I. Hallyburton

发表

Assay donovani Assay with an Axenic Amastigote High-Content Intracellular Leishmania Comparison of a High-Throughput

Lorna, S. Cameron, I. Gilbert, 2013 .

AssayAssay with an Axenic Amastigote High-Content Intracellular Leishmania Comparison of a High-Throughput

S. Cameron, I. Gilbert, D. Gray, 2013 .

A novel multiple-stage antimalarial agent that inhibits protein synthesis

David W. Gray, E. Winzeler, S. Meister, 2015, Nature.

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

L. Stojanovski, K. Read, I. Gilbert, 2018, ACS infectious diseases.

Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase

I. Gilbert, D. Robinson, L. S. Torrie, 2022, ACS infectious diseases.

The Suppression of Galactose Metabolism in Procylic Form Trypanosoma brucei Causes Cessation of Cell Growth and Alters Procyclin Glycoprotein Structure and Copy Number*

J. R. Roper, M. Ferguson, A. Prescott, 2005, Journal of Biological Chemistry.

Escaping from Flatland: Antimalarial Activity of sp3-Rich Bridged Pyrrolidine Derivatives.

Mark B. Anderson, C. Swain, K. Booker‐Milburn, 2020, ACS medicinal chemistry letters.

Initiating a crystallographic analysis of recombinant (S)-2-hydroxypropylphosphonic acid epoxidase from Streptomyces wedmorensis.

S. Cameron, W. Hunter, I. Hallyburton, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Juan A. Bueren-Calabuig, Andrei V. Pisliakov, David W. Gray, 2019, Proceedings of the National Academy of Sciences.

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase

David W. Gray, K. Read, I. Gilbert, 2016, ACS infectious diseases.

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

David W. Gray, E. Winzeler, S. Meister, 2016, Journal of medicinal chemistry.

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials

E. Winzeler, S. Meister, S. Norval, 2016, Journal of medicinal chemistry.

Quinol derivatives as potential trypanocidal agents

I. Gilbert, A. Fairlamb, P. Wyatt, 2012, Bioorganic & medicinal chemistry.

Induction of diverse secondary metabolites in Aspergillus fumigatus by microbial co-culture

Alan T. Bull, Marcel Jaspars, Wael E Houssen, 2013 .

Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

S. Cameron, I. Gilbert, A. Fairlamb, 2013, Antimicrobial Agents and Chemotherapy.

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2015, Journal of medicinal chemistry.

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

Irene Hallyburton, Alan H. Fairlamb, L. Stojanovski, 2010, Biochemical pharmacology.

N-Myristoyltransferase inhibitors as new leads to treat sleeping sickness

Ian H. Gilbert, Chidochangu P. Mpamhanga, Michael Hodgkinson, 2010, Nature.

An Open Drug Discovery Competition: Experimental Validation of Predictive Models in a Series of Novel Antimalarials.

Benedict Irwin, Benedict W J Irwin, Gareth Conduit, 2020, Journal of medicinal chemistry.

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library

David W. Gray, S. Norval, L. Stojanovski, 2015, ChemMedChem.

Non-Classical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open Source Antimalarials.

G. S. Walker, Mark B. Anderson, R. Obach, 2020, Journal of medicinal chemistry.

Whole Organism High-Content Screening by Label-Free, Image-Based Bayesian Classification for Parasitic Diseases

Ian H. Gilbert, Andrew L. Hopkins, Irene Hallyburton, 2012, PLoS neglected tropical diseases.

Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis

Stuart P. McElroy, S. Norval, Frederick R. C. Simeons, 2014, Journal of medicinal chemistry.

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2018, Journal of medicinal chemistry.

Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode

Stuart P. McElroy, S. Norval, L. Stojanovski, 2015, ChemMedChem.

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

Julie Clark, George Papadatos, Jeremy N. Burrows, 2016, ACS central science.

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

Ian H. Gilbert, Irene Hallyburton, Alan H. Fairlamb, 2011, Journal of medicinal chemistry.

Hexameric Assembly of the Bifunctional Methylerythritol 2,4-Cyclodiphosphate Synthase and Protein-Protein Associations in the Deoxy-xylulose-dependent Pathway of Isoprenoid Precursor Biosynthesis*

W. Eisenreich, A. Bacher, F. Rohdich, 2004, Journal of Biological Chemistry.

The hepatic PP1 glycogen‐targeting subunit interaction with phosphorylase a can be blocked by C‐terminal tyrosine deletion or an indole drug

J. Treadway, S. Munro, Ian R. Kelsall, 2007, FEBS letters.

Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488

S. Norval, K. Read, I. Gilbert, 2011, ChemMedChem.

Lead optimization of a pyrazole sulfonamide series of trypanosoma brucei N myristoyltransferase inhibitors

Stuart P. McElroy, S. Norval, Frederick R. C. Simeons, 2014 .

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

E. Winzeler, S. Meister, J. Rayner, 2016, Nature.

Screening a protein kinase inhibitor library against Plasmodium falciparum

I. Gilbert, A. Fairlamb, P. Wyatt, 2017, Malaria Journal.

Preparation, biological evaluation and QSAR analysis of urea substituted 2,4-diamino-pyrimidine anti-malarials.

K. Read, M. Gleeson, Jennifer Riley, 2022, RSC medicinal chemistry.

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2023, Journal of Medicinal Chemistry.

Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

David W. Gray, S. Cameron, I. Gilbert, 2013, Antimicrobial Agents and Chemotherapy.

Preparation, biological & cheminformatics-based assessment of N2,N4-diphenylpyrimidine-2,4-diamine as potential Kinase-targeted antimalarials.

Mark B. Anderson, K. Read, M. Gleeson, 2021, Bioorganic & medicinal chemistry.