Bing Zhang

发表

Targeting the subpocket in xanthine oxidase: Design, synthesis, and biological evaluation of 2-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives.

Bing Zhang, Xiwen Dai, Ziyang Bao, 2019, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of N-(3-cyano-1H-indol-5/6-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamides and 5-(6-oxo-1,6-dihydropyrimidin-2-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.

Jun Gao, Peng Zhang, R. Dai, 2021, European journal of medicinal chemistry.

Scaffold hopping of celastrol provides derivatives containing pepper ring, pyrazine and oxazole substructures as potent autophagy inducers against breast cancer cell line MCF-7.

Lei Zhang, Yan-hua Mou, Peng Zhang, 2022, European journal of medicinal chemistry.

Discovery of a Colon-Targeted Azo Prodrug of Tofacitinib through the Establishment of Colon-Specific Delivery Systems Constructed by 5-ASA-PABA-MAC and 5-ASA-PABA-Diamine for the Treatment of Ulcerative Colitis.

Qiushi Li, Yan-hua Mou, Ting-jian Zhang, 2022, Journal of medicinal chemistry.

Novel 3-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-1,2,4-oxadiazol-5(4H)-ones as promising xanthine oxidase inhibitors: Design, synthesis and biological evaluation.

Qian Zou, Jun Gao, Bing Zhang, 2019, Bioorganic chemistry.

Synthesis and biological evaluation of indole-3-carboxamide derivatives as antioxidant agents

Chun Hu, Zhe Jin, Qingguo Meng, 2019 .

Intramolecular hydrogen bond interruption and scaffold hopping of TMC-5 led to 2-(4-alkoxy-3-cyanophenyl)pyrimidine-4/5-carboxylic acids and 6-(4-alkoxy-3-cyanophenyl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones as potent pyrimidine-based xanthine oxidase inhibitors.

Ting-jian Zhang, M. Sun, Bing Zhang, 2021, European journal of medicinal chemistry.

Synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenylpyrimidine derivatives with 4-amino or 4-hydroxy as a pharmacophore element binding with xanthine oxidase active site.

Jun Gao, Ming Sun, Bing Zhang, 2021, Bioorganic & medicinal chemistry.

Thiazolidinedione-Based Structure Modification of Celastrol Provides Thiazolidinedione-Conjugated Derivatives as Potent Agents against Non-Small-Cell Lung Cancer Cells through a Mitochondria-Mediated Apoptotic Pathway.

Yan-hua Mou, Bing Zhang, Qing Mao, 2022, Journal of natural products.

Design, synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives as novel xanthine oxidase inhibitors.

Dan Liu, Bing Zhang, Xiwen Dai, 2019, European journal of medicinal chemistry.

Design, synthesis, and biological activity of a novel series of benzofuran derivatives against oestrogen receptor-dependent breast cancer cell lines.

Chun Hu, Zhe Jin, Li Jin, 2020, Bioorganic chemistry.

Design, synthesis and biological evaluation of 1-alkyl-5/6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.

Qian Zou, Jun Gao, Bing Zhang, 2020, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel FXIa inhibitors with 2-phenyl-1H-imidazole-5-carboxamide moiety as P1 fragment.

Yan-hua Mou, Jun Gao, Yan Y. Zhang, 2021, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of imidazolopyridone derivatives as novel BRD4 inhibitors.

Huibin Zhang, Jinpei Zhou, Yifei Yang, 2020, Bioorganic & medicinal chemistry.

Exploiting the 7-methylimidazo[1,5-a]pyrazin-8(7H)-one scaffold for the development of novel chemical inhibitors for Bromodomain and Extraterminal Domain (BET) family.

Huibin Zhang, Jinpei Zhou, Yifei Yang, 2019, Bioorganic chemistry.

Identification of 5-[5-cyano-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxamido] thiazole-4-carboxylic acid as a promising dual inhibitor of urate transporter 1 and xanthine oxidase.

Jun Gao, M. Sun, Bing Zhang, 2023, European journal of medicinal chemistry.