Kazunori Suzuki

发表

TAK-063, a phosphodiesterase 10A inhibitor, modulates neuronal activity in various brain regions in phMRI and EEG studies with and without ketamine challenge

Steven C. R. Williams, D. Cash, C. Simmons, 2016, Neuroscience.

TAK‐063, a novel PDE10A inhibitor with balanced activation of direct and indirect pathways, provides a unique opportunity for the treatment of schizophrenia

H. Kimura, Kazunori Suzuki, 2018, CNS neuroscience & therapeutics.

Translational Development Strategies for TAK-063, a Phosphodiesterase 10A Inhibitor

H. Kimura, K. Asin, Kazunori Suzuki, 2020, International Journal of Neuropsychopharmacology.

Balanced Activation of Striatal Output Pathways by Faster Off-Rate PDE10A Inhibitors Elicits Not Only Antipsychotic-Like Effects But Also Procognitive Effects in Rodents

Nidhi Kaushal, H. Kimura, Kazunori Suzuki, 2019, The international journal of neuropsychopharmacology.

Expression profile of BDNF-responsive genes during cerebellar granule cell development.

S. Nakanishi, Masaaki Sato, Kazunori Suzuki, 2006, Biochemical and biophysical research communications.

Characterization of the Third α-Amylase Inhibitor, αAI-3, in the Common Bean (Phaseolus vulgaris L.)

M. Ishimoto, Kazunori Suzuki, 1999 .

Growth Inhibitory Effect of an α-Amylase Inhibitor from the Wild Common Bean Resistant to the Mexican Bean Weevil (Zabrotes subfasciatus)

M. Ishimoto, K. Kitamura, Kazunori Suzuki, 1993 .

Oryzacystatins Exhibit Growth-inhibitory and Lethal Effects on Different Species of Bean Insect Pests, Callosobruchus chinensis (Coleoptera) and Riptortus clavatus (Hemiptera).

S. Arai, M. Ishimoto, K. Abe, 1996, Bioscience, biotechnology, and biochemistry.

Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A.

Christer Halldin, Vladimir Stepanov, Akihiro Takano, 2015, Nuclear medicine and biology.

Plant Regeneration and Chromosome Doubling of Wild Gladiolus Species

Kazunori Suzuki, T. Gonai, M. Kasumi, 2005 .

Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor.

Hironori Kokubo, Makoto Fushimi, Kosuke Nakashima, 2014, Journal of medicinal chemistry.

NMDA Receptor Stimulation and Brain-Derived Neurotrophic Factor Upregulate Homer 1a mRNA via the Mitogen-Activated Protein Kinase Cascade in Cultured Cerebellar Granule Cells

S. Nakanishi, Masaaki Sato, Kazunori Suzuki, 2001, The Journal of Neuroscience.

Interspecific Hybridization of Wild Gladiolus Species Using a Dendrogram Based on RAPD Analysis

E. Inoue, Tetsuya Yamada, Kazunori Suzuki, 2005 .

De Novo Mutations in PDE10A Cause Childhood-Onset Chorea with Bilateral Striatal Lesions

L. Vissers, J. Hardy, C. Davies, 2016, American journal of human genetics.

The Phosphodiesterase 10A Selective Inhibitor TAK-063 Improves Cognitive Functions Associated with Schizophrenia in Rodent Models

H. Kimura, N. Suzuki, Kazunori Suzuki, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Heme Oxygenase-1 Inhibits Atherosclerotic Lesion Formation in LDL-Receptor Knockout Mice

A. Lusis, D. Sugawara, H. Itabe, 2001, Circulation research.

In Vivo Pharmacological Characterization of TAK-063, a Potent and Selective Phosphodiesterase 10A Inhibitor with Antipsychotic-Like Activity in Rodents

Haruhide Kimura, Akina Harada, Kazunori Suzuki, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Oxygenase-1 Inhibits Atherosclerotic Lesion Formation in LDL-Receptor Knockout

D. Sugawara, H. Itabe, Xu-ping Wang, 2001 .

Neuronal Depolarization Controls Brain-Derived Neurotrophic Factor-Induced Upregulation of NR2C NMDA Receptor via Calcineurin Signaling

S. Nakanishi, Y. Morishima, Masaaki Sato, 2005, The Journal of Neuroscience.

Effects of photoperiod and temperature on termination of summer diapause in pupae of Antheraea yamamai

Kazunori Suzuki, Y. Kato, S. Sakate, 1982 .

Dietary intake of the citrus flavonoid hesperidin affects stress-resilience and brain kynurenine levels in a subchronic and mild social defeat stress model in mice

E. Inoue, A. Okuno, Atsushi Toyoda, 2019, Bioscience, biotechnology, and biochemistry.

Combined treatment with a selective PDE10A inhibitor TAK‐063 and either haloperidol or olanzapine at subeffective doses produces potent antipsychotic‐like effects without affecting plasma prolactin levels and cataleptic responses in rodents

M. Corsi, A. Ugolini, Clizia Capuani, 2017, Pharmacology research & perspectives.

TAK-063, a PDE10A Inhibitor with Balanced Activation of Direct and Indirect Pathways, Provides Potent Antipsychotic-Like Effects in Multiple Paradigms

M. Miyamoto, H. Kimura, Hirobumi Suzuki, 2016, Neuropsychopharmacology.

Phosphodiesterase 10A Inhibition Leads to Brain Region-Specific Recovery Based on Stroke Type

Morteza Dehghani, S. Carmichael, H. Kimura, 2020, Translational Stroke Research.

Preparation of an Inoculum of White Spot Syndrome Virus for Challenge Tests in Penaeus japonicus

T. Nishizawa, K. Muroga, M. Arimoto, 2002 .

Characterization of Binding and Inhibitory Properties of TAK-063, a Novel Phosphodiesterase 10A Inhibitor

Maki Miyamoto, Kosuke Nakashima, T. Taniguchi, 2015, PloS one.

Floral scent of wild Gladiolus species and the selection of breeding material for this character

M. Nakayama, Kazunori Suzuki, N. Oyama-Okubo, 2008 .

A pivotal role of calcineurin signaling in development and maturation of postnatal cerebellar granule cells.

S. Nakanishi, Masaaki Sato, Kazunori Suzuki, 2005, Proceedings of the National Academy of Sciences of the United States of America.

TAK-063, a Novel Phosphodiesterase 10A Inhibitor, Protects from Striatal Neurodegeneration and Ameliorates Behavioral Deficits in the R6/2 Mouse Model of Huntington’s Disease

H. Kimura, Kazunori Suzuki, A. Harada, 2017, The Journal of Pharmacology and Experimental Therapeutics.

CO2 Reduction Promoted by Imidazole Supported on a Phosphonium-Type Ionic-Liquid-Modified Au Electrode at a Low Overpotential

H. Masuda, H. Yamaguchi, Go Iijima, 2018 .