H. Morton

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Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis

J. Archer, A. Hoerauf, D. Kempf, 2019, Science Translational Medicine.

Use of iodoacetylene as a dipolarphile in the synthesis of 5-iodoisoxazole derivatives.

Y. Ku, Y. Pu, T. Grieme, 2001, Organic letters.

L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor.

D. Denis, C. Chan, S. Charleson, 1989, Canadian journal of physiology and pharmacology.

Leukotrienes and Asthma

R. Dixon, J. Metzger, D. Riendeau, 1992 .

N-(Boc)-L-(2-Bromoallyl)-glycine: A versatile intermediate for the synthesis of optically active unnatural amino acids

H. Morton, M. Leanna, 1993 .

Therapeutic potential of 5-lipoxygenase inhibitors: the discovery and development of MK-886, a novel-mechanism leukotriene inhibitor

R. Dixon, C. Yoakim, C. Rouzer, 1992 .

Fractional conversion of thromboxane A2 and B2 to urinary 2,3-dinor-thromboxane B2 and 11-dehydrothromboxane B2 in the cynomolgus monkey.

C. Patrono, J. Rokach, J. Gillard, 1989, Biochimica et biophysica acta.

Synthesis of the C-13 side chain precursors of the 9-dihydrotaxane analogue ABT-271.

J. A. Demattei, P. Nichols, M. Rasmussen, 2000, Organic letters.

Synthesis, isolation, and characterization of ABT-578 equilibrium isomers

S. Chemburkar, H. Morton, M. Dhaon, 2007 .

The affinities of prostaglandin H2 and thromboxane A2 for their receptor are similar in washed human platelets.

J. Gillard, P. Halushka, T. Morinelli, 1988, Biochemical and biophysical research communications.

The enantioselective synthesis of the potent dopamine D1 agonist (1R,3S)-3-(1'-adamantyl)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran (A77636)

S. Didomenico, R. Perner, M. Deninno, 1992 .

Synthesis of A-79175: a second generation 5-lipoxygenase inhibitor

S. Chemburkar, Y. Ku, D. Dickman, 1997 .

Homoallylic chiral induction in the synthesis of 2,4-disubstituted tetrahydrofurans by iodoetherification. Synthetic scope and chiral induction mechanism

J. Springer, M. Labelle, Y. Guindon, 1988 .

Dimethylboron bromide and diphenylboron bromide. Acetal and ketal cleavage. Cleavage of MEM, MOM, and MTM ethers.

C. Yoakim, H. Morton, Yvan Quindon, 1983 .

Deoxygenation of sulfoxides with boron bromide reagents

H. Morton, J. G. Atkinson, Y. Giundon, 1984 .

The Enantioselective Synthesis of the Potent Dopamine D1 Agonist (1R, 3S)-3-(1′-Adamantyl)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2- benzopyran (A77636)

S. Didomenico, R. Perner, M. Deninno, 1993 .

Confirmation and prevention of halogen exchange: practical and highly efficient one-pot synthesis of dibromo- and dichloropyridazinones

Ji Zhang, J. Ji, H. Morton, 2006 .

Confirmation and Prevention of Halogen Exchange: Practical and Highly Efficient One-Pot Synthesis of Dibromo- and Dichloropyridazinones.

Ji Zhang, J. Ji, H. Morton, 2007 .

An efficient multikilogram synthesis of ABT-963 : A selective COX-2 inhibitor

F. A. Kerdesky, Ji Zhang, H. Morton, 2006 .

A practical and scaleable synthesis of A-224817.0, a novel nonsteroidal ligand for the glucocorticoid receptor.

S. King, Y. Ku, T. Grieme, 2003, The Journal of organic chemistry.

Development of a catalytic enantioselective conjugate addition of 1,3-dicarbonyl compounds to nitroalkenes for the synthesis of endothelin-A antagonist ABT-546. Scope, mechanism, and further application to the synthesis of the antidepressant rolipram.

S. King, D. Barnes, S. Wittenberger, 2002, Journal of the American Chemical Society.

Catalytic Enantioselective Conjugate Addition of 1,3-Dicarbonyl Compounds to Nitroalkenes

S. King, D. Barnes, S. Wittenberger, 1999 .

Synthesis of α-amino and α-alkoxy aldehydes via oxoammonium oxidation

T. Sowin, H. Morton, M. Leanna, 1992 .

A process for the preparation of 5-hydroxymethylthiazole

H. Morton, M. Leanna, 1995 .

.beta.-Acylvinyl anion equivalents: preparation of 1-lithio-3-(tert-butyldimethylsiloxy)-1,3-cyclohexadiene and its reaction with electrophiles

E. Piers, H. Morton, E. Piers*, 1979 .

Reaction of (trimethylstanyl)copper(I) reagents with α,β-acettylenic esters: Stereocontrolled synthesis of alkyl (E)- and (Z)-3-tribethylstannyl-2-alkenoates

E. Piers, H. Morton, J. Chong, 1989 .

Cleavage of carbonoxygen bonds. Dimethylboron bromide. A new reagent for ether cleavage

C. Yoakim, Y. Guindon, H. Morton, 1983 .

Synthesis of α-halomethyl ketones: Oxidative hydrolysis of vinyl halides

H. Morton, M. Leanna, 1993 .

Reaction of (trimethylstannyl) copper reagents with α, β-acetylenic esters

E. Piers, H. Morton, J. Chong, 1981 .

Stereoselective conjugate addition of lithium (phenylthio)(trimethylstannyl) cuprate to .alpha.,.beta.-acetylenic esters. Preparation of (E)- and (Z)-4-lithio-1,3-pentadienes and their reaction with electrophiles

E. Piers, H. Morton, 1980 .

Synthetic utility of chiral tetrahydrofurans: Preparation of (1R, 3R, 5S)-1, 3-dimethyl-2, 9-dioxabicyclo[3.3.1]nonane

Y. Guindon, H. Morton, S. Daigneault, 1986 .

Use of Iodoacetylene as a Dipolarophile in the Synthesis of 5-Iodoisoxazole Derivatives.

S. King, Y. Ku, Y. Pu, 2002 .

Seven-membered ring annulation and spiro-annulation processes via preparation and thermal rearrangement of β-(2-vinylcyclopropyl) α,β-unsaturated ketones

E. Piers, H. Morton, R. W. Thies, 1983 .

Stereoselective preparation of lithium phenylthio[2,2-dimethyl-cis-(and trans-)-3-vinylcyclopropyl]cuprates and their reaction with .beta.-iodocyclohexenones. Cope rearrangement of 3-(2,2-dimethyl-3-vinylcyclopropyl)-2-cyclohexen-1-ones

E. Piers, H. Morton, I. Nagakura, 1978 .

The stereospecific preparation of an hydroxyethylene isostere precursor via a novel piperidine-2,5-dione template

H. Morton, M. Leanna, D. Plata, 1991 .

Dimethylboron bromide--interconversion of protecting groups: preparation of MTM [(methylthio)methyl] ethers, O,S-acetals, and cyanomethyl ethers

Y. Guindon, H. Morton, 1985 .

Dimethylboron bromide and diphenylboron bromide: cleavage of acetals and ketals

C. Yoakim, Y. Guindon, H. Morton, 1984 .

Efficient asymmetric synthesis of ABT-594; a potent, orally effective analgesic

W. Arnold, S. King, M. Holladay, 1998 .

Efficient Asymmetric Synthesis of ABT-594; a Potent, Orally Effective Analgesic.

W. Arnold, S. King, M. Holladay, 1999 .

Symmetrical alkoxysilyl ethers. A new class of alcohol-protecting groups. Preparation of tert-butoxydiphenylsilyl ethers

C. Yoakim, J. Gillard, Y. Guindon, 1988 .

Preparation of ethyl 5(s),6-epoxy-3(r)-(methoxymethoxy)hexanoate: a key chiral intermediate for mevinolin and compactin.

C. Yoakim, M. Bernstein, Y. Guindon, 1985 .

New synthetic applications of dialkylboron halide reagents

C. Yoakim, Y. Girard, S. Berthiaume, 1988 .

Synthesis of N-(Tert-butoxycarbonyl)-3-(4-thiazoIyl)-L-alanine

L. Bhagavatula, T. Zydowsky, H. Morton, 1990 .

An Efficient Synthesis of an Angiotensin II Antagonist (A-81988)

B. Narayanan, S. Wittenberger, F. A. Kerdesky, 1993 .

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity

A. Hoerauf, D. Kempf, S. Ward, 2019, PLoS neglected tropical diseases.

MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes.

H E Morton, C. Rouzer, A. Ford-hutchinson, 1990, The Journal of biological chemistry.

(Trialkylstannyl)copper(I) reagents: preparation and reaction with α,β-unsaturated carbonyl systems. Preparation of β-trialkylstannyl α,β-unsaturated ketones

E. Piers, H. Morton, J. Chong, 1987 .

Synthesis of A-79175: A Second Generation 5-Lipoxygenase Inhibitor.

S. Chemburkar, Y. Ku, D. Dickman, 1997 .

Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents.

P. Suzdak, Michael D B Swedberg, R. Henry, 1999, Journal of medicinal chemistry.

Lithium phenylthio(trimethylstannyl)cuprate, a new reagent for conjugate addition of the Me3Sn group. The synthesis of β-trimethylstannyl-αβ-unsaturated ketones

E. Piers, H. Morton, E. Piers*, 1978 .

Thromboxane A2 and prostaglandin endoperoxide analogue effects on porcine renal blood flow.

A. Ford-hutchinson, J. Hadden, H. Morton, 1990, The American journal of physiology.

Catalytic Enantioselective Conjugate Addition of 1,3-Dicarbonyl Compounds to Nitroalkenes

S. King, D. Barnes, S. Wittenberger, 1999 .