P. Phuan

发表

Experimental Evaluation of Proposed Small-Molecule Inhibitors of Water Channel Aquaporin-1

C. Esteva‐Font, Byung-Ju Jin, Marc O. Anderson, 2016, Molecular Pharmacology.

Inhibition of Ca2+‐activated Cl− channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea

A. Verkman, J. Thiagarajah, W. Namkung, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cells*

A. Verkman, W. Namkung, P. Phuan, 2010, The Journal of Biological Chemistry.

Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1

A. Verkman, Marc O. Anderson, P. Phuan, 2016, Journal of enzyme inhibition and medicinal chemistry.

Combination potentiator ('co-potentiator') therapy for CF caused by CFTR mutants, including N1303K, that are poorly responsive to single potentiators.

A. Verkman, J. Son, W. Finkbeiner, 2018, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Small molecule screen yields inhibitors of pseudomonas homoserine lactone‐induced host responses

A. Verkman, J. Nguyen, P. Haggie, 2014, Cellular microbiology.

SYNERGY-BASED SMALL-MOLECULE SCREEN USING A HUMAN LUNG EPITHELIAL CELL LINE F508-CFTR CORRECTORS THAT AUGMENT VX-809 MAXIMAL EFFICACY

G. Lukács, A. Verkman, W. Finkbeiner, 2014 .

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G. Lukács, W. Finkbeiner, A. Roldán, 2014 .

Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ΔF508 cystic fibrosis transmembrane conductance regulator protein.

Dean J Tantillo, John M. Knapp, A S Verkman, 2012, Journal of medicinal chemistry.

A Small-molecule Screen Yields Idiotype-specific Blockers of Neuromyelitis Optica Immunoglobulin G Binding to Aquaporin-4*

A. Verkman, J. Bennett, Marc O. Anderson, 2012, The Journal of Biological Chemistry.

High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators.

A. Verkman, J. Son, M. Kurth, 2017, Journal of medicinal chemistry.

Synthesis and evaluation of tetrahydropyrazolopyridine inhibitors of anion exchange protein SLC26A4 (pendrin).

A. Verkman, J. Son, P. Haggie, 2019, Bioorganic & medicinal chemistry letters.

Small‐molecule CFTR activators increase tear secretion and prevent experimental dry eye disease

A. Verkman, M. Levin, P. Phuan, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Pharmacokinetics of Quinacrine Efflux from Mouse Brain via the P-glycoprotein Efflux Transporter

S. Prusiner, S. Ghaemmaghami, S. DeArmond, 2012, PloS one.

Inhibition of Ca 2 (cid:1) -activated Cl (cid:2) channels by gallotannins as a possible molecular basis for health beneﬁts of red wine and green tea

J. Thiagarajah, W. Namkung, A. Verkman, 2010 .

1-BENZYLSPIRO[PIPERIDINE-4,1'-PYRIDO[3,4-b]indole] 'co-potentiators' for minimal function CFTR mutants.

A. Verkman, J. Son, P. Haggie, 2020, European journal of medicinal chemistry.

Complement-dependent Cytotoxicity in Neuromyelitis Optica Requires Aquaporin-4 Protein Assembly in Orthogonal Arrays*

A. Verkman, J. Ratelade, Lukmanee Tradtrantip, 2012, The Journal of Biological Chemistry.

Affinity-matured ‘aquaporumab’ anti-aquaporin-4 antibody for therapy of seropositive neuromyelitis optica spectrum disorders

A. Verkman, J. Bennett, Lukmanee Tradtrantip, 2020, Neuropharmacology.

Potential Therapeutic Benefit of C1-Esterase Inhibitor in Neuromyelitis Optica Evaluated In Vitro and in an Experimental Rat Model

A. Verkman, Nithi Asavapanumas, Lukmanee Tradtrantip, 2014, PloS one.

Diuresis and reduced urinary osmolality in rats produced by small‐molecule UT‐A‐selective urea transport inhibitors

A. Verkman, C. Esteva‐Font, Marc O. Anderson, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Convenient preparation of naphthyridines from halopyridines: sequential Heck coupling and cyclization

M. Kozlowski, P. Phuan, 2001 .

Six-Membered Hetarenes with One Nitrogen or Phosphorus Atom

R. Streubel, J. A. Joule, F. Mathey, 2005 .

A priori theoretical prediction of selectivity in asymmetric catalysis: design of chiral catalysts by using quantum molecular interaction fields.

M. Kozlowski, James C Ianni, Venkatachalam Annamalai, 2006, Angewandte Chemie.

CFTR Activator Increases Intestinal Fluid Secretion and Normalizes Stool Output in a Mouse Model of Constipation

T. Ma, A. Verkman, J. Thiagarajah, 2016, Cellular and molecular gastroenterology and hepatology.

Enantioselective synthesis of binaphthyl polymers using chiral asymmetric phenolic coupling catalysts: oxidative coupling and tandem glaser/oxidative coupling.

M. Kozlowski, Xu Xie, P. Phuan, 2007, The Journal of organic chemistry.

Novel pathways for the formation of chiral binaphthyl polymers: oxidative asymmetric phenolic coupling alone and in tandem with the Glaser-Hay coupling.

M. Kozlowski, Xu Xie, P. Phuan, 2003, Angewandte Chemie.

Antihyperglycemic activities of cryptolepine analogues: an ethnobotanical lead structure isolated from Cryptolepis sanguinolenta.

P. Imbach, G. Reaven, D. Bierer, 1998, Journal of medicinal chemistry.

Fluorinated ΔF508-CFTR correctors and potentiators for PET imaging.

Danielle M. Solano, A. Verkman, M. Kurth, 2012, Bioorganic & medicinal chemistry letters.

ΔF508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles.

A. Verkman, D. Tantillo, M. Kurth, 2014, Bioorganic & medicinal chemistry letters.

Discriminating between cellular and misfolded prion protein by using affinity to 9-aminoacridine compounds.

F. Cohen, S. Prusiner, B. C. May, 2007, The Journal of general virology.

Nanomolar potency and metabolically stable inhibitors of kidney urea transporter UT-B.

A. Verkman, Marc O. Anderson, C. Yao, 2012, Journal of medicinal chemistry.

1,1-Difluoroethyl-substituted triazolothienopyrimidines as inhibitors of a human urea transport protein (UT-B): new analogs and binding model.

Y. Liu, A. Verkman, C. Esteva‐Font, 2013, Bioorganic & medicinal chemistry letters.

Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases.

A. Verkman, M. Levin, Sujin Lee, 2017, Journal of medicinal chemistry.

A small molecule screen identifies selective inhibitors of urea transporter UT-A.

A. Verkman, C. Esteva‐Font, Marc O. Anderson, 2013, Chemistry & biology.

Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation

L. Galietta, A. Verkman, M. Donowitz, 2017, Translational research : the journal of laboratory and clinical medicine.

Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A).

A. Verkman, Marc O. Anderson, L. Ferrera, 2017, Journal of medicinal chemistry.

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity

G. Lukács, N. Pedemonte, L. Galietta, 2019, Scientific Reports.

The aquaporin-4 water channel as a potential drug target in neurological disorders

Alex J. Smith, A. Verkman, Marc O. Anderson, 2017, Expert opinion on therapeutic targets.

Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide.

A. Verkman, P. Haggie, P. Phuan, 2016, Journal of the American Society of Nephrology : JASN.

Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis

A. Verkman, W. Finkbeiner, P. Haggie, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation.

A. Verkman, P. Haggie, Sujin Lee, 2018, JCI insight.

Biology of AQP4 and Anti‐AQP4 Antibody: Therapeutic Implications for NMO

A. Verkman, A. Verkman, Nithi Asavapanumas, 2013, Brain pathology.

Small‐molecule inhibitors of NMO‐IgG binding to aquaporin‐4 reduce astrocyte cytotoxicity in neuromyelitis optica

M. Papadopoulos, A. Verkman, S. Saadoun, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Anti–Aquaporin‐4 monoclonal antibody blocker therapy for neuromyelitis optica

M. Papadopoulos, A. Verkman, S. Saadoun, 2012, Annals of neurology.

Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product*♦

G. Lukács, A. Verkman, W. Finkbeiner, 2016, The Journal of Biological Chemistry.

C1q-targeted monoclonal antibody prevents complement-dependent cytotoxicity and neuropathology in in vitro and mouse models of neuromyelitis optica

A. Verkman, A. Rosenthal, M. Leviten, 2013, Acta Neuropathologica.

Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression

G. Lukács, A. Verkman, W. Finkbeiner, 2014, Science Translational Medicine.

Cell division modulates prion accumulation in cultured cells

F. Cohen, S. Prusiner, S. Ghaemmaghami, 2007, Proceedings of the National Academy of Sciences.

ABSOLUTE CONFIGURATION AND BIOLOGICAL PROPERTIES OF ENANTIOMERS OF CFTR INHIBITOR BPO-27.

J. Fettinger, A. Verkman, C. Yao, 2013, ACS medicinal chemistry letters.

Nanomolar-potency ‘co-potentiator’ therapy for cystic fibrosis caused by a defined subset of minimal function CFTR mutants

A. Verkman, W. Finkbeiner, P. Haggie, 2019, Scientific Reports.

CFTR modulator therapy for cystic fibrosis caused by the rare c.3700A>G mutation.

A. Verkman, W. Finkbeiner, P. Haggie, 2020, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Potentiators of Defective ΔF508–CFTR Gating that Do Not Interfere with Corrector Action

G. Lukács, A. Verkman, W. Finkbeiner, 2015, Molecular Pharmacology.

Benzopyrimido‐pyrrolo‐oxazine‐dione CFTR inhibitor (R)‐BPO‐27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins

A. Verkman, M. Donowitz, Jianyi Yin, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

ΔF508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter

G. Lukács, A. Verkman, W. Finkbeiner, 2018, SLAS discovery : advancing life sciences R & D.

Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters.

A. Verkman, C. Esteva‐Font, Marc O. Anderson, 2015, Biochimica et biophysica acta.

Cyanoquinolines with Independent Corrector and Potentiator Activities Restore ΔPhe508-Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Function in Cystic Fibrosis

John M. Knapp, G. Lukács, A. Verkman, 2011, Molecular Pharmacology.

Discovery, synthesis and structure-activity analysis of symmetrical 2,7-disubstituted fluorenones as urea transporter inhibitors.

A. Verkman, C. Esteva‐Font, Marc O. Anderson, 2015, MedChemComm.

Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration.

A. Verkman, Baoxue Yang, Marc O. Anderson, 2012, Journal of the American Society of Nephrology : JASN.

Is the A-ring of sparteine essential for high enantioselectivity in the asymmetric lithiation-substitution of N-Boc-pyrrolidine?

M. Kozlowski, J. Ianni, P. Phuan, 2004, Journal of the American Chemical Society.

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity

G. Lukács, N. Pedemonte, A. Verkman, 2019, Scientific Reports.

Functional fluorescently labeled bithiazole ΔF508-CFTR corrector imaged in whole body slices in mice.

A. Verkman, N. Derichs, J. Sutcliffe, 2011, Bioconjugate chemistry.

Synergy-Based Small-Molecule Screen Using a Human Lung Epithelial Cell Line Yields ΔF508-CFTR Correctors That Augment VX-809 Maximal Efficacy

G. Lukács, A. Verkman, P. Phuan, 2014, Molecular Pharmacology.

SYNERGY-BASED SMALL-MOLECULE SCREEN USING A HUMAN LUNG EPITHELIAL CELL LINE F508-CFTR CORRECTORS THAT AUGMENT VX-809 MAXIMAL EFFICACY

G. Lukács, A. Verkman, P. Phuan, 2014 .

Synthetic analogues of irlbacholine: a novel antifungal plant metabolite isolated from Irlbachia alata.

D. Bierer, T. Truong, P. Phuan, 1999, Journal of natural products.

Symposium Session Summaries

G. Lukács, A. Verkman, A. Verkman, 2014 .

1,1-Difluoroethyl-substituted triazolothienopyrimidines as inhibitors of a human urea transport protein (UT-B): new analogs and binding model.

Y. Liu, A. Verkman, C. Esteva‐Font, 2013, Bioorganic & medicinal chemistry letters.

Nanomolar potency and metabolically stable inhibitors of kidney urea transporter UT-B.

A. Verkman, Marc O. Anderson, C. Yao, 2012, Journal of medicinal chemistry.