Jianing Zeng

发表

Antipeptide Immunocapture with In-Sample Calibration Curve Strategy for Sensitive and Robust LC-MS/MS Bioanalysis of Clinical Protein Biomarkers in Formalin-Fixed Paraffin-Embedded Tumor Tissues.

Yan J. Zhang, Rasa Santockyte, J. Mccarty, 2020, Analytical chemistry.

Post-pellet-digestion precipitation and solid phase extraction: A practical and efficient workflow to extract surrogate peptides for ultra-high performance liquid chromatography--tandem mass spectrometry bioanalysis of a therapeutic antibody in the low ng/mL range.

Naiyu Zheng, M. Arnold, A. Aubry, 2015, Journal of chromatography. A.

Calculation and mitigation of isotopic interferences in liquid chromatography-mass spectrometry/mass spectrometry assays and its application in supporting microdose absolute bioavailability studies.

Hao Jiang, Jian Wang, Jianing Zeng, 2012, Analytical chemistry.

Eliminating Preparation of Multi-Sample External Calibration Curves and Dilution of Study Samples using Multiple Isotopologue Reaction Monitoring (MIRM) Technique in Quantitative LC-MS/MS Bioanalysis.

Yan J. Zhang, R. Pillutla, Naiyu Zheng, 2019, Analytical chemistry.

Sensitivity-based analytical approaches to support human absolute bioavailability studies.

Jim X. Shen, Hao Jiang, X. Xu, 2014, Bioanalysis.

A rugged and accurate liquid chromatography-tandem mass spectrometry method for the determination of asunaprevir, an NS3 protease inhibitor, in plasma.

Hao Jiang, Jianing Zeng, Yuan-Qing Xia, 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

A highly sensitive and selective LC-MS/MS method to quantify asunaprevir, an HCV NS3 protease inhibitor, in human plasma in support of pharmacokinetic studies.

Hao Jiang, T. Garimella, T. Eley, 2016, Journal of pharmaceutical and biomedical analysis.

Multiplexed LC-MS/MS method for the simultaneous quantitation of three novel hepatitis C antivirals, daclatasvir, asunaprevir, and beclabuvir in human plasma.

Hao Jiang, T. Eley, B. He, 2015, Journal of pharmaceutical and biomedical analysis.

A validated LC-MS/MS method for the simultaneous determination of BMS-791325, a hepatitis C virus NS5B RNA polymerase inhibitor, and its metabolite in plasma.

Hao Jiang, Z. Ouyang, Yuan-qing Xia, 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

A convenient strategy for quantitative determination of drug concentrations in tissue homogenates using a liquid chromatography/tandem mass spectrometry assay for plasma samples.

Hao Jiang, Naiyu Zheng, Jianing Zeng, 2011, Analytical chemistry.

Fully validated LC-MS/MS assay for the simultaneous quantitation of coadministered therapeutic antibodies in cynomolgus monkey serum.

Hao Jiang, Jianing Zeng, Mark E Arnold, 2013, Analytical chemistry.

Innovative use of LC-MS/MS for simultaneous quantitation of neutralizing antibody, residual drug, and human immunoglobulin G in immunogenicity assay development.

R. Dodge, A. Allentoff, Hao Jiang, 2014, Analytical Chemistry.

An exploratory universal LC-MS/MS assay for bioanalysis of hinge region-stabilized human IgG4 mAbs in clinical studies.

Hao Jiang, Craig Titsch, M. Jemal, 2014, Bioanalysis.

LC-MS/MS bioanalysis of plasma 1, 14-tetradecanedioic acid and 1, 16-hexadecanedioic acid as candidate biomarkers for organic anion-transporting polypeptide mediated drug-drug interactions.

Yan J. Zhang, Rasa Santockyte, J. Gan, 2018, Bioanalysis.

Detection of Weak Organic Anion–Transporting Polypeptide 1B Inhibition by Probenecid with Plasma-Based Coproporphyrin in Humans

Yueping Zhang, T. Mariappan, Vinay K. Holenarsipur, 2020, Drug Metabolism and Disposition.

Full-scan high resolution accurate mass spectrometry (HRMS) in regulated bioanalysis: LC-HRMS for the quantitation of prednisone and prednisolone in human plasma.

T. Olah, Yuan-qing Xia, M. Jemal, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Critical reagent screening and characterization: benefits and approaches for protein biomarker assays by hybrid LC-MS.

Rasa Santockyte, Naiyu Zheng, Jianing Zeng, 2019, Bioanalysis.

Critical considerations for immunocapture enrichment LC-MS bioanalysis of protein therapeutics and biomarkers.

Naiyu Zheng, Yue Zhao, H. Gu, 2018, Bioanalysis.

Preclinical Characterization of Linrodostat Mesylate, a Novel, Potent, and Selective Oral Indoleamine 2,3-Dioxygenase 1 Inhibitor

J. Hunt, J. Gullo-Brown, A. Balog, 2020, Molecular Cancer Therapeutics.

Simultaneous determination of a selective adenosine 2A agonist, BMS-068645, and its acid metabolite in human plasma by liquid chromatography-tandem mass spectrometry--evaluation of the esterase inhibitor, diisopropyl fluorophosphate, in the stabilization of a labile ester-containing drug.

S. Unger, P. Crane, Naiyu Zheng, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

2019 White Paper on Recent Issues in Bioanalysis: Chromatographic Assays (Part 1 - Innovation in Small Molecules and Oligonucleotides & Mass Spectrometric Method Development Strategies for Large Molecule Bioanalysis).

C. Holliman, K. Bateman, T. Olah, 2019, Bioanalysis.

Recommendations for Validation of LC-MS/MS Bioanalytical Methods for Protein Biotherapeutics

Surinder Kaur, Jianing Zeng, Faye Vazvaei, 2014, The AAPS Journal.

Quantitation of a PEGylated protein in monkey serum by UHPLC-HRMS using a surrogate disulfide-containing peptide: A new approach to bioanalysis and in vivo stability evaluation of disulfide-rich protein therapeutics.

Yan J. Zhang, A. Allentoff, Naiyu Zheng, 2016, Analytica chimica acta.

Opportunities and challenges for hybrid immunoaffinity LC–MS approach for quantitative analysis of protein biomarkers

Yue Zhao, H. Gu, Jianing Zeng, 2018, Future science OA.

Fit-for-purpose protein biomarker assay validation strategies using hybrid immunocapture-liquid chromatography-tandem-mass spectrometry platform: Quantitative analysis of total soluble cluster of differentiation 73.

Yan J. Zhang, Long Yuan, Yue Zhao, 2020, Analytica chimica acta.

Determination of a neuroprotective agent (S)-(+)-BMS-204352 in human, rat and dog plasma by enantioselective liquid chromatography-tandem mass spectrometry.

N. Srinivas, H. Palme, M. Arnold, 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

UHPLC-MS/MS bioanalysis of urinary DHEA, cortisone and their hydroxylated metabolites as potential biomarkers for CYP3A-mediated drug-drug interactions.

F. LaCreta, Naiyu Zheng, Xuewen Ma, 2016, Bioanalysis.

Development and characterization of a pre-treatment procedure to eliminate human monoclonal antibody therapeutic drug and matrix interference in cell-based functional neutralizing antibody assays.

Hao Jiang, R. Dodge, Craig Titsch, 2015, Journal of immunological methods.

Practical and efficient strategy for evaluating oral absolute bioavailability with an intravenous microdose of a stable isotopically-labeled drug using a selected reaction monitoring mass spectrometry assay.

Hao Jiang, Jianing Zeng, Mark E Arnold, 2012, Analytical chemistry.

A sensitive and accurate liquid chromatography-tandem mass spectrometry method for quantitative determination of the novel hepatitis C NS5A inhibitor BMS-790052 (daclastasvir) in human plasma and urine.

Hao Jiang, M. Bifano, J. Ryan, 2012, Journal of chromatography. A.

Recommendations for Validation of LC-MS/MS Bioanalytical Methods for Protein Biotherapeutics

Yan J. Zhang, Jean W. Lee, F. Garofolo, 2014, The AAPS Journal.

Pharmacokinetics of 6‐hydroxybuspirone and its enantiomers administered individually or following buspirone administration in humans

R. Croop, R. Dockens, Jianing Zeng, 2007, Biopharmaceutics & drug disposition.

Bioanalysis of dried saliva spot (DSS) samples using detergent-assisted sample extraction with UHPLC-MS/MS detection.

Naiyu Zheng, M. Arnold, A. Aubry, 2016, Analytica chimica acta.

CYP2D6 CATALYZES 5-HYDROXYLATION OF 1-(2-PYRIMIDINYL)-PIPERAZINE, AN ACTIVE METABOLITE OF SEVERAL PSYCHOACTIVE DRUGS, IN HUMAN LIVER MICROSOMES

Mingshe Zhu, Donglu Zhang, Nirmala Raghavan, 2005, Drug Metabolism and Disposition.

Detection of Weak Organic Anion-Transporting Polypeptide (OATP) 1B Inhibition by Probenecid (PROB) with Plasma-Based Coproporphyrin in Humans

Yueping Zhang, T. Mariappan, Vinay K. Holenarsipur, 2020 .

Development of oral extended release formulations of 6‐hydroxybuspirone

Jianing Zeng, Peter Ferrie, Peter Timmins, 2012, Biopharmaceutics & drug disposition.

UHPLC-MS/MS bioanalysis of human plasma coproporphyrins as potential biomarkers for organic anion-transporting polypeptide-mediated drug interactions.

Kumar A. Shah, Yan J. Zhang, Rasa Santockyte, 2018, Bioanalysis.

Current advances and strategies towards fully automated sample preparation for regulated LC-MS/MS bioanalysis.

Hao Jiang, Naiyu Zheng, Jianing Zeng, 2014, Bioanalysis.

Cynomolgus Monkey as a Clinically Relevant Model to Study Transport Involving Renal Organic Cation Transporters: In Vitro and In Vivo Evaluation

A. D. Rodrigues, Hao Jiang, P. Marathe, 2015, Drug Metabolism and Disposition.

METABOLISM, PHARMACOKINETICS, AND PROTEIN COVALENT BINDING OF RADIOLABELED MAXIPOST (BMS-204352) IN HUMANS

R. Reeves, R. Krishna, R. Dai, 2005, Drug Metabolism and Disposition.

Improved liquid-liquid extraction with inter-well volume replacement dilution workflow and its application to quantify BMS-927711 in rat dried blood spots by UHPLC-MS/MS.

Naiyu Zheng, Jianing Zeng, Mark E Arnold, 2014, Journal of pharmaceutical and biomedical analysis.

Effective screening approach to select esterase inhibitors used for stabilizing ester-containing prodrugs analyzed by LC-MS/MS.

Naiyu Zheng, Jianing Zeng, Mark E Arnold, 2010, Bioanalysis.

The integration of ligand binding and LC-MS-based assays into bioanalytical strategies for protein analysis.

Yan J. Zhang, T. Olah, J. Zeng, 2014, Bioanalysis.

Determination of Real Time in Vivo Drug Receptor Occupancy for a Covalent Binding Drug as a Clinical Pharmacodynamic Biomarker by Immunocapture-LC-MS/MS.

Robert J. Neely, Yan J. Zhang, B. Warrack, 2019, Analytical chemistry.

Effect of dose and input rate on the brain penetration of BMS‐204352 following intravenous administration to rats

R. Krishna, N. Srinivas, H. Palme, 2002, Biopharmaceutics & drug disposition.

2017 White Paper on recent issues in bioanalysis: a global perspective on immunogenicity guidelines & biomarker assay performance (Part 3 - LBA: immunogenicity, biomarkers and PK assays).

Sam H Haidar, Lauren F. Stevenson, Barry van der Strate, 2017, Bioanalysis.

Esterase inhibitors as ester-containing drug stabilizers and their hydrolytic products: potential contributors to the matrix effects on bioanalysis by liquid chromatography/tandem mass spectrometry.

Naiyu Zheng, Jianing Zeng, Mark E Arnold, 2012, Rapid communications in mass spectrometry : RCM.

High-Throughput Therapeutic Antibody Interference-Free High-Resolution Mass Spectrometry Assay for Monitoring M-Proteins in Multiple Myeloma.

Z. Ouyang, Rasa Santockyte, Craig Titsch, 2020, Analytical chemistry.

Synthesis of a stable isotopically labeled universal surrogate peptide for use as an internal standard in LC-MS/MS bioanalysis of human IgG and Fc-fusion protein drug candidates.

A. Allentoff, C. Mapelli, V. Lee, 2014, Journal of labelled compounds & radiopharmaceuticals.

Semiquantification and Isotyping of Antidrug Antibodies by Immunocapture-LC/MS for Immunogenicity Assessment

Hao Jiang, Linlin Luo, Jianing Zeng, 2017 .

A simplified and completely automated workflow for regulated LC-MS/MS bioanalysis using cap-piercing direct sampling and evaporation-free solid phase extraction.

Naiyu Zheng, Jianing Zeng, Zheng Ouyang, 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

A rapid, accurate and robust UHPLC-MS/MS method for quantitative determination of BMS-927711, a CGRP receptor antagonist, in plasma in support of non-clinical toxicokinetic studies.

Naiyu Zheng, Jianing Zeng, Yuan-Qing Xia, 2013, Journal of pharmaceutical and biomedical analysis.

Overcoming interference with the detection of a stable isotopically labeled microtracer in the evaluation of beclabuvir absolute bioavailability using a concomitant microtracer approach

Hao Jiang, Craig Titsch, Barry Jones, 2017, Journal of pharmaceutical and biomedical analysis.

A rugged and accurate liquid chromatography-tandem mass spectrometry method for quantitative determination of BMS-790052 in plasma.

Hao Jiang, Jianing Zeng, Zheng Ouyang, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

IQ consortium perspective: complementary LBA and LC-MS in protein therapeutics bioanalysis and biotransformation assessment.

Jianing Zeng, Surinder Kaur, Kevin P Bateman, 2020, Bioanalysis.

"Center punch" and "whole spot" bioanalysis of apixaban in human dried blood spot samples by UHPLC-MS/MS.

Naiyu Zheng, Jianing Zeng, Yan Song, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

In-Sample Calibration Curve Using Multiple Isotopologue Reaction Monitoring of a Stable Isotopically Labeled Analyte for Instant LC-MS/MS Bioanalysis and Quantitative Proteomics.

Yan J. Zhang, R. Pillutla, Naiyu Zheng, 2019, Analytical chemistry.

Perspectives on exploring hybrid LBA/LC-MS approach for clinical immunogenicity testing.

Hao Jiang, H. Myler, R. Pillutla, 2019, Bioanalysis.

Application of in-sample calibration curve methodology for regulated bioanalysis: Critical considerations in method development, validation and sample analysis.

R. Pillutla, Long Yuan, Q. Ji, 2020, Journal of pharmaceutical and biomedical analysis.

Full-scan high resolution accurate mass spectrometry (HRMS) in regulated bioanalysis: LC-HRMS for the quantitation of prednisone and prednisolone in human plasma.

T. Olah, Yuan-qing Xia, M. Jemal, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Naiyu Zheng, M. Arnold, A. Aubry, 2015, Journal of chromatography. A.

Innovative use of LC-MS/MS for simultaneous quantitation of neutralizing antibody, residual drug, and human immunoglobulin G in immunogenicity assay development.

R. Dodge, A. Allentoff, Hao Jiang, 2014, Analytical chemistry.

2016 White Paper on recent issues in bioanalysis: focus on biomarker assay validation (BAV): (Part 2 - Hybrid LBA/LCMS and input from regulatory agencies).

Barry Jones, Jianing Zeng, An Song, 2016, Bioanalysis.

The integration of ligand binding and LC-MS-based assays into bioanalytical strategies for protein analysis.

Yan J. Zhang, T. Olah, Jianing Zeng, 2014, Bioanalysis.