Qing Mao

发表

Targeting the subpocket in xanthine oxidase: Design, synthesis, and biological evaluation of 2-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives.

Bing Zhang, Xiwen Dai, Ziyang Bao, 2019, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of N-(3-cyano-1H-indol-5/6-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamides and 5-(6-oxo-1,6-dihydropyrimidin-2-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.

Jun Gao, Peng Zhang, R. Dai, 2021, European journal of medicinal chemistry.

Scaffold hopping of celastrol provides derivatives containing pepper ring, pyrazine and oxazole substructures as potent autophagy inducers against breast cancer cell line MCF-7.

Lei Zhang, Yan-hua Mou, Peng Zhang, 2022, European journal of medicinal chemistry.

Stereoselective synthesis of trifluoroethyl 3,2'-spirooxindole γ-lactam through the organocatalytic cascade reaction of 3-((2,2,2-trifluoroethyl)amino)indolin-2-one.

Bo Han, Gu Zhan, Qian Zhao, 2020, Organic & biomolecular chemistry.

Discovery of a Colon-Targeted Azo Prodrug of Tofacitinib through the Establishment of Colon-Specific Delivery Systems Constructed by 5-ASA-PABA-MAC and 5-ASA-PABA-Diamine for the Treatment of Ulcerative Colitis.

Qiushi Li, Yan-hua Mou, Ting-jian Zhang, 2022, Journal of medicinal chemistry.

Novel 3-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-1,2,4-oxadiazol-5(4H)-ones as promising xanthine oxidase inhibitors: Design, synthesis and biological evaluation.

Qian Zou, Jun Gao, Bing Zhang, 2019, Bioorganic chemistry.

Highly diastereoselective assembly of isoxazole and trifluoromethyl containing spiro[pyrrolidin-oxindoles] from N-2,2,2-trifluoroethyl-substituted isatin imines and styrylisoxazoles

Wei Huang, Qian Zhao, Qing Mao, 2021 .

Amine-catalyzed and functional group-controlled chemo- and regioselective synthesis of multi-functionalized CF3-benzene via a metal-free process

Gu He, Bo Han, Wei Huang, 2019, Green Chemistry.

Intramolecular hydrogen bond interruption and scaffold hopping of TMC-5 led to 2-(4-alkoxy-3-cyanophenyl)pyrimidine-4/5-carboxylic acids and 6-(4-alkoxy-3-cyanophenyl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones as potent pyrimidine-based xanthine oxidase inhibitors.

Ting-jian Zhang, M. Sun, Bing Zhang, 2021, European journal of medicinal chemistry.

Synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenylpyrimidine derivatives with 4-amino or 4-hydroxy as a pharmacophore element binding with xanthine oxidase active site.

Jun Gao, Ming Sun, Bing Zhang, 2021, Bioorganic & medicinal chemistry.

Thiazolidinedione-Based Structure Modification of Celastrol Provides Thiazolidinedione-Conjugated Derivatives as Potent Agents against Non-Small-Cell Lung Cancer Cells through a Mitochondria-Mediated Apoptotic Pathway.

Yan-hua Mou, Bing Zhang, Qing Mao, 2022, Journal of natural products.

Construction of CF3-Functionalized Fully Substituted Benzonitriles through Rauhut-Currier Reaction Initiated [3 + 3] Benzannulation.

Bo Han, Cheng Peng, Gu Zhan, 2021, The Journal of organic chemistry.

Design, synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives as novel xanthine oxidase inhibitors.

Dan Liu, Bing Zhang, Xiwen Dai, 2019, European journal of medicinal chemistry.

NHC-catalysed retro-aldol/aldol cascade reaction enabling solvent-controlled stereodivergent synthesis of spirooxindoles

Gu Zhan, Wei Huang, Qian Zhao, 2021 .

Design, synthesis and biological evaluation of 1-alkyl-5/6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.

Qian Zou, Jun Gao, Bing Zhang, 2020, European journal of medicinal chemistry.

Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways

Qinglin Jiang, Cheng Peng, Wei Huang, 2020, International journal of molecular sciences.

Design, synthesis and biological evaluation of novel FXIa inhibitors with 2-phenyl-1H-imidazole-5-carboxamide moiety as P1 fragment.

Yan-hua Mou, Jun Gao, Yan Y. Zhang, 2021, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation.

Bo Han, Cheng Peng, Gu He, 2021, European journal of medicinal chemistry.

Identification of 5-[5-cyano-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxamido] thiazole-4-carboxylic acid as a promising dual inhibitor of urate transporter 1 and xanthine oxidase.

Jun Gao, M. Sun, Bing Zhang, 2023, European journal of medicinal chemistry.