Ruili Huang

发表

A Grid Algorithm for High Throughput Fitting of Dose-Response Curve Data

Ruili Huang, Yuhong Wang, Ajit Jadhav, 2010, Current chemical genomics.

Prediction of Cytochrome P450 Profiles of Environmental Chemicals with QSAR Models Built from Drug‐Like Molecules

Ruili Huang, Christopher P Austin, Raymond R Tice, 2012, Molecular informatics.

Dose-Response Modeling of High-Throughput Screening Data

Ruili Huang, Noel Southall, Fred Parham, 2009, Journal of biomolecular screening.

Predictive Models for Cytochrome P450 Isozymes Based on Quantitative High Throughput Screening Data

Ruili Huang, Menghang Xia, Christopher P. Austin, 2011, J. Chem. Inf. Model..

Tox21Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Chemicals and Drugs

Ruili Huang, Anton Simeonov, Menghang Xia, 2016, Front. Environ. Sci..

Scheme 1, Synthetic route to ML367 is a 2 step process

Ruili Huang, Menghang Xia, David J. Maloney, 2013 .

Pharmacogenomics of the National Cancer Institute’s 60-Tumor Cell Panel

Ruili Huang, David G. Covell, Anders Wallqvist, 2008 .

Structure Based Model for the Prediction of Phospholipidosis Induction Potential of Small Molecules

Ruili Huang, Menghang Xia, Christopher P. Austin, 2012, J. Chem. Inf. Model..

Perspectives on validation of high-throughput assays supporting 21st century toxicity testing.

Thomas Hartung, Ruili Huang, Raymond R Tice, 2013, ALTEX.

A Data Analysis Pipeline Accounting for Artifacts in Tox21 Quantitative High-Throughput Screening Assays

Ruili Huang, Raymond R Tice, Menghang Xia, 2015, Journal of biomolecular screening.

Chemoinformatic Analysis of NCI Preclinical Tumor Data: Evaluating Compound Efficacy from Mouse Xenograft Data, NCI-60 Screening Data, and Compound Descriptors

Ruili Huang, Anders Wallqvist, David G. Covell, 2007, J. Chem. Inf. Model..

Corrigendum to Performance of the BG1Luc ER TA method in a qHTS format.

Ruili Huang, Menghang Xia, David Allen, 2016, ALTEX.

Application of dynamic topic models to toxicogenomics data

Ruili Huang, Weida Tong, Zhichao Liu, 2016, BMC Bioinformatics.

The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform.

Ruili Huang, Christopher P Austin, Menghang Xia, 2010, Drug discovery today.

Predictive Modeling of Tox21 Data

Ruili Huang, Ruili Huang, 2019, Challenges and Advances in Computational Chemistry and Physics.

Evaluating Chemical Structure Similarity as an Indicator of Cellular Growth Inhibition

Ruili Huang, Narmada Thanki, Anders Wallqvist, 2006, J. Chem. Inf. Model..

A Quantitative High-Throughput Screening Data Analysis Pipeline for Activity Profiling.

Ruili Huang, Ruili Huang, 2016, Methods in molecular biology.

Paradigm Shift in Toxicity Testing and Modeling

Ruili Huang, Menghang Xia, Christopher P. Austin, 2012, The AAPS Journal.

The NCATS BioPlanet – An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics

Ruili Huang, Anton Simeonov, Rajarshi Guha, 2019, Front. Pharmacol..

Weighted feature significance: a simple, interpretable model of compound toxicity based on the statistical enrichment of structural features.

Ruili Huang, Christopher P Austin, Raymond R Tice, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

Predictive Models to Identify Small Molecule Activators and Inhibitors of Opioid Receptors

Ruili Huang, Anton Simeonov, Menghang Xia, 2021, J. Chem. Inf. Model..

Mining of high throughput screening database reveals AP-1 and autophagy pathways as potential targets for COVID-19 therapeutics

Ruili Huang, Anton Simeonov, Menghang Xia, 2020, Scientific Reports.

An Integrated Systems Biology Approach Identifies the Proteasome as A Critical Host Machinery for ZIKV and DENV Replication

Ruili Huang, Anton Simeonov, Menghang Xia, 2021, Genom. Proteom. Bioinform..

ehp CERAPP : Collaborative Estrogen Receptor Activity Prediction Project

Ruili Huang, Igor V. Tetko, Eva Bay Wedebye, 2016 .

CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity

Ruili Huang, Scott Boyer, Xin Hu, 2020, Environmental health perspectives.

A bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker.

Ruili Huang, Christopher P Austin, Menghang Xia, 2008, Toxicology in vitro : an international journal published in association with BIBRA.

Detection of Phospholipidosis Induction

Ruili Huang, Christopher P Austin, Menghang Xia, 2014, Journal of biomolecular screening.

Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

Ruili Huang, Menghang Xia, David M. Reif, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel.

Ruili Huang, Christopher P Austin, Menghang Xia, 2009, Analytical biochemistry.

Cell-Based High-Throughput Screening for Aromatase Inhibitors in the Tox21 10K Library.

Ruili Huang, Raymond R Tice, Menghang Xia, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Quantitative High-Throughput Profiling of Environmental Chemicals and Drugs that Modulate Farnesoid X Receptor

Ruili Huang, Menghang Xia, Jui-Hua Hsieh, 2014, Scientific Reports.

Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memory

Ruili Huang, Christopher P Austin, Menghang Xia, 2009, Proceedings of the National Academy of Sciences.

Two High Throughput Screen Assays for Measurement of TNF-α in THP-1 Cells

Ruili Huang, Christopher P Austin, Menghang Xia, 2011, Current chemical genomics.

Identification of genotoxic compounds using isogenic DNA repair deficient DT40 cell lines on a quantitative high throughput screening platform.

Ruili Huang, Raymond R Tice, Menghang Xia, 2015, Mutagenesis.

Assessment of the DNA damaging potential of environmental chemicals using a quantitative high‐throughput screening approach to measure p53 activation

Ruili Huang, Menghang Xia, Junguk Hur, 2017, Environmental and molecular mutagenesis.

Identification of Thyroid Hormone Receptor Active Compounds Using a Quantitative High-Throughput Screening Platform

Ruili Huang, Menghang Xia, Keith Houck, 2014, Current chemical genomics and translational medicine.

Preparation of an elastomer with broad damping temperature range based on EPDM/ENR blend

Ruili Huang, Zhijie Jiang, Xun Lu, 2017 .

Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity.

Ruili Huang, Paul Shinn, Menghang Xia, 2010, Environmental science & technology.

The NCATS Pharmaceutical Collection: a 10-year update.

Ruili Huang, Paul Shinn, Anton Simeonov, 2019, Drug discovery today.

The Toxmatrix: Chemo-Genomic Profiling Identifies Interactions That Reveal Mechanisms of Toxicity.

Ruili Huang, Paul Shinn, Anton Simeonov, 2017, Chemical research in toxicology.

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

Ruili Huang, Misha Itkin, Paul Shinn, 2016, Nature Medicine.

Comprehensive Characterization of Cytochrome P450 Isozyme Selectivity across Chemical Libraries

Ruili Huang, Noel Southall, Christopher P. Austin, 2009, Nature Biotechnology.

Linking tumor cell cytotoxicity to mechanism of drug action: An integrated analysis of gene expression, small‐molecule screening and structural databases

Ruili Huang, Narmada Thanki, Anders Wallqvist, 2005, Proteins.

Expanding biological space coverage enhances the prediction of drug adverse effects in human using in vitro activity profiles

Ruili Huang, Anton Simeonov, Menghang Xia, 2018, Scientific Reports.

Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels.

Ruili Huang, Christopher P Austin, Raymond R Tice, 2011, Toxicology and applied pharmacology.

In Silico Prediction of hPXR Activators Using Structure-Based Pharmacophore Modeling.

Ruili Huang, Menghang Xia, Harutoshi Kato, 2017, Journal of pharmaceutical sciences.

Drug-Induced Rhabdomyolysis Atlas (DIRA) for idiosyncratic adverse drug reaction management.

Ruili Huang, Weida Tong, Menglong Li, 2019, Drug Discovery Today.

Profiling of the Tox21 Chemical Collection for Mitochondrial Function to Identify Compounds that Acutely Decrease Mitochondrial Membrane Potential

Ruili Huang, Sam Michael, Anton Simeonov, 2014, Environmental health perspectives.

Discovery of Transcriptional Targets Regulated by Nuclear Receptors Using a Probabilistic Graphical Model.

Ruili Huang, Weida Tong, Mikyung Lee, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor.

Ruili Huang, Menghang Xia, Kamel Mansouri, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies

Ruili Huang, Anton Simeonov, Menghang Xia, 2018, Environmental health perspectives.

Anticancer medicines in development: assessment of bioactivity profiles within the National Cancer Institute anticancer screening data

Ruili Huang, Anders Wallqvist, D. Covell, 2007, Molecular Cancer Therapeutics.

Why are most phospholipidosis inducers also hERG blockers?

Ruili Huang, Menghang Xia, Jinghua Zhao, 2017, Archives of Toxicology.

Targeting changes in cancer: assessing pathway stability by comparing pathway gene expression coherence levels in tumor and normal tissues

Ruili Huang, Anders Wallqvist, D. Covell, 2006, Molecular Cancer Therapeutics.

Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors

Ruili Huang, Paul Shinn, Menghang Xia, 2011, Environmental health perspectives.

Identification of small molecule compounds that inhibit the HIF-1 signaling pathway

Ruili Huang, Christopher P Austin, Menghang Xia, 2009, Molecular Cancer.

Use of gradient laminating to prepare NR/ENR composites with excellent damping performance

Ruili Huang, Xun Lu, Rui Qin, 2018, Materials & Design.

A quantitative high-throughput screen for modulators of IL-6 signaling: a model for interrogating biological networks using chemical libraries.

Ruili Huang, Menghang Xia, Noel Southall, 2009, Molecular bioSystems.

Anticancer metal compounds in NCI's tumor-screening database: putative mode of action.

Ruili Huang, Anders Wallqvist, D. Covell, 2005, Biochemical pharmacology.

Application of a homogenous membrane potential assay to assess mitochondrial function.

Ruili Huang, Christopher P Austin, Raymond R Tice, 2012, Physiological genomics.

Drugs aimed at targeting characteristic karyotypic phenotypes of cancer cells

Ruili Huang, Anders Wallqvist, D. Covell, 2005, Molecular Cancer Therapeutics.

Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening.

Ruili Huang, Christopher P Austin, Menghang Xia, 2008, Chemical research in toxicology.

Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action.

Ruili Huang, Christopher P Austin, Paul Shinn, 2010, Biochemical pharmacology.

CERAPP: Collaborative Estrogen Receptor Activity Prediction Project

Ruili Huang, Igor V. Tetko, Eva Bay Wedebye, 2016, Environmental health perspectives.

Identification of chemical compounds that induce HIF-1alpha activity.

Ruili Huang, Christopher P Austin, Raymond R Tice, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

Using in Vitro High Throughput Screening Assays to Identify Potential Endocrine-Disrupting Chemicals

Ruili Huang, Menghang Xia, David M. Reif, 2012, Environmental health perspectives.

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death

Ruili Huang, Christopher P Austin, Raymond R Tice, 2012, Proceedings of the National Academy of Sciences.

The pilot phase of the NIH Chemical Genomics Center.

Ruili Huang, Sam Michael, Christopher P Austin, 2009, Current topics in medicinal chemistry.

Compound Cytotoxicity Profiling Using Quantitative High-Throughput Screening

Ruili Huang, Menghang Xia, Noel Southall, 2007, Environmental health perspectives.

Population-Based in Vitro Hazard and Concentration–Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study

Ruili Huang, Menghang Xia, Christopher P. Austin, 2015, Environmental health perspectives.

Identifying Compounds with Genotoxicity Potential Using Tox21 High-Throughput Screening Assays.

Ruili Huang, Raymond R Tice, Menghang Xia, 2019, Chemical research in toxicology.

Development and Validation of a Computational Model for Androgen Receptor Activity

Ruili Huang, Menghang Xia, David Allen, 2016, Chemical research in toxicology.

Predictive endocrine testing in the 21st century using in vitro assays of estrogen receptor signaling responses.

Ruili Huang, Menghang Xia, David M. Reif, 2014, Environmental science & technology.

Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair‐deficient chicken DT40 cell lines

Ruili Huang, Menghang Xia, Srilatha Sakamuru, 2011, Environmental and molecular mutagenesis.

Assessment of in vitro and in vivo activities in the National Cancer Institute's anticancer screen with respect to chemical structure, target specificity, and mechanism of action.

Ruili Huang, Anders Wallqvist, D. Covell, 2006, Journal of medicinal chemistry.

Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening.

Ruili Huang, Christopher P Austin, Wenwei Huang, 2009, Biochemistry.

Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model.

Ruili Huang, Christopher P Austin, Raymond R Tice, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Identification of Modulators That Activate the Constitutive Androstane Receptor From the Tox21 10K Compound Library

Ruili Huang, Menghang Xia, Srilatha Sakamuru, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Comprehensive analysis of pathway or functionally related gene expression in the National Cancer Institute's anticancer screen.

Ruili Huang, Anders Wallqvist, D. Covell, 2006, Genomics.

Mechanism Profiling of Hepatotoxicity Caused by Oxidative Stress Using Antioxidant Response Element Reporter Gene Assay Models and Big Data

Ruili Huang, Menghang Xia, Marlene T. Kim, 2015, Environmental health perspectives.

Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays

Ruili Huang, Paul Shinn, Anton Simeonov, 2015, PloS one.