K. Hasebe

发表

Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology.

N. Yamaotsu, S. Hirono, H. Nagase, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of pyrrolomorphinan derivatives as kappa opioid agonists.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2010, Bioorganic & medicinal chemistry letters.

Aerobic oxidation of indolomorphinan without the 4,5-epoxy bridge and subsequent rearrangement of the oxidation product to spiroindolinonyl-C-normorphinan derivative.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2009, Bioorganic & medicinal chemistry.

Possible Pharmacotherapy of the Opioid κ Receptor Agonist for Drug Dependence

M. Narita, Tsutomu Suzuki, H. Nagase, 2004 .

Pharmacological effect of TRK-380, a novel selective human β3-adrenoceptor agonist, on mammalian detrusor strips.

S. Okazaki, S. Yoshikawa, H. Mochizuki, 2012, Urology.

Synthesis of a stable iminium salt and propellane derivatives.

S. Hirono, H. Nagase, K. Kamiya, 2008, The Journal of organic chemistry.

Structure-antitussive activity relationships of naltrindole derivatives. Identification of novel and potent antitussive agents.

J. Kamei, S. Ueno, H. Nagase, 2008, Journal of medicinal chemistry.

A synthesis of polycyclic aromatic compounds by the calcium acetate-induced aromatization of polyoxoalkanedioates generated from diesters and acetoacetate dianion

M. Yamaguchi, T. Minami, K. Hasebe, 1990 .

Reactions of α-Lithiatd 4H-1-Benzothiopyran-4-one and 1,2-Dihydrocyclopenta[b][1]benzothiopyran-9(3H)-one Derivatives

M. Yamaguchi, I. Hirao, K. Hasebe, 1985 .

Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2008, Bioorganic & medicinal chemistry letters.

An Oxidative Dimerization of Anthrones by Oxygen-Metal Acetate System

M. Yamaguchi, T. Minami, K. Hasebe, 1989 .

A biomimetic synthesis of polycyclic polyoxygenated aromatic compounds via polyketides

M. Yamaguchi, T. Minami, K. Hasebe, 1986 .

Catalytic Aerobic Oxidation of nor-Binaltorphimine (nor-BNI) Analogs without 4,5-Epoxy Bridge Affords a More Selective Ligand for κ Opioid Receptor than the Representative κ Antagonist nor-BNI

H. Nagase, H. Mochizuki, H. Fujii, 2007 .

A diastereo- and enantioselective Michael addition of chiral amide enolates to α, β-unsaturated esters a stereoelective synthesis of (+)-dehydroiridodiol and (−)-isodehydroiridodiol

M. Yamaguchi, T. Minami, K. Hasebe, 1986 .

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: part 1.

H. Nagase, H. Mochizuki, H. Fujii, 2011, Bioorganic & medicinal chemistry letters.

Synthesis of a new opioid ligand having the oxabicyclo[3.2.1]octane skeleton using a new rearrangement reaction.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2009, Bioorganic & medicinal chemistry letters.

Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 1: Synthesis of triplet drugs with morphinan skeletons.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2011, Bioorganic & medicinal chemistry letters.

Synthesis of Novel Triplet Drugs with 1,3,5-Trioxazatriquinane Skeletons and Their Pharmacologies. Part 1. Synthesis of Triplet Drugs with Morphinan Skeletons.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2011 .

Novel synthesis of a 1,3,5-trioxazatriquinane skeleton using a nitrogen clamp.

H. Nagase, K. Yoza, Mayumi Nakajima, 2009, Organic letters.

Possible pharmacotherapy of the opioid kappa receptor agonist for drug dependence.

M. Narita, Tsutomu Suzuki, H. Nagase, 2004, Annals of the New York Academy of Sciences.

Effects of a novel β3‐adrenoceptor agonist, AJ‐9677, on relaxation of the detrusor muscle: An in vitro study

H. Shinbo, A. Otsuka, S. Ozono, 2008, International journal of urology : official journal of the Japanese Urological Association.

Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2008, Bioorganic & medicinal chemistry letters.