybenzamine hydrochloride at high specific activity

D. Ahern, C. N. Filer, J. Morrison, 1987 .

Synthesis of trans-2,3-dihydroxy-2, 3-dihydrobenzoic acid and related substances from 4-carbo-tert-butoxyoxepin

G. A. Berchtold, C. N. Filer, R. Demarinis, 1974 .

Ibotenic acid: on the mechanism of its conversion to [3H] muscimol

C. N. Filer, 2018, Journal of Radioanalytical and Nuclear Chemistry.

Tritium labelling of insect neurotransmitter and TAAR1 agonist (±)-octopamine

D. Ahern, C. N. Filer, P. S. Patterson, 2014, Journal of Radioanalytical and Nuclear Chemistry.

Tritiation of the botanically derived toxin dihydrorotenone

C. N. Filer, Judith A. Egan, 2021, Journal of Radioanalytical and Nuclear Chemistry.

Cannabinoids as Cocrystals

C. N. Filer, 2022, Medical Cannabis and Cannabinoids.

Creation of a nitrosamine library labelled with ^14C or tritium

C. N. Filer, 2023, Journal of Radioanalytical and Nuclear Chemistry.

Dithizone-14C labelling and characterization

C. N. Filer, M. Suryan, C. Peng, 2003 .

Isotopic fractionation of organic compounds in chromatography

C. N. Filer, 1999 .

Synthesis of [diene-(14)C] curcumin at high specific activity.

C. N. Filer, J. Lacy, C. Wright, 2016, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

Vicarious nucleophilic substitution: a dramatically shortened synthesis of 2-amino-6-nitrobenzoic acid labelled with carbon-14

C. N. Filer, Terence P. Kelly, C. Wright, 2011 .

Ethyl-³H analogues of plant natural products: Biologically active proxy radioligands via vinyl group tritiation.

C. N. Filer, D. Orphanos, 2016, Applied Radiation and Isotopes.

Tritiation and characterization of several biologically active nightshade alkaloids

C. N. Filer, Judith A. Egan, R. Seguin, 2014, Journal of Radioanalytical and Nuclear Chemistry.

Colforsin analogues: tritiation and characterization.

C. N. Filer, Judith A. Egan, R. P. Nugent, 2004, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

The synthesis of glycine receptor radioligands [21, 22-3H] dihydrostrychnine and [2-3H] strychnine at high specific activity

D. Ahern, C. N. Filer, 1989 .

The Use of 3H NMR in the Preparation of Tritiated Neurochemicals

C. N. Filer, 1987 .

On the Uncatalyzed Thermal Conversion of Cannabidiol to Delta-9-Tetrahydrocannabinol.

C. N. Filer, 2023, Cannabis and cannabinoid research.

APORPHINES. 58. N‐(2‐CHLOROETHYL)(8,9‐2H)NORAPOMORPHINE, AN IRREVERSIBLE LIGAND FOR DOPAMINE RECEPTORS: SYNTHESIS AND APPLICATION

P. Seeman, D. Grigoriadis, J. Neumeyer, 1984 .

Aporphines. 58. N-(2-chloroethyl) [8,9-2H]norapomorphine, an irreversible ligand for dopamine receptors: synthesis and application.

P. Seeman, D. Grigoriadis, J. Neumeyer, 1984, Journal of medicinal chemistry.

Chirality in Cannabinoid Research.

C. N. Filer, 2020, Cannabis and cannabinoid research.

Radiolabelling of bisphenol A and several related analogues.

S. Pounds, C. N. Filer, C. Wright, 2022, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

Tritiation of several intrinsically activated photoaffinity agents at high specific activity

D. Ahern, C. N. Filer, D. Orphanos, 2011 .

Mirfentanil and A-4334: Tritiation at high specific activity.

C. N. Filer, Judith A. Egan, R. P. Nugent, 2010, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

Terminal alkyne semi-tritiation with Lindlar catalyst and its mechanism implications

C. N. Filer, 2020, Journal of Radioanalytical and Nuclear Chemistry.

Cannabinoid Photochemistry: An Underexplored Opportunity.

C. N. Filer, 2022, Cannabis and cannabinoid research.

Tritiation of several antihypertensive agents at high specific activity.

C. N. Filer, Judith A. Egan, J. Andrews, 2008, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

Tritium labelling and characterization of the potent imidazoline I1 receptor antagonist [5,7-3H] (+/-)-efaroxan at high specific activity.

C. N. Filer, Judith A. Egan, 2003, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

High specific activity tritiation of TCP and BTCP.

C. N. Filer, Charles A. Hainley, S. Hurt, 2009, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

Selective D ring side chain tritiation of steroidal natural products

C. N. Filer, Charles A. Hainley, 2017, Journal of Radioanalytical and Nuclear Chemistry.

APORPHINES. 28. PREPARATION OF (-)-N-(3H- AND -2H)PROPYLNORAPOMORPHINE

J. Neumeyer, S. Law, D. Ahern, 1981 .

Aporphines. 28. Preparation of (-)-N-[3H- and -2H]propylnorapomorphine

J. Neumeyer, S. Law, D. Ahern, 1980 .

Synthesis of [7-(14) C]bergapten.

C. N. Filer, T. Rodgers, 2014, Journal of labelled compounds & radiopharmaceuticals.

Electrophilic addition of benzeneselenenyl chloride to hydroxyalkynes

D. Ahern, C. N. Filer, E. Shelton, 1980 .

Aporphines. 27. Mechanistic aspects of the rearrangement of thebaine and codeine analogs in methanesulfonic acid. Improved method for the synthesis of N-alkylated aporphines

J. Neumeyer, A. Soloway, C. N. Filer, 1980 .

Synthesis of the rice herbicide HW-52 [dichlorophenyl ring 14C(U)]

I. Kimura, C. N. Filer, T. Ueda, 1993 .

Synthesis of [15, 16- ³H] beta-funaltrexamine.

C. N. Filer, R. Seguin, 2013, Journal of labelled compounds & radiopharmaceuticals.

An efficient synthesis of trace amine-associated receptor agonist [1-14 C]tyramine.

C. N. Filer, D. Orphanos, 2018, Journal of labelled compounds & radiopharmaceuticals.

An effective and scalable 14C radiolabelling of several biogenic indole derivatives at high specific activity.

C. N. Filer, D. Orphanos, 2020, Applied Radiation and Isotopes.

Tritiation of nonpeptide substance P antagonist CP-96,345 and its azido analogue. Synthetic and characterization details.

C. N. Filer, Judith A. Egan, 2003, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

(.+-.)-[Methyl-3H and -2H]mianserin. Participants in a dramatic instance of HPLC isotopic fractionation

D. Ahern, C. N. Filer, R. Fazio, 1981 .

Tritiation of imipramine and pseudo irreversible analogues 3-cyanoimipramine and 2-nitroimipramine at high specific activity.

D. Ahern, C. N. Filer, Eileen V. Johnson, 2006, Applied Radiation and Isotopes.

Luminescence enhancement by deuterium.

C. N. Filer, 2023, Journal of labelled compounds & radiopharmaceuticals.

Tritiation of CEP‐1347 at high specific activity using several methods

R. Hudkins, S. Pounds, C. N. Filer, 2005 .

High specific activity tritium labeling of anti‐tumor agent CEP‐2563

R. Hudkins, C. N. Filer, Judith A. Egan, 2005 .

MicroED and cannabinoid research

C. N. Filer, 2021, Journal of Cannabis Research.

The synthesis and characterization of [2,3-3H] gamma-aminobutyric acid via 4-aminotetrolic acid at high specific activity.

D. Ahern, C. N. Filer, A. G. Laseter, 2003, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

Morphinan alkaloids labeled with tritium: synthesis and applications.

C. N. Filer, 2013, Journal of labelled compounds & radiopharmaceuticals.

Tritiation and characterization of several suicide substrate enzyme inactivators.

C. N. Filer, Judith A. Egan, 2014, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.