Haiming Zhang

发表

C-H Bond Functionalizations with Palladium(II): Intramolecular Oxidative Annulations of Arenes.

B. Stoltz, E. M. Ferreira, Haiming Zhang, 2008, Tetrahedron.

Palladium-Catalyzed Enantioselective Decarboxylative Allylic Alkylation of Acyclic α-N-Pyrrolyl/Indolyl Ketones.

B. Stoltz, Haiming Zhang, E. J. Alexy, 2020, Organic letters.

Development of a Practical Synthesis of ERK Inhibitor GDC-0994

F. Gosselin, H. Iding, S. Koenig, 2017 .

Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders.

Alan G. E. Wilson, D. Augeri, S. D. Kimball, 2009, Journal of medicinal chemistry.

Palladium-Catalyzed Site-Selective Amidation of Dichloroazines.

F. Gosselin, I. S. Young, Chong Han, 2018, Organic letters.

An Efficient Second-Generation Manufacturing Process for the pan-RAF Inhibitor Belvarafenib

F. Gosselin, S. Bachmann, Eduardo V Mercado-Marin, 2021, Organic Process Research & Development.

Synthesis of β- and γ-carbolines by the palladium/copper-catalyzed coupling and copper-catalyzed or thermal cyclization of terminal acetylenes

R. Larock, Haiming Zhang, 2002 .

Direct oxidative Heck cyclizations: intramolecular Fujiwara-Moritani arylations for the synthesis of functionalized benzofurans and dihydrobenzofurans.

B. Stoltz, E. M. Ferreira, Haiming Zhang, 2004, Angewandte Chemie.

Process Development of Tryptophan Hydroxylase Inhibitor LX1031, a Drug Candidate for the Treatment of Irritable Bowel Syndrome

S. Iimura, Haiming Zhang, Ngiap-Kie Lim, 2020 .

Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932).

Alan G. E. Wilson, W. K. Sonnenburg, D. Augeri, 2010, Journal of medicinal chemistry.

High-Level Data Fusion Enables the Chemoinformatically Guided Discovery of Chiral Disulfonimide Catalysts for Atropselective Iodination of 2-Amino-6-arylpyridines.

Brennan T. Rose, S. Chin, S. Denmark, 2022, Journal of the American Chemical Society.

Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036.

F. Gosselin, M. Sigman, Chong Han, 2022, Journal of the American Chemical Society.

One-pot synthesis of 4-substituted 3-amino-2-cyanothiophenes involving O-ethyl thioformate.

Haiming Zhang, Ngiap-Kie Lim, M. Bednarz, 2014, Organic letters.

Synthesis of β- and γ-Carbolines by the Palladium/Copper-Catalyzed Coupling and Cyclization of Terminal Acetylenes

R. Larock, Haiming Zhang, 2002 .

Practical Synthesis of 5-Fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a Key Intermediate in the Preparation of Potent Deoxycytidine Kinase Inhibitors

Haiming Zhang, P. Keyes, Wenxue Wu, 2009 .

Development of an Efficient Manufacturing Process for Reversible Bruton’s Tyrosine Kinase Inhibitor GDC-0853

F. Gosselin, D. Linder, Jessica L. Defreese, 2018, Organic Process Research & Development.

Highly Stereoselective Synthesis of Tetrasubstituted Acyclic All-Carbon Olefins via Enol Tosylation and Suzuki-Miyaura Coupling.

F. Gosselin, D. B. Collum, Chong Han, 2017, Journal of the American Chemical Society.

Synthesis of β- and γ-Carbolines by the Palladium-Catalyzed Iminoannulation of Internal Alkynes

R. Larock, Haiming Zhang, 2001 .

Synthesis of Annulated γ-Carbolines by Palladium-Catalyzed Intramolecular Iminoannulation

R. Larock, Haiming Zhang, 2002 .

Synthesis of annulated gamma-carbolines and heteropolycycles by the palladium-catalyzed intramolecular annulation of alkynes.

R. Larock, Haiming Zhang, 2003, The Journal of organic chemistry.

Asymmetric Hydrogenation of Unfunctionalized, Tetrasubstituted, Acyclic Olefins.

S. Denmark, F. Gosselin, S. Bachmann, 2019, Angewandte Chemie.

Palladium-Catalyzed Enantioselective Decarboxylative Allylic Alkylation of Protected Benzoin-Derived Enol Carbonates.

B. Stoltz, Haiming Zhang, E. J. Alexy, 2019, Advanced synthesis & catalysis.

Efficient Manufacturing Process for the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) via a Crystallization-Driven Diastereoselective Pictet–Spengler Condensation

F. Gosselin, Cheol K. Chung, Alec Fettes, 2021, Organic Process Research & Development.

Single-step synthesis of 3-hydroxycarbazoles by annulation of electron-rich anilines and quinones

B. Stoltz, Chong Han, C. Gu, 2016 .

A fit for purpose synthesis of Bruton’s tyrosine kinase inhibitor GDC-0852

F. Gosselin, Haiming Zhang, Ngiap-Kie Lim, 2020 .

Single-Step Synthesis of 5,6,7,8-Tetrahydroindolizines via Annulation of 2-Formylpiperidine and 1,3-Dicarbonyl Compounds.

Haiming Zhang, Ngiap-Kie Lim, Simona S. Capomolla, 2015, Organic letters.

Negishi Approach to 1,5-Disubstituted 3-Amino-1H-1,2,4-triazoles.

C. Gu, Haiming Zhang, Jeff Shen, 2015, Organic letters.

Practical Synthesis of a Stable Precursor for Positron Emission Tomography Imaging Agent 18F-GTP1

F. Gosselin, P. O'shea, W. Nack, 2020 .

Phosphoramidates as Steering Elements for Highly Selective Access to Complementary Imidazo[1,2-a]pyrimidine Isomers.

F. Gosselin, P. O'shea, W. Nack, 2019, Organic letters.

Process Development of Sotagliflozin, a Dual Inhibitor of Sodium–Glucose Cotransporter-1/2 for the Treatment of Diabetes

S. Iimura, Youchu Wang, Xiaodong Gu, 2020 .

Synthesis of 9,10-Phenanthrenes via Palladium-Catalyzed Aryne Annulation by o-Halostyrenes and Formal Synthesis of (±)-Tylophorine.

T. Yao, Haiming Zhang, Yanna Zhao, 2016, Organic letters.

Highly Diastereoselective α-Arylation of Cyclic Nitriles.

F. Gosselin, Haiming Zhang, Michael E. Dalziel, 2017, Organic letters.

Synthesis of Highly Stereodefined Tetrasubstituted Acyclic All-Carbon Olefins via a Syn-Elimination Approach.

Bronwyn L. Bensema, F. Gosselin, D. Tantillo, 2017, Organic letters.

Catalytic Enantioselective Synthesis of Acyclic Quaternary Centers: Palladium-Catalyzed Decarboxylative Allylic Alkylation of Fully Substituted Acyclic Enol Carbonates.

B. Stoltz, Haiming Zhang, E. J. Alexy, 2018, Journal of the American Chemical Society.

Magnesium Ethoxide Promoted Conversion of Nitriles to Amidines and Its Application in 5,6-Dihydroimidazobenzoxazepine Synthesis.

Chong Han, R. Angelaud, Haiming Zhang, 2018, Organic letters.

A chemoselective Reformatsky–Negishi approach to α-haloaryl esters

J. Crawford, J. Drobnick, Wendy Lee, 2014 .

Stereoconvergent and -divergent Synthesis of Tetrasubstituted Alkenes by Nickel-Catalyzed Cross-Couplings.

F. Gosselin, Cian Kingston, M. Sigman, 2021, Journal of the American Chemical Society.

Lithium Hexamethyldisilazide-Mediated Enolization of Highly Substituted Aryl Ketones: Structural and Mechanistic Basis of the E/Z Selectivities.

F. Gosselin, D. B. Collum, A. McClory, 2017, Journal of the American Chemical Society.

Palladium-catalyzed enantioselective decarboxylative allylic alkylation of fully substituted N-acyl indole-derived enol carbonates† †Electronic supplementary information (ESI) available: Experimental procedures, NMR and IR spectra, SFC traces, X-ray crystallographic data. CCDC 1908785. For ESI and c

B. Stoltz, Haiming Zhang, E. J. Alexy, 2019, Chemical science.

Practical synthesis of potent sphingosine-1-phosphate lyase inhibitors THI and LX2931

C. Guohua, Weifeng Hu, Renmao Liu, 2013 .

Aryl to aryl palladium migration in the Heck and Suzuki coupling of o-halobiaryls.

W. Jenks, R. Larock, M. Campo, 2007, Journal of the American Chemical Society.

Convergent Synthesis of PI3K Inhibitor GDC-0908 Featuring Palladium-Catalyzed Direct C-H Arylation toward Dihydrobenzothienooxepines.

F. Gosselin, Beryl X. Li, Haiming Zhang, 2018, The Journal of organic chemistry.

Synthesis of Chiral Tryptamines via a Regioselective Indole Alkylation.

Cheol K. Chung, Jie Xu, Haiming Zhang, 2018, Organic letters.

Synthesis of 3-Aryl-Substituted 4-Aminopyrazoles from Acetophenones

Haiming Zhang, Andreas Stumpf, Tyler A. Tuck, 2022, Synthesis.

RAPID AND CONVERGENT SYNTHESIS OF A 2,4'-LINKED TRI-OXAZOLE IN AN APPROACH TO POLY-OXAZOLES (Dedicated to Professor Dr. Ei-ichi Negishi on the occasion of his 77th birthday)

S. Virgil, Haiming Zhang, Daniel D. Caspi, 2012 .

Direct Oxidative Heck Cyclizations: Intramolecular Fujiwara—Moritani Arylations for the Synthesis of Functionalized Benzofurans and Dihydrobenzofurans.

B. Stoltz, E. M. Ferreira, Haiming Zhang, 2005 .

Synthesis of beta- and gamma-carbolines by the palladium-catalyzed iminoannulation of alkynes.

R. Larock, Haiming Zhang, 2002, The Journal of organic chemistry.

A Strecker approach to 2-substituted ethyl 5-aminothiazole-4-carboxylates

F. Gosselin, R. Angelaud, A. McClory, 2016 .

Synthesis of 1-substituted 3-amino-1H-1,2,4-triazoles from ethyl N-(5-phenyl-1,2,4-oxadiazol-3-yl)formimidate

Haiming Zhang, Jeff Shen, 2015 .

Synthesis of 1‐Substituted 3‐Amino‐1H‐1,2,4‐triazoles from Ethyl N‐(5‐Phenyl‐1,2,4‐oxadiazol‐3‐yl)formimidate.

Haiming Zhang, Jeff Shen, 2015 .

First-Generation Asymmetric Synthesis of the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) Featuring a Highly Efficient Pictet–Spengler Reaction and a C–N Coupling Reaction

F. Gosselin, Cheol K. Chung, Jie Xu, 2021, Organic Process Research & Development.

Oxidative Heck‐Type Reactions (Fujiwara–Moritani Reactions)

B. Stoltz, E. M. Ferreira, Haiming Zhang, 2009 .

Global Diastereoconvergence in the Ireland-Claisen Rearrangement of Isomeric Enolates: Synthesis of Tetrasubstituted α-Amino Acids.

K. Houk, B. Stoltz, Haiming Zhang, 2020, Journal of the American Chemical Society.

Palladium-catalyzed α,β-dehydrogenation of acyclic ester equivalents promoted by a novel electron deficient phosphinooxazoline ligand.

B. Stoltz, Haiming Zhang, E. J. Alexy, 2019, Tetrahedron.

Discovery and Development of Non-Covalent, Reversible Bruton’s Tyrosine Kinase Inhibitor Fenebrutinib (GDC-0853)

J. Crawford, Haiming Zhang, Haiming Zhang, 2019, ACS Symposium Series.

Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036.

F. Gosselin, S. Bachmann, R. Angelaud, 2023, Organic letters.

Data Science-Enabled Palladium-Catalyzed Enantioselective Aryl-Carbonylation of Sulfonimidamides.

F. Gosselin, F. Toste, M. Sigman, 2023, Journal of the American Chemical Society.

Negishi Approach to 1,5-Disubstituted 3-Amino-1H-1,2,4-triazoles.

C. Gu, Haiming Zhang, Jeff Shen, 2015, Organic letters.

B. Stoltz, Haiming Zhang, E. J. Alexy, 2019, Chemical science.

Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders.

Alan G. E. Wilson, D. Augeri, J. Tarver, 2009, Journal of medicinal chemistry.