S. Kasai

发表

TX‐1877, a bifunctional hypoxic cell radiosensitizer, enhances anticancer host response: Immune cell migration and nitric oxide production

H. Nagasawa, Y. Uto, H. Hori, 2005, International journal of cancer.

KMI-008, a novel beta-secretase inhibitor containing a hydroxymethylcarbonyl isostere as a transition-state mimic: design and synthesis of substrate-based octapeptides.

B. Szabó, Y. Kiso, Tooru Kimura, 2003, Bioorganic & medicinal chemistry letters.

Identification of peptidomimetic HTLV-I protease inhibitors containing hydroxymethylcarbonyl (HMC) isostere as the transition-state mimic.

Y. Kiso, Tooru Kimura, Y. Hayashi, 2004, Bioorganic & medicinal chemistry letters.

New antimetastatic hypoxic cell radiosensitizers: design, synthesis, and biological activities of 2-nitroimidazole-acetamide, TX-1877, and its analogues.

H. Nagasawa, S. Oka, Y. Uto, 2001, Bioorganic & medicinal chemistry.

TX-1877: design, synthesis, and biological activities as a BRM-functional hypoxic cell radiosensitizer.

A. Nishioka, S. Yoshida, H. Nagasawa, 1998, International journal of radiation oncology, biology, physics.

Design, synthesis, and biological activity of anti-angiogenic hypoxic cell radiosensitizer haloacetylcarbamoyl-2-nitroimidazoles.

H. Hori, M. Shimamura, S. Inayama, 1997, Bioorganic & medicinal chemistry.

Design and synthesis of new mitochondrial cytotoxin N-thiadiazolylanilines that inhibit tumor cell growth.

H. Hori, H. Ise, N. Noguchi, 1996, Bioorganic & medicinal chemistry.

Design and synthesis of highly active Alzheimer's beta-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability.

Y. Kiso, Y. Hamada, Tooru Kimura, 2005, Bioorganic & medicinal chemistry letters.

KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine.

S. Kitazume, T. Saido, Y. Kiso, 2004, Bioorganic & medicinal chemistry letters.

Design and synthesis of BACE1 inhibitors containing a novel norstatine derivative (2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyric acid.

Y. Kiso, Tooru Kimura, Y. Hayashi, 2007, Bioorganic & medicinal chemistry letters.

Combined effects of tirapazamine and mild hyperthermia on anti-angiogenic agent (TNP-470) treated tumors-reference to the effect on intratumor quiescent cells.

Y. Nishimura, K. Ono, H. Nagasawa, 2000, International journal of radiation oncology, biology, physics.

Usefulness of Tirapazamine as a Combined Agent in Chemoradiation and Thermo‐chemoradiation Therapy at Mild Temperatures: Reference to the Effect on Intratumor Quiescent Cells

K. Ono, Minoru Suzuki, H. Nagasawa, 2000, Japanese journal of cancer research : Gann.

Design and synthesis of antiangiogenic/heparin-binding arginine dendrimer mimicking the surface of endostatin.

Yoshihiro Uto, H. Nagasawa, Y. Uto, 2002, Bioorganic & medicinal chemistry letters.

The first total synthesis of vinaxanthone, a fungus metabolite possessing multiple bioactivities

K. Tatsuta, S. Hosokawa, S. Kasai, 2007 .

Change in oxygenation status in intratumour total and quiescent cells following gamma-ray irradiation, tirapazamine administration, cisplatin injection and bleomycin treatment.

K. Ono, H. Nagasawa, Y. Uto, 2000, The British journal of radiology.

Potentially lethal damage repair by total and quiescent tumor cells following various DNA-damaging treatments.

K. Ono, H. Nagasawa, Y. Uto, 1999, Radiation medicine.

Changes in the Sensitivity of Intratumor Cells during Fractionated Tirapazamine Administration

K. Ono, Minoru Suzuki, H. Nagasawa, 2000, Japanese journal of cancer research : Gann.

Modification of tirapazamine-induced cytotoxicity in combination with mild hyperthermia and/or nicotinamide: reference to effect on quiescent tumour cells.

K. Ono, H. Nagasawa, Y. Uto, 1999, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.