C. Tsai

MLL-fusions, here we show that transcriptional-memory from cells-of-origin predicts AML patient survival and allows β-catenin independent transformation in MLL- CSCs-derived from hematopoietic stem cells (HSCs)-enriched LSK population but not myeloid-granulocyte progenitors. Mechanistically, β-caten

Amanda, B. Lenhard, B., 2017 .

Transcriptional memory from cells-of- origin overrides β -catenin requirement of MLL cancer stem cells

Boris Lenhard, Amanda J. Wilson, Magdalena Zarowiecki, 2017 .

Epigenetic therapies by targeting aberrant histone methylome in AML: molecular mechanisms, current preclinical and clinical development

C. So, C. Tsai, Chiou-Tsun Tsai, 2016, Oncogene.

Functional reconstruction of human AML reveals stem cell origin and vulnerability of treatment-resistant MLL-rearranged leukemia

B. Lenhard, G. Mufti, J. Zuna, 2021, Science Translational Medicine.

AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine

Pei-Ming Yang, Jung-Hsin Lin, Ting-Rong Chern, 2013, Oncotarget.

Metabolic targeting of HIF-1α potentiates the therapeutic efficacy of oxaliplatin in colorectal cancer

C. Shun, Tzu-Tang Wei, C. Tsai, 2019, Oncogene.

Amplification of mixed lineage leukemia gene perturbs hematopoiesis and cooperates with partial tandem duplication to induce acute myeloid leukemia

M. Caligiuri, C. So, J. Rane, 2017, Haematologica.