M. Loriga

发表

Structure-based selectivity optimization of piperidine-pteridine derivatives as potent Leishmania pteridine reductase inhibitors.

A. Cavalli, P. Michels, V. Hannaert, 2012, Journal of medicinal chemistry.

Quinoxaline 1,4-dioxide: a versatile scaffold endowed with manifold activities.

P. Corona, A. Carta, M. Loriga, 2005, Current medicinal chemistry.

Synthesis, anti-mycobacterial, anti-trichomonas and anti-candida in vitro activities of 2-substituted-6,7-difluoro-3-methylquinoxaline 1,4-dioxides.

S. Zanetti, L. Sechi, A. Carta, 2004, European journal of medicinal chemistry.

4‐Substituted Anilino Imidazo[1,2‐a] and Triazolo[4,3‐a]quinoxalines. Synthesis and Evaluation of in vitro Biological Activity.

R. Loddo, P. Corona, G. Sanna, 2007 .

4-Substituted anilino imidazo[1,2-a] and triazolo[4,3-a]quinoxalines. Synthesis and evaluation of in vitro biological activity.

R. Loddo, P. Corona, G. Sanna, 2006, European journal of medicinal chemistry.

Synthesis and in vitro antitumor activity of new quinoxaline derivatives.

P. Corona, A. Carta, M. Loriga, 2009, European journal of medicinal chemistry.

Synthesis of variously substituted 3-phenoxymethyl quinoxalin-2-ones and quinoxalines capable to potentiate in vitro the antiproliferative activity of anticancer drugs in multi-drug resistant cell lines.

R. Loddo, S. Piras, P. la Colla, 2006, Medicinal chemistry (Shariqah (United Arab Emirates)).

Synthesis of 3,6,7-substituted-quinoxalin-2-ones for evaluation of antimicrobial and anticancer activity. Part 2.

S. Zanetti, L. Sechi, A. Carta, 1999, Farmaco.

Synthesis and biological evaluation of substituted benzo[h]cinnolinones and 3H-benzo[6,7]cyclohepta[1,2-c]pyridazinones: higher homologues of the antihypertensive and antithrombotic 5H-indeno[1,2-c]pyridazinones.

D. Barlocco, G. Pinna, M. M. Curzu, 1989, Journal of medicinal chemistry.

Quinoxaline chemistry. Part 13: 3-Carboxy-2-benzylamino-substituted quinoxalines and N-[4-[(3-carboxyquinoxalin-2-yl) aminomethyl]benzoyl]-L-glutamates: synthesis and evaluation of in vitro anticancer activity.

P. Corona, M. Loriga, G. Paglietti, 2000, Farmaco.

Quinoxaline chemistry. Part 7. 2-[aminobenzoates]- and 2-[aminobenzoylglutamate]-quinoxalines as classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity.

S. Piras, M. Loriga, G. Paglietti, 1997, Farmaco.

Synthesis and evaluation for biological activity of 3-alkyl and 3-halogenoalkyl-quinoxalin-2-ones variously substituted. Part 4.

R. Loddo, A. Carta, M. Loriga, 2002, Farmaco.

5-acetyl-2-arylbenzimidazoles as antiviral agents. Part 4.

P. Corona, G. Sanna, G. Giliberti, 2012, European journal of medicinal chemistry.

Quinoxaline chemistry. Part 16. 4-substituted anilino and 4-substituted phenoxymethyl pyrrolo[1,2-a]quinoxalines and N-[4-(pyrrolo[1,2-a]quinoxalin-4-yl)amino and hydroxymethyl]benzoyl glutamates. Synthesis and evaluation of in vitro biological activity.

R. Loddo, P. Corona, P. la Colla, 2003, Farmaco.

Design, synthesis, and preliminary in vitro and in silico antiviral activity of [4,7]phenantrolines and 1-oxo-1,4-dihydro-[4,7]phenantrolines against single-stranded positive-sense RNA genome viruses.

M. Ferrone, M. Fermeglia, S. Pricl, 2007, Bioorganic & medicinal chemistry.

Synthesis and pharmacological evaluation of 4,4a,5,6-tetrahydro-7,8-disubstituted-benzo[h]cinnolin-3(2H)-ones.

G. Pinna, M. M. Curzu, M. D'Amico, 1997, Farmaco.

Quinoxaline chemistry. Part 11. 3-Phenyl-2[phenoxy- and phenoxymethyl]-6(7) or 6,8-substituted quinoxalines and N-[4-(6(7)-substituted or 6,8-disubstituted-3-phenylquinoxalin-2-yl)hydroxy or hydroxymethyl] benzoylglutamates. Synthesis and evaluation of in vitro anticancer activity and enzymatic inhi

Maria Paola Costi, P. Corona, M. Loriga, 1998, Farmaco.

Quinoxaline chemistry. Part 11. 3-phenyl-2[phenoxy- and phenoxymethyl]-6(7) or 6,8-substituted quinoxalines and N-[4-(6(7)-substituted or 6,8-disubstituted-3-phenylquinoxalin-2-yl)hydroxy or hydroxymethyl]benzoylglutamates. Synthesis and evaluation of in

Maria Paola Costi, P. Corona, M. Loriga, 1998 .

Synthesis and in vitro antitumor activity of new quinoxaline derivatives.

P. Corona, A. Carta, M. Loriga, 2009, European journal of medicinal chemistry.

Preparation and biological evaluation of 6/7-trifluoromethyl(nitro)-, 6,7-difluoro-3-alkyl (aryl)-substituted-quinoxalin-2-ones. Part 3.

S. Zanetti, L. Sechi, A. Carta, 1999, Farmaco.

Synthesis of substituted 2-ethoxycarbonyl- and 2-carboxyquinoxalin-3-ones for evaluation of antimicrobial and anticancer activity.

S. Zanetti, L. Sechi, A. Carta, 1998, Farmaco.

Synthesis of substituted 2-ethoxycarbonyl- and 2-carboxyquinoxalin-3-ones for evaluation of antimicrobial and anticancer activity.

S. Zanetti, L. Sechi, A. Carta, 1998, Farmaco.

Quinoxalin-2-ones. Part 5. Synthesis and antimicrobial evaluation of 3-alkyl-, 3-halomethyl- and 3-carboxyethylquinoxaline-2-ones variously substituted on the benzo-moiety.

S. Zanetti, L. Sechi, A. Carta, 2003, Farmaco.

2-Phenyl-6(7)-R-substituted quinoxalines N-oxides. Synthesis, structure elucidation and antimicrobial activity

S. Zanetti, G. Fadda, M. Loriga, 1990 .

Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: evaluation of in vitro anti-cancer and anti-folate activities.

Maria Paola Costi, P. Corona, S. Ferrari, 2008, European journal of medicinal chemistry.

Novel 3-benzoyl-2-piperazinylquinoxaline derivatives as potential antitumor agents

Maria Paola Costi, S. Piras, A. Carta, 2006 .

Quinoxaline chemistry. Part XVII. Methyl [4-(substituted 2-quinoxalinyloxy) phenyl] acetates and ethyl N-([4-(substituted 2-quinoxalinyloxy) phenyl] acetyl) glutamates analogs of methotrexate: synthesis and evaluation of in vitro anticancer activity.

S. Piras, M. Loriga, G. Paglietti, 2004, Farmaco.

Quinoxaline chemistry. Part 15. 4-[2-Quinoxalylmethylenimino]-benzoylglutamates and -benzoates, 4-[2-quinoxalylmethyl-N-methylamino]-benzoylglutamates as analogues of classical antifolate agents. Synthesis, elucidation of structures and in vitro evaluation of antifolate and anticancer activities.

Maria Paola Costi, S. Piras, A. Venturelli, 2003, Farmaco.

Quinoxaline chemistry. Part 14. 4-(2-Quinoxalylamino)-phenylacetates and 4-(2-quinoxalylamino)-phenylacetyl-L-glutamates as analogues--homologues of classical antifolate agents. Synthesis and evaluation of in vitro anticancer activity.

S. Piras, M. Loriga, G. Paglietti, 2002, Farmaco.

Quinoxaline chemistry. Part 12. 3-Carboxy-2[phenoxy]-6(7)substituted quinoxalines and N-[4-(6(7) substituted-3-carboxyquinoxalin-2-yl)hydroxy] benzoylglutamates. Synthesis and evaluation of in vitro anticancer activity.

P. Corona, M. Loriga, G. Paglietti, 1998, Farmaco.

Quinoxaline chemistry. Part 10. Quinoxaline 10-oxa-analogues of trimetrexate (TMQ) and of 5,8-dideazafolic acid. Synthesis and evaluation of in vitro anticancer activity.

P. Corona, M. Loriga, G. Paglietti, 1998, Farmaco.

Quinoxaline chemistry. Part 9. Quinoxaline analogues of trimetrexate (TMQ) and 10-propargyl-5,8-dideazafolic acid (CB 3717) and its precursors. Synthesis and evaluation of in vitro anticancer activity.

M. Loriga, G. Paglietti, G. Vitale, 1998, Farmaco.

Synthesis and antiviral activity of new phenylimidazopyridines and N-benzylidenequinolinamines derived by molecular simplification of phenylimidazo[4,5-g]quinolines.

I. Briguglio, R. Loddo, S. Piras, 2014, European journal of medicinal chemistry.

Synthesis, anti‐Mycobacterial, anti‐Trichomonas and anti‐Candida in vitro Activities of 2‐Substituted‐6,7‐difluoro‐3‐methylquinoxaline 1,4‐Dioxides.

S. Zanetti, L. Sechi, A. Carta, 2004 .

2,6-dialkylpiperazines. VIII (1)-N1-arylalkyl-N4-(2'-pyridyl)-2,6-dimethylpiperazines as adrenolytic and vasodilator agents.

G. Cignarella, M. Loriga, L. Dorigotti, 1977, Il Farmaco; edizione scientifica.

Synthesis and anti-picornaviridae in vitro activity of a new class of helicase inhibitors the N,N'-bis[4-(1H(2H)-benzotriazol-1(2)-yl)phenyl] alkyldicarboxamides.

M. Ferrone, M. Fermeglia, S. Pricl, 2007, Medicinal chemistry (Shariqah (United Arab Emirates)).

Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

Maria Paola Costi, Giuseppe Paglietti, Francisco Gamarro, 2008, Proceedings of the National Academy of Sciences.

Quinoxaline chemistry. Part 5. 2-(R)-benzylaminoquinoxalines as nonclassical antifolate agents. Synthesis and evaluation of in vitro anticancer activity.

M. Fiore, M. Loriga, G. Paglietti, 1996, Farmaco.

Quinoxaline chemistry. Part 4. 2(R)-anilinoquinoxalines as nonclassical antifolate agents. Synthesis, structure elucidation and evaluation of in vitro anticancer activity.

M. Fiore, M. Loriga, G. Paglietti, 1995, Farmaco.

Synthesis and evaluation of gastroprotective and antiulcer activity of some 2-substituted-1H-imidazo[4,5-b] pyridines and -1H-benzimidazoles.

M. V. Varoni, M. Demontis, S. Piras, 1992, Farmaco.

2-Arylbenzimidazoles as antiviral and antiproliferative agents--Part 2.

R. Loddo, P. Corona, P. la Colla, 2009, Medicinal chemistry (Shariqah (United Arab Emirates)).

2-Arylbenzimidazoles as antiviral and antiproliferative agents. Part 1.

R. Loddo, P. la Colla, A. Carta, 2008, Medicinal chemistry (Shariqah (United Arab Emirates)).

Quinoxaline chemistry. Part 6--Synthesis and evaluation of antiulcer and gastroprotective activity of 2-[arylmethylmercapto-, arylmethylsulfinyl-, piperazinyl-3-R-substituted]quinoxalines.

M. V. Varoni, M. Demontis, S. Piras, 1996, Il Farmaco.

Role of B1 Kinin Receptors in Pain Response in Low Kallikrein Wistar Rats

M. V. Varoni, M. Demontis, M. Loriga, 2006, Veterinary Research Communications.

Styrylbenzimidazoles. Synthesis and biological activity - part 3.

R. Loddo, P. Corona, G. Giliberti, 2010, Medicinal chemistry (Shariqah (United Arab Emirates)).

Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

Maria Paola Costi, W. Hunter, F. Gamarro, 2008, Proceedings of the National Academy of Sciences.

Structure-based selectivity optimization of piperidine-pteridine derivatives as potent Leishmania pteridine reductase inhibitors.

A. Cavalli, P. Michels, V. Hannaert, 2012, Journal of medicinal chemistry.